G McGovern

Summary

Affiliation: Veterinary Laboratories Agency
Country: UK

Publications

  1. pmc Scrapie-specific pathology of sheep lymphoid tissues
    Gillian McGovern
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, United Kingdom
    PLoS ONE 2:e1304. 2007
  2. doi request reprint Frequency and distribution of nerves in scrapie-affected and unaffected Peyer's patches and lymph nodes
    G McGovern
    VLA Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK
    Vet Pathol 46:233-40. 2009
  3. pmc Scrapie affects the maturation cycle and immune complex trapping by follicular dendritic cells in mice
    Gillian McGovern
    Veterinary Laboratories Agency Lasswade, Penicuik, Midlothian, United Kingdom
    PLoS ONE 4:e8186. 2009
  4. doi request reprint Occurrence and cellular localization of PrPd in kidneys of scrapie-affected sheep in the absence of inflammation
    S Siso
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Pathol 215:126-34. 2008
  5. doi request reprint Increased immunohistochemical labelling for prion protein occurs in diverse neurological disorders of sheep: relevance for normal cellular PrP function
    M Jeffrey
    Animal Health and Veterinary Laboratories Agency, Lasswade Veterinary Laboratory, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 OPZ, Scotland, UK
    J Comp Pathol 147:46-54. 2012
  6. ncbi request reprint Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep
    M Jeffrey
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Midlothian, UK
    J Pathol 209:4-14. 2006
  7. ncbi request reprint Murine scrapie infection causes an abnormal germinal centre reaction in the spleen
    G McGovern
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Comp Pathol 130:181-94. 2004
  8. pmc Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scrapie to the brain
    Neil A Mabbott
    Neuropathogenesis Unit, Institute for Animal Health, Edinburgh EH9 3JF, Scotland, United Kingdom
    J Virol 76:5131-9. 2002

Detail Information

Publications8

  1. pmc Scrapie-specific pathology of sheep lymphoid tissues
    Gillian McGovern
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, United Kingdom
    PLoS ONE 2:e1304. 2007
    ..The nature of the sub-cellular changes in FDCs and TBMs differs from those of scrapie infected neurones and glial cells suggesting that different PrP(d)/cell membrane interactions occur in different cell types...
  2. doi request reprint Frequency and distribution of nerves in scrapie-affected and unaffected Peyer's patches and lymph nodes
    G McGovern
    VLA Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK
    Vet Pathol 46:233-40. 2009
    ..It is therefore possible that a general increase in nerve density of the intestine during early phases of life may contribute to an increased susceptibility of young animals to oral prion infection...
  3. pmc Scrapie affects the maturation cycle and immune complex trapping by follicular dendritic cells in mice
    Gillian McGovern
    Veterinary Laboratories Agency Lasswade, Penicuik, Midlothian, United Kingdom
    PLoS ONE 4:e8186. 2009
    ..We therefore support the hypothesis that TSEs cause an abnormality in immune function...
  4. doi request reprint Occurrence and cellular localization of PrPd in kidneys of scrapie-affected sheep in the absence of inflammation
    S Siso
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Pathol 215:126-34. 2008
    ..Either of these pathogenetic mechanisms could lead to environmental contamination via urine...
  5. doi request reprint Increased immunohistochemical labelling for prion protein occurs in diverse neurological disorders of sheep: relevance for normal cellular PrP function
    M Jeffrey
    Animal Health and Veterinary Laboratories Agency, Lasswade Veterinary Laboratory, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 OPZ, Scotland, UK
    J Comp Pathol 147:46-54. 2012
    ....
  6. ncbi request reprint Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep
    M Jeffrey
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Midlothian, UK
    J Pathol 209:4-14. 2006
    ....
  7. ncbi request reprint Murine scrapie infection causes an abnormal germinal centre reaction in the spleen
    G McGovern
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Comp Pathol 130:181-94. 2004
    ..Contrary to previous dogma, these results show that a pathological response within the immune system follows scrapie infection...
  8. pmc Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scrapie to the brain
    Neil A Mabbott
    Neuropathogenesis Unit, Institute for Animal Health, Edinburgh EH9 3JF, Scotland, United Kingdom
    J Virol 76:5131-9. 2002
    ..We conclude that treatments that specifically inhibit the TNFR signaling pathway may present an opportunity for early intervention in peripherally transmitted TSEs...