Andrew J Larner

Summary

Affiliation: Walton Centre for Neurology and Neurosurgery
Country: UK

Publications

  1. ncbi request reprint Antony van Leeuwenhoek and the description of diaphragmatic flutter (respiratory myoclonus)
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, United Kingdom
    Mov Disord 20:917-8. 2005
  2. pmc Migraine and restless legs syndrome: is there an association?
    Paul R Cannon
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    J Headache Pain 12:405-9. 2011
  3. pmc Comparing diagnostic accuracy of cognitive screening instruments: a weighted comparison approach
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Dement Geriatr Cogn Dis Extra 3:60-5. 2013
  4. pmc Familial transient global amnesia
    R Rhys Davies
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Case Rep Neurol 4:236-9. 2012
  5. pmc Telemedicine and Older Neurology Outpatients: Use of NHS Direct and of the Internet in the UK
    Aj Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Can Geriatr J 14:104-7. 2011
  6. doi request reprint Neurological update: dementia
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    J Neurol 261:635-9. 2014
  7. doi request reprint Codex (cognitive disorders examination) for the detection of dementia and mild cognitive impairment
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Cognitive Function Clinic, Liverpool, L9 7LJ, United Kingdom Electronic address
    Presse Med 42:e425-8. 2013
  8. doi request reprint Delusion of pregnancy: a case revisited
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, United Kingdom Tel 44 151 529 5727 Fax 44 151 529 8552 E mail
    Behav Neurol 27:293-4. 2013
  9. pmc Thyroid dysfunction and headache
    Andrew J Larner
    J Headache Pain 7:51-2. 2006
  10. pmc Late onset migraine with aura: how old is too old?
    A J Larner
    J Headache Pain 8:251-2. 2007

Detail Information

Publications99

  1. ncbi request reprint Antony van Leeuwenhoek and the description of diaphragmatic flutter (respiratory myoclonus)
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, United Kingdom
    Mov Disord 20:917-8. 2005
    ..The completeness of the clinical description merits the eponymous description of Leeuwenhoek's disease...
  2. pmc Migraine and restless legs syndrome: is there an association?
    Paul R Cannon
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    J Headache Pain 12:405-9. 2011
    ..We undertook a systematic review of the evidence, which supports this association, and consider possible shared pathogenic mechanisms and the implications for current clinical practice...
  3. pmc Comparing diagnostic accuracy of cognitive screening instruments: a weighted comparison approach
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Dement Geriatr Cogn Dis Extra 3:60-5. 2013
    ....
  4. pmc Familial transient global amnesia
    R Rhys Davies
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Case Rep Neurol 4:236-9. 2012
    ..A pathophysiological mechanism akin to that in migraine attacks, comorbidity reported in a number of the examples of familial TGA, is one possibility. The study of familial TGA cases might facilitate the understanding of TGA aetiology...
  5. pmc Telemedicine and Older Neurology Outpatients: Use of NHS Direct and of the Internet in the UK
    Aj Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Can Geriatr J 14:104-7. 2011
    ..Although Internet access and use was also low compared to other age groups, access did increase over time. Hence, future generations of older people may be amenable to health contacts and inputs via cyberspace...
  6. doi request reprint Neurological update: dementia
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    J Neurol 261:635-9. 2014
    ..This is only likely to be achieved by a deeper understanding of the clinical and pathophysiological phenomena of dementia disorders, many examples of which have appeared in the Journal of Neurology in 2013 and which are reviewed here. ..
  7. doi request reprint Codex (cognitive disorders examination) for the detection of dementia and mild cognitive impairment
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Cognitive Function Clinic, Liverpool, L9 7LJ, United Kingdom Electronic address
    Presse Med 42:e425-8. 2013
    ..Dementia is a major public health problem. Rapid and simple tests, easy to use for screening of dementia and mild cognitive impairment (MCI), are required...
  8. doi request reprint Delusion of pregnancy: a case revisited
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, United Kingdom Tel 44 151 529 5727 Fax 44 151 529 8552 E mail
    Behav Neurol 27:293-4. 2013
    ....
