Eranga N Vithana

Summary

Country: UK

Publications

  1. ncbi SLC4A11 mutations in Fuchs endothelial corneal dystrophy
    Eranga N Vithana
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore
    Hum Mol Genet 17:656-66. 2008
  2. ncbi Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2)
    Eranga N Vithana
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751
    Nat Genet 38:755-7. 2006
  3. doi Genotype-phenotype correlation analysis for three primary angle closure glaucoma-associated genetic polymorphisms
    Xin Wei
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 55:1143-8. 2014
  4. doi Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length
    Monisha E Nongpiur
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 54:5824-8. 2013
  5. doi Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations
    Belinda K Cornes
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Hum Mol Genet 21:437-45. 2012
  6. ncbi Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia
    Chiea Chuen Khor
    Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore
    Hum Mol Genet 22:5288-94. 2013
  7. pmc Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line
    Jun Liu
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 53:3270-9. 2012
  8. doi Relationship of smoking and cardiovascular risk factors with polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese persons
    Peter Cackett
    Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 118:846-52. 2011
  9. pmc Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy
    Jodhbir S Mehta
    Singapore Eye Research Institute, Singapore 2Singapore National Eye Centre, Singapore
    Mol Vis 14:1277-81. 2008
  10. pmc Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice
    Veluchamy A Barathi
    Singapore Eye Research Institute, 11 Third Hospital Avenue, 168751 Singapore, Singapore
    Dis Model Mech 6:1146-58. 2013

