Research Topics
| A R FooksSummaryAffiliation: Veterinary Laboratories Agency Country: UK Publications
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Publications
Case report: isolation of a European bat lyssavirus type 2a from a fatal human case of rabies encephalitisAnthony R Fooks
Rabies Research and Diagnostic Group, Veterinary Laboratories Agency Weybridge WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Surrey, United Kingdom
J Med Virol 71:281-9. 2003..Brain smears from each infected animal were positive by the FAT and viable virus was isolated. This fatal incident is only the second confirmed case of an EBLV type-2 infection in a human after exposure to bats...
Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparisonEdward Wright
MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
J Gen Virol 89:2204-13. 2008....
A robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in AfricaEdward Wright
Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
Vaccine 27:7178-86. 2009..These results suggest the proposed pseudotype assay is a suitable option for undertaking lyssavirus serosurveillance in areas most affected by these infections...
Experimental infection of foxes with European Bat Lyssaviruses type-1 and 2Florence Cliquet
WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, Community Reference Laboratory for Rabies, Community Reference Laboratory for Rabies Serology, AFSSA Malzeville, France
BMC Vet Res 5:19. 2009..The purpose of this study was to investigate the susceptibility of foxes to EBLVs using silver foxes (Vulpes vulpes) as a model...
A molecular epidemiological study of rabies epizootics in kudu (Tragelaphus strepsiceros) in NamibiaKaren Mansfield
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency VLA, Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, New Haw, Addlestone, Surrey, KT15 3NB, UK
BMC Vet Res 2:2. 2006..A panel of 37 rabies virus isolates were collected and studied, originating mainly from the northern and central regions of Namibia, between 1980 and 2003...
Risk factors associated with travel to rabies endemic countriesA R Fooks
Rabies Research and Diagnostic Group WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Veterinary Laboratories Agency Weybridge, Surrey, UK
J Appl Microbiol 94:31S-36S. 2003..Rabies should form part of a differential diagnosis for any patient presenting with a history of travel to a rabies endemic country and displaying an undiagnosed encephalopathy...
Detection of high levels of European bat lyssavirus type-1 viral RNA in the thyroid gland of experimentally-infected Eptesicus fuscus batsA R Fooks
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency Weybridge, Surrey, UK
Zoonoses Public Health 56:270-7. 2009....
Epidemiology of rabies in Southeast EuropeN Johnson
Veterinary Laboratories Agency Weybridge, Addlestone, UK
Dev Biol (Basel) 131:189-98. 2008..Throughout the region there is evidence for cross-border movement of rabies by both wildlife and canine vectors...
Molecular epidemiology of lyssaviruses in EurasiaL M McElhinney
Veterinary Laboratories Agency Weybridge, Surrey, Addlestone, United Kingdom
Dev Biol (Basel) 131:125-31. 2008....
Inflammatory responses in the nervous system of mice infected with a street isolate of rabies virusN Johnson
Veterinary Laboratories Agency Weybridge, Surrey, Addlestone, United Kingdom
Dev Biol (Basel) 131:65-72. 2008..We suggest that damage to the DRG and spinal cord could be due to a combination of both virus infection and the infiltration of T-cells...
Phylogenetic analysis of rabies viruses from Sudan provides evidence of a viral clade with a unique molecular signatureD A Marston
Rabies and Wildlife Zoonoses Group, WHO Collaborating Centre of Rabies and Rabies Related Viruses, Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
Virus Res 145:244-50. 2009..The high sequence identity in all Sudanese isolates studied, demonstrates the presence of a single rabies virus biotype for which the principal reservoir is the domestic dog...
Identification of a conserved linear epitope at the N terminus of the rabies virus glycoproteinK L Mansfield
Rabies Research and Diagnostic Group (WHO Collaborating Centre, Veterinary Laboratories Agency-Weybridge, Woodham Lane, New Haw, Surrey, KT15 3NB, UK
J Gen Virol 85:3279-83. 2004..In a multimeric form, the peptide could induce an epitope-specific response following immunization in rabbits and mice...
Isolation of European bat lyssavirus type 2 from a Daubenton's bat (Myotis daubentonii) in ShropshireS L Harris
Rabies and Wildlife Zoonoses Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, Veterinary Laboratories Agency - Weybridge, New Haw, Addlestone, Surrey
Vet Rec 161:384-6. 2007
Quantitative risk assessment to compare the risk of rabies entering the UK from Turkey via quarantine, the Pet Travel Scheme and the EU Pet Movement PolicyV Ramnial
Risk Analysis Workgroup, Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency, Addlestone, Surrey, UK
Epidemiol Infect 138:1114-25. 2010..In addition, EUPMP(listed) and EUPMP(unlisted) (at an increased level of importation) present a higher risk than quarantine or PETS at 100% compliance and at an uncertain level of compliance...
