M Vordermeier

Summary

Affiliation: Veterinary Laboratories Agency
Country: UK

Publications

  1. pmc Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    H Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 70:3026-32. 2002
  2. pmc Enhancement of the sensitivity of the whole-blood gamma interferon assay for diagnosis of Mycobacterium bovis infections in cattle
    Michel Denis
    AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand
    Clin Vaccine Immunol 14:1483-9. 2007
  3. ncbi request reprint Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations
    Adam O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 26:166-73. 2008
  4. pmc Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased interleukin-1 beta responses
    Michael Coad
    TB Research Group, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Vet Res 41:14. 2010
  5. ncbi request reprint Synthetic peptide vaccination in cattle: induction of strong cellular immune responses against peptides derived from the Mycobacterium bovis antigen Rv3019c
    H Martin Vordermeier
    Veterinary Labortories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 23:4375-84. 2005
  6. pmc Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis
    H Martin Vordermeier
    TB Research Group, VLA Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Infect Immun 77:3364-73. 2009
  7. doi request reprint Antigen mining to define Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected animals: A VLA perspective
    M Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Surrey, UK
    Transbound Emerg Dis 56:240-7. 2009
  8. ncbi request reprint Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattle
    H M Vordermeier
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet J 171:229-44. 2006
  9. pmc Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG
    H Martin Vordermeier
    TB Research Group, VLA Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 74:1416-8. 2006
  10. pmc Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level
    H Martin Vordermeier
    TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Vaccine Immunol 14:1203-9. 2007

