Paul Flicek

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Ensembl's 10th year
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 38:D557-62. 2010
  2. pmc Cooperativity and rapid evolution of cobound transcription factors in closely related mammals
    Klara Stefflova
    Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK
    Cell 154:530-40. 2013
  3. pmc Ensembl 2013
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Nucleic Acids Res 41:D48-55. 2013
  4. pmc The functional spectrum of low-frequency coding variation
    Gabor T Marth
    Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Genome Biol 12:R84. 2011
  5. pmc Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
    Marilyn B Renfree
    The Australian Research Council Centre of Excellence in Kangaroo Genomics, Australia
    Genome Biol 12:R81. 2011
  6. pmc Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cell 148:335-48. 2012
  7. pmc Ensembl 2012
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Nucleic Acids Res 40:D84-90. 2012
  8. pmc Locus Reference Genomic sequences: an improved basis for describing human DNA variants
    Raymond Dalgleish
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Genome Med 2:24. 2010
  9. pmc A standard variation file format for human genome sequences
    Martin G Reese
    Omicia, 2200 Powell Street, Suite 525, Emeryville, CA 94608, USA
    Genome Biol 11:R88. 2010
  10. pmc Uncovering information on expression of natural antisense transcripts in Affymetrix MOE430 datasets
    Sebastian Oeder
    Institute of Medical Microbiology, Immunology and Hygiene Technical University Munich, Munich, Germany
    BMC Genomics 8:200. 2007

Collaborators

Detail Information

Publications62

  1. pmc Ensembl's 10th year
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 38:D557-62. 2010
    ....
  2. pmc Cooperativity and rapid evolution of cobound transcription factors in closely related mammals
    Klara Stefflova
    Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK
    Cell 154:530-40. 2013
    ....
  3. pmc Ensembl 2013
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Nucleic Acids Res 41:D48-55. 2013
    ..Ensembl data are accessible through the genome browser at http://www.ensembl.org and through other tools and programmatic interfaces...
  4. pmc The functional spectrum of low-frequency coding variation
    Gabor T Marth
    Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Genome Biol 12:R84. 2011
    ....
  5. pmc Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
    Marilyn B Renfree
    The Australian Research Council Centre of Excellence in Kangaroo Genomics, Australia
    Genome Biol 12:R81. 2011
    ..Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development...
  6. pmc Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cell 148:335-48. 2012
    ..Repeat-driven dispersal of CTCF binding is a fundamental, ancient, and still highly active mechanism of genome evolution in mammalian lineages...
  7. pmc Ensembl 2012
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Nucleic Acids Res 40:D84-90. 2012
    ..Of these, 55 species appear on the main Ensembl website and six species are provided on the Ensembl preview site (Pre!Ensembl; http://pre.ensembl.org) with preliminary support. The past year has also seen improvements across the project...
  8. pmc Locus Reference Genomic sequences: an improved basis for describing human DNA variants
    Raymond Dalgleish
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
    Genome Med 2:24. 2010
    ..Further information can be found on the LRG web site: http://www.lrg-sequence.org...
  9. pmc A standard variation file format for human genome sequences
    Martin G Reese
    Omicia, 2200 Powell Street, Suite 525, Emeryville, CA 94608, USA
    Genome Biol 11:R88. 2010
    ....
  10. pmc Uncovering information on expression of natural antisense transcripts in Affymetrix MOE430 datasets
    Sebastian Oeder
    Institute of Medical Microbiology, Immunology and Hygiene Technical University Munich, Munich, Germany
    BMC Genomics 8:200. 2007
    ..The ability to quantitatively assess changes in NAT expression for many different transcripts in multiple samples would facilitate our understanding of this relatively new class of RNA molecules...
  11. pmc The need for speed
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Genome Biol 10:212. 2009
    ..DNA sequence data are being produced at an ever-increasing rate. The Bowtie sequence-alignment algorithm uses advanced data structures to help data analysis keep pace with data generation...
  12. ncbi request reprint Sense from sequence reads: methods for alignment and assembly
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Methods 6:S6-S12. 2009
    ..We discuss the current algorithmic approaches and future directions of these fundamental tools and provide specific examples for some commonly used tools...
  13. pmc Gene prediction: compare and CONTRAST
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK
    Genome Biol 8:233. 2007
    ....