  9. pmc Thyroid dysfunction and headache
    Andrew J Larner
    J Headache Pain 7:51-2. 2006
    ..The role of thyroid dysfunction in the aetiology of headache remains uncertain...
  10. pmc Late onset migraine with aura: how old is too old?
    A J Larner
    J Headache Pain 8:251-2. 2007
  11. pmc Headache related to use of cholinesterase inhibitors: study of a Cognitive Function Clinic population
    Andrew J Larner
    J Headache Pain 7:440-1. 2006
  12. pmc Migraine with aura and restless legs syndrome
    Andrew J Larner
    J Headache Pain 8:141-2. 2007
  13. pmc Guidelines for the management of headache in primary care: are they being used?
    Andrew J Larner
    J Headache Pain 6:420-1. 2005
    ..The results suggest that headache guidelines are seldom, if ever, applied in this geographical location...
  14. doi request reprint Charles Dickens (1812-1870) and epilepsy
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Epilepsy Behav 24:422-5. 2012
    ....
  15. ncbi request reprint Mini-mental Parkinson (MMP) as a dementia screening test: comparison with the Mini-Mental State Examination (MMSE)
    Andrew J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Curr Aging Sci 5:136-9. 2012
    ..Its item content addresses some of the acknowledged shortcomings of the MMSE. Pragmatic use of MMP in general cognitive clinics has not previously been examined...
  16. doi request reprint Intrafamilial clinical phenotypic heterogeneity with progranulin gene p.Glu498fs mutation
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
    J Neurol Sci 316:189-90. 2012
    ..The mechanisms underpinning this heterogeneity, as seen with other GRN mutations, are currently unknown. Since all GRN mutations lead to progranulin haploinsufficiency, other modifying factors, possibly genetic, are implicated...
  17. doi request reprint Robert Lawson (?1846-1896)
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    J Neurol 259:792-3. 2012
    ..As Lawson is likely to be an unfamiliar name to most neurologists, and does not appear in the Oxford Dictionary of National Biography, we offer this brief account of his life and work...
  18. doi request reprint Screening utility of the Montreal Cognitive Assessment (MoCA): in place of--or as well as--the MMSE?
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Int Psychogeriatr 24:391-6. 2012
    ....
  19. ncbi request reprint DemTect: 1-year experience of a neuropsychological screening test for dementia
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Age Ageing 36:326-7. 2007
  20. ncbi request reprint The R269H mutation in presenilin-1 presenting as late-onset autosomal dominant Alzheimer's disease
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    J Neurol Sci 252:173-6. 2007
    ..Late-onset AD may be associated with deterministic PS1 mutations; these should be sought when the family history suggests autosomal dominant disease transmission...
  21. ncbi request reprint Francis Kilvert (1840-1879): an early self-report of cluster headache?
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Cephalalgia 28:763-6. 2008
    ..This may be one of the earliest accounts by a patient, rather than a physician, of cluster headache...
  22. pmc Referral guidelines for suspected central nervous system or brain tumours
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    J Neurol Neurosurg Psychiatry 77:1305-6. 2006
  23. ncbi request reprint Neuroinhibitory molecules in Alzheimer's disease
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, L9 7LJ, UK
    J Alzheimers Dis 10:75-80. 2006
    ..The molecular species responsible for neuroinhibitory effects in the Alzheimer's disease brain are beginning to be elucidated...
  24. doi request reprint Epileptic seizures in AD patients
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Neuromolecular Med 12:71-7. 2010
    ..In summary, epileptic seizures are part of the AD phenotype, and merit further investigation...
  25. ncbi request reprint Transient global amnesia in the district general hospital
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool L9 7LJ, UK
    Int J Clin Pract 61:255-8. 2007
    ..Although rare, TGA is a diagnosis both hospital physicians and general practitioners need to be aware of in order to avoid potential pitfalls. The critical importance of collateral history in reaching the diagnosis is emphasised...
