Ludvic Zrinzo

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Skewering the subthalamic nucleus via a parietal approach
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, UK
    Stereotact Funct Neurosurg 89:70-5. 2011
  2. doi request reprint The role of imaging in the surgical treatment of movement disorders
    Ludvic Zrinzo
    Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
    Neuroimaging Clin N Am 20:125-40. 2010
  3. doi request reprint Avoiding the ventricle: a simple step to improve accuracy of anatomical targeting during deep brain stimulation
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London
    J Neurosurg 110:1283-90. 2009
  4. ncbi request reprint Clinical safety of brain magnetic resonance imaging with implanted deep brain stimulation hardware: large case series and review of the literature
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    World Neurosurg 76:164-72; discussion 69-73. 2011
  5. ncbi request reprint Surgical anatomy of the pedunculopontine and peripeduncular nuclei
    L Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Br J Neurosurg 22:S19-24. 2008
  6. ncbi request reprint Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Institute of Neurology, University College London, UK
    Brain 131:1588-98. 2008
  7. doi request reprint Targeting of the pedunculopontine nucleus by an MRI-guided approach: a cadaver study
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    J Neural Transm 118:1487-95. 2011
  8. pmc Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom, Department of Clinical Neurology, University of Oxford, Oxford, OX3 9DU, United Kingdom
    J Neurosci 32:10541-53. 2012
  9. ncbi request reprint Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK
    Brain 134:359-74. 2011
  10. ncbi request reprint Minimizing brain shift in stereotactic functional neurosurgery
    Erika A Petersen
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK
    Neurosurgery 67:ons213-21; discussion ons221. 2010