Collaborators

Detail Information

Publications32

  1. ncbi SLC4A11 mutations in Fuchs endothelial corneal dystrophy
    Eranga N Vithana
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore
    Hum Mol Genet 17:656-66. 2008
    ....
  2. ncbi Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2)
    Eranga N Vithana
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751
    Nat Genet 38:755-7. 2006
    ..Mutations in SLC4A11, which encodes a membrane-bound sodium-borate cotransporter, cause loss of function of the protein either by blocking its membrane targeting or nonsense-mediated decay...
  3. doi Genotype-phenotype correlation analysis for three primary angle closure glaucoma-associated genetic polymorphisms
    Xin Wei
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 55:1143-8. 2014
    ..The purpose of this study was to investigate whether these single nucleotide polymorphisms (SNPs) affect the phenotype of PACG patients...
  4. doi Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length
    Monisha E Nongpiur
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 54:5824-8. 2013
    ..The purpose of this study was to investigate the associations of these loci with the ocular biometric parameters anterior chamber depth (ACD) and axial length (AL)...
  5. doi Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations
    Belinda K Cornes
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Hum Mol Genet 21:437-45. 2012
    ..In addition, it may also provide several candidate genes for interrogation for POAG, keratoconus and possible racial/ethnic variations...
  6. ncbi Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia
    Chiea Chuen Khor
    Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore
    Hum Mol Genet 22:5288-94. 2013
    ..These new data advance our understanding of the molecular pathogenesis of severe myopia. ..
  7. pmc Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line
    Jun Liu
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 53:3270-9. 2012
    ..To investigate the effects of SLC4A11 gene depletion in human corneal endothelial cells...
  8. doi Relationship of smoking and cardiovascular risk factors with polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese persons
    Peter Cackett
    Singapore Eye Research Institute, Singapore, Republic of Singapore
    Ophthalmology 118:846-52. 2011
    ..The present study aimed to determine risk factors for PCV and to compare associations with those for CNV secondary to AMD...
  9. pmc Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy
    Jodhbir S Mehta
    Singapore Eye Research Institute, Singapore 2Singapore National Eye Centre, Singapore
    Mol Vis 14:1277-81. 2008
    ..To analyze for the presence of lipids in conjunctival fibroblasts of a patient with Schnyder corneal dystrophy (SCD)...
  10. pmc Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice
    Veluchamy A Barathi
    Singapore Eye Research Institute, 11 Third Hospital Avenue, 168751 Singapore, Singapore
    Dis Model Mech 6:1146-58. 2013
    ..M2 receptor antagonists might thus provide a targeted therapeutic approach to the management of this refractive error. ..
  11. pmc Differential expression of the Slc4 bicarbonate transporter family in murine corneal endothelium and cell culture
    William Shei
    Singapore Eye Research Institute, Singapore
    Mol Vis 19:1096-106. 2013
    ....
  12. doi Collagen-related genes influence the glaucoma risk factor, central corneal thickness
    Eranga N Vithana
    Singapore Eye Research Institute, Singapore
    Hum Mol Genet 20:649-58. 2011
    ..5 × 10⁻⁹). These findings implicate the involvement of collagen genes influencing CCT and thus, possibly the pathogenesis of glaucoma...
  13. doi A novel mutation in transforming growth factor-beta induced protein (TGFβIp) reveals secondary structure perturbation in lattice corneal dystrophy
    Rajamani Lakshminarayanan
    Singapore National Eye Centre, Singapore 168751, Singapore
    Br J Ophthalmol 95:1457-62. 2011
    ..To describe mutations in the transforming growth factor-beta induced (TGFBI) gene in Asian patients with Bowman's membrane as well as stromal corneal dystrophies, and to elucidate their structural implications, using model peptides...
  14. pmc SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery
    Li Fong Seet
    Ocular Wound Healing and Therapeutics Group, Singapore Eye Research Institute, Singapore, Singapore
    PLoS ONE 5:e9415. 2010
    ..The evidence presented in this report is strongly supportive for the targeting of SPARC to increase the success of glaucoma filtration surgery...
  15. pmc Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population
    Eranga N Vithana
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore
    Mol Vis 16:1640-5. 2010
    ..7% of primary open-angle glaucoma (POAG) in Europeans. The aim of this study was to investigate the frequency of NTF4 mutations in Chinese POAG patients...
  16. doi Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy
    Jodhbir S Mehta
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore
    Invest Ophthalmol Vis Sci 49:184-8. 2008
    ..The aim of our study was to determine whether mutations of the TCF8 gene, recently implicated in posterior polymorphous dystrophy, may also play a role in the development of the more common Fuchs endothelial corneal dystrophy (FECD)...
  17. doi Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects
    Chelvin C A Sng
    Singapore Eye Research Institute, National University of Singapore, Singapore
    Ophthalmic Res 45:191-6. 2011
    ..The aim of this study was to examine this association in Chinese persons with choroidal neovascularization (CNV) secondary to AMD and polypoidal choroidal vasculopathy (PCV)...
  18. ncbi Expression of the Primary Angle Closure Glaucoma (PACG) Susceptibility Gene PLEKHA7 in Endothelial and Epithelial Cell Junctions in the Eye
    Mei Chin Lee
    Singapore Eye Research Institute, Singapore Duke NUS Graduate Medical School, Singapore
    Invest Ophthalmol Vis Sci 55:3833-41. 2014
    ..We aimed to determine PLEKHA7's localization in the eye and its association with AJCs to elucidate its potential role in PACG...
  19. doi Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
    Eranga N Vithana
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Nat Genet 44:1142-6. 2012
    ..50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG...
  20. ncbi Novel SLC4A11 mutations in patients with recessive congenital hereditary endothelial dystrophy (CHED2). Mutation in brief #958. Online
    Vedam L Ramprasad
    ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Hum Mutat 28:522-3. 2007
    ..2240+1G>A; c.2437-1G>A). Interestingly, the c.2398C>T (p.Gln800X) and c.2437-1G>A identified in two affected siblings represent the first compound heterozygous mutations in the SLC4A11 gene...
  21. pmc Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes
    Tin Aung
    Singapore National Eye Centre, Singapore 2Singapore Eye Research Institute, Singapore
    Mol Vis 14:1313-8. 2008
    ..To investigate the possible involvement of CHX10 and MFRP in PACG, we sequenced both genes in PACG patients with small ocular dimensions...
  22. ncbi Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31
    Evelyne C Deery
    School of Biological Sciences, Queen Mary, University of London, London E1 4NS, UK
    Hum Mol Genet 11:3209-19. 2002
    ..With the need to replenish disc proteins on a daily basis, such conditions will exist in rod photoreceptors and this may underlie the disease pathology...
  23. ncbi Molecular analysis of the myocilin gene in Chinese subjects with chronic primary-angle closure glaucoma
    Tin Aung
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 46:1303-6. 2005
    ..To address this, the MYOC gene was screened in a cohort of 106 patients with chronic PACG...
  24. ncbi Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations
    Kelvin Y C Lee
    Singapore National Eye Centre
    Invest Ophthalmol Vis Sci 46:3812-6. 2005
    ..The aim of this study was to investigate the spectrum of mutations in this gene in BCD patients from Singapore, and to characterize their phenotype...
  25. ncbi A large deletion in the adRP gene PRPF31: evidence that haploinsufficiency is the cause of disease
    Leen Abu-Safieh
    Institute of Ophthalmology, University College London, London, UK
    Mol Vis 12:384-8. 2006
    ..To report a large deletion that encompasses more than 90% of PRPF31 gene and two other neighboring genes in their entirety in an adRP pedigree that appears to show only the typical clinical features of retinitis pigmentosa...
  26. ncbi Lack of association between interleukin-1 gene cluster polymorphisms and glaucoma in Chinese subjects
    Alicia C S How
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 48:2123-6. 2007
    ..The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma in Chinese patients with either POAG or primary-angle closure glaucoma (PACG)...
  27. ncbi Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa
    Bernardo V Alvarez
    Membrane Protein Research Group, Department of Physiology, University of Alberta, Edmonton Alberta, Canada
    Invest Ophthalmol Vis Sci 48:3459-68. 2007
    ..CA4 was screened in a panel of patients with RP, to expand the mutation spectrum of this novel adRP gene and understand its pathogenic mechanism...
  28. ncbi Bradyopsia in an Asian man
    Jacob Y C Cheng
    Arch Ophthalmol 125:1138-40. 2007
  29. doi Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese
    Mineo Ozaki
    Ozaki Eye Hospital and Dept of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Invest Ophthalmol Vis Sci 49:3976-80. 2008
    ..The purpose of this study was to test this association in Japanese subjects with XFS/XFG...
  30. doi Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy
    Kelvin Y Lee
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:2613-9. 2008
    ..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
  31. ncbi Lack of association between the rs2664538 polymorphism in the MMP-9 gene and primary angle closure glaucoma in Singaporean subjects
    Tin Aung
    Singapore National Eye Centre, National University Hospital, Singapore
    J Glaucoma 17:257-8. 2008
    ..The aim of this study was to confirm this association in Singaporean Chinese subjects with both acute and chronic PACG...
  32. ncbi Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa
    Christina F Chakarova
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EV, UK
    Hum Mol Genet 11:87-92. 2002
    ..The identification of mutations in a third pre-mRNA splicing factor gene further highlights a novel mechanism of photoreceptor degeneration due to defects in the splicing process...