S G N Grant

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 4:5. 2008
  2. pmc Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro
    Erik J MacLaren
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    Mol Cell Neurosci 47:93-9. 2011
  3. pmc Homozygous mutation of focal adhesion kinase in embryonic stem cell derived neurons: normal electrophysiological and morphological properties in vitro
    P Charlesworth
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK
    BMC Neurosci 7:47. 2006
  4. pmc Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays
    Maksym V Kopanitsa
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    BMC Neurosci 7:61. 2006
  5. pmc Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes
    Tomás J Ryan
    Genes to Cognition Program, Wellcome Trust Sanger Institute, Cambridge, UK
    BMC Neurosci 9:6. 2008
  6. pmc Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation
    Sergei A Manakov
    European Bioinformatics Institute, Hinxton, Cambridge CB101SD, UK
    BMC Genomics 10:419. 2009
  7. pmc Automated design of genomic Southern blot probes
    Mike D R Croning
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    BMC Genomics 11:74. 2010
  8. doi request reprint A general basis for cognition in the evolution of synapse signaling complexes
    S G N Grant
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Cold Spring Harb Symp Quant Biol 74:249-57. 2009
  9. ncbi request reprint The synapse proteome and phosphoproteome: a new paradigm for synapse biology
    S G N Grant
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK
    Biochem Soc Trans 34:59-63. 2006
  10. ncbi request reprint Synapse signalling complexes and networks: machines underlying cognition
    Seth G N Grant
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB1D 1SA, UK
    Bioessays 25:1229-35. 2003

Collaborators

Detail Information

Publications59

  1. pmc Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 4:5. 2008
    ..In addition, we have compared staining of AMPArs with that for PSD-95, a major constituent of glutamatergic synapses. We also examined tissue from knock-out mice to confirm the validity of the immunostaining...
  2. pmc Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro
    Erik J MacLaren
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    Mol Cell Neurosci 47:93-9. 2011
    ..These data show multiple susceptibility genes for complex psychiatric disorders, regulate neural network physiology and demonstrate a new assay system with wide application...
  3. pmc Homozygous mutation of focal adhesion kinase in embryonic stem cell derived neurons: normal electrophysiological and morphological properties in vitro
    P Charlesworth
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK
    BMC Neurosci 7:47. 2006
    ..Here we report a study of focal adhesion kinase (FAK), which has been implicated in synapse formation and regulation of ion channels, using the ESN system to circumvent the embryonic lethality of homozygous FAK mutant mice...
  4. pmc Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays
    Maksym V Kopanitsa
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    BMC Neurosci 7:61. 2006
    ....
  5. pmc Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes
    Tomás J Ryan
    Genes to Cognition Program, Wellcome Trust Sanger Institute, Cambridge, UK
    BMC Neurosci 9:6. 2008
    ..Studies of rodent NMDA receptors show that the C-terminal intracellular domain forms a signalling complex with enzymes and scaffold proteins, which is important for neuronal and behavioural plasticity..
  6. pmc Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation
    Sergei A Manakov
    European Bioinformatics Institute, Hinxton, Cambridge CB101SD, UK
    BMC Genomics 10:419. 2009
    ..While specific microRNAs are known to be involved in neural development, the extent to which global microRNA and mRNA profiles are coordinately regulated in neural development is unknown...
  7. pmc Automated design of genomic Southern blot probes
    Mike D R Croning
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    BMC Genomics 11:74. 2010
    ..This is a labor intensive process often requiring several attempts to find a suitable probe for laboratory testing...
  8. doi request reprint A general basis for cognition in the evolution of synapse signaling complexes
    S G N Grant
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Cold Spring Harb Symp Quant Biol 74:249-57. 2009
    ..Mutations in genes encoding the complexes result in many human diseases of the nervous system. This general mechanism of cognition provides a useful template for studying evolution of behavior in all animals...
  9. ncbi request reprint The synapse proteome and phosphoproteome: a new paradigm for synapse biology
    S G N Grant
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK
    Biochem Soc Trans 34:59-63. 2006
    ..This review will highlight this change in knowledge and discuss current technical and interpretative limitations challenged by synapse proteomics...
  10. ncbi request reprint Synapse signalling complexes and networks: machines underlying cognition
    Seth G N Grant
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB1D 1SA, UK
    Bioessays 25:1229-35. 2003
    ..Supplementary material for this article can be found on the BioEssays website http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html...
  11. ncbi request reprint Toward a molecular catalogue of synapses
    Seth G N Grant
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, Cambridgeshire, UK
    Brain Res Rev 55:445-9. 2007
    ..A case will be made for developing approaches that can be used to generate a general catalogue of synapse types based on molecular markers, which should have wide application...
  12. ncbi request reprint Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases
    Seth G N Grant
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK
    Hum Mol Genet 14:R225-34. 2005
    ..genes2cognition.org) that links human and mouse genetics with proteomic studies...
  13. pmc Neurotransmitters drive combinatorial multistate postsynaptic density networks
    Marcelo P Coba
    Genes to Cognition, Wellcome Trust Sanger Institute, Cambridgeshire, UK
    Sci Signal 2:ra19. 2009
    ..These combinatorial networks confer high information-processing capacity and functional diversity on synapses, and their elucidation may provide new insights into disease mechanisms and new opportunities for drug discovery...
  14. pmc Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins
    Esperanza Fernandez
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Cambridge, UK
    Mol Syst Biol 5:269. 2009
    ..This targeted TAP tagging strategy is generally applicable to mammalian proteomics and systems biology approaches to disease...
  15. ncbi request reprint Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry
    Mark O Collins
    The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
    Sci STKE 2005:pl6. 2005
    ..This strategy should be widely applicable to the characterization of protein phosphorylation in diverse tissues, organelles, and in cell culture...
  16. pmc Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus
    Marcelo P Coba
    Genes to Cognition, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    J Biol Chem 283:34101-7. 2008
    ..These data support a network model of postsynaptic integration where kinase signaling networks are recruited by differential synaptic activity and control both local synaptic events and activity-dependent gene expression...
  17. pmc Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies
    Peter C Cuthbert
    Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom
    J Neurosci 27:2673-82. 2007
    ..This provides a mechanism for discriminating patterns of synaptic activity that lead to long-lasting changes in synaptic strength as well as distinct aspects of cognition in the mammalian nervous system...
  18. pmc The role of neuronal complexes in human X-linked brain diseases
    Frederic Laumonnier
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, UK
    Am J Hum Genet 80:205-20. 2007
    ..We propose that systematic studies of PSD and NRC/MASC genes in mice and humans will give a high yield of novel genes important for human disease and new mechanistic insights into higher cognitive functions...
  19. pmc Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent
    Douglas Strathdee
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom Centre for Neuroscience Research, University of Edinburgh, Edinburgh, Scotland
    PLoS ONE 1:e4. 2006
    ..A single copy of the DNA construct can be inserted by targeting into regions of chromatin that allow the desired developmental and tissue-specific expression of the transgene...
  20. ncbi request reprint Organization of brain complexity--synapse proteome form and function
    A J Pocklington
    Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
    Brief Funct Genomic Proteomic 5:66-73. 2006
    ..This pointed to simple design principles underlying synaptic organisation. Drawing together the results of proteomic and analytical study, we sketch out a model for synaptic functional organisation...
  21. pmc Network activity-independent coordinated gene expression program for synapse assembly
    Luis M Valor
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 104:4658-63. 2007
    ..Thus, two distinct sequentially active gene expression programs underlie the genomic programs of synapse function...
  22. ncbi request reprint Integrating synapse proteomics with transcriptional regulation
    L M Valor
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Behav Genet 37:18-30. 2007
    ..We discuss the need for global approaches combining genetics, transcriptomics and proteomics in order to understand cognitive function and disruption in diseases...
  23. pmc Clustered gene expression changes flank targeted gene loci in knockout mice
    Luis M Valor
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    PLoS ONE 2:e1303. 2007
    ..Gene expression profiling using microarrays is a powerful technology widely used to study regulatory networks. Profiling of mRNA levels in mutant organisms has the potential to identify genes regulated by the mutated protein...
  24. ncbi request reprint Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome
    Mark O Collins
    Genes to Cognition, The Wellcome Trust Sanger Institute, Hinxton, UK
    J Neurochem 97:16-23. 2006
    ..These synapse proteome data sets offer a basis for future research in synaptic biology and will provide useful information in brain disease and mental disorder studies...
  25. doi request reprint Neuroproteomics: understanding the molecular organization and complexity of the brain
    Alex Bayes
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Nat Rev Neurosci 10:635-46. 2009
    ..Furthermore, neuroproteomics is contributing to the elucidation of disease mechanisms and is a powerful tool for the identification of biomarkers...
  26. pmc In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93
    Ilse Delint-Ramirez
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    J Neurosci 30:8162-70. 2010
    ..These data show critical roles for scaffold proteins and their interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes...
  27. doi request reprint Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder
    Mark O Collins
    Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, United Kingdom
    Mol Cell Proteomics 7:1331-48. 2008
    ..This supports the hypothesis that disordered regions in proteins allow kinases, phosphatases, and phosphorylation-dependent binding proteins to gain access to target sequences to regulate local protein conformation and activity...