Collaborators

Detail Information

Publications42

  1. pmc Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    H Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 70:3026-32. 2002
    ....
  2. pmc Enhancement of the sensitivity of the whole-blood gamma interferon assay for diagnosis of Mycobacterium bovis infections in cattle
    Michel Denis
    AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand
    Clin Vaccine Immunol 14:1483-9. 2007
    ..Therefore, the use of ESAT-6/CFP-10 with anti-IL-10 could be useful to detect cattle potentially infected with tuberculosis, which are not detected using current procedures...
  3. ncbi request reprint Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations
    Adam O Whelan
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 26:166-73. 2008
    ..Measurement of central memory responses induced by TB vaccine candidates in cattle may provide a useful correlate of protection and warrants further investigation in challenge experiments...
  4. pmc Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased interleukin-1 beta responses
    Michael Coad
    TB Research Group, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Vet Res 41:14. 2010
    ..The desensitising effect is associated with decreased IL-1beta and elevated IL-10 responses, but importantly, does not influence antigen specific IFN-gamma responses...
  5. ncbi request reprint Synthetic peptide vaccination in cattle: induction of strong cellular immune responses against peptides derived from the Mycobacterium bovis antigen Rv3019c
    H Martin Vordermeier
    Veterinary Labortories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 23:4375-84. 2005
    ..Peptide vaccination boosted responses primed by DNA vaccination. In conclusion, emulsigen and CpG motif containing ODN constitute a promising adjuvant formulation to deliver peptides to veterinary species...
  6. pmc Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis
    H Martin Vordermeier
    TB Research Group, VLA Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Infect Immun 77:3364-73. 2009
    ..These findings also have implications for human tuberculosis vaccine development...
  7. doi request reprint Antigen mining to define Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected animals: A VLA perspective
    M Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Surrey, UK
    Transbound Emerg Dis 56:240-7. 2009
    ..In addition, we draw general conclusions from our experience, and discuss potential future approaches in this area...
  8. ncbi request reprint Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattle
    H M Vordermeier
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet J 171:229-44. 2006
    ....
  9. pmc Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG
    H Martin Vordermeier
    TB Research Group, VLA Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 74:1416-8. 2006
    ..Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination...
  10. pmc Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level
    H Martin Vordermeier
    TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Vaccine Immunol 14:1203-9. 2007
    ....
  11. ncbi request reprint Development of cattle TB vaccines in the UK
    Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet Immunol Immunopathol 112:38-48. 2006
    ..These significant advances are detailed in this review with a summary of future directions that TB vaccine development for cattle is likely to take...
  12. pmc Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guérin
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, UK
    Immunology 112:461-70. 2004
    ....
  13. doi request reprint Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle
    Martin Vordermeier
    Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vet Microbiol 151:8-13. 2011
    ..Finally, we present an up-date of our current approaches in this area...
  14. doi request reprint ELISPOT assays to enumerate bovine IFN-γ-secreting cells for the development of novel vaccines against bovine tuberculosis
    Martin Vordermeier
    Department of Bacteriology, TB Research Group, Veterinary Laboratories Agency, WeybridgeAddlestone, Surrey, UK
    Methods Mol Biol 792:219-27. 2012
    ..This is particularly the case for vaccines against diseases that require protective cell-mediated immunity, such as tuberculosis. This chapter describes ELISPOT assays detecting bovine IFN-γ...
  15. ncbi request reprint Improved immunogenicity of DNA vaccination with mycobacterial HSP65 against bovine tuberculosis by protein boosting
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, KT15 3NB, UK
    Vet Microbiol 93:349-59. 2003
    ....
  16. pmc Adjuvants induce distinct immunological phenotypes in a bovine tuberculosis vaccine model
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Vaccine Immunol 16:1443-8. 2009
    ..These results demonstrate the importance of testing adjuvant formulations directly in the target species and the necessity of measuring different types of immune response when evaluating immune responses...
  17. pmc Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis
    H Martin Vordermeier
    TB Research Group, Veterinary Laboratory Agency, Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UK
    Infect Immun 72:6255-61. 2004
    ..In conclusion, the use of CyaA fusion proteins with ESAT-6 and CFP10 has the potential to improve the sensitivity of immunodiagnostic tests detecting bovine tuberculosis in cattle...
  18. pmc Characterization of two in vivo-expressed methyltransferases of the Mycobacterium tuberculosis complex: antigenicity and genetic regulation
    Paul Golby
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, UK
    Microbiology 154:1059-67. 2008
    ....
  19. pmc Minimum infective dose of Mycobacterium bovis in cattle
    Gillian S Dean
    TB Research Group, Veterinary Laboratories Agency, Weybridge, UK
    Infect Immun 73:6467-71. 2005
    ..bovis infection regardless of the dose. This information should be useful in modeling the dynamics of bovine tuberculosis in cattle and in assessing the risk of transmission...
  20. pmc Simultaneous measurement of antigen-stimulated interleukin-1 beta and gamma interferon production enhances test sensitivity for the detection of Mycobacterium bovis infection in cattle
    Gareth J Jones
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Clin Vaccine Immunol 17:1946-51. 2010
    ..In conclusion, we have demonstrated that the use of an additional readout system, such as IL-1β, can potentially complement IFN-γ by increasing overall test sensitivity for the detection of M. bovis infection in cattle...
  21. ncbi request reprint Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organism
    R Glyn Hewinson
    TB Research Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
    Vet Microbiol 112:127-39. 2006
    ..bovis and BCG will allow insight into how BCG became attenuated following serial passage on artificial growth media and reveal clues into how to improve the vaccine efficacy of BCG...
  22. pmc Screening of predicted secreted antigens from Mycobacterium bovis identifies potential novel differential diagnostic reagents
    Gareth J Jones
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Clin Vaccine Immunol 17:1344-8. 2010