  26. ncbi request reprint A possible account of synaesthesia dating from the seventeenth century
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
    J Hist Neurosci 15:245-9. 2006
    ..The details come to us through the physician John Finch, the scientist Robert Boyle, and the author Jonathan Swift. The details in the account suggest the possibility that this may be an early report of colored-touch synaesthesia...
  27. doi request reprint NHS Direct telephone helpline: frequency of use over time and by age and gender in an outpatient population
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Telemed J E Health 15:199-201. 2009
    ..These findings indicate a steady growth in awareness and use of NHS Direct, yet large numbers of patients reaching secondary care have not utilized this primary care resource...
  28. ncbi request reprint Monogenic Mendelian disorders in general neurological practice
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Int J Clin Pract 62:744-6. 2008
    ..All such patients are probably best referred to specialist clinics where expertise in diagnosis, genetic counselling and testing, and management has been developed...
  29. pmc Trigeminal autonomic cephalalgias: frequency in a general neurology clinic setting
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    J Headache Pain 9:325-6. 2008
    ..Increased awareness of this diagnostic category is required to ensure effective deployment of effective, evidence-based treatments...
  30. ncbi request reprint Delusion of pregnancy in frontotemporal lobar degeneration with motor neurone disease (FTLD/MND)
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Behav Neurol 19:199-200. 2008
    ..A patient with delusion of pregnancy as an early feature of FTLD/MND is presented to illustrate the need to consider neurodegenerative disease as well as primary psychiatric disorder as the underlying cause of this striking symptom...
  31. doi request reprint Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update
    Andrew J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    J Alzheimers Dis 17:259-65. 2009
    ..This area, which may also be relevant to neurodegenerative disorders resulting from other genetic mutations, such as those in the tau gene, currently remains ill-understood...
  32. doi request reprint Mutation negative "early-onset familial Alzheimer disease": consider screening for tau gene mutations
    Andrew J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Alzheimer Dis Assoc Disord 22:194-5. 2008
    ..As these genes prove to be negative in patients with a clinical diagnosis of early-onset familial Alzheimer disease, a search for tau gene mutations may be appropriate, as illustrated by the following case...
  33. ncbi request reprint Transient acute neurologic sequelae of sexual activity: headache and amnesia
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
    J Sex Med 5:284-8. 2008
    ..These syndromes may be alarming not only to patients but also to medical practitioners unfamiliar with them, initiating inappropriate investigations or advice...
  34. ncbi request reprint Acute aphasia in MS revisited
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Int MS J 14:76-7. 2007
  35. ncbi request reprint Addenbrooke's Cognitive Examination-Revised (ACE-R) in day-to-day clinical practice
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Age Ageing 36:685-6. 2007
  36. ncbi request reprint Down syndrome in the neurology clinic: Too much? Too little? Too late?
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Downs Syndr Res Pract 12:69-71. 2007
    ..It is suggested that closer liaison between neurologists and psychiatrists with an interest in learning disability might improve the management of neurological problems in patients with Down syndrome...
  37. ncbi request reprint Dr David Livingstone (1813-1873): some neurological observations
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, United Kingdom
    Scott Med J 53:35-7. 2008
  38. ncbi request reprint Addenbrooke's Cognitive Examination (ACE) for the diagnosis and differential diagnosis of dementia
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, United Kingdom
    Clin Neurol Neurosurg 109:491-4. 2007
    ..This study measured diagnostic accuracy of ACE in a large cohort of consecutive patients referred to a dedicated Cognitive Function Clinic...
  39. ncbi request reprint The effect of levodopa on respiration and word intelligibility in people with advanced Parkinson's disease
    Miet De Letter
    Department of Oto Rhino Laryngology, Center for Speech and Hearing Disorders, Ghent University Hospital, Ghent, Belgium
    Clin Neurol Neurosurg 109:495-500. 2007
    ..Although the etiology of this dysarthria is multifactorial, disorders of respiration may strongly contribute to it. The aim of this study was to evaluate the effects of levodopa on measures of respiration and intelligibility...
