Alimuddin I Zumla

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Reflections on the white plague
    Alimuddin Zumla
    Centre for Infectious Diseases and International Health, University College London Medical School, UCL Windeyer Institute of Medical Sciences, London, UK
    Lancet Infect Dis 9:197-202. 2009
  2. doi request reprint Tropical diseases: definition, geographic distribution, transmission, and classification
    Alimuddin Zumla
    Department of Infection, Division of Infection and Immunity, University College London Medical School, University College London Hospitals NHS Foundation Trust, London WC1E 6AJ, UK
    Infect Dis Clin North Am 26:195-205. 2012
  3. pmc Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus
    Raija K Ahmed
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Nobelsvag 16, SE 17182 Solna, Sweden
    BMC Infect Dis 12:41. 2012
  4. doi request reprint Drug-resistant tuberculosis--current dilemmas, unanswered questions, challenges, and priority needs
    Alimuddin Zumla
    University College London, Centre for Clinical Microbiology, Division of Infection and Immunity, London, UK
    J Infect Dis 205:S228-40. 2012
  5. doi request reprint Advancing the development of tuberculosis therapy
    Alimuddin Zumla
    Division of Infection and Immunity, University College London, London NW3 2PF, UK
    Nat Rev Drug Discov 11:171-2. 2012
  6. pmc Differential susceptibility of PCR reactions to inhibitors: an important and unrecognised phenomenon
    Jim F Huggett
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, 46 Cleveland Street, University College London, London, W1T 4JF, UK
    BMC Res Notes 1:70. 2008
  7. pmc Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
    Anil Pooran
    Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London Medical School, University College London, 43 Cleveland Street, London W1T 4JF, UK
    BMC Pulm Med 10:7. 2010
  8. doi request reprint Trials and tribulations of an African-led research and capacity development programme: the case for EDCTP investments
    A Zumla
    University of Zambia, Lusaka, Zambia
    Trop Med Int Health 15:489-94. 2010
  9. ncbi request reprint World TB Day 2010: Eradicating tuberculosis in sub-Saharan Africa needs effective and committed north-south partnerships
    Ben Marais
    University College London Medical School
    S Afr Med J 100:153-4. 2010
  10. ncbi request reprint Turning the tide against tuberculosis
    Alimuddin Zumla
    Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London W1T 4JF, UK
    Lancet 367:877-8. 2006

Collaborators

Detail Information

Publications47

  1. doi request reprint Reflections on the white plague
    Alimuddin Zumla
    Centre for Infectious Diseases and International Health, University College London Medical School, UCL Windeyer Institute of Medical Sciences, London, UK
    Lancet Infect Dis 9:197-202. 2009
    ..Although this investment introduces optimism for eventual control of the White Plague, past failures remind us not to be complacent...
  2. doi request reprint Tropical diseases: definition, geographic distribution, transmission, and classification
    Alimuddin Zumla
    Department of Infection, Division of Infection and Immunity, University College London Medical School, University College London Hospitals NHS Foundation Trust, London WC1E 6AJ, UK
    Infect Dis Clin North Am 26:195-205. 2012
    ..In tropical countries, apart from noncommunicable diseases, a severe burden of disease is caused by an array of different microorganisms, parasites, land and sea animals, and arthropods...
  3. pmc Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus
    Raija K Ahmed
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Nobelsvag 16, SE 17182 Solna, Sweden
    BMC Infect Dis 12:41. 2012
    ..A better understanding of biomarkers associated with TB will aid to guide the development of better targets for TB diagnosis and for the development of improved TB vaccines...
  4. doi request reprint Drug-resistant tuberculosis--current dilemmas, unanswered questions, challenges, and priority needs
    Alimuddin Zumla
    University College London, Centre for Clinical Microbiology, Division of Infection and Immunity, London, UK
    J Infect Dis 205:S228-40. 2012
    ....
  5. doi request reprint Advancing the development of tuberculosis therapy
    Alimuddin Zumla
    Division of Infection and Immunity, University College London, London NW3 2PF, UK
    Nat Rev Drug Discov 11:171-2. 2012
    ....
  6. pmc Differential susceptibility of PCR reactions to inhibitors: an important and unrecognised phenomenon
    Jim F Huggett
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, 46 Cleveland Street, University College London, London, W1T 4JF, UK
    BMC Res Notes 1:70. 2008
    ..To test this assumption we performed inhibition assessment on DNA extracts from human urine samples, fresh urine and EDTA using different PCR reactions...
  7. pmc Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
    Anil Pooran
    Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London Medical School, University College London, 43 Cleveland Street, London W1T 4JF, UK
    BMC Pulm Med 10:7. 2010
    ..tb...