Rabies epidemiology and control in Turkey: past and presentN Johnson
Rabies and Wildlife Zoonoses Group, WHO Collaborating Centre for Characterisation of Rabies and Rabies related Viruses, Veterinary Laboratories Agency Weybridge, Surrey, UK
Epidemiol Infect 138:305-12. 2010..This review considers the current state of rabies in Turkey including current control measures, the varying epidemiology of the disease throughout this country and the prospects for rabies elimination...
Human rabies due to lyssavirus infection of bat originN Johnson
Veterinary Laboratories Agency Weybridge, Surrey, United Kingdom
Vet Microbiol 142:151-9. 2010..Many diagnostic techniques are unable to differentiate rabies virus from other genotypes so it is possible that some human and animal cases go unreported. Furthermore, current vaccines have limited efficacy against some genotypes...
Molecular epidemiology of canid rabies in Sudan: evidence for a common origin of rabies with EthiopiaN Johnson
Rabies Research and Diagnostic Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, Veterinary Laboratories Agency, Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
Virus Res 104:201-5. 2004..The Sudanese group of viruses belong to the Africa 1a group of viruses that are present throughout much of north Africa...
Molecular epidemiological study of Arctic rabies virus isolates from Greenland and comparison with isolates from throughout the Arctic and Baltic regionsK L Mansfield
Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, VLA, Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, New Haw, Addlestone, Surrey KT15 3NB, UK
Virus Res 116:1-10. 2006..The broad distribution of rabies in the Arctic regions including Greenland, Canada and Alaska provides evidence for the movement of rabies across borders...
Rabies human diploid cell vaccine elicits cross-neutralising and cross-protecting immune responses against European and Australian bat lyssavirusesS M Brookes
Rabies Research and Diagnostic Group, Virology Department, World Health Organisation Collaborating Centre Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey, UK
Vaccine 23:4101-9. 2005..Levels of protection were lower following intra-cranial (i.c.) challenge. Our data provides strong evidence for broad spectrum cross-neutralisation and cross-protection of phylogroup I lyssaviruses using rabies HDCV...
Comparative analysis of the full genome sequence of European bat lyssavirus type 1 and type 2 with other lyssaviruses and evidence for a conserved transcription termination and polyadenylation motif in the G-L 3' non-translated regionD A Marston
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency VLA, Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, New Haw, Addlestone, Surrey KT15 3NB, UK
J Gen Virol 88:1302-14. 2007..This observation may explain differences in pathogenicity between lyssavirus strains, dependent on the length of the untranslated region, which might affect transcriptional activity and RNA stability...
Evidence for trans-border movement of rabies by wildlife reservoirs between countries in the Balkan PeninsularN Johnson
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
Vet Microbiol 120:71-6. 2007..We speculate that natural barriers such as the Balkan mountains may play a significant role in constraining the southerly spread of rabies in southeast Europe...
Ability of rabies vaccine strains to elicit cross-neutralising antibodiesS M Brookes
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Addlestone, Surrey, United Kingdom
Dev Biol (Basel) 125:185-93. 2006..The continuing occurrence of non-classical lyssaviruses in Europe emphasizes the need for continual surveillance of bats and other species...
Up-regulation of chemokine gene transcripts and T-cell infiltration into the central nervous system and dorsal root ganglia are characteristics of experimental European bat lyssavirus type 2 infection of miceK L Mansfield
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency VLA Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Addlestone, Surrey, United Kingdom
J Neurovirol 14:218-28. 2008....
Wildlife rabies in Western Turkey: the spread of rabies through the western provinces of TurkeyN Johnson
Rabies Research and Diagnostic Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Veterinary Laboratories Agency, Weybridge, Surrey, UK
Epidemiol Infect 134:369-75. 2006....
Quantifying antigenic relationships among the lyssavirusesD L Horton
Rabies and Wildlife Zoonoses, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
J Virol 84:11841-8. 2010..The use of passive immune globulin is a crucial component of rabies postexposure prophylaxis, and here we also show that it is possible to predict the reactivity of immune globulin against divergent lyssaviruses...
