Lorenzo Gonzalez

Summary

Affiliation: Veterinary Laboratories Agency
Country: UK

Publications

  1. ncbi request reprint Comparative titration of experimental ovine BSE infectivity in sheep and mice
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK
    J Gen Virol 88:714-7. 2007
  2. doi request reprint Digestion and transportation of bovine spongiform encephalopathy-derived prion protein in the sheep intestine
    Mark P Dagleish
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Gen Virol 91:3116-23. 2010
  3. doi request reprint Factors influencing temporal variation of scrapie incidence within a closed Suffolk sheep flock
    Lorenzo Gonzalez
    Animal Health and Veterinary Laboratories Agency AHVLA, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK
    J Gen Virol 93:203-11. 2012
  4. pmc Monitoring of clinical signs in goats with transmissible spongiform encephalopathies
    Timm Konold
    Neuropathology, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, KT15 3NB, UK
    BMC Vet Res 6:13. 2010
  5. doi request reprint Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA, Pentlands Science Park, Penicuik EH26 0PZ, UK
    J Gen Virol 91:2630-41. 2010
  6. ncbi request reprint Distinct profiles of PrP(d) immunoreactivity in the brain of scrapie- and BSE-infected sheep: implications for differential cell targeting and PrP processing
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK
    J Gen Virol 84:1339-50. 2003
  7. pmc Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, United Kingdom
    Vet Res 41:48. 2010
  8. ncbi request reprint Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Gen Virol 86:827-38. 2005
  9. ncbi request reprint Adaptation and evaluation of a rapid test for the diagnosis of sheep scrapie in samples of rectal mucosa
    Lorenzo Gonzalez
    Veterinary Laboratories Agency, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Vet Diagn Invest 20:203-8. 2008
  10. doi request reprint Disease phenotype in sheep after infection with cloned murine scrapie strains
    Silvia Sisó
    Department of Pathology, Animal Health and Veterinary Laboratories Agency AHVLA Lasswade, Pentlands Science Park, Midlothian, UK
    Prion 6:174-83. 2012