Collaborators

Detail Information

Publications41

  1. doi request reprint Skewering the subthalamic nucleus via a parietal approach
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, UK
    Stereotact Funct Neurosurg 89:70-5. 2011
    ..A frontal burr hole around the level of the coronal suture is the conventional entry point when performing subthalamic nucleus (STN) deep brain stimulation (DBS). However, alternative approaches may sometimes be necessary...
  2. doi request reprint The role of imaging in the surgical treatment of movement disorders
    Ludvic Zrinzo
    Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
    Neuroimaging Clin N Am 20:125-40. 2010
    ..Documentation of electrode contact location by means of stereotactic imaging is essential to audit surgical targeting accuracy and to further the knowledge of structure-to-function relationships within the human brain...
  3. doi request reprint Avoiding the ventricle: a simple step to improve accuracy of anatomical targeting during deep brain stimulation
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London
    J Neurosurg 110:1283-90. 2009
    ..Special attention was focused on the impact that ventricular involvement of the electrode trajectory had on targeting accuracy...
  4. ncbi request reprint Clinical safety of brain magnetic resonance imaging with implanted deep brain stimulation hardware: large case series and review of the literature
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    World Neurosurg 76:164-72; discussion 69-73. 2011
    ..Functional MRI may shed light on the mechanism of action of DBS. MRI safety in DBS patients is therefore an important consideration...
  5. ncbi request reprint Surgical anatomy of the pedunculopontine and peripeduncular nuclei
    L Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Br J Neurosurg 22:S19-24. 2008
    ..The precise understanding and use of anatomical terminology together with accurate postoperative lead localization are essential when reporting on the clinical effects of novel DBS targets...
  6. ncbi request reprint Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Institute of Neurology, University College London, UK
    Brain 131:1588-98. 2008
    ..Direct MRI localization may allow greater individual accuracy than that afforded by atlas-based coordinates when localizing the human PPN and may be relevant to groups evaluating the clinical role of PPN DBS...
  7. doi request reprint Targeting of the pedunculopontine nucleus by an MRI-guided approach: a cadaver study
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Box 146, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    J Neural Transm 118:1487-95. 2011
    ..The results support the accuracy of the described specific MR imaging protocol...
  8. pmc Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom, Department of Clinical Neurology, University of Oxford, Oxford, OX3 9DU, United Kingdom
    J Neurosci 32:10541-53. 2012
    ..We conclude that synchronization at 60-90 Hz in the basal ganglia cortical network is prokinetic but likely through a modulatory effect rather than any involvement in explicit motor processing...
  9. ncbi request reprint Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK
    Brain 134:359-74. 2011
    ..The cortical topography and frequencies involved in the alpha and beta networks suggest that these networks may be involved in attentional and executive, particularly motor planning, processes, respectively...
  10. ncbi request reprint Minimizing brain shift in stereotactic functional neurosurgery
    Erika A Petersen
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK
    Neurosurgery 67:ons213-21; discussion ons221. 2010
    ..Stereotactic functional neurosurgical interventions depend on precise anatomic targeting before lesioning or deep brain stimulation (DBS) electrode placement...
  11. doi request reprint Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson's disease
    Anam Anzak
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK
    Neuroimage 64:284-9. 2013
    ..These results are consistent with a frequency-specific role of the STN in executive processes such as suppression of habitual responses and 'switching-on' of more controlled processing strategies...
  12. pmc Deep brain stimulation effects in dystonia: time course of electrophysiological changes in early treatment
    Diane Ruge
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 26:1913-21. 2011
    ..Clinical benefit is delayed because engrams of abnormal movement persist and take time to normalize. Our observations suggest that plasticity may be a driver of long-term therapeutic effects of deep brain stimulation in dystonia...
  13. pmc Therapeutic subthalamic nucleus deep brain stimulation reverses cortico-thalamic coupling during voluntary movements in Parkinson's disease
    Josh Kahan
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 7:e50270. 2012
    ..Furthermore, we confirm that fMRI is both feasible and is tolerated well by these patients provided strict safety measures are adhered to...
  14. pmc Optimized beamforming for simultaneous MEG and intracranial local field potential recordings in deep brain stimulation patients
    Vladimir Litvak
    UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Neuroimage 50:1578-88. 2010
    ..Our findings demonstrate that physiologically meaningful information can be extracted from heavily contaminated MEG signals and pave the way for further analysis of combined MEG-LFP recordings in DBS patients...
  15. pmc Resting state functional MRI in Parkinson's disease: the impact of deep brain stimulation on 'effective' connectivity
    Joshua Kahan
    1 Sobell Department for Motor Neurosciences and Movement Disorders, UCL Institute of Neurology, London, UK
    Brain 137:1130-44. 2014
    ..Our findings highlight the distributed effects of stimulation on the resting motor network and provide a framework for analysing effective connectivity in resting state functional MRI with strong a priori hypotheses. ..
  16. doi request reprint Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus
    Raul Martínez-Fernández
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1922-30. 2011
    ....
  17. doi request reprint Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's disease
    Tessel Boertien
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1835-43. 2011
    ..In this review we discuss the published evidence from functional imaging studies of patients with subthalamic nucleus-deep brain stimulation to date, together with how these data inform the mechanism of action of deep brain stimulation...
  18. doi request reprint Improving targeting in image-guided frame-based deep brain stimulation
    Etienne M Holl
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
    Neurosurgery 67:437-47. 2010
    ..Deep brain stimulation (DBS) is commonly used in the treatment of movement disorders such as Parkinson disease (PD), dystonia, and other tremors...
  19. doi request reprint A gamma band specific role of the subthalamic nucleus in switching during verbal fluency tasks in Parkinson's disease
    Anam Anzak
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, WC1N 3BG, UK
    Exp Neurol 232:136-42. 2011
    ..The mechanisms of this deficit are unclear. We aimed to identify and characterise verbal fluency related processing within the subthalamic nucleus through analysis of local field potentials...
  20. pmc Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    J Parkinsons Dis 3:139-44. 2013
    ..However, it is unclear whether bilateral deep brain stimulation of the subthalamic nucleus also causes impairment in decision making...
  21. pmc Treatment of dysarthria following subthalamic nucleus deep brain stimulation for Parkinson's disease