  40. doi request reprint Not all morning headaches are due to brain tumours
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Pract Neurol 9:80-4. 2009
    ..As ever, history taking is key to the diagnosis. Attention to the possibility of analgesic medication overuse is particularly pertinent, but other treatable conditions such as depression and epilepsy must not be overlooked...
  41. doi request reprint Intrafamilial clinical phenotypic heterogeneity with MAPT gene splice site IVS10+16C>T mutation
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, United Kingdom
    J Neurol Sci 287:253-6. 2009
    ..Possible explanations for the intra- and interfamilial clinical heterogeneity associated with this MAPT mutation are discussed...
  42. doi request reprint Jane Austen's (1775-1817) references to headache: fact and fiction
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    J Med Biogr 18:211-5. 2010
    ....
  43. doi request reprint Epileptic seizures in Alzheimer's disease: another fine MESS?
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    J Alzheimers Dis 25:417-9. 2011
    ..The authors suggest a pragmatic approach to developing the evidence base in order to inform decisions on seizure treatment, based on prior pragmatic studies in epilepsy...
  44. ncbi request reprint Getting it wrong: the clinical misdiagnosis of Alzheimer's disease
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Int J Clin Pract 58:1092-4. 2004
    ..Analysis of diagnostic errors may permit avoidance of similar pitfalls in future...
  45. ncbi request reprint Visual failure caused by vitamin B12 deficiency optic neuropathy
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Int J Clin Pract 58:977-8. 2004
    ..Clues to the possible diagnosis include a history of, or risk factors for, pernicious anaemia, or previous resective gastrointestinal surgery...
  46. doi request reprint Presenilin-1 mutation Alzheimer's disease: a genetic epilepsy syndrome?
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Epilepsy Behav 21:20-2. 2011
    ..Nevertheless, PSEN1 AD should now be recognized, using the new International League Against Epilepsy nomenclature, as a genetic epilepsy syndrome...
  47. pmc Lewis Carroll's Humpty Dumpty: an early report of prosopagnosia?
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    J Neurol Neurosurg Psychiatry 75:1063. 2004
  48. ncbi request reprint "Frontal variant Alzheimer's disease": a reappraisal
    Andrew J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Clin Neurol Neurosurg 108:705-8. 2006
    ..The proposed usage would also emphasise differential diagnosis...
  49. doi request reprint Camptodactyly: a 10-year series
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Eur J Dermatol 21:771-5. 2011
    ..It is possible that camptodactyly is a heterogeneous disorder. Further studies are required to ascertain whether this is the case, and to probe further the inheritance and pathogenesis of the disorder...
  50. ncbi request reprint Clinical-anatomical correlation in a selective phonemic speech production impairment
    A J Larner
    Dementia Research Group, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Sci 219:23-9. 2004
    ....
  51. ncbi request reprint Ophthalmological observations made during the mid-19th-century European encounter with Africa
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
    Arch Ophthalmol 122:267-72. 2004
    ..This affords an opportunity to compare observations made in Saharan and sub-Saharan Africa...
  52. ncbi request reprint Early-onset Alzheimer's disease with presenilin-1 M139V mutation: clinical, neuropsychological and neuropathological study
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Eur J Neurol 10:319-23. 2003
    ..This clinical and pathological heterogeneity in patients with the same PSEN-1 mutation suggests phenotype modulation by genetic and/or epigenetic factors...
  53. ncbi request reprint Cholinesterase inhibitors: beyond Alzheimer’s disease
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    Expert Rev Neurother 10:1699-705. 2010
    ..Clinical practice with respect to non-Alzheimer’s disease indications for ChEIs may vary according to jurisdiction, specifically with regards to whether national guidelines effectively limit off-licence drug use...
  54. doi request reprint Referrals to the neurology clinic from oral and maxillofacial surgery clinics
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    Br J Oral Maxillofac Surg 49:576-7. 2011
    ....