  8. doi request reprint Trials and tribulations of an African-led research and capacity development programme: the case for EDCTP investments
    A Zumla
    University of Zambia, Lusaka, Zambia
    Trop Med Int Health 15:489-94. 2010
    ..The recent 255 million Euros EDCTP investment in sub-Saharan Africa through south-north partnerships is expected to enhance existing African-led R&D programmes. African governments and scientists must rise to the challenge...
  9. ncbi request reprint World TB Day 2010: Eradicating tuberculosis in sub-Saharan Africa needs effective and committed north-south partnerships
    Ben Marais
    University College London Medical School
    S Afr Med J 100:153-4. 2010
    ..World TB Day provides an opportunity to reflect on the poor state of TB control globally, particularly in sub-Saharan African countries (SSA)...
  10. ncbi request reprint Turning the tide against tuberculosis
    Alimuddin Zumla
    Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London W1T 4JF, UK
    Lancet 367:877-8. 2006
  11. doi request reprint Viewpoint: Scientific dogmas, paradoxes and mysteries of latent Mycobacterium tuberculosis infection
    Alimuddin Zumla
    Department of Infection, University College London Medical School, London, UK
    Trop Med Int Health 16:79-83. 2011
    ..Until such strategies and policies are realized, WHO and TB experts will have to settle for global TB control rather than eradication...
  12. ncbi request reprint Drugs for neglected diseases
    Alimuddin Zumla
    Centre for Infectious Diseases and International Health, Royal Free and University College London, UK
    Lancet Infect Dis 2:393. 2002
  13. pmc Impact of HIV infection on tuberculosis
    A Zumla
    Centre for Infectious Diseases, University College London, Royal Free and University College Medical School, Windeyer Institute of Medical Sciences, Room G41, 46 Cleveland Street, London W1P 6DB, UK
    Postgrad Med J 76:259-68. 2000
    ....
  14. ncbi request reprint Multidrug-resistant tuberculosis--can the tide be turned?
    A Zumla
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, Windeyer Institute for Medical Science, London, UK
    Lancet Infect Dis 1:199-202. 2001
    ..Not only is there a global increase in the disease itself, there is a worrying rise in the number of cases resistant to the two principal antituberculosis drugs, isoniazid and rifampicin--so called multidrug resistance...
  15. ncbi request reprint Immunologic aspects of tropical lung disease
    Alimuddin I Zumla
    Center for Infectious Diseases and International Health, University College London, Windeyer Institute of Medical Sciences, Room G41, 46 Cleveland Street, London W1P 6DB, UK
    Clin Chest Med 23:283-308, vii. 2002
    ..Paradoxically, while the immune response has evolved to confer protection against invading antigens, much human pathology arises when the immune responses are evoked...
  16. ncbi request reprint Non-tuberculous mycobacterial pulmonary infections
    Alimuddin I Zumla
    Centre for Infectious Diseases and International Health, University College London, Windeyer Institute, Room G41, 46 Cleveland Street, London W1P 6DB, UK
    Clin Chest Med 23:369-76. 2002
    ....
  17. ncbi request reprint Expression of a novel cytokine, IL-4delta2, in HIV and HIV-tuberculosis co-infection
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and UCL Medical School, University College London, London, UK
    AIDS 19:1601-6. 2005
    ..However data on interleukin (IL)-4 expression in HIV or AIDS are un-interpretable because of failure to distinguish between IL-4 and its splice variant and natural antagonist, IL-4delta2...
  18. ncbi request reprint The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, London, UK
    Tuberculosis (Edinb) 87:237-41. 2007
    ..The differential stability of the Th2 agonist, IL-4, compared to the antagonist IL-4delta2, represents a hitherto undescribed post-transcriptional regulatory mechanism that may modulate the polarisation of Th1/Th2 responses in human TB...
  19. ncbi request reprint The resurgence of disease: social and historical perspectives on the 'new' tuberculosis
    Matthew Gandy
    Department of Geography, University College London, UK
    Soc Sci Med 55:385-96; discussion 397-401. 2002
    ..It is concluded that tuberculosis research requires a combination of advances in bio-medical knowledge with a broader understanding of the evolving relationship between disease and modern societies...
  20. doi request reprint Tuberculosis due to high-dose challenge in partially immune individuals: a problem for vaccination?
    Graham A W Rook
    UCL Centre for Infectious Diseases and International Health, University College London Medical School, London, United Kingdom
    J Infect Dis 199:613-8. 2009
    ..tuberculosis and the susceptibilities of these pathways to regulation and suppression. There are important implications for the screening, testing, and likely success of vaccine candidates...
  21. doi request reprint The biosocial dynamics of tuberculosis
    John M Grange
    Centre for Infectious Diseases and International Health, University College London, London, UK
    Trop Med Int Health 14:124-30. 2009
    ....
