Qasim Ayub

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. doi request reprint Genetic variation in South Asia: assessing the influences of geography, language and ethnicity for understanding history and disease risk
    Qasim Ayub
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Brief Funct Genomic Proteomic 8:395-404. 2009
  2. pmc FOXP2 targets show evidence of positive selection in European populations
    Qasim Ayub
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Am J Hum Genet 92:696-706. 2013
  3. pmc Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing
    Johanna Maria de Gruijter
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands
    Investig Genet 2:24. 2011
  4. pmc A calibrated human Y-chromosomal phylogeny based on resequencing
    Wei Wei
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 23:388-95. 2013
  5. pmc A map of human genome variation from population-scale sequencing
    Richard M Durbin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Nature 467:1061-73. 2010
  6. pmc A genome-wide survey of genetic variation in gorillas using reduced representation sequencing
    Aylwyn Scally
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e65066. 2013
  7. pmc Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation
    Yali Xue
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, United Kingdom
    Genetics 183:1065-77. 2009
  8. pmc Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data
    Min Hu
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Hum Genet 131:665-74. 2012
  9. pmc A worldwide survey of human male demographic history based on Y-SNP and Y-STR data from the HGDP-CEPH populations
    Wentao Shi
    The Wellcome Trust Sanger Institute, Hinxton, Cambs, United Kingdom
    Mol Biol Evol 27:385-93. 2010
  10. pmc Deleterious- and disease-allele prevalence in healthy individuals: insights from current predictions, mutation databases, and population-scale resequencing
    Yali Xue
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Am J Hum Genet 91:1022-32. 2012

Collaborators

Detail Information

Publications16

  1. doi request reprint Genetic variation in South Asia: assessing the influences of geography, language and ethnicity for understanding history and disease risk
    Qasim Ayub
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Brief Funct Genomic Proteomic 8:395-404. 2009
    ....
  2. pmc FOXP2 targets show evidence of positive selection in European populations
    Qasim Ayub
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Am J Hum Genet 92:696-706. 2013
    ....
  3. pmc Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing
    Johanna Maria de Gruijter
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands
    Investig Genet 2:24. 2011
    ..abstract:..
  4. pmc A calibrated human Y-chromosomal phylogeny based on resequencing
    Wei Wei
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 23:388-95. 2013
    ..In all, we provide a nearly 10-fold increase in the number of Y markers with phylogenetic information, and novel historical insights derived from placing them on a calibrated phylogenetic tree...
  5. pmc A map of human genome variation from population-scale sequencing
    Richard M Durbin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Nature 467:1061-73. 2010
    ..These methods and public data will support the next phase of human genetic research...
  6. pmc A genome-wide survey of genetic variation in gorillas using reduced representation sequencing
    Aylwyn Scally
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e65066. 2013
    ....
  7. pmc Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation
    Yali Xue
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, United Kingdom
    Genetics 183:1065-77. 2009
    ....
  8. pmc Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data
    Min Hu
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Hum Genet 131:665-74. 2012
    ....
  9. pmc A worldwide survey of human male demographic history based on Y-SNP and Y-STR data from the HGDP-CEPH populations
    Wentao Shi
    The Wellcome Trust Sanger Institute, Hinxton, Cambs, United Kingdom
    Mol Biol Evol 27:385-93. 2010
    ..However, some unexpected demographic histories were also found, including low growth rates in the Hazara and Kalash from Pakistan and recent expansion of the Mozabites in North Africa...
  10. pmc Deleterious- and disease-allele prevalence in healthy individuals: insights from current predictions, mutation databases, and population-scale resequencing
    Yali Xue
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Am J Hum Genet 91:1022-32. 2012
    ....
  11. pmc High altitude adaptation in Daghestani populations from the Caucasus
    Luca Pagani
    The Wellcome Trust Sanger Institute, Hinxton, UK
    Hum Genet 131:423-33. 2012
    ..These variants illustrate both the common pathways of adaptation to high altitude in different populations and features specific to the Daghestani populations, showing how even a mildly hypoxic environment can lead to genetic adaptation...
  12. pmc A comparison of Y-chromosomal lineage dating using either resequencing or Y-SNP plus Y-STR genotyping
    Wei Wei
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Forensic Sci Int Genet 7:568-72. 2013
    ..In principle, systematic comparisons of this kind can in future studies be used to identify the combinations of Y-SNP and Y-STR markers, and time estimation methodologies, that correspond best to resequencing data...
  13. pmc Insights into hominid evolution from the gorilla genome sequence
    Aylwyn Scally
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nature 483:169-75. 2012
    ..The use of the genome sequence in these and future analyses will promote a deeper understanding of great ape biology and evolution...
  14. pmc A systematic survey of loss-of-function variants in human protein-coding genes
    Daniel G MacArthur
    Wellcome Trust Sanger Institute, Hinxton, UK
    Science 335:823-8. 2012
    ..We describe functional and evolutionary differences between LoF-tolerant and recessive disease genes and a method for using these differences to prioritize candidate genes found in clinical sequencing studies...
  15. pmc Variation in genome-wide mutation rates within and between human families
    Donald F Conrad
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Nat Genet 43:712-4. 2011
    ..These observations suggest considerable variation in mutation rates within and between families...
  16. pmc The variant call format and VCFtools
    Petr Danecek
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Bioinformatics 27:2156-8. 2011
    ..VCFtools is a software suite that implements various utilities for processing VCF files, including validation, merging, comparing and also provides a general Perl API...