  55. ncbi request reprint Acute amnesia in MS revisited
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    Int MS J 16:102-4. 2009
    ..Nonetheless, as illustrated by the following case report, acute onset of demyelinating disease with the clinical phenotype of amnesia may on occasion be the presenting feature of MS...
  56. ncbi request reprint Searching the Internet for medical information: frequency over time and by age and gender in an outpatient population in the UK
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    J Telemed Telecare 12:186-8. 2006
    ..Data on health-information-seeking behaviour through Internet searching are relevant not only to clinical consultation, but also to the possibilities of targeting health-related information and to email consultation...
  57. pmc Late presentation of primary headache associated with sexual activity: is non-invasive angiography worthwhile?
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    J Headache Pain 7:139-40. 2006
    ..It is suggested that non-invasive angiography is not routinely indicated in late presentations of headache associated with sexual activity...
  58. doi request reprint Margiad Evans (1909-1958): a history of epilepsy in a creative writer
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Epilepsy Behav 16:596-8. 2009
    ..They also give some insights into the consequences of epilepsy for a creative writer...
  59. ncbi request reprint David Livingstone's uvulectomy
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    J Med Biogr 14:104-8. 2006
    ..The practice of uvulectomy in indigenous African societies and some contemporary ideas about uvulectomy are also considered in order to try to ascertain why Livingstone elected to undergo this procedure...
  60. ncbi request reprint Headache induced by dopamine agonists prescribed for prolactinoma: think SUNCT!
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Int J Clin Pract 60:360-1. 2006
    ..Endocrinologists treating patients with prolactinoma need to be aware of this syndrome as its pathophysiology and treatment differ from that of other headache syndromes...
  61. pmc Acupuncture use for the treatment of headache prior to neurological referral
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    J Headache Pain 6:97-9. 2005
    ..In this study, 12% of patients with headache attending general neurology outpatient clinics had already received acupuncture; of the remainder, 73% said they would be willing to try it...
  62. ncbi request reprint "Dementia unmasked": atypical, acute aphasic, presentations of neurodegenerative dementing disease
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Clin Neurol Neurosurg 108:8-10. 2005
    ....
  63. ncbi request reprint Delayed motor and visual complications after attempted suicide
    Andrew J Larner
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool L9 7LJ, UK
    Lancet 366:1826. 2005
  64. ncbi request reprint Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery Fazakerley, Liverpool, UK
    J Neurol 253:139-58. 2006
    ..This article reviews the clinical phenotypes of reported PSEN1 mutations, emphasizing their heterogeneity, and suggesting that other factors, both genetic and epigenetic,must contribute to disease phenotype...
  65. ncbi request reprint Caleb Hillier Parry (1755-1822): clinician, scientist, friend of Edward Jenner (1749-1823)
    Andrew J Larner
    University of Liverpool, UK
    J Med Biogr 13:189-94. 2005
    ..He also undertook experimental work and published extensively, including the first book devoted to angina...
  66. doi request reprint Teleneurology: an overview of current status
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Pract Neurol 11:283-8. 2011
    ..Teleneurology will increasingly impact on all neurologists...
  67. ncbi request reprint Familial early-onset dementia with tau intron 10 + 16 mutation with clinical features similar to those of Alzheimer disease
    Mark Doran
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool L9 7LJ, England
    Arch Neurol 64:1535-9. 2007
    ....
  68. ncbi request reprint FAQs: memory loss
    Crispin A H Fisher
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool
    Practitioner 250:14-6, 19, 21. 2006
  69. ncbi request reprint "A transcript of actual life": headache in the novels of Jane Austen
    Andrew J Larner
    From the Walton Centre for Neurology and Neurosurgery Neurology, Liverpool, UK
    Headache 50:692-6. 2010
    ..As an authorial device, headache may have served Jane Austen as a culturally sanctioned form of bodily expression...
  70. ncbi request reprint Prominent behavioural and psychiatric symptoms in early-onset Alzheimer's disease in a sib pair with the presenilin-1 gene R269G mutation
    M Doran
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    Eur Arch Psychiatry Clin Neurosci 254:187-9. 2004
    ....