The application of genetic markers for EBLV surveillance in European bat speciesS L Harris
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency VLA, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Surrey, UK
Dev Biol (Basel) 131:347-63. 2008..Application of this approach identified the species of a bat infected with EBLV-2 in Surrey as Myotis daubentoni (Daubenton's bat)...
Molecular epidemiology of rabies viruses in EuropeL M McElhinney
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Surrey, United Kingdom
Dev Biol (Basel) 125:17-28. 2006..Phylogenetic analysis of 198 unique sequences demonstrated numerous groups of viruses clustered at both geographical and host-species levels...
Phylogenetic comparison of rabies viruses from disease outbreaks on the Svalbard IslandsN Johnson
Rabies and Wildlife Zoonoses Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Veterinary Laboratories Agency Weybridge, Surrey, UK
Vector Borne Zoonotic Dis 7:457-60. 2007..Arctic fox migration has likely contributed to the establishment of another zoonotic disease, Echinococcus multilocularis, on Svalbard in recent years...
Development of a real-time, differential RT-PCR TaqMan assay for lyssavirus genotypes 1, 5 and 6P R Wakeley
Technology Transfer Unit, Biotechnology Department, Veterinary Laboratories Agency, Weybridge, Surrey, United Kingdom
Dev Biol (Basel) 126:227-36; discussion 326-7. 2006..Rapid genotyping of two recent EBLV2 cases in the U.K. in Daubenton's bats and a recently imported human case of rabies has been performed using this test...
Repeated detection of European bat lyssavirus type 2 in dead bats found at a single roost site in the UKAshley C Banyard
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, KT15 3NB, UK
Arch Virol 154:1847-50. 2009..We also report sequence data from both cases and compare data with those derived from other EBLV-2 isolations in the UK...
Tick-borne encephalitis virus - a review of an emerging zoonosisK L Mansfield
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency, Surrey, UK
J Gen Virol 90:1781-94. 2009..We also discuss the factors which may have influenced an apparent increase in the number of reported human cases each year, despite the availability of effective vaccines...
Molecular epidemiology of rabies in Botswana: a comparison between antibody typing and nucleotide sequence phylogenyN Johnson
Rabies Research and Diagnostic Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Veterinary Laboratories Agency, Weybridge, Woodham Lane, Addlestone KT15 3NB, UK
Vet Microbiol 101:31-8. 2004....
Airborne transmission of lyssavirusesN Johnson
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency (VLA, Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, New Haw, Addlestone KT15 3NB, UK
J Med Microbiol 55:785-90. 2006..This could present a particular hazard to personnel exposed to aerosols of infectious RABV following accidental release in a laboratory environment...
European bat lyssaviruses: an emerging zoonosisA R Fooks
Rabies Research and Diagnostic Group, Veterinary Laboratories Agency (Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, New Haw, Addlestone, Surrey KT15 3NB, UK
Epidemiol Infect 131:1029-39. 2003..This review provides a brief history of EBLVs, their distribution in host species and the public health risks...
Occupational lyssavirus risks and post-vaccination monitoringS M Brookes
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Addlestone, Surrey, United Kingdom
Dev Biol (Basel) 125:165-73. 2006..0 IU/ml for those in contact with non-RABV lyssaviruses in order to ensure that all individuals had antibody levels capable of neutralising the phylogroup I lyssaviruses...
A new outbreak of rabies in rare Ethiopian wolves (Canis simensis)N Johnson
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey KT15 3NB, United Kingdom
Arch Virol 155:1175-7. 2010..Sequence comparison of a partial fragment of the nucleoprotein-coding gene demonstrated that all viruses showed 100% sequence identity, suggesting a single introduction of rabies virus...
Phylogenetic comparison of the genus Lyssavirus using distal coding sequences of the glycoprotein and nucleoprotein genesN Johnson
Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, Weybridge, UK
Arch Virol 147:2111-23. 2002..Comparison of the phylogenetic analysis for this partial region of the glycoprotein suggest that it gives comparable results to studies that have used larger regions of the Lyssavirus genome...
Case report: rapid ante-mortem diagnosis of a human case of rabies imported into the UK from the PhilippinesJemma Smith
Rabies Research and Diagnostic Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, Veterinary Laboratories Agency (Weybridge, Surrey, United Kingdom
J Med Virol 69:150-5. 2003..Subsequent phylogenetic analysis demonstrated that this isolate was closely related to that of canine variants currently circulating in the Philippines...
