A M Zorn

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc The KH domain protein encoded by quaking functions as a dimer and is essential for notochord development in Xenopus embryos
    A M Zorn
    Center for Developmental Biology, Department of Zoology, University of Texas at Austin, 78712, USA
    Genes Dev 11:2176-90. 1997
  2. ncbi Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways
    A M Zorn
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Dev Biol 209:282-97. 1999
  3. ncbi Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin
    A M Zorn
    Wellcome Trust Cancer Research Campaign Institute of Cancer and Developmental Biology, Cambridge
    Mol Cell 4:487-98. 1999
  4. ncbi Gene expression in the embryonic Xenopus liver
    A M Zorn
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Mech Dev 103:153-7. 2001
  5. ncbi eFGF and its mode of action in the community effect during Xenopus myogenesis
    H J Standley
    Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR and Department of Zoology, University of Cambridge, UK
    Development 128:1347-57. 2001
  6. ncbi Differential expression of VegT and Antipodean protein isoforms in Xenopus
    F Stennard
    Wellcome CRC Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    Mech Dev 86:87-98. 1999
  7. ncbi Remarkable sequence conservation of transcripts encoding amphibian and mammalian homologues of quaking, a KH domain RNA-binding protein
    A M Zorn
    Center for Developmental Biology and Genetics Institute, Department of Zoology, University of Texas at Austin, 78712, USA
    Gene 188:199-206. 1997
  8. ncbi Wnt signalling: antagonistic Dickkopfs
    A M Zorn
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK
    Curr Biol 11:R592-5. 2001
  9. ncbi Nonradioactive in situ hybridization to xenopus tissue sections
    K Butler
    Wellcome, CRC Institute, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Methods 23:303-12. 2001
  10. pmc Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling
    K Shimizu
    Wellcome Trust Cancer Research Campaign Institute, Cambridge CB2 1QR, United Kingdom
    Mol Cell Biol 21:3901-12. 2001

Collaborators

Detail Information

Publications10

  1. pmc The KH domain protein encoded by quaking functions as a dimer and is essential for notochord development in Xenopus embryos
    A M Zorn
    Center for Developmental Biology, Department of Zoology, University of Texas at Austin, 78712, USA
    Genes Dev 11:2176-90. 1997
    ..Xqua function appears to be required for the accumulation of important mRNAs such as Xnot, Xbra, and gsc. These results indicate an essential role for the quaking RNA-binding protein during early vertebrate embryogenesis...
  2. ncbi Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways
    A M Zorn
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Dev Biol 209:282-97. 1999
    ..These results provide a starting point for understanding the molecular events underlying the progressive determination of endodermally derived organs, such as the liver and foregut...
  3. ncbi Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin
    A M Zorn
    Wellcome Trust Cancer Research Campaign Institute of Cancer and Developmental Biology, Cambridge
    Mol Cell 4:487-98. 1999
    ..Two additional Sox proteins, XSox17 alpha and XSox3, likewise bind to beta-catenin and inhibit its TCF-mediated signaling activity. These results reveal an unexpected mechanism by which Sox proteins can modulate Wnt signaling pathways...
  4. ncbi Gene expression in the embryonic Xenopus liver
    A M Zorn
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Mech Dev 103:153-7. 2001
    ....
  5. ncbi eFGF and its mode of action in the community effect during Xenopus myogenesis
    H J Standley
    Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR and Department of Zoology, University of Cambridge, UK
    Development 128:1347-57. 2001
    ..Finally, we demonstrate that FGF signalling is essential for endogenous community interactions. We conclude that eFGF is likely to mediate the community effect in Xenopus myogenesis...
  6. ncbi Differential expression of VegT and Antipodean protein isoforms in Xenopus
    F Stennard
    Wellcome CRC Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    Mech Dev 86:87-98. 1999
    ..We conclude that the developmental role of VegT/Apod is mediated by two different proteins, with entirely different patterns of expression and response to growth factors...
  7. ncbi Remarkable sequence conservation of transcripts encoding amphibian and mammalian homologues of quaking, a KH domain RNA-binding protein
    A M Zorn
    Center for Developmental Biology and Genetics Institute, Department of Zoology, University of Texas at Austin, 78712, USA
    Gene 188:199-206. 1997
    ..Overall, the high sequence conservation of quaking sequences suggests an important conserved function in vertebrate development, probably in the regulation of RNA metabolism...
  8. ncbi Wnt signalling: antagonistic Dickkopfs
    A M Zorn
    Wellcome CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK
    Curr Biol 11:R592-5. 2001
    ..Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway...
  9. ncbi Nonradioactive in situ hybridization to xenopus tissue sections
    K Butler
    Wellcome, CRC Institute, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Methods 23:303-12. 2001
    ..Therefore thorough analysis of gene expression patterns often requires in situ hybridization on presectioned material whereby probe has equal accessibility to all tissue...
  10. pmc Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling
    K Shimizu
    Wellcome Trust Cancer Research Campaign Institute, Cambridge CB2 1QR, United Kingdom
    Mol Cell Biol 21:3901-12. 2001
    ..We conclude that Swift is a novel coactivator of Smad2 and that Swift has a critical role in embryonic TGFbeta-induced gene transcription. Our results suggest that Swift may be a general component of TGFbeta signaling...