  22. doi request reprint New and improved diagnostics for detection of drug-resistant pulmonary tuberculosis
    Justin O'Grady
    Department of Infection, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, UK
    Curr Opin Pulm Med 17:134-41. 2011
    ..During the past decade, there have been significant advances in diagnostic technologies for TB and drug-resistant TB. The purpose of this article is to review the current data, recommendations and evidence base for these tests...
  23. doi request reprint Nucleic acid detection and quantification in the developing world
    Jim Huggett
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, London, UK
    Biochem Soc Trans 37:419-23. 2009
    ..As nucleic acid amplification techniques become both simpler and cheaper, their impact is likely to play an increasingly crucial role in research and diagnosis in the developing world...
  24. ncbi request reprint Infection and disease caused by environmental mycobacteria
    Alimuddin Zumla
    Center for Infectious Diseases and International Health, Royal Free and University College Medical School, Windeyer Institute of Medical Sciences, London, UK
    Curr Opin Pulm Med 8:166-72. 2002
    ..avium subspecies paratuberculosis, in human inflammatory bowel disease. These aspects change the status of EM from mere curiosities to important direct, indirect, and putative causes of serious and increasingly common human disease...
  25. ncbi request reprint Immune systems in developed and developing countries; implications for the design of vaccines that will work where BCG does not
    Graham A W Rook
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, UK
    Tuberculosis (Edinb) 86:152-62. 2006
    ..The development of such vaccines, that might work where BCG does not, will require a greater understanding of the roles of the many types of regulatory T cell in tuberculosis...
  26. ncbi request reprint Problems of developing molecular diagnostic tests for opportunistic pathogens: the example of Pneumocystis jirovecii
    Jim F Huggett
    Centre for Infectious Diseases and International Health, University College London, London, United Kingdom
    J Eukaryot Microbiol 53:S85-6. 2006
  27. ncbi request reprint Expression of IL-4 mRNA in peripheral blood mononuclear cells from normal donors in relation to expression of TLR2
    Jung Su Chang
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Immunol Lett 106:194-7. 2006
    ..We conclude that in T cell populations from normal donors, expression of IL-4 (but not of its antagonist, IL-4delta2, or of IL-10) is associated with high TLR2 and low TLR1...
  28. ncbi request reprint Tuberculosis: amplification-based clinical diagnostic techniques
    Jim F Huggett
    Centre for Infectious Diseases, Royal Free and University College Medical School, University College London, Windeyer Building, W1T 4JF London, UK
    Int J Biochem Cell Biol 35:1407-12. 2003
    ..Early diagnosis of tuberculosis is critical for the successful management of patients allowing informed use of chemotherapy ensuring that the right patients are treated with the right antimicrobials...
  29. ncbi request reprint Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting?
    Graham A W Rook
    Centre for Infectious Disease and International Health, University College London, Windeyer Institute of Medical Sciences, London W1T 4JF, UK
    Vaccine 23:2115-20. 2005
    ..A successful vaccine, rather than driving a Th1 response, might need to suppress this pre-existing subversive Th2-like component...
  30. ncbi request reprint In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Am J Respir Crit Care Med 172:501-8. 2005
    ..A putative explanation is the simultaneous presence of a subversive Th2 response. However, interpretation is confounded by interleukin 4delta2 (IL-4delta2), a splice variant and inhibitor of IL-4...
  31. ncbi request reprint Immune responses to tuberculosis in developing countries: implications for new vaccines
    Graham A W Rook
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, London W1T 4JF, UK
    Nat Rev Immunol 5:661-7. 2005
    ..We propose that a successful vaccine needs to block this immunopathology, because it is not the quantity of T(H)1-cell activity that matters but, rather, its context...
  32. ncbi request reprint Lung remodeling in pulmonary tuberculosis
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Thoracic and HIV Medicine, Royal Free Hospital, London, United Kingdom
    J Infect Dis 192:1201-9. 2005
    ..Further studies are needed to identify and develop specific immunotherapeutic interventions that target immunopathology, since they have the potential to substantially reduce spread...
  33. ncbi request reprint Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, UK
    AIDS 19:2038-41. 2005
    ..ELISPOT test performance appears to be independent of HIV-associated immunosuppression...
  34. pmc Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation
    Helen A Fletcher
    The Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 112:669-73. 2004
    ..tuberculosis induces unusual, previously unrecognized, immunological events. We tentatively hypothesize that progression to active disease might depend upon the underlying ratio of IL-4 to IL-4delta2...
  35. doi request reprint Rapid diagnosis of tuberculosis through the detection of mycobacterial DNA in urine by nucleic acid amplification methods
    Clare Green
    University College London Medical School, Centre for Infectious Diseases and International Health, Department of Infection, Windeyer Institute of Medical Sciences, London, UK
    Lancet Infect Dis 9:505-11. 2009
    ..This Review discusses the developments and application of nucleic acid amplification of mycobacterial transrenal DNA for improved tuberculosis diagnostics...