Quantitative risk assessment of rabies entering Great Britain from North America via cats and dogsRowena D Jones
Veterinary Laboratories Agency, Woodham Lane, Addlestone, Surrey, KT15 3NB, UK
Risk Anal 25:533-42. 2005..22 x 10(-6), 95th percentile) than quarantine (1.01 x 10(-5), 95th percentile). These results, and other scientific evidence, directly informed the decision to expand the PETS scheme to North America as of December 2002...
Susceptibility of sheep to European bat lyssavirus type-1 and -2 infection: a clinical pathogenesis studySharon M Brookes
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency VLA, Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, New Haw, Addlestone, UK
Vet Microbiol 125:210-23. 2007..This study suggests that inter-species animal-to-animal transmission of a bat variant of rabies virus to a terrestrial mammal host may be limited, and may not always result in fatal encephalitis...
Molecular diversity and evolutionary history of rabies virus strains circulating in the BalkansL M McElhinney
Wildlife Zoonoses and Vector borne Diseases Research Group, Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, UK
J Gen Virol 92:2171-80. 2011....
Development of a real-time, TaqMan reverse transcription-PCR assay for detection and differentiation of lyssavirus genotypes 1, 5, and 6P R Wakeley
World Health Organization Collaborating Centre for the Characterization of Rabies and Rabies Related Viruses, Department of Virology, Veterinary Laboratories Agency, Addlestone, United Kingdom
J Clin Microbiol 43:2786-92. 2005..We propose that within a geographically constrained area, this assay will be a useful tool for the detection and differentiation of members of the Lyssavirus genus...
Identification of European bat lyssavirus isolates with short genomic insertionsNicholas Johnson
Rabies and Wildlife Zoonoses Group, WHO Collaborating Centre for the Characterization of Rabies and Rabies Related Viruses, Veterinary Laboratories Agency, Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
Virus Res 128:140-3. 2007....
Assessment of a novel real-time pan-flavivirus RT-polymerase chain reactionNicholas Johnson
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency, Addlestone, United Kingdom
Vector Borne Zoonotic Dis 10:665-71. 2010..The assay has been used to survey 160 bird samples and 1000 mosquito samples from the United Kingdom and found no evidence for WNV...
Rabies emergence among foxes in TurkeyNicholas Johnson
Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, KT15 3NB, UK
J Wildl Dis 39:262-70. 2003....
European bat lyssavirus type 2 RNA in Myotis daubentoniiNicholas Johnson
Rbies and Wildlife Zoonoses group, Veterinary Laboratories Agency, Addlestone, Surrey, United Kingdom
Emerg Infect Dis 12:1142-4. 2006..High levels of genomic RNA were found in the brain and were also detectable in the tongue, bladder, and stomach...
The immune response to rabies virus infection and vaccinationNicholas Johnson
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom
Vaccine 28:3896-901. 2010..This could help identify ways in which the response to prophylactic vaccination can be enhanced and how the natural immune response to infection can be boosted to combat neuroinvasion...
Experimental study of European bat lyssavirus type-2 infection in Daubenton's bats (Myotis daubentonii)Nicholas Johnson
Rabies and Wildlife Zoonoses Group, WHO Collaborating Centre for the Characterisation of Rabies and Rabies Related Viruses, Veterinary Laboratories Agency Weybridge, Woodham Lane, Addlestone, Surrey KT15 3NB, UK
J Gen Virol 89:2662-72. 2008..We conclude that EBLV-2 is most likely transmitted in saliva by a shallow bite...
Reassessing the risk from rabies: a continuing threat to the UK?Ashley C Banyard
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK
Virus Res 152:79-84. 2010..We highlight the current diagnostic necessity for testing indigenous and foreign cases and comment on current UK government policy in light of a European call to harmonise rabies legislation across Europe...
Lyssavirus infection activates interferon gene expression in the brainNicholas Johnson
Rabies and Wildlife Zoonoses Group WHO Collaborating Centre for the Characterization of Rabies and Rabies related Viruses, Department of Virology, Veterinary Laboratories Agency Weybridge, Addlestone, Surrey, UK
J Gen Virol 87:2663-7. 2006..Induction of this response was also observed following infection with the related European bat lyssaviruses, a group of zoonotic viruses capable of causing fatal, rabies-like disease in mammalian species...
