Elin Grundberg

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Global analysis of the impact of environmental perturbation on cis-regulation of gene expression
    Elin Grundberg
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS Genet 7:e1001279. 2011
  2. pmc Population genomics in a disease targeted primary cell model
    Elin Grundberg
    Department of Human Genetics, McGill University, Montreal H3A 1B1, Canada
    Genome Res 19:1942-52. 2009
  3. doi request reprint Global patterns of cis variation in human cells revealed by high-density allelic expression analysis
    Bing Ge
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Nat Genet 41:1216-22. 2009
  4. pmc Tissue effect on genetic control of transcript isoform variation
    Tony Kwan
    Department of Human Genetics, McGill University, Montreal, Canada
    PLoS Genet 5:e1000608. 2009
  5. pmc Targeted screening of cis-regulatory variation in human haplotypes
    Dominique J Verlaan
    Department of Human Genetics, McGill University, Montreal H3A 1B1, Canada
    Genome Res 19:118-27. 2009
  6. doi request reprint Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells
    Elin Grundberg
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Physiol Genomics 33:301-11. 2008
  7. ncbi request reprint Spectrum of mutations in MMACHC, allelic expression, and evidence for genotype-phenotype correlations
    Jordan P Lerner-Ellis
    Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada
    Hum Mutat 30:1072-81. 2009
  8. ncbi request reprint Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines
    Aabida Saferali
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Epigenetics 5:50-60. 2010
  9. doi request reprint Analysis of the impact of genetic variation on human gene expression
    Elin Grundberg
    Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, McGill University, Montreal, QC, Canada
    Methods Mol Biol 628:321-39. 2010
  10. pmc Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease
    Dominique J Verlaan
    McGill University and Genome Quebec Innovation Centre, Quebec, Canada
    Am J Hum Genet 85:377-93. 2009

Collaborators

Detail Information

Publications11

  1. pmc Global analysis of the impact of environmental perturbation on cis-regulation of gene expression
    Elin Grundberg
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS Genet 7:e1001279. 2011
    ..5%), but that detection of such specific interactions can be achieved by a combination of functional genomic approaches as described here...
  2. pmc Population genomics in a disease targeted primary cell model
    Elin Grundberg
    Department of Human Genetics, McGill University, Montreal H3A 1B1, Canada
    Genome Res 19:1942-52. 2009
    ..5, P = 2.6 x 10(-15)). Our results suggest that primary cells relevant to disease phenotypes complement traditional approaches for prioritization and validation of GWAS hits for follow-up studies...
  3. doi request reprint Global patterns of cis variation in human cells revealed by high-density allelic expression analysis
    Bing Ge
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Nat Genet 41:1216-22. 2009
    ..The dense collection of associations will facilitate large-scale isolation of cis-regulatory SNPs...
  4. pmc Tissue effect on genetic control of transcript isoform variation
    Tony Kwan
    Department of Human Genetics, McGill University, Montreal, Canada
    PLoS Genet 5:e1000608. 2009
    ....
  5. pmc Targeted screening of cis-regulatory variation in human haplotypes
    Dominique J Verlaan
    Department of Human Genetics, McGill University, Montreal H3A 1B1, Canada
    Genome Res 19:118-27. 2009
    ....
  6. doi request reprint Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells
    Elin Grundberg
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Physiol Genomics 33:301-11. 2008
    ..This resource will allow utilization of osteoblasts as a model to study specific gene networks and gene families related to human bone physiology and diseases...
  7. ncbi request reprint Spectrum of mutations in MMACHC, allelic expression, and evidence for genotype-phenotype correlations
    Jordan P Lerner-Ellis
    Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada
    Hum Mutat 30:1072-81. 2009
    ..Differential or preferential MMACHC transcript levels may provide a clue as to why individuals carrying c.394C>T generally present later in life...
  8. ncbi request reprint Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines
    Aabida Saferali
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Epigenetics 5:50-60. 2010
    ..We conclude that non-transformed primary cells may be less susceptible to epigenetic anomalies and therefore may provide a more accurate reflection of gene expression in vivo...
  9. doi request reprint Analysis of the impact of genetic variation on human gene expression
    Elin Grundberg
    Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, McGill University, Montreal, QC, Canada
    Methods Mol Biol 628:321-39. 2010
    ..We discuss the general approach and critical considerations for carrying out expression quantitative trait mapping in human tissues...
  10. pmc Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease
    Dominique J Verlaan
    McGill University and Genome Quebec Innovation Centre, Quebec, Canada
    Am J Hum Genet 85:377-93. 2009
    ..78 x 10(-8)). This study demonstrates the requirement of multiple parallel allele-specific tools for the investigation of noncoding disease variants and functional fine-mapping of human disease-associated haplotypes...
  11. pmc A genome-wide association study reveals variants in ARL15 that influence adiponectin levels
    J Brent Richards
    Departments of Medicine, Human Genetics, and Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000768. 2009
    ..Expression studies in humans indicated that ARL15 is well-expressed in skeletal muscle. These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk...