Angelo Fortunato

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. ncbi Uncover genetic interactions in Caenorhabditis elegans by RNA interference
    Angelo Fortunato
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Cambridge, Hinxton, UK
    Biosci Rep 25:299-307. 2005
  2. ncbi Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Genet 38:896-903. 2006
  3. ncbi Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 7:R4. 2006
  4. ncbi Quantitative high-throughput analysis of synthetic genetic interactions in Caenorhabditis elegans by RNA interference
    Angelo Fortunato
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK and Molecular Medicine, Department of Neuroscience, University of Siena, Via A Moro n 5, 53100 Siena, Italy
    Genomics 93:392-6. 2009

Detail Information

Publications4

  1. ncbi Uncover genetic interactions in Caenorhabditis elegans by RNA interference
    Angelo Fortunato
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Cambridge, Hinxton, UK
    Biosci Rep 25:299-307. 2005
    ..In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner...
  2. ncbi Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Genet 38:896-903. 2006
    ..We propose that these genes function as general buffers of genetic variation and that these hub genes may act as modifier genes in multiple, mechanistically unrelated genetic diseases in humans...
  3. ncbi Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 7:R4. 2006
    ..As lin-35 is the worm ortholog of the mammalian tumor suppressor gene p105Rb, misregulation of RNAi may be important during human oncogenesis...
  4. ncbi Quantitative high-throughput analysis of synthetic genetic interactions in Caenorhabditis elegans by RNA interference
    Angelo Fortunato
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK and Molecular Medicine, Department of Neuroscience, University of Siena, Via A Moro n 5, 53100 Siena, Italy
    Genomics 93:392-6. 2009
    ..Fifteen synthetic genetic interactions of efl-1/E2F with the genes of chromosome III were detected, measured and ranked by statistical relevance...