Rabies remains a 'neglected disease'A R Fooks
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency (Weybridge, WHO Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, United Kingdom
Euro Surveill 10:211-2. 2005
Investigation of a human case of rabies in the United KingdomNicholas Johnson
Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
J Clin Virol 25:351-6. 2002..Comparison of both the nucleoprotein and glycoprotein coding sequences of this isolate with an imported case of human rabies from 1996, also from Nigeria, showed that the two viruses were 99% homologous...
European bat lyssavirus in Scottish batsSharon M Brookes
World Health Organization Collaborating Centre for the Characterisation of Rabies and Rabies-Related Viruses, Surrey, United Kingdom
Emerg Infect Dis 11:572-8. 2005..The RT-PCR included pan lyssavirus-primers (N gene) and internal PCR control primers for ribosomal RNA. EBLV-2 RNA was not detected in any of the saliva samples tested, and live virus was not detected in virus isolation tests...
A quantitative release assessment for the noncommercial movement of companion animals: risk of rabies reintroduction to the United kingdomA D Goddard
Centre for Epidemiology and Risk Analysis, Animal Health and Veterinary Laboratories Agency, Addlestone, Surrey, KT15 3NB, UK
Risk Anal 32:1769-83. 2012..The results of this risk assessment, along with other evidence, formed a scientific evidence base to inform policy decision with respect to companion animal movement...
Canine vaccine recipients recognize an immunodominant region of the rabies virus glycoproteinN Johnson
Rabies Research and Diagnostic Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
J Gen Virol 83:2663-9. 2002....
The feasibility of developing a risk assessment for the impact of climate change on the emergence of Crimean-Congo haemorrhagic fever in livestock in Europe: a reviewP Gale
Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, UK
J Appl Microbiol 108:1859-70. 2010..The species of migratory bird is also an important consideration in the release assessment with greater abundance and biodiversity of ground-dwelling birds in southern Europe than in northern Europe...
Assessing the impact of climate change on vector-borne viruses in the EU through the elicitation of expert opinionP Gale
Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK
Epidemiol Infect 138:214-25. 2010..This work will facilitate identification of appropriate risk management options in relation to adaptations to climate change...
Live viral vectors: construction of a replication-deficient recombinant adenovirusAnthony R Fooks
Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, United Kingdom
Methods Mol Med 87:37-50. 2003
Molecular epidemiology of terrestrial rabies in the former Soviet UnionIvan V Kuzmin
Rabies Group, Institute for Natural Foci Infections, Prospekt Mira, 7, Omsk, 644080 Russia
J Wildl Dis 40:617-31. 2004..In the glycoprotein gene, evidence of positive selection was strongly suggested in codons 156, 160, and 183. At these sites, no link between amino acid substitutions and phylogenetic placement or specific host species was detected...
Identification of a European bat lyssavirus type 2 in a Daubenton's bat found in LancashireAnthony R Fooks
Vet Rec 155:606-7. 2004
Prevention of rabies virus infection in dogs by a recombinant canine adenovirus type-2 encoding the rabies virus glycoproteinRongliang Hu
Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Science, 1068 Qinglong Road, Changchun, Jilin 130062, PR China
Microbes Infect 8:1090-7. 2006..The immunity lasts for months with a protective level of neutralizing antibody. This recombinant virus would be an alternative to the attenuated and the inactivated rabies vaccines and be prospective in immunizing dogs against rabies...
Identification of a European bat lyssavirus type 2 in a Daubenton's bat found in Staines, Surrey, UKAnthony R Fooks
Vet Rec 155:434-5. 2004
Detection of antibodies to EBLV-2 in Daubenton's bats in the UKAnthony R Fooks
Vet Rec 154:245-6. 2004
Human case of EBL type 2 following exposure to bats in Angus, ScotlandAnthony R Fooks
Vet Rec 151:679. 2002
European bat lyssavirus type 2 in a bat found in LancashireNicholas Johnson
Vet Rec 151:455-6. 2002
Paralytic rabies after a two week holiday in IndiaTom Solomon
Viral CNS Infections Group, Division of Neurological Science, University of Liverpool, Walton Centre for Neurology and Neurosurgery, Liverpool L9 7LJ
BMJ 331:501-3. 2005
Factors influencing the antibody response of dogs vaccinated against rabiesLorna J Kennedy
Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Vaccine 25:8500-7. 2007....
Genetic characterisation of attenuated SAD rabies virus strains used for oral vaccination of wildlifeLutz Geue
Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, WHO Collaborating Centre for Rabies Surveillance and Research, Wusterhausen, Germany
Vaccine 26:3227-35. 2008..Our data also supports the idea of a possible recombination that had occurred during the derivation of the European branch of SAD viruses. If confirmed, this recombination event would be the first one reported among RABV vaccine strains...
