Affiliation: Wellcome Trust Genome Campus
Martín H, Shales M, Fernandez PiÃ±ar P, Wei P, Molina M, Fiedler D, et al
. Differential genetic interactions of yeast stress response MAPK pathways. Mol Syst Biol. 2015;11:800 pubmed publisher
..This suggests that conditional genetic interactions are a powerful tool to dissect the functional importance of the different response mechanisms of the cell. ..
Studer R, Rodriguez Mias R, Haas K, Hsu J, Viéitez C, Sole C, et al
. Evolution of protein phosphorylation across 18 fungal species. Science. 2016;354:229-232 pubmed
..Our results provide an evolutionary history for phosphosites and suggest that rapid evolution of phosphorylation can contribute strongly to phenotypic diversity. ..
Wagih O, Galardini M, Busby B, Memon D, Typas A, Beltrao P. A resource of variant effect predictions of single nucleotide variants in model organisms. Mol Syst Biol. 2018;14:e8430 pubmed publisher
..cerevisiae strains in 43 conditions. This resource is available through mutfunc (www.mutfunc.com), a tool by which users can query precomputed predictions by providing amino acid or nucleotide-level variants. ..
Strumillo M, Beltrao P. Towards the computational design of protein post-translational regulation. Bioorg Med Chem. 2015;23:2877-82 pubmed publisher
..These advances create an opportunity to move synthetic biology forward by making use of a level of regulation that is of yet unexplored. ..
Ochoa D, Bradley D, Beltrao P. Evolution, dynamics and dysregulation of kinase signalling. Curr Opin Struct Biol. 2018;48:133-140 pubmed publisher
..A better understanding of these evolutionary processes will facilitate the study of disease related genomic alterations that target these signalling circuits. ..
Wagih O, Sugiyama N, Ishihama Y, Beltrao P. Uncovering Phosphorylation-Based Specificities through Functional Interaction Networks. Mol Cell Proteomics. 2016;15:236-45 pubmed publisher
Ochoa D, Jonikas M, Lawrence R, El Debs B, Selkrig J, Typas A, et al
. An atlas of human kinase regulation. Mol Syst Biol. 2016;12:888 pubmed publisher
..This provides a global view of human phosphorylation-based signaling and the necessary context to better understand kinase-driven decision-making. ..
Invergo B, Brochet M, Yu L, Choudhary J, Beltrao P, Billker O. Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation. Cell Rep. 2017;21:2017-2029 pubmed publisher
..The results reveal the central role of protein phosphorylation in the atypical cell cycle regulation of a divergent eukaryote. ..