Alex Gutteridge

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi request reprint Conformational change in substrate binding, catalysis and product release: an open and shut case?
    Alex Gutteridge
    EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    FEBS Lett 567:67-73. 2004
  2. ncbi request reprint Conformational changes observed in enzyme crystal structures upon substrate binding
    Alex Gutteridge
    European Bioinformatics Institute, EMBL Outstation Hinxton, Wellcome Trust Genome Campus, CB10 1SD Hinxton Cambridge, UK
    J Mol Biol 346:21-8. 2005
  3. ncbi request reprint Understanding nature's catalytic toolkit
    Alex Gutteridge
    EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Trends Biochem Sci 30:622-9. 2005
  4. ncbi request reprint Using a neural network and spatial clustering to predict the location of active sites in enzymes
    Alex Gutteridge
    EBI, Wellcome Trust Genome Campus, EMBL Outstation, Hinxton, Cambridgeshire CB10 1SD, UK
    J Mol Biol 330:719-34. 2003
  5. pmc Effective function annotation through catalytic residue conservation
    Richard A George
    Inpharmatica, 60 Charlotte Street, London W1T 2NU, United Kingdom
    Proc Natl Acad Sci U S A 102:12299-304. 2005
  6. pmc Prediction of drug-target interaction networks from the integration of chemical and genomic spaces
    Yoshihiro Yamanishi
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Bioinformatics 24:i232-40. 2008
  7. pmc MIMOX: a web tool for phage display based epitope mapping
    Jian Huang
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    BMC Bioinformatics 7:451. 2006

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Conformational change in substrate binding, catalysis and product release: an open and shut case?
    Alex Gutteridge
    EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
    FEBS Lett 567:67-73. 2004
    ..In some enzymes there is significant movement of the binding residues, usually on surface loops...
  2. ncbi request reprint Conformational changes observed in enzyme crystal structures upon substrate binding
    Alex Gutteridge
    European Bioinformatics Institute, EMBL Outstation Hinxton, Wellcome Trust Genome Campus, CB10 1SD Hinxton Cambridge, UK
    J Mol Biol 346:21-8. 2005
    ..Knowing the extent of induced fit in enzymes is important for our understanding of the principles of enzyme catalysis and also for improving ligand docking and structural template searching...
  3. ncbi request reprint Understanding nature's catalytic toolkit
    Alex Gutteridge
    EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Trends Biochem Sci 30:622-9. 2005
    ....
  4. ncbi request reprint Using a neural network and spatial clustering to predict the location of active sites in enzymes
    Alex Gutteridge
    EBI, Wellcome Trust Genome Campus, EMBL Outstation, Hinxton, Cambridgeshire CB10 1SD, UK
    J Mol Biol 330:719-34. 2003
    ..The method correctly identifies the putative active site in each case. In most cases the likely functional residues are identified correctly, as well as some potentially novel functional groups...
  5. pmc Effective function annotation through catalytic residue conservation
    Richard A George
    Inpharmatica, 60 Charlotte Street, London W1T 2NU, United Kingdom
    Proc Natl Acad Sci U S A 102:12299-304. 2005
    ....
  6. pmc Prediction of drug-target interaction networks from the integration of chemical and genomic spaces
    Yoshihiro Yamanishi
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Bioinformatics 24:i232-40. 2008
    ..Therefore, there is a strong incentive to develop new methods capable of detecting these potential drug-target interactions efficiently...
  7. pmc MIMOX: a web tool for phage display based epitope mapping
    Jian Huang
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    BMC Bioinformatics 7:451. 2006
    ..Most of the existing tools have not been implemented as an online service until now however, making it less convenient for the community to access, utilize, and evaluate them...