Martin Vordermeier

Summary

Affiliation: Veterinary Laboratories Agency
Country: UK

Publications

  1. pmc Global gene transcriptome analysis in vaccinated cattle revealed a dominant role of IL-22 for protection against bovine tuberculosis
    Sabin Bhuju
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1003077. 2012
  2. pmc Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers
    Elihú Aranday-Cortés
    TB Research Group, Animal Health and Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    PLoS ONE 7:e30626. 2012
  3. pmc Differential effects of Mycobacterium bovis--derived polar and apolar lipid fractions on bovine innate immune cells
    Chris Pirson
    TB Research Group, Animal Health and Veterinary Laboratories Agency Weybridge, New Haw, Surrey, Addlestone, KT15 3NB, United Kingdom
    Vet Res 43:54. 2012
  4. pmc Effects of vaccination against paratuberculosis on tuberculosis in goats: diagnostic interferences and cross-protection
    Bernat Pérez de Val
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, Edifici CReSA, 08193, Bellaterra, Catalonia, Spain
    BMC Vet Res 8:191. 2012
  5. pmc The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia
    Martin Vordermeier
    Animal Health and Veterinary Laboratories Agency, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Comp Immunol Microbiol Infect Dis 35:227-32. 2012
  6. doi request reprint Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection
    Martin Vordermeier
    TB Research Group, Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Trop Anim Health Prod 44:651-5. 2012
  7. doi request reprint DIVA reagents for bovine tuberculosis vaccines in cattle
    Martin Vordermeier
    Animal Health and Veterinary Laboratories Agency, Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Expert Rev Vaccines 10:1083-91. 2011
  8. pmc Field evaluation of the efficacy of Mycobacterium bovis bacillus Calmette-Guerin against bovine tuberculosis in neonatal calves in Ethiopia
    Gobena Ameni
    Veterinary Laboratories Agency, TB Research Group, New Haw, Addelstone, Surrey, United Kingdom
    Clin Vaccine Immunol 17:1533-8. 2010
  9. ncbi request reprint Low-dose Mycobacterium bovis infection in cattle results in pathology indistinguishable from that of high-dose infection
    Linda Johnson
    Department of Pathology, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Tuberculosis (Edinb) 87:71-6. 2007
  10. pmc Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle
    Adam O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, United Kingdom
    PLoS ONE 5:e8527. 2010

