Peter J Campbell
Affiliation: Wellcome Trust Genome Campus
Lee Six H, Øbro N, Shepherd M, Grossmann S, Dawson K, Belmonte M, et al
. Population dynamics of normal human blood inferred from somatic mutations. Nature. 2018;561:473-478 pubmed publisher
..Harnessing naturally occurring mutations to report the clonal architecture of an organ enables the high-resolution reconstruction of somatic cell dynamics in humans. ..
Bolli N, Maura F, Minvielle S, Gloznik D, Szalat R, Fullam A, et al
. Genomic patterns of progression in smoldering multiple myeloma. Nat Commun. 2018;9:3363 pubmed publisher
..These results provide a unique insight into myelomagenesis with potential implications for the definition of smoldering disease and timing of treatment initiation. ..
Mitchell T, Turajlic S, Rowan A, Nicol D, Farmery J, O Brien T, et al
. Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal. Cell. 2018;173:611-623.e17 pubmed publisher
..Early development of ccRCC follows well-defined evolutionary trajectories, offering opportunity for early intervention. ..
Campbell P. Somatic and germline genetics at the JAK2 locus. Nat Genet. 2009;41:385-6 pubmed
..A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus. ..
Martincorena I, Campbell P. Somatic mutation in cancer and normal cells. Science. 2015;349:1483-9 pubmed publisher
..We briefly summarize a number of the lessons learned over 5 years of cancer genome sequencing and discuss their implications for our understanding of cancer progression and aging. ..
Meier B, Cooke S, Weiss J, Bailly A, Alexandrov L, Marshall J, et al
. C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Genome Res. 2014;24:1624-36 pubmed publisher
..Thus, experimental model systems combined with genome sequencing can recapture and mechanistically explain mutational signatures associated with human disease. ..
Maciejowski J, Li Y, Bosco N, Campbell P, de Lange T. Chromothripsis and Kataegis Induced by Telomere Crisis. Cell. 2015;163:1641-54 pubmed publisher
..We propose that chromothripsis in human cancer may arise through TREX1-mediated fragmentation of dicentric chromosomes formed in telomere crisis. ..
Shlien A, Raine K, Fuligni F, Arnold R, Nik Zainal S, Dronov S, et al
. Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer. Cell Rep. 2016;16:2032-46 pubmed publisher
..Systematic integration of transcriptome with genome data reveals the rules by which transcriptional machinery interprets somatic mutation. ..
Campbell P. Cliques and Schisms of Cancer Genes. Cancer Cell. 2017;32:129-130 pubmed publisher
..In this issue of Cancer Cell, Mina et al. systematically characterize patterns of co-mutation and mutual exclusivity in 6,456 cancers across 23 tumor types. ..