  14. pmc Ensembl 2008
    P Flicek
    European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Nucleic Acids Res 36:D707-14. 2008
    ..We have also introduced new comparative genomics-based data mining options and report on the continued development of our software infrastructure...
  15. pmc Ensembl 2011
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 39:D800-6. 2011
    ..Since our previous report, we have substantially improved the presentation and integration of both data of disease relevance and the regulatory state of different cell types...
  16. pmc Using several pair-wise informant sequences for de novo prediction of alternatively spliced transcripts
    Paul Flicek
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Genome Biol 7:S8.1-9. 2006
    ..MARS is able to use an arbitrary number of informant sequences and predicts a number of alternative transcripts at each gene locus...
  17. pmc Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Science 328:1036-40. 2010
    ..Our results reveal large interspecies differences in transcriptional regulation and provide insight into regulatory evolution...
  18. pmc Ensembl variation resources
    Yuan Chen
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    BMC Genomics 11:293. 2010
    ..Maximising the utility of the data requires that it be stored in an accessible manner that facilitates the integration of variation data with other genome resources such as gene annotation and comparative genomics...
  19. ncbi request reprint Ensembl 2014
    Paul Flicek
    European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD and Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nucleic Acids Res 42:D749-55. 2014
    ..Our REST service has been extended with additional support for comparative genomics and ontology information. Finally, we provide updated information about our methods for data access and resources for user training. ..
  20. pmc A database and API for variation, dense genotyping and resequencing data
    Daniel Rios
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    BMC Bioinformatics 11:238. 2010
    ..The 1000 Genomes Project and similar efforts in other species are challenging the methods previously used for storage and manipulation of such data necessitating the redesign of existing genome-wide bioinformatics resources...
  21. pmc A CTCF-independent role for cohesin in tissue-specific transcription
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genome Res 20:578-88. 2010
    ....
  22. pmc Latent regulatory potential of human-specific repetitive elements
    MICHELLE C WARD
    University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge CB2 0RE, UK
    Mol Cell 49:262-72. 2013
    ..This study reveals the latent regulatory potential of the repetitive human genome and illustrates the species specificity of mechanisms that control it...
  23. pmc eHive: an artificial intelligence workflow system for genomic analysis
    Jessica Severin
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    BMC Bioinformatics 11:240. 2010
    ..The number of calculations required for this task grows approximately quadratically with the number of species. We currently support 50 species in Ensembl and we expect the number to continue to grow in the future...
  24. pmc Consistent annotation of gene expression arrays
    Benoit Ballester
    European Bioinformatics Institute EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    BMC Genomics 11:294. 2010
    ....
  25. pmc A map of human genome variation from population-scale sequencing
    Richard M Durbin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Nature 467:1061-73. 2010
    ..These methods and public data will support the next phase of human genetic research...
  26. pmc Insights into hominid evolution from the gorilla genome sequence
    Aylwyn Scally
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nature 483:169-75. 2012
    ..The use of the genome sequence in these and future analyses will promote a deeper understanding of great ape biology and evolution...
  27. ncbi request reprint WiggleTools: parallel processing of large collections of genome-wide datasets for visualization and statistical analysis
    Daniel R Zerbino
    European Molecular Biology Laboratory, European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Bioinformatics 30:1008-9. 2014
    ....
  28. pmc A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis
    Thomas A Down
    Wellcome Trust Cancer Research UK Gurdon Institute, and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Biotechnol 26:779-85. 2008
    ....
  29. pmc Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor
    William McLaren
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Bioinformatics 26:2069-70. 2010
    ..In Ensembl, a web-based tool (the SNP Effect Predictor) and API interface can now functionally annotate variants in all Ensembl and Ensembl Genomes supported species...
  30. pmc The variant call format and VCFtools
    Petr Danecek
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Bioinformatics 27:2156-8. 2011
    ..VCFtools is a software suite that implements various utilities for processing VCF files, including validation, merging, comparing and also provides a general Perl API...
  31. pmc Extensive compensatory cis-trans regulation in the evolution of mouse gene expression
    Angela Goncalves
    European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2376-84. 2012
    ..We propose that expression levels of genes regulated by this mechanism are fine-tuned by cis variants that arise following regulatory changes in trans, suggesting that many cis variants are not the primary targets of natural selection...
