Panagiotis Deloukas

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 5:e1000445. 2009
  2. pmc Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    J Neuroinflammation 6:22. 2009
  3. pmc Association of warfarin dose with genes involved in its action and metabolism
    Mia Wadelius
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, 751 85 Uppsala, Sweden
    Hum Genet 121:23-34. 2007
  4. pmc DNA sequence and structural properties as predictors of human and mouse promoters
    Pelin Akan
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Gene 410:165-76. 2008
  5. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
  6. pmc High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta
    Caroline Daelemans
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1 SA, UK
    BMC Genet 11:25. 2010
  7. pmc Data analysis issues for allele-specific expression using Illumina's GoldenGate assay
    Matthew E Ritchie
    Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia
    BMC Bioinformatics 11:280. 2010
  8. ncbi request reprint The HapMap project and its application to genetic studies of drug response
    P Deloukas
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK
    Pharmacogenomics J 4:88-90. 2004
  9. ncbi request reprint The DNA sequence and comparative analysis of human chromosome 10
    P Deloukas
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nature 429:375-81. 2004
  10. ncbi request reprint The DNA sequence and comparative analysis of human chromosome 20
    P Deloukas
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 414:865-71. 2001

Detail Information

Publications27

  1. pmc Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 5:e1000445. 2009
    ..Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height...
  2. pmc Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    J Neuroinflammation 6:22. 2009
    ....
  3. pmc Association of warfarin dose with genes involved in its action and metabolism
    Mia Wadelius
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, 751 85 Uppsala, Sweden
    Hum Genet 121:23-34. 2007
    ..Translation of this knowledge into clinical guidelines for warfarin prescription will be likely to have a major impact on the safety and efficacy of warfarin...
  4. pmc DNA sequence and structural properties as predictors of human and mouse promoters
    Pelin Akan
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Gene 410:165-76. 2008
    ..Interestingly, all mouse promoter sets showed ATG codon depletion irrespective of the presence of a TATA-box, possibly reflecting a weaker contribution to TSS specificity in mouse...
  5. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
    ..We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls...
  6. pmc High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta
    Caroline Daelemans
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1 SA, UK
    BMC Genet 11:25. 2010
    ..Using two allele-specific high-throughput technologies alongside bioinformatics predictions, normal term human placenta was screened to find new imprinted genes and to ascertain the extent of ASE in this tissue...
  7. pmc Data analysis issues for allele-specific expression using Illumina's GoldenGate assay
    Matthew E Ritchie
    Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia
    BMC Bioinformatics 11:280. 2010
    ..This platform exploits coding SNPs to obtain relative expression measurements for alleles at approximately 1500 positions in the genome...
  8. ncbi request reprint The HapMap project and its application to genetic studies of drug response
    P Deloukas
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK
    Pharmacogenomics J 4:88-90. 2004
  9. ncbi request reprint The DNA sequence and comparative analysis of human chromosome 10
    P Deloukas
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nature 429:375-81. 2004
    ..Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence...
  10. ncbi request reprint The DNA sequence and comparative analysis of human chromosome 20
    P Deloukas
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 414:865-71. 2001
    ....
  11. pmc DNA sequence and analysis of human chromosome 9
    S J Humphray
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 429:369-74. 2004
    ..We have also detected recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection...
  12. pmc The DNA sequence and analysis of human chromosome 13
    A Dunham
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Nature 428:522-8. 2004
    ..Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb...
  13. pmc Relative impact of nucleotide and copy number variation on gene expression phenotypes
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Science 315:848-53. 2007
    ..Interrogation of the genome for both types of variants may be an effective way to elucidate the causes of complex phenotypes and disease in humans...
  14. ncbi request reprint The DNA sequence and analysis of human chromosome 6
    A J Mungall
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 425:805-11. 2003
    ..Within the essential immune loci of the major histocompatibility complex, we find HLA-B to be the most polymorphic gene on chromosome 6 and in the human genome...
  15. ncbi request reprint The DNA sequence and biological annotation of human chromosome 1
    S G Gregory
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nature 441:315-21. 2006
    ....
  16. pmc Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies
    Ines Barroso
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Diabetes 57:3161-5. 2008
    ..We aimed to investigate whether data from a large-scale mapping approach would replicate this association in novel Ashkenazi samples and in U.K. populations and whether these data would allow us to refine the association signal...
  17. pmc Genetic variation in LIN28B is associated with the timing of puberty
    Ken K Ong
    Medical Research Council MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:729-33. 2009
    ..These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development...
  18. pmc LDL-cholesterol concentrations: a genome-wide association study
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Lancet 371:483-91. 2008
    ..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
  19. pmc Genome-wide associations of gene expression variation in humans
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 1:e78. 2005
    ..In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level...
  20. ncbi request reprint RNAi--prospects for a general technique for determining gene function
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK CB10 1SA
    Parasitol Today 16:347-9. 2000
    ....
  21. ncbi request reprint RNA-mediated interference as a tool for identifying drug targets
    N J O'Neil
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, England
    Am J Pharmacogenomics 1:45-53. 2001
    ..RNAi can also help to identify the biochemical mode of action of a drug or pesticide and to identify other genes encoding products that may respond or interact with specific compounds...
  22. pmc High-throughput genotyping of Salmonella enterica serovar Typhi allowing geographical assignment of haplotypes and pathotypes within an urban District of Jakarta, Indonesia
    Stephen Baker
    The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    J Clin Microbiol 46:1741-6. 2008
    ..The study also provides insight into the evolution of serovar Typhi and demonstrates the value of a molecular epidemiological technique that is exchangeable, that is internet friendly, and that has global utility...
  23. pmc Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    BMC Genet 8:24. 2007
    ..Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D...
  24. pmc A histone map of human chromosome 20q13.12
    Pelin Akan
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 4:e4479. 2009
    ..We present a systematic search for regulatory elements in a 3.5 Mb region on human chromosome 20q13.12, a region associated with a number of medical conditions such as type II diabetes and obesity...
  25. pmc A functional genomic analysis of cell morphology using RNA interference
    A A Kiger
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    J Biol 2:27. 2003
    ..With the advent of RNA-interference (RNAi) technology, it is now possible to screen systematically for genes controlling specific cell-biological processes, including those required to generate distinct morphologies...
  26. ncbi request reprint Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans
    B Sönnichsen
    Cenix BioScience GmbH, Tatzberg 47 51, D 01307 Dresden, Germany
    Nature 434:462-9. 2005
    ....
  27. ncbi request reprint Caenorhabditis elegans has scores of homoeobox-containing genes
    T R Burglin
    Department of Molecular Biology, Massachusetts General Hospital, Boston
    Nature 341:239-43. 1989
    ..We estimate that the number of homoeobox-containing genes in C. elegans is at least 60, constituting approximately 1% of the estimated total number of genes...