  28. doi request reprint The origin and evolution of synapses
    Tomás J Ryan
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    Nat Rev Neurosci 10:701-12. 2009
    ..The phylogeny of the molecular components of the synapse provides a new model for studying synapse diversity and complexity, and their implications for brain evolution...
  29. ncbi request reprint The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data
    Henning Hermjakob
    European Bioinformatics Institute, EBI Hinxton, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Biotechnol 22:177-83. 2004
    ....
  30. ncbi request reprint Supramolecular signalling complexes in the nervous system
    M O Collins
    Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    Subcell Biochem 43:185-207. 2007
    ..In addition, we describe the characterisation of a number of multiprotein complexes associated with ion channels (NMDAR, P2X7 and Kir2) and GPCRs (5-HT2A/5-HT2C, D2 and mGluR5) and discuss common their common components and organisation...
  31. ncbi request reprint Proteomics in postgenomic neuroscience: the end of the beginning
    Jyoti Choudhary
    Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK
    Nat Neurosci 7:440-5. 2004
    ..The combination of proteomics with other global functional genomic approaches at the levels of genome and transcriptome, together with network biology, will provide important bridges between genes, physiology and pathology...
  32. pmc G2Cdb: the Genes to Cognition database
    Mike D R Croning
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 37:D846-51. 2009
    ..G2Cdb can be freely accessed at http://www.genes2cognition.org...
  33. pmc High throughput protein expression screening in the nervous system--needs and limitations
    Chris N G Anderson
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    J Physiol 575:367-72. 2006
    ..We review existing large-scale protein expression studies and the specific technical obstacles that need to be overcome before applying the scaling used in nucleic acid based approaches...
  34. doi request reprint The role of DNA copy number variation in schizophrenia
    Gloria W C Tam
    The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    Biol Psychiatry 66:1005-12. 2009
    ..Here, we review the major findings in the recent literature, which begin to unravel the genetic and biological architecture of this complex human neuropsychiatric disorder...
  35. pmc Evolutionary expansion and anatomical specialization of synapse proteome complexity
    Richard D Emes
    Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB, UK
    Nat Neurosci 11:799-806. 2008
    ..We propose that the evolution of synapse complexity around a core proto-synapse has contributed to invertebrate-vertebrate differences and to brain specialization...
  36. pmc NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840
    Jary Y Delgado
    Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
    J Neurosci 27:13210-21. 2007
    ..Together, our results show that GluR1 phosphorylation at T840 is regulated by NMDA receptor activation and suggest that decreases in GluR1 phosphorylation at T840 may have a role in LTD...
  37. pmc A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
    Francesca Zalfa
    Dipartimento di Biologia, Universita Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
    Nat Neurosci 10:578-87. 2007
    ..Through our functional analysis of this FMRP target we provide evidence that dysregulation of mRNA stability may contribute to the cognitive impairments in individuals with FXS...
  38. pmc Inhibition of the dopamine D1 receptor signaling by PSD-95
    Jingping Zhang
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
    J Biol Chem 282:15778-89. 2007
    ..These studies demonstrate a role for a glutamatergic scaffold in dopamine receptor signaling and trafficking and identify a new potential target for the modulation of abnormal dopaminergic function...
  39. ncbi request reprint Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn
    Shigeyuki Nada
    Department of Oncogene Research, Research Institute for Microbial Disease, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 278:47610-21. 2003
    ..These results suggest that PSD-93 serves as a membrane-anchored substrate of Fyn and plays a role in the regulation of Fyn-mediated modification of NMDA receptor function...
  40. ncbi request reprint SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor
    Noboru H Komiyama
    Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
    J Neurosci 22:9721-32. 2002
    ..A comparison of SynGAP and PSD-95 mutants suggests that PSD-95 couples NMDARs to multiple downstream signaling pathways with very different roles in LTP and learning...
  41. pmc Clustering of neuronal potassium channels is independent of their interaction with PSD-95
    Matthew N Rasband
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 159:663-72. 2002
    ..These data suggest that the primary function of PSD-95 at juxtaparanodes lies outside of its accepted role in mediating the high density clustering of Kv1 potassium channels at these sites...
  42. pmc Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling
    Michela Fagiolini
    Neuronal Circuit Development, Institute of Physical and Chemical Research, RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 100:2854-9. 2003
    ..Taken together, our results demonstrate that the cellular basis generating individual sensory response properties is separable in the developing neocortex...
  43. ncbi request reprint Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice
    Emer M Garry
    Division of Preclinical Veterinary Sciences, R D SVS, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    Curr Biol 13:321-8. 2003
    ..Disruption of CaM kinase II docking to the NMDA receptor and activation may be responsible for the lack of neuropathic behavioral reflex sensitization in PSD-95 mutant mice...