    Elina Tripoliti
    Sobell Department, Unit of Functional Neurosurgery, UCL, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:2434-6. 2011
    ..Speech impairment is a frequent side effect of the surgery. This study examined the efficacy of an intensive speech treatment, the Lee Silverman Voice Treatment (LSVT) on dysarthria after STN-DBS...
  22. ncbi request reprint Cortical evoked potentials from pallidal stimulation in patients with primary generalized dystonia
    Stephen Tisch
    Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:265-73. 2008
    ..Because the EP is larger and more consistently present with stimulation of posteroventral GPi than GPe, it may provide a physiological tool to identify contacts within the optimal surgical target...
  23. doi request reprint Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation
    Elina Tripoliti
    Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, London, United Kingdom
    Mov Disord 23:2377-83. 2008
    ....
  24. pmc Genotype and phenotype in Parkinson's disease: lessons in heterogeneity from deep brain stimulation
    Aikaterina Angeli
    Sobell Department of Motor Neuroscience, University College London UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 28:1370-5. 2013
    ..DBS cohorts include large numbers of gene positive PD patients and can be clinically instructive in the exploration of genotype-phenotype relationships. ..
  25. pmc Involvement of the subthalamic nucleus in engagement with behaviourally relevant stimuli
    Paul Sauleau
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N3BG, UK
    Eur J Neurosci 29:931-42. 2009
    ..The latter process is partly modulated by dopamine. Weakness in this function might contribute to the behavioural impairment that can follow BG lesions and surgery...
  26. ncbi request reprint The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia?
    James Gratwicke
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurosci Biobehav Rev 37:2676-88. 2013
    ..Controlled trials of deep brain stimulation of the nucleus basalis of Meynert for Parkinson's disease dementia and Alzheimer's disease are required to evaluate potential efficacy and the mechanisms of possible cognitive changes. ..
  27. ncbi request reprint Predictive factors of speech intelligibility following subthalamic nucleus stimulation in consecutive patients with Parkinson's disease
    Elina Tripoliti
    Unit of Functional Neurosurgery, University College London UCL Institute of Neurology, London, United Kingdom
    Mov Disord 29:532-8. 2014
    ..Consistent preoperative speech evaluation would help inform patients about the possible effects of surgery. Appropriate consideration of speech deficits might assist surgical targeting, particularly of the left electrode...
  28. doi request reprint Urinary incontinence following deep brain stimulation of the pedunculopontine nucleus
    Iciar Aviles-Olmos
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Acta Neurochir (Wien) 153:2357-60. 2011
    ..Proximity between caudal PPN and brainstem structures implicated in control of micturition is a possible explanation...
  29. doi request reprint MRI-guided subthalamic nucleus deep brain stimulation without microelectrode recording: can we dispense with surgery under local anaesthesia?
    Takeshi Nakajima
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, UK
    Stereotact Funct Neurosurg 89:318-25. 2011
    ..This study compares the clinical outcome of MRI-guided STN DBS performed under LA or GA in a consecutive patient series...
  30. pmc Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging
    Christian Lambert
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 60:83-94. 2012
    ....
  31. ncbi request reprint Deep brain stimulation between 1947 and 1987: the untold story
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
    Neurosurg Focus 29:E1. 2010
    ..Some of the questionable behavior in surgery for psychiatric illness, including the bygone era of DBS, was at the hands of nonneurosurgeons. These practices have been deemed as "dubious and precarious by yesterday's standards."..
  32. ncbi request reprint Future of brain stimulation: new targets, new indications, new technology
    Marwan Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK Department of Clinical Neuroscience, Umea University, Umea, Sweden
    Mov Disord 28:1784-92. 2013
    ....
  33. pmc Pallidal stimulation for primary generalised dystonia: effect on cognition, mood and quality of life
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    J Neurol 261:164-73. 2014
    ..The dissociation between GPi-DBS improving dystonia, but not having a significant positive impact on the patients' QoL, warrants further investigation. ..
  34. doi request reprint The risk of hardware infection in deep brain stimulation surgery is greater at impulse generator replacement than at the primary procedure
    Joshua Pepper
    Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK
    Stereotact Funct Neurosurg 91:56-65. 2013
    ..We examined all patients who underwent DBS procedures over the last 9 years in our centre to assess the infection rate and possible factors related to surgery that may predispose to infection...
  35. doi request reprint Reducing hemorrhagic complications in functional neurosurgery: a large case series and systematic literature review
    Ludvic Zrinzo
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
    J Neurosurg 116:84-94. 2012
    ..Estimating the true incidence of and risk factors for hemorrhage in functional neurosurgery is a challenging issue...
  36. doi request reprint An approach to deep brain stimulation for severe treatment-refractory Tourette syndrome: the UK perspective
    Andrea E Cavanna
    Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, UK
    Br J Neurosurg 25:38-44. 2011
    ..The present article illustrates the UK perspective on DBS in TS and proposes consensus-based recommendations for double-blind controlled trials...
  37. ncbi request reprint Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination
    Anna Sadnicka
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 28:1874-7. 2013
    ....
  38. doi request reprint Deep brain stimulation in the treatment of chorea
    Thomas C Edwards
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Mov Disord 27:357-63. 2012
    ..As both these disorders are often refractory to medication and difficult to treat, deep brain stimulation may be a useful treatment option in the future...
  39. doi request reprint Strawberries on the brain--intracranial capillary hemangioma: two case reports and systematic literature review in children and adults
    Bilal Mirza
    Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, United Kingdom Electronic address
    World Neurosurg 80:900.e13-21. 2013
    ..Capillary hemangioma in the cranial cavity is rare. This report describes 2 additional cases presenting shortly after pregnancy and provides a systematic review summarizing clinical experience to date...
  40. doi request reprint Deep brain stimulation in cluster headache: hypothalamus or midbrain tegmentum?
    Manjit S Matharu
    Institute of Neurology, Queen Square, London, UK
    Curr Pain Headache Rep 14:151-9. 2010
    ....
  41. ncbi request reprint Pallidal stimulation modifies after-effects of paired associative stimulation on motor cortex excitability in primary generalised dystonia
    Stephen Tisch
    Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Box 146 8 11 Queen Square, London WC1N 3BG, UK
    Exp Neurol 206:80-5. 2007
    ..To determine the effect of globus pallidus internus (GPi) deep brain stimulation (DBS) on motor cortex plasticity in patients with primary generalised dystonia...