Rabies virus in a dog imported to the UK from Sri LankaAnthony R Fooks
Vet Rec 162:598. 2008
A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogsZiguo Yuan
Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, PR China
Vaccine 26:1314-21. 2008..Antibody titers were maintained for over 6 months. This suggests that pseudorabies virus could be an effective live vector for recombinant rabies oral vaccination...
Isolation of EBLV-2 in a Daubenton's bat (Myotis daubentonii) found in OxfordshireAnthony R Fooks
Vet Rec 159:534-5. 2006
Oral vaccination of dogs (Canis familiaris) with baits containing the recombinant rabies-canine adenovirus type-2 vaccine confers long-lasting immunity against rabiesShoufeng Zhang
Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, China
Vaccine 26:345-50. 2008..This demonstrated that the recombinant vaccine could be orally administrated and the bait was effective for the oral vaccination of dogs...
Pivotal role of dogs in rabies transmission, ChinaXianchun Tang
Chinese Academy of Science, Beijing, People's Republic of China
Emerg Infect Dis 11:1970-2. 2005..We review the incidence of rabies in China based on data from 1950 and 2004, obtained mainly from epidemiologic bulletins published by the Chinese Ministry of Health...
Review of human rabies cases in the UK and in GermanyNicholas Johnson
Vet Rec 157:715. 2005
Antibodies against Lagos bat virus in megachiroptera from West AfricaDavid T S Hayman
University of Cambridge, Cambridge, UK
Emerg Infect Dis 14:926-8. 2008..Neutralizing antibodies were detected in Eidolon helvum (37%), Epomophorus gambianus (3%), and Epomops buettikoferi (33%, 2/6) from Ghana. These findings confirm the presence of LBV in West Africa...
Serological reactivity of baculovirus-expressed Ebola virus VP35 and nucleoproteinsJan Groen
Institute of Virology, Erasmus MC, Dr. Molenwaterplein 40, 3015GD, Rotterdam, The Netherlands
Microbes Infect 5:379-85. 2003..r-NP ELISA proved to be a sensitive and specific assay for EBOV diagnosis and for epidemiological studies for both EBOV subtypes Reston and Zaire. The use of r-VP35 in an ELISA format has no additional value for EBOV serodiagnosis...
Intradermal pre-exposure rabies vaccine elicits long lasting immunityDavid Brown
Virus Reference Department, Centre for Infections, HPA, London, UK
Vaccine 26:3909-12. 2008..Using a schedule that administers 0.6 ml of rabies vaccine over three clinic visits the boosting interval could be extended towards ten years; substantially cheaper than the standard licensed intramuscular dosing schedule...
Rabies antibody levels in bat handlers in the United Kingdom: immune response before and after purified chick embryo cell rabies booster vaccinationJill Morris
Immunisation Department, Centre for Infections, Health Protection Agency, London, UK
Hum Vaccin 3:165-70. 2007..We recommend that the first rabies booster vaccination is given one year after the primary course and subsequent boosters are given every three to five years thereafter...
Antigenic characterisation of yeast-expressed lyssavirus nucleoproteinsIndre Kucinskaite
Institute of Biotechnology, V Graiciuno 8, 02241, Vilnius, Lithuania
Virus Genes 35:521-9. 2007..These recombinant proteins have the potential for use as components of serological assays for lyssaviruses...
Rabies encephalitis in malaria-endemic area, Malawi, AfricaMacpherson Mallewa
Divisions of Neurological Science, Medical Microbiology, and School of Tropical Medicine at University of Liverpool, Liverpool, United Kingdom
Emerg Infect Dis 13:136-9. 2007..5%) of 133 cases. Four patients had unusual clinical manifestations, and rabies was only diagnosed postmortem. Three (11.5%) of 26 fatal cases originally attributed to cerebral malaria were due to rabies...
Rabies in North America and EuropeChristopher J Finnegan
Rabies Research and Diagnostics Group, Department of Virology, Veterinary Laboratories Agency (Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
J R Soc Med 95:9-13. 2002
Viruses selectively upregulate Toll-like receptors in the central nervous systemClive S McKimmie
Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, UK
Biochem Biophys Res Commun 336:925-33. 2005..Upregulation of TLR 3 and 9 was dependent upon the type-I interferon response and may act to increase the threshold of sensitivity to detect virus infection in cells surrounding virally infected cells...