  71. ncbi request reprint Meralgia paresthetica following gynecologic and obstetric surgery
    G Peters
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Int J Gynaecol Obstet 95:42-3. 2006
  72. ncbi request reprint Pathological heterogeneity of clinically diagnosed corticobasal degeneration
    M Doran
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, L9 7LJ, Liverpool, UK
    J Neurol Sci 216:127-34. 2003
    ....
  73. ncbi request reprint Use of the internet and of the NHS direct telephone helpline for medical information by a cognitive function clinic population
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Int J Geriatr Psychiatry 18:118-22. 2003
    ..Internet websites and medical telephone helplines are relatively new and huge resources of medical information ("cybermedicine" and "telemedicine", respectively) accessible to the general public without prior recourse to a doctor...
  74. ncbi request reprint Pseudostatus epilepticus in pregnancy
    G Peters
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Int J Gynaecol Obstet 97:47. 2007
  75. ncbi request reprint Use of internet medical websites and NHS direct by neurology outpatients before consultation
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Int J Clin Pract 56:219-21. 2002
    ..A comparison was made between patients' searches and their final diagnosis. Patients' views on the use of the information received were sought...
  76. ncbi request reprint Isolated familial hypomagnesaemia with novel neurological features: causal link or chance concurrence?
    A J Larner
    St Mary s Hospital, Praed Street, London, UK
    Eur J Neurol 8:495-9. 2001
    ..The pathogenesis of this unusual neurological and ophthalmological syndrome therefore remains uncertain...
  77. ncbi request reprint What role do community pharmacists currently play in the management of headache? A hospital-based perspective
    K K Gahir
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Int J Clin Pract 58:257-9. 2004
    ..Community pharmacists may represent an underused resource in the management of headaches in primary care, but would require specific training to fulfil such a role...
  78. ncbi request reprint Fornix damage from solitary subependymal giant cell astrocytoma causing postoperative amnesic syndrome
    I Ibrahim
    Neurrehabilitation, Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Br J Hosp Med (Lond) 70:478-9. 2009
    ..This article reports the cognitive impairments associated with left fornix damage which became apparent following surgical removal of a solitary subependymal giant cell astrocytoma...
  79. ncbi request reprint Single-photon emission computed tomography perfusion imaging in the differential diagnosis of dementia: a retrospective regional audit
    M Doran
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Int J Clin Pract 59:496-500. 2005
    ....
  80. ncbi request reprint Frontotemporal dementia in elderly individuals
    Atik Baborie
    Department of Neuropathology, Walton Centre for Neurology and Neurosurgery, Liverpool, England, UK
    Arch Neurol 69:1052-60. 2012
    ..To determine whether cases of frontotemporal lobar degeneration (FTLD) do exist in elderly individuals and have clinical and neuropathological features distinct from those with presenile onset...
  81. ncbi request reprint Charles Meller and John Kirk: medical practitioners and practice on Livingstone's Zambesi expedition, 1858-64
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool L9 7LJ, UK
    J Med Biogr 10:129-34. 2002
  82. ncbi request reprint Did Charles Dickens describe progressive supranuclear palsy in 1857?
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
    Mov Disord 17:832-3. 2002
    ..A character from one of Charles Dickens's lesser known works is presented, whose attributes suggest a possible diagnosis of progressive supranuclear palsy...
  83. ncbi request reprint Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer's disease
    D A Lozsadi
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Dement Geriatr Cogn Disord 22:121-4. 2006
    ..To investigate the frequency of epilepsy at the time of diagnosis of Alzheimer's disease (AD)...
  84. ncbi request reprint Late-onset temporal lobe epilepsy with unilateral mesial temporal sclerosis and cognitive decline: a diagnostic dilemma
    D A Lozsadi
    Mersey Regional Epilepsy Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, UK
    Seizure 17:473-6. 2008
    ....