  32. pmc nGASP--the nematode genome annotation assessment project
    Avril Coghlan
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Bioinformatics 9:549. 2008
    ..elegans genome. Predictions were compared to reference gene sets consisting of confirmed or manually curated gene models from WormBase...
  33. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
  34. ncbi request reprint The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
    Gautier Koscielny
    European Molecular Biology Laboratory, European Bioinformatics Institute EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Medical Research Council Harwell Mammalian Genetics Unit and Mary Lyon Centre, Harwell, Oxfordshire OX11 0RD, UK and Mouse Informatics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 42:D802-9. 2014
    ..As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases. ..
  35. ncbi request reprint Locus Reference Genomic: reference sequences for the reporting of clinically relevant sequence variants
    Jacqueline A L Macarthur
    European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, National Center for Biotechnology Information, Bethesda, MD 20894, USA, and Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Nucleic Acids Res 42:D873-8. 2014
    ..Currently >700 LRGs have been created, of which >400 are publicly available. The aim is to create an LRG for every locus with clinical implications. ..
  36. pmc The 1000 Genomes Project: data management and community access
    Laura Clarke
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Methods 9:459-62. 2012
    ..Members of the project data coordination center have developed and deployed several tools to enable widespread data access...
  37. pmc De novo assembly and genotyping of variants using colored de Bruijn graphs
    Zamin Iqbal
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 44:226-32. 2012
    ..Last, we estimate classical human leukocyte antigen (HLA) genotypes at HLA-B, the most variable gene in the human genome...
  38. pmc Considerations for the inclusion of 2x mammalian genomes in phylogenetic analyses
    Albert J Vilella
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK
    Genome Biol 12:401. 2011
    ..A response to 2x genomes - depth does matter by MC Milinkovitch, R Helaers, E Depiereux, AC Tzika and T Gabaldón. Genome Biol 2010, 11:R16...
  39. pmc Ensembl BioMarts: a hub for data retrieval across taxonomic space
    Rhoda J Kinsella
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Database (Oxford) 2011:bar030. 2011
    ..ensembl.org/biomart/martview/; http://plants.ensembl.org/biomart/martview/; http://protists.ensembl.org/biomart/martview/; http://fungi.ensembl.org/biomart/martview/; http://bacteria.ensembl.org/biomart/martview/...
  40. pmc Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level
    Alexander W Bruce
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    Genome Res 19:994-1005. 2009
    ..These relationships have never been reported in mammalian systems for any transcription factor...
  41. pmc Population genomics of human gene expression
    Barbara E Stranger
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 39:1217-24. 2007
    ..We also explore several methodologies that improve the current state of analysis of gene expression variation...
  42. ncbi request reprint Functional annotation of noncoding sequence variants
    Graham R S Ritchie
    1 European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK 2 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Nat Methods 11:294-6. 2014
    ..Here we present genome-wide annotation of variants (GWAVA), a tool that supports prioritization of noncoding variants by integrating various genomic and epigenomic annotations. ..
  43. ncbi request reprint The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
    Danielle Welter
    European Bioinformatics Institute EMBL EBI, European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA and Division of Policy, Communication and Education, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 42:D1001-6. 2014
    ..This article presents a number of recent improvements to the Catalog, including novel ways for users to interact with the Catalog and changes to the curation infrastructure...
  44. pmc DbVar and DGVa: public archives for genomic structural variation
    Ilkka Lappalainen
    European Bioinformatics Institute, Hinxton, CB10 1SD Cambridgeshire, UK
    Nucleic Acids Res 41:D936-41. 2013
    ..Additionally, we have made significant improvements in providing access to these data via web and FTP interfaces...
  45. doi request reprint Maps for the world of genomic medicine: the 2011 CSHL Personal Genomes meeting
    Xiangqun Zheng-Bradley
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Hum Mutat 33:1016-9. 2012
    ....
  46. ncbi request reprint Optimized design and assessment of whole genome tiling arrays
    Stefan Graf
    EMBL European Bioinformatics Institute, Hinxton, Cambridge, UK
    Bioinformatics 23:i195-204. 2007
    ..We have identified a number of design parameters to be optimized including uniqueness of the probe sequences within the whole genome, melting temperature and self-hybridization potential...