Collaborators

Detail Information

Publications20

  1. pmc Global gene transcriptome analysis in vaccinated cattle revealed a dominant role of IL-22 for protection against bovine tuberculosis
    Sabin Bhuju
    Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1003077. 2012
    ..This experiment confirmed the importance of IL-22 as predictor of vaccine efficacy...
  2. pmc Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers
    Elihú Aranday-Cortés
    TB Research Group, Animal Health and Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    PLoS ONE 7:e30626. 2012
    ....
  3. pmc Differential effects of Mycobacterium bovis--derived polar and apolar lipid fractions on bovine innate immune cells
    Chris Pirson
    TB Research Group, Animal Health and Veterinary Laboratories Agency Weybridge, New Haw, Surrey, Addlestone, KT15 3NB, United Kingdom
    Vet Res 43:54. 2012
    ..These data demonstrate that pathogenic mycobacterial polar lipids may significantly hamper the ability of the host APCs to induce an appropriate immune response to an invading pathogen...
  4. pmc Effects of vaccination against paratuberculosis on tuberculosis in goats: diagnostic interferences and cross-protection
    Bernat Pérez de Val
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, Edifici CReSA, 08193, Bellaterra, Catalonia, Spain
    BMC Vet Res 8:191. 2012
    ..To address this issue, goat kids previously vaccinated against PTB were experimentally infected with TB...
  5. pmc The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia
    Martin Vordermeier
    Animal Health and Veterinary Laboratories Agency, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Comp Immunol Microbiol Infect Dis 35:227-32. 2012
    ....
  6. doi request reprint Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection
    Martin Vordermeier
    TB Research Group, Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Trop Anim Health Prod 44:651-5. 2012
    ..Our results suggested subtle differences in the cytokine profile because only infection-induced IL-6 production was significantly increased in monocytes from the more susceptible Holstein cattle...
  7. doi request reprint DIVA reagents for bovine tuberculosis vaccines in cattle
    Martin Vordermeier
    Animal Health and Veterinary Laboratories Agency, Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Expert Rev Vaccines 10:1083-91. 2011
    ..We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program...
  8. pmc Field evaluation of the efficacy of Mycobacterium bovis bacillus Calmette-Guerin against bovine tuberculosis in neonatal calves in Ethiopia
    Gobena Ameni
    Veterinary Laboratories Agency, TB Research Group, New Haw, Addelstone, Surrey, United Kingdom
    Clin Vaccine Immunol 17:1533-8. 2010
    ..In conclusion, the present trial demonstrated an encouraging protective effect of BCG against bTB in a natural transmission setting in Ethiopia...
  9. ncbi request reprint Low-dose Mycobacterium bovis infection in cattle results in pathology indistinguishable from that of high-dose infection
    Linda Johnson
    Department of Pathology, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Tuberculosis (Edinb) 87:71-6. 2007
    ..These studies confirm that within the same time period, the smallest possible infective dose, properly administered, can produce pathology indistinguishable from a dose 1000-fold greater...
  10. pmc Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle
    Adam O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, United Kingdom
    PLoS ONE 5:e8527. 2010
    ..This work will serve as a baseline for future studies into the genetic basis of host preference, and in particular the molecular basis of virulence in M. bovis...
  11. pmc The burden of mycobacterial disease in ethiopian cattle: implications for public health
    Stefan Berg
    TB Research Group, Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    PLoS ONE 4:e5068. 2009
    ..Furthermore, Ethiopia has one of the highest incidence rates of human extrapulmonary TB in the world, a clinical presentation that is often associated with transmission of M. bovis from cattle to humans...
  12. ncbi request reprint Development of cattle TB vaccines in the UK
    Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet Immunol Immunopathol 112:38-48. 2006
    ..These significant advances are detailed in this review with a summary of future directions that TB vaccine development for cattle is likely to take...
  13. doi request reprint Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle
    Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet Microbiol 151:8-13. 2011
    ..Finally, we present an up-date of our current approaches in this area...
  14. ncbi request reprint Immunogenicity comparison of the intradermal or endobronchial boosting of BCG vaccinates with Ad5-85A
    Adam Whelan
    TB Research Group, Animal Health and Veterinary Laboratories Agency, Weybridge, Surrey KT 15 3NB, UK
    Vaccine 30:6294-300. 2012
    ..These results contribute to our understanding on how different vaccination strategies may affect different compartments of the immune response and in turn to the development of safer and more effective vaccines...
  15. pmc Evaluation of gamma interferon and antibody tuberculosis tests in alpacas
    Shelley Rhodes
    Animal Health and Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, United Kingdom
    Clin Vaccine Immunol 19:1677-83. 2012
    ....
  16. pmc Recognition of mycobacterial epitopes by T cells across mammalian species and use of a program that predicts human HLA-DR binding peptides to predict bovine epitopes
    Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 71:1980-7. 2003
    ..bovis-infected cattle. The results obtained in this study support the approach of using bioinformatics to increase the efficiency of epitope screening and selection...
  17. pmc Antigen mining with iterative genome screens identifies novel diagnostics for the Mycobacterium tuberculosis complex
    Katie Ewer
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Vaccine Immunol 13:90-7. 2006
    ..Evaluation of the peptides identified from the three dominant antigens by use of larger field studies is now a priority...
  18. doi request reprint Gene expression profiling and antigen mining of the tuberculin production strain Mycobacterium bovis AN5
    M Carmen Garcia Pelayo
    TB Research Group, VLA Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, UK
    Vet Microbiol 133:272-7. 2009
    ..Our results show that field strains of M. bovis show some significant differences in gene expression to AN5, and that this differential gene expression may impact on the antigen profiles expressed by AN5 during in vitro culture...
  19. doi request reprint ELISPOT assays to enumerate bovine IFN-γ-secreting cells for the development of novel vaccines against bovine tuberculosis
    Martin Vordermeier
    Department of Bacteriology, TB Research Group, Veterinary Laboratories Agency, WeybridgeAddlestone, Surrey, UK
    Methods Mol Biol 792:219-27. 2012
    ..This is particularly the case for vaccines against diseases that require protective cell-mediated immunity, such as tuberculosis. This chapter describes ELISPOT assays detecting bovine IFN-γ...
  20. ncbi request reprint Immunohistochemical markers augment evaluation of vaccine efficacy and disease severity in bacillus Calmette-Guerin (BCG) vaccinated cattle challenged with Mycobacterium bovis
    Linda Johnson
    Department of Pathology, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK
    Vet Immunol Immunopathol 111:219-29. 2006
    ..Lymph node evaluation using light microscopy and immunohistochemical markers is useful to assess the immune response and discriminate granulomas to determine vaccine efficacy and disease severity...