  85. ncbi request reprint Camptodactyly in a neurology outpatient clinic
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, L9 7LJ, UK
    Int J Clin Pract 55:592-5. 2001
    ..Camptodactyly is not infrequently observed in the general neurology outpatient clinic. It merits attention in order to avoid confusion with other, neurogenic, causes of clawing, and so avoid unnecessary investigation...
  86. ncbi request reprint Missed diagnosis of vitamin B12 deficiency presenting with paraesthetic symptoms
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Int J Clin Pract 56:377-8. 2002
    ..Two cases in which the diagnosis was initially overlooked are presented, emphasising that the paraesthesia associated with vitamin B12 deficiency may be central (myelopathic) or peripheral (neuropathic) in origin...
  87. ncbi request reprint Alzheimer's disease: targets for drug development
    A J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK
    Mini Rev Med Chem 2:1-9. 2002
    ..This article gives a broad overview of the spectrum of targets for AD treatment, with particular emphasis on amyloid beta-peptides and tau protein...
  88. pmc False localising signs
    A J Larner
    Walton Centre for Neorology and Neurosurgery, Lower Lane, Fazkerley, Liverpool L9 7IJ, UK
    J Neurol Neurosurg Psychiatry 74:415-8. 2003
    ..Awareness that signs may be false localising has implications for diagnostic investigation...
  89. ncbi request reprint Obstructive sleep apnoea syndrome presenting in a neurology outpatient clinic
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Int J Clin Pract 57:150-2. 2003
    ..Since OSAS is associated with increased morbidity and mortality, yet is frequently amenable to treatment, neurologists should be familiar with the heterogeneous presentations of this condition...
  90. ncbi request reprint Subependymal nodular heterotopia
    A J Larner
    Walton Centre for Neurology and Neurosurgery, Liverpool
    Br J Hosp Med (Lond) 67:382. 2006
  91. ncbi request reprint EEG findings in dementia with Lewy bodies causing diagnostic confusion with sporadic Creutzfeldt-Jakob disease
    M Doran
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK
    Eur J Neurol 11:838-41. 2004
    ..Periodic sharp wave complexes have occasionally been reported in DLB and should not therefore dissuade one from the diagnosis when other clinical and neuropsychological features are consistent with validated diagnostic criteria...
  92. doi request reprint An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis
    S H Wong
    Department of Neurology, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    J Neurol Neurosurg Psychiatry 81:1167-9. 2010
    ..The effectiveness of a combination immunomodulatory regimen was tested in consecutive VGKC+LE patients...
  93. ncbi request reprint Disseminated enteropathy-type T-cell lymphoma: cauda equina syndrome complicating coeliac disease
    M Doran
    Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerely, Liverpool L9 7LJ, UK
    Clin Neurol Neurosurg 107:517-20. 2005
    ..Although rare, disseminated enteropathy-type T-cell lymphoma should enter the differential diagnosis in any patient with coeliac disease developing new neurological signs...
  94. ncbi request reprint Myelopathy following influenza vaccination in inflammatory CNS disorder treated with chronic immunosuppression
    A J Larner
    Department of Neurology, St Mary s Hospital, Praed Street, London, UK
    Eur J Neurol 7:731-3. 2000
    ..Although influenza vaccination is recommended in patients receiving chronic immunosuppression, its use may on occasion be associated with neurological complications previously reported in immunocompetent individuals...
  95. ncbi request reprint Medical hazards of the internet: gambling in Parkinson's disease
    Andrew J Larner
    Mov Disord 21:1789. 2006
  96. ncbi request reprint Language function and dysfunction in corticobasal degeneration
    Andrew J Larner
    Neurology 62:1238; author reply 1238. 2004
  97. pmc Braille alexia: an apperceptive tactile agnosia?
    Andrew J Larner
    J Neurol Neurosurg Psychiatry 78:907-8. 2007
  98. doi request reprint Re: Activities of daily living in frontotemporal dementia and Alzheimer disease
    Andrew J Larner
    Neurology 70:658. 2008