  47. pmc Finding and sharing: new approaches to registries of databases and services for the biomedical sciences
    Damian Smedley
    European Bioinformatics Institute, Genome Campus, Hinxton, Cambridgeshire, CB10 1SA
    Database (Oxford) 2010:baq014. 2010
    ..We expect such approaches will result in improved discovery, uptake and utilization of data resources. Database URL: http://www.casimir.org.uk/casimir_ddf...
  48. ncbi request reprint Evolution of transcription factor binding in metazoans - mechanisms and functional implications
    Diego Villar
    University of Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nat Rev Genet 15:221-33. 2014
    ..We then consider what might explain the differences in genome evolution between metazoan phyla and outline the conceptual and technological challenges facing this research field. ..
  49. pmc Variation in genome-wide mutation rates within and between human families
    Donald F Conrad
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Nat Genet 43:712-4. 2011
    ..These observations suggest considerable variation in mutation rates within and between families...
  50. pmc The landscape of histone modifications across 1% of the human genome in five human cell lines
    Christoph M Koch
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SA, United Kingdom
    Genome Res 17:691-707. 2007
    ..These results provide an overview of the functional relationship among histone modifications and gene expression in human cells...
  51. pmc An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)
    Vardhman K Rakyan
    Institute of Cell and Molecular Science, Barts and The London, London E1 2AT, United Kingdom
    Genome Res 18:1518-29. 2008
    ....
  52. pmc EGASP: the human ENCODE Genome Annotation Assessment Project
    Roderic Guigo
    Centre de Regulacio Genomica, Institut Municipal d Investigació Mèdica Universitat Pompeu Fabra, E08003 Barcelona, Catalonia, Spain
    Genome Biol 7:S2.1-31. 2006
    ..These annotations were not available to the prediction groups prior to the submission deadline, so that their predictions were blind and an external advisory committee could perform a fair assessment...
  53. pmc Gene finding in the chicken genome
    Eduardo Eyras
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Centre de Regulacio Genomica, E08003 Barcelona, Catalonia, Spain
    BMC Bioinformatics 6:131. 2005
    ..We used the chicken sequence to test comparative and homology-based gene-finding methods followed by experimental validation as an effective genome annotation method...
  54. ncbi request reprint Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
    ....
  55. pmc Leveraging the mouse genome for gene prediction in human: from whole-genome shotgun reads to a global synteny map
    Paul Flicek
    Department of Computer Science and Engineering, Washington University, St Louis, Missouri 63130, USA
    Genome Res 13:46-54. 2003
    ..Our human annotation using the mouse assembly is conservative, predicting only 25,622 genes, and appears to be one of the best de novo annotations of the human genome to date...
  56. pmc Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    Ewan Birney
    Nature 447:799-816. 2007
    ..Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function...
  57. pmc Genome analysis of the platypus reveals unique signatures of evolution
    Wesley C Warren
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 453:175-83. 2008
    ..Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation...
  58. doi request reprint SNP and haplotype mapping for genetic analysis in the rat
    Kathrin Saar
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strae 10, 13125 Berlin, Germany
    Nat Genet 40:560-6. 2008
    ..We provide a detailed SNP map and demonstrate its utility for mapping of quantitative trait loci. This community resource is openly available and augments the genetic tools for this workhorse of physiological studies...
  59. pmc TranscriptSNPView: a genome-wide catalog of mouse coding variation
    Fiona Cunningham
    Nat Genet 38:853. 2006
  60. pmc Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets
    David S Johnson
    Department of Genetics, Stanford University Medical Center, Stanford, California 94305, USA
    Genome Res 18:393-403. 2008
    ..The spike-in DNA samples and the data presented here provide a stable benchmark against which future ChIP platforms, protocol improvements, and analysis methods can be evaluated...
  61. ncbi request reprint Recommendations of the 2006 Human Variome Project meeting
    Richard G H Cotton
    Genomic Disorders Research Centre, St Vincent s Hospital Melbourne, 35 Victoria Parade, Melbourne, Victoria 3065, Australia
    Nat Genet 39:433-6. 2007
    ..Here we summarize the background of the project, the meeting and its recommendations...