    ..In summary, we have identified three peptide cocktails for prioritization in larger trials to discriminate between M. bovis infection and BCG vaccination...
  23. ncbi request reprint Protective immunity against Mycobacterium bovis induced by vaccination with Rv3109c--a member of the esat-6 gene family
    Philip J Hogarth
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 23:2557-64. 2005
    ..Significantly, Rv3019c also stimulated IFN-gamma responses in PBMC from BCG vaccinated cattle, indicating its potential for use in a heterologous prime-boost strategy in conjunction with BCG in the target species...
  24. pmc Screening of predicted secreted antigens from Mycobacterium bovis reveals the immunodominance of the ESAT-6 protein family
    Gareth J Jones
    TB Research Group, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 78:1326-32. 2010
    ..However, despite this considerable homology, peptide-mapping experiments also revealed that immunodominant peptides were located in regions of amino acid variability...
  25. pmc Is interleukin-4delta3 splice variant expression in bovine tuberculosis a marker of protective immunity?
    Shelley G Rhodes
    Veterinary Laboratories Agency, Surrey KT15 3NB, United Kingdom
    Infect Immun 75:3006-13. 2007
    ..bovis infection in cattle and are in accordance with clinical studies that have suggested a role for IL-4 splice variants in protective immunity in tuberculosis...
  26. pmc Mycobacterium bovis-BCG vaccination induces specific pulmonary transcriptome biosignatures in mice
    Elihu Aranday Cortes
    TB Research Group, Veterinary Laboratories Agency, Addlestone, United Kingdom
    PLoS ONE 5:e11319. 2010
    ..bovis. Further, these biosignatures should be detectable without in vitro antigenic challenge...
  27. ncbi request reprint Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells
    A Wangoo
    Department of Pathology, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, KT15 3NB, UK
    J Comp Pathol 133:223-34. 2005
    ..Such disease correlates may help to inform the development of improved diagnostic methods and support vaccine development programmes...
  28. ncbi request reprint The interferon-gamma field trial: background, principles and progress
    M Vordermeier
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey
    Vet Rec 155:37-8. 2004
    ..Here, Martin Vordermeier, Tony Goodchild, Richard Clifton-Hadley and Ricardo de la Rua describe the background to the trial, discuss the principle of the test and provide an update of progress so far..
  29. doi request reprint Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines
    G Dean
    Bovine TB, AHVLA Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
    Vaccine 32:1304-10. 2014
    ..Using histopathology, as a novel parameter of protection, we show that boosting BCG vaccinated cattle with Ad5-85A induced significantly better protection than BCG alone. ..
  30. pmc Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Imperial College London, Wright Fleming Institute, Norfolk Place, London W2 1PG, United Kingdom
    Infect Immun 73:2991-8. 2005
    ....
  31. ncbi request reprint Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine and Department of Pediatric Infectious Diseases, Faculty of Medicine, Imperial College London, Wright Fleming Institute, UK
    J Immunol 174:4237-43. 2005
    ..The demonstration that there is infection stage-specific immunity to tuberculosis has implications for vaccine design...
  32. ncbi request reprint Cattle as a model for development of vaccines against human tuberculosis
    Bryce M Buddle
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Tuberculosis (Edinb) 85:19-24. 2005
    ....
  33. pmc Association of tuberculin-boosted antibody responses with pathology and cell-mediated immunity in cattle vaccinated with Mycobacterium bovis BCG and infected with M. bovis
    Konstantin Lyashchenko
    Chembio Diagnostic Systems, Inc, Medford, New York, USA
    Infect Immun 72:2462-7. 2004
    ....
  34. pmc A DNA prime-Mycobacterium bovis BCG boost vaccination strategy for cattle induces protection against bovine tuberculosis
    Margot A Skinner
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Infect Immun 71:4901-7. 2003
    ..The use of the prime-boost strategy suggested that a combination of vaccines may be better than a single vaccine for protection against tuberculosis...
  35. ncbi request reprint Effect of oral vaccination of cattle with lipid-formulated BCG on immune responses and protection against bovine tuberculosis
    Bryce M Buddle
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Vaccine 23:3581-9. 2005
    ..Oral vaccination of BCG in a lipid-formulation to calves was shown to induce some positive tuberculin skin test reactions, but could also induce protection against bovine tuberculosis...
  36. pmc Vaccination of cattle with a CpG oligodeoxynucleotide-formulated mycobacterial protein vaccine and Mycobacterium bovis BCG induces levels of protection against bovine tuberculosis superior to those induced by vaccination with BCG alone
    D Neil Wedlock
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Infect Immun 73:3540-6. 2005
    ..These results suggest that a combination of a CpG ODN-formulated protein vaccine and BCG offers better protection against bovine tuberculosis than does BCG alone...
  37. pmc The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis
    Margot A Skinner
    AgResearch, Wallaceville Animal Research Centre, P O Box 40063, Upper Hutt, New Zealand
    Infect Immun 73:4441-4. 2005
    ..bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity...
  38. pmc Screening of highly expressed mycobacterial genes identifies Rv3615c as a useful differential diagnostic antigen for the Mycobacterium tuberculosis complex
    Ben Sidders
    Department of Pathology and Infectious Disease, The Royal Veterinary College, London, United Kingdom
    Infect Immun 76:3932-9. 2008
    ....
  39. ncbi request reprint Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines
    Zhou Xing
    Infectious Diseases Division, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Gene Ther 5:485-92. 2005
    ..Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines...
  40. pmc Enhanced protection against bovine tuberculosis after coadministration of Mycobacterium bovis BCG with a Mycobacterial protein vaccine-adjuvant combination but not after coadministration of adjuvant alone
    D Neil Wedlock
    AgResearch, Hopkirk Research Institute, Palmerston North, New Zealand
    Clin Vaccine Immunol 15:765-72. 2008
    ..Vaccination of cattle with a combination of BCG and protein tuberculosis vaccine enhances protection against tuberculosis...
  41. ncbi request reprint Vaccines for bovine tuberculosis: current views and future prospects
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, RG207NN, UK
    Expert Rev Vaccines 4:891-903. 2005
    ..These strategies are also highly applicable to the fight against tuberculosis in humans...
  42. ncbi request reprint Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFNgamma post-vaccination, but induce similar levels of protection against bovine tuberculosis
    D Neil Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 118:50-8. 2007
    ..The results also show that post-vaccination antigen-specific IFN-gamma levels in whole blood is not always a reliable indicator of protection against a subsequent virulent challenge...