  44. ncbi request reprint Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms
    Patricio Opazo
    Department of Physiology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 23:3679-88. 2003
    ..Together, our results indicate that the role of PI3-kinase in LTP is not limited to its role as an upstream regulator of MAPK signaling but also includes signaling through ERK-independent pathways that regulate LTP induction...
  45. ncbi request reprint Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity
    Wei Dong Yao
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 41:625-38. 2004
    ..Our findings uncover a previously unappreciated role of PSD-95 in psychostimulant action and identify a molecular and cellular mechanism shared between drug-related plasticity and learning...
  46. ncbi request reprint Proteomic analysis of in vivo phosphorylated synaptic proteins
    Mark O Collins
    Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, UK
    J Biol Chem 280:5972-82. 2005
    ..These data substantially increase existing knowledge of synapse protein phosphorylation and support a model where the synapse phosphoproteome is functionally organized into a highly interconnected signaling network...
  47. ncbi request reprint Analyses of murine postsynaptic density-95 identify novel isoforms and potential translational control elements
    Matthew Bence
    Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Brain Res Mol Brain Res 133:143-52. 2005
    ..The variety of mRNA isoforms and regulatory elements identified provides for a high degree of diversity in the structure and function of PSD-95 proteins...
  48. ncbi request reprint Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development
    Karen Porter
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh UK
    Eur J Neurosci 21:351-62. 2005
    ..These data support the model that synaptic signalling complexes are heterogeneous and individual components show temporal and spatial specificity during development...
  49. ncbi request reprint Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines
    Hakan Toresson
    Division of Neuroscience, College of Medicine and Veterinary Medicine, University of Edinburgh, 1 George Square, Edinburgh, UK
    Eur J Neurosci 22:1793-8. 2005
    ....
  50. ncbi request reprint Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
    Niels Plath
    Molecular Neurobiology, Department of Biology Chemistry Pharmacy, Freie Universitat Berlin, 14195 Berlin, Germany
    Neuron 52:437-44. 2006
    ..In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage...
  51. ncbi request reprint Reconstructing protein complexes: from proteomics to systems biology
    J Douglas Armstrong
    School of Informatics, University of Edinburgh, Edinburgh, UK
    Proteomics 6:4724-31. 2006
    ..The techniques discussed are generally applicable and could be used to examine lists of proteins involved with the biological response to electric or magnetic fields...
  52. pmc The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour
    Andrew J Pocklington
    School of Informatics, Edinburgh University, Edinburgh, UK
    Mol Syst Biol 2:2006.0023. 2006
    ..These studies of synapse proteome organisation suggest that molecular networks with simple design principles underpin synaptic signalling properties with important roles in physiology, behaviour and disease...
  53. ncbi request reprint Neurone specific regulation of dendritic spines in vivo by post synaptic density 95 protein (PSD-95)
    Catherine A Vickers
    Department of Pre Clinical Veterinary Sciences, RDSVS Summerhall, University of Edinburgh, Edinburgh EH9 1QH, UK
    Brain Res 1090:89-98. 2006
    ..Thus, PSD-95 is an important regulator of neuronal structure as well as plasticity in vivo...
  54. pmc Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression
    Gordon W McLean
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, G61 1BD, United Kingdom
    Genes Dev 18:2998-3003. 2004
    ..However, increased keratinocyte cell death was observed after fak deletion in vitro and in vivo. Our work provides the first experimental proof implicating FAK in tumorigenesis, and this is associated with enhanced apoptosis...
  55. ncbi request reprint PDZ domain proteins: plug and play!
    Claire Nourry
    U119 INSERM and Institut Paoli Calmettes, Laboratory of Molecular Pharmacology, 27 Boulevard Lei Roure, 13009 Marseille, France
    Sci STKE 2003:RE7. 2003
    ....
  56. ncbi request reprint AMPA receptor trafficking and GluR1
    Seth G N Grant
    Science 310:234-5; author reply 234-5. 2005
  57. ncbi request reprint Putting tubby on the MAP
    Seth G N Grant
    Nat Genet 30:347-8. 2002
  58. ncbi request reprint Systems biology in neuroscience: bridging genes to cognition
    Seth G N Grant
    Division of Neuroscience, 1 George Square, Edinburgh EH8 9JZ, UK
    Curr Opin Neurobiol 13:577-82. 2003
    ..A neuroscience systems biology programme, organized as a consortium, is proposed...
  59. ncbi request reprint Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice
    Mark W Barnett
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:1355-65. 2006
    ....