Detail Information

Publications27

  1. ncbi request reprint Comparative titration of experimental ovine BSE infectivity in sheep and mice
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK
    J Gen Virol 88:714-7. 2007
    ..c. challenge with a 10(-3) dilution of 0.5 g of a brainstem pool from BSE-affected sheep, indicating that resistance to natural infection in sheep of this genotype must reside in some mechanism of peripheral pathogenesis...
  2. doi request reprint Digestion and transportation of bovine spongiform encephalopathy-derived prion protein in the sheep intestine
    Mark P Dagleish
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Gen Virol 91:3116-23. 2010
    ..BSE-derived PrP(res) is less protease resistant than scrapie PrP over a short time-course and the disappearance of detectable PrP(res) from the gut lumen results from both absorption and digestion by intestinal contents...
  3. doi request reprint Factors influencing temporal variation of scrapie incidence within a closed Suffolk sheep flock
    Lorenzo Gonzalez
    Animal Health and Veterinary Laboratories Agency AHVLA, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK
    J Gen Virol 93:203-11. 2012
    ....
  4. pmc Monitoring of clinical signs in goats with transmissible spongiform encephalopathies
    Timm Konold
    Neuropathology, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, KT15 3NB, UK
    BMC Vet Res 6:13. 2010
    ..The brain and selected lymphoid tissue were examined by postmortem tests for disease confirmation...
  5. doi request reprint Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA, Pentlands Science Park, Penicuik EH26 0PZ, UK
    J Gen Virol 91:2630-41. 2010
    ..We therefore conclude that natural scrapie strains exist and that they can be revealed by detailed pathological examinations, which can be harmonized between laboratories to produce comparable results...
  6. ncbi request reprint Distinct profiles of PrP(d) immunoreactivity in the brain of scrapie- and BSE-infected sheep: implications for differential cell targeting and PrP processing
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK
    J Gen Virol 84:1339-50. 2003
    ..Moreover, variations in PrP(d) conformation would appear to be also influenced by the cell type supporting infection, arguing that it is modulated by the interaction between the infectious agent and the host...
  7. pmc Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, United Kingdom
    Vet Res 41:48. 2010
    ....
  8. ncbi request reprint Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Gen Virol 86:827-38. 2005
    ....
  9. ncbi request reprint Adaptation and evaluation of a rapid test for the diagnosis of sheep scrapie in samples of rectal mucosa
    Lorenzo Gonzalez
    Veterinary Laboratories Agency, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Vet Diagn Invest 20:203-8. 2008
    ....
  10. doi request reprint Disease phenotype in sheep after infection with cloned murine scrapie strains
    Silvia Sisó
    Department of Pathology, Animal Health and Veterinary Laboratories Agency AHVLA Lasswade, Pentlands Science Park, Midlothian, UK
    Prion 6:174-83. 2012
    ..Further re-isolation experiments in mice are in progress in order to determine whether the original cloned murine disease phenotype will reemerge...
  11. pmc Immunohistochemical and biochemical characteristics of BSE and CWD in experimentally infected European red deer (Cervus elaphus elaphus)
    Stuart Martin
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK
    BMC Vet Res 5:26. 2009
    ..This study compares the immunohistochemical and biochemical characteristics of BSE and CWD in experimentally-infected European red deer (Cervus elpahus elaphus)...
  12. doi request reprint Three serial passages of bovine spongiform encephalopathy in sheep do not significantly affect discriminatory test results
    Michael Stack
    Veterinary Laboratories Agency VLA, Woodham Lane, Addlestone, Surrey, UK
    J Gen Virol 90:764-8. 2009
    ..Discrimination between experimental sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge...
  13. ncbi request reprint Monitoring for bovine spongiform encephalopathy in sheep in Great Britain, 1998-2004
    Michael Stack
    Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
    J Gen Virol 87:2099-107. 2006
    ..66%. This estimate is lower than calculated previously (5%), when the analysis was based on the results of strain typing in mice...
  14. doi request reprint High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age
    Lorenzo Gonzalez
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, United Kingdom
    Vet Res 40:65. 2009
    ..The results of this study have implications for surveillance and control policies for scrapie in goats...
  15. pmc Susceptibility to scrapie and disease phenotype in sheep: cross-PRNP genotype experimental transmissions with natural sources
    Lorenzo Gonzalez
    Animal Health and Veterinary Laboratories Agency, Pentlands Science Park, Bush Loan, Midlothian, EH26 0PZ, United Kingdom
    Vet Res 43:55. 2012
    ....
  16. pmc Experimental transmission of bovine spongiform encephalopathy to European red deer (Cervus elaphus elaphus)
    Mark P Dagleish
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Near Edinburgh, EH26 0PZ, UK
    BMC Vet Res 4:17. 2008
    ..Chronic wasting disease (CWD), also a TSE, naturally infects several cervid species in North America and is spreading rapidly in both captive and free-ranging populations...
  17. doi request reprint CD21 B cell populations are altered following subcutaneous scrapie inoculation in sheep
    Samantha L Eaton
    Moredun Research Institute, Penicuik, Edinburgh, EH26 0PZ, UK
    Vet Immunol Immunopathol 131:105-9. 2009
    ..Immunohistochemistry was used to attempt detection of the abnormal form of prion protein (PrP(sc)) in draining LNs adjacent to inoculation sites, with negative results at those time points...
  18. ncbi request reprint The neuropathologic phenotype of experimental ovine BSE is maintained after blood transfusion
    Silvia Sisó
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Midlothian, UK
    Blood 108:745-8. 2006
    ..This suggests that a change in the pathologic phenotype of vCJD would not be expected as a result of exposure to infected blood...
  19. doi request reprint Cellular and sub-cellular pathology of animal prion diseases: relationship between morphological changes, accumulation of abnormal prion protein and clinical disease
    Martin Jeffrey
    Veterinary Laboratories Agency, Lasswade Laboratory, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK
    Acta Neuropathol 121:113-34. 2011
    ..Thus, the proximate cause of clinical disease in animal prion disease is uncertain, but may not involve PrP(d)...
  20. doi request reprint Infectious titres of sheep scrapie and bovine spongiform encephalopathy agents cannot be accurately predicted from quantitative laboratory test results
    Lorenzo Gonzalez
    Animal Health and Veterinary Laboratories Agency AHVLA, AHVLA Lasswade, Pentlands Science Park, Penicuick, Midlothian EH26 0PZ, UK
    J Gen Virol 93:2518-27. 2012
    ..Furthermore, the near inverse correlation between infectious titres and Western blot results (high protease pre-treatment) argues for a dissociation between infectivity and PrP(res)...
  21. pmc Idiopathic Brainstem Neuronal Chromatolysis (IBNC): a novel prion protein related disorder of cattle?
    Martin Jeffrey
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Midlothian EH26 0PZ, UK
    BMC Vet Res 4:38. 2008
    ..Between the years of 1988 and 1991 IBNC occurred in Scotland with an incidence of 7 cases per 100,000 beef suckler cows over the age of 6 years...
  22. pmc Strain-associated variations in abnormal PrP trafficking of sheep scrapie
    Martin Jeffrey
    Veterinary Laboratories Agency Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Edinburgh, UK
    Brain Pathol 19:1-11. 2009
    ..These results imply that strains may contain or result in production of multiple isoforms of PrP(d)...
  23. pmc Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy
    Martin Jeffrey
    Animal Health Veterinary Laboratories Agency, Pentlands Science Park, Bush Loan Penicuik, Midlothian, UK
    Brain Pathol 22:58-66. 2012
    ..We also observed that the membrane alterations consistently seen in murine scrapie and other infectious TSEs were not present in 101LL mice with plaques, suggesting differences in the pathogenesis of these conditions...
  24. doi request reprint Sensory circumventricular organs in health and disease
    Silvia Sisó
    Department of Pathology, Pentlands Science Park, Penicuik, Midlothian, Scotland, UK
    Acta Neuropathol 120:689-705. 2010
    ..It is concluded that studies of the CVOs and related structures may help in the early diagnosis and treatment of such disorders...
  25. pmc Neuroinvasion in prion diseases: the roles of ascending neural infection and blood dissemination
    Silvia Sisó
    Veterinary Laboratories Agency VLA Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    Interdiscip Perspect Infect Dis 2010:747892. 2010
    ..We review here published data supporting this view and additional data suggesting that neuroinvasion may concurrently or independently involve the blood vascular system...
  26. ncbi request reprint Successful induction of ovine pulmonary adenocarcinoma in lambs of different ages and detection of viraemia during the preclinical period
    Daniela Salvatori
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK
    J Gen Virol 85:3319-24. 2004
    ..The feasibility of inducing OPA in older lambs and detecting JSRV viraemia in preclinical stages enables improved studies on the pathogenesis, assessment of vaccines, diagnosis and control of the disease...
  27. ncbi request reprint Systemic immune responses following infection with Jaagsiekte sheep retrovirus and in the terminal stages of ovine pulmonary adenocarcinoma
    Christina Summers
    Moredun Research Institute, Pentland Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Gen Virol 83:1753-7. 2002
    ..The CD4 lymphocytopaenia and neutrophilia reported previously in adult OPA cases were demonstrated but similar phenotypic changes were not identified during experimental infection...