Loems Ziegler-Heitbrock

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Expression of M-Ficolin in human monocytes and macrophages
    Marion Frankenberger
    Clinical Cooperation Group, Inflammatory Lung Diseases, GSF National Research Center for Environment and Health and Asklepios Fachkliniken Gauting, Robert Koch Allee 29, D 82131, Gauting Munich, Germany
    Mol Immunol 45:1424-30. 2008
  2. ncbi request reprint Mechanism of glucocorticoid-induced depletion of human CD14+CD16+ monocytes
    Farshid Dayyani
    Institute for Immunology and Medizinische Poliklinik, University of Muenchen, Germany
    J Leukoc Biol 74:33-9. 2003
  3. pmc Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy
    Bernard Burke
    Tumor Targeting Group, Section of Oncology and Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom
    Am J Pathol 163:1233-43. 2003
  4. ncbi request reprint Impact of type-I-interferon on monocyte subsets and their differentiation to dendritic cells. An in vivo and ex vivo study in multiple sclerosis patients treated with interferon-beta
    F Then Bergh
    Institute of Immunology, Ludwig Maximilians Universitat, Munich, Germany
    J Neuroimmunol 146:176-88. 2004
  5. ncbi request reprint MBL and MoBL
    Loems Ziegler-Heitbrock
    Br J Haematol 130:795; author reply 795-6. 2005
  6. ncbi request reprint IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3
    Löms Ziegler-Heitbrock
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 171:285-90. 2003
  7. ncbi request reprint The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
  8. ncbi request reprint Monocyte chemoattractant chemokines in cystic fibrosis
    Satish Rao
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Cyst Fibros 8:97-103. 2009
  9. doi request reprint Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint
    Marion Frankenberger
    Comprehensive Pneumology Center, Helmholtz Zentrum Munchen, Ludwig Maximilians University and Asklepios Fachklinik Gauting, Munich, Germany
    Eur J Immunol 42:957-74. 2012
  10. doi request reprint Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1α mRNA
    Karl J Staples
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Immunobiology 216:832-9. 2011

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Expression of M-Ficolin in human monocytes and macrophages
    Marion Frankenberger
    Clinical Cooperation Group, Inflammatory Lung Diseases, GSF National Research Center for Environment and Health and Asklepios Fachkliniken Gauting, Robert Koch Allee 29, D 82131, Gauting Munich, Germany
    Mol Immunol 45:1424-30. 2008
    ..These data show that M-Ficolin expression is silenced in macrophages but can be re-activated after prolonged activation via TLRs...
  2. ncbi request reprint Mechanism of glucocorticoid-induced depletion of human CD14+CD16+ monocytes
    Farshid Dayyani
    Institute for Immunology and Medizinische Poliklinik, University of Muenchen, Germany
    J Leukoc Biol 74:33-9. 2003
    ..Our studies show a selective depletion of CD14(+)CD16(+) monocytes by GC treatment in vivo and in vitro, an effect to which the modestly increased level of GCR may contribute...
  3. pmc Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy
    Bernard Burke
    Tumor Targeting Group, Section of Oncology and Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom
    Am J Pathol 163:1233-43. 2003
    ..The hypoxia up-regulated genes identified could be important for the survival and functioning of macrophages in hypoxic diseased tissues, and their promoters could prove useful in macrophage-delivered gene therapy...
  4. ncbi request reprint Impact of type-I-interferon on monocyte subsets and their differentiation to dendritic cells. An in vivo and ex vivo study in multiple sclerosis patients treated with interferon-beta
    F Then Bergh
    Institute of Immunology, Ludwig Maximilians Universitat, Munich, Germany
    J Neuroimmunol 146:176-88. 2004
    ..Addition of IFNb to the medium further reduced the induction of CD1a+CD14+ cells.IFNb induces a novel immunophenotypic shift in pro-inflammatory monocytes, which appears to be related to reduced formation of dendritic cell precursors...
  5. ncbi request reprint MBL and MoBL
    Loems Ziegler-Heitbrock
    Br J Haematol 130:795; author reply 795-6. 2005
  6. ncbi request reprint IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3
    Löms Ziegler-Heitbrock
    Institute for Immunology, University of Munich, Munich, Germany
    J Immunol 171:285-90. 2003
    ..Of note, LPS-induced trans-activation does not target this module, since it is independent of the IRF-1 motif but completely depends on Stat3...
  7. ncbi request reprint The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
    ..The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease...
  8. ncbi request reprint Monocyte chemoattractant chemokines in cystic fibrosis
    Satish Rao
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Cyst Fibros 8:97-103. 2009
    ..In this study, we sought to assess the levels of monocyte chemoattractants CCL2 and CX3CL1 in the blood and airways of patients with CF, and expression of their respective receptors CCR2 and CX3CR1 on blood monocytes...
  9. doi request reprint Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint
    Marion Frankenberger
    Comprehensive Pneumology Center, Helmholtz Zentrum Munchen, Ludwig Maximilians University and Asklepios Fachklinik Gauting, Munich, Germany
    Eur J Immunol 42:957-74. 2012
    ..Furthermore, CD16-positive MDMs showed a higher phagocytosis for opsonized Escherichia coli. The data demonstrate that CD16-positive monocytes form a distinct type of cell, which gives rise to a distinct macrophage phenotype...
  10. doi request reprint Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1α mRNA
    Karl J Staples
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Immunobiology 216:832-9. 2011
    ..Taken together, the data support the hypothesis that hypoxia affects monocyte to macrophage maturation, resulting in a distinct gene