  36. ncbi request reprint Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis
    Jung Su Chang
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, London, United Kingdom
    J Immunol 176:3010-8. 2006
    ..We conclude that M. tuberculosis exerts direct effects on patterns of TLR expression, partly via changes in mRNA half-life. The significance of these changes in the pathogenesis of disease deserves further investigation...
  37. ncbi request reprint Mycobacterium vaccae (SRL172) immunotherapy as an adjunct to standard antituberculosis treatment in HIV-infected adults with pulmonary tuberculosis: a randomised placebo-controlled trial
    Alwyn Mwinga
    University of Zambia University College London Tuberculosis HIV Research and Training Project, Lusaka, Zambia
    Lancet 360:1050-5. 2002
    ..Mortality rates of HIV-infected patients treated for tuberculosis remain high. This study aimed to assess the effect on mortality of immunotherapy with single-dose SRL172 added to standard antituberculosis chemotherapy in such patients...
  38. pmc The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis
    Sanjay Lala
    Centre for Gastroenterology, Royal Free and University College Medical School and Royal Free Hospital NHS Trust, London, UK
    BMC Infect Dis 7:96. 2007
    ..To further define a role for NOD2 in disease pathogenesis, we analysed NOD2 transcriptional responses in pulmonary leucocytes and mononuclear cells harvested from patients with pulmonary tuberculosis (PTB)...
  39. ncbi request reprint Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study
    Chifumbe Chintu
    University of Zambia University College London Medical School Research and Training Project, University Teaching Hospital, Lusaka, Zambia
    Lancet 360:985-90. 2002
    ..We undertook a study of children who died from respiratory diseases at University Teaching Hospital, Lusaka, Zambia...
  40. ncbi request reprint Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses
    Francis Kasolo
    UNZA UCLMS University of Zambia University College London Medical School Tuberculosis HIV Research and Training Project, the JICA Infectious Diseases Project, Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia
    J Pediatr 140:367-9. 2002
    ..The low specificity precludes the use of polymerase chain reaction as an alternative to histopathologic diagnosis...
  41. ncbi request reprint Validation of housekeeping genes for normalizing RNA expression in real-time PCR
    Keertan Dheda
    Royal Free Medical School, London, UK
    Biotechniques 37:112-4, 116, 118-9. 2004
    ..Validations of housekeeping genes are highly specific for a particular experimental model and are a crucial component in assessing any new model...
  42. ncbi request reprint Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses
    Kennedy Lishimpi
    The UNZA UCLMS University of Zambia University College London Medical School Research and Training Project, Lusaka, Zambia
    AIDS 16:932-4. 2002
    ..carinii DNA (sensitivity 68%; specificity 100%; positive predictive value 100%; negative predictive value 87%). This method requires further validation in clinical practice...
  43. pmc An assessment of air as a source of DNA contamination encountered when performing PCR
    Nina Witt
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, London, United Kingdom
    J Biomol Tech 20:236-40. 2009
    ..This demonstrates that the personnel and immediate laboratory environment are not necessarily to blame for the observed contamination...
  44. doi request reprint Tuberculosis in association with HIV/AIDS emerges as a major nonobstetric cause of maternal mortality in Sub-Saharan Africa
    John Grange
    Department of Infection, Centre for Infectious Diseases and International Health, University College London Medical School, London, UK
    Int J Gynaecol Obstet 108:181-3. 2010
    ..Maternal deaths from tuberculosis are now on the increase in the UK, and due diligence and watchful surveillance are required in European prenatal services...
  45. doi request reprint Establishing a new service role in tuberculosis care: the tuberculosis link worker
    Gillian M Craig
    University College London Centre for Infectious Diseases and International Health, London, UK
    J Adv Nurs 61:413-24. 2008
    ..This paper is a report of a study to develop a social outreach model of care, including the role of a link worker in developing collaborative care pathways, for marginalized groups with tuberculosis...
  46. ncbi request reprint Whole blood versus plasma spots for measurement of HIV-1 viral load in HIV-infected African patients
    Peter Mwaba
    University of Zambia University College London Medical School UNZA UCLMS Research and Training Project, University Teaching Hospital, Lusaka, Zambia
    Lancet 362:2067-8. 2003
    ..04 (SD 0.29). Dried whole blood stored on filter paper at room temperature shows potential as a field-friendly alternative to plasma for measurement of HIV-1 viral load...
  47. ncbi request reprint Editorial overview: Infectious diseases
    Alimuddin I Zumla
    Curr Opin Pulm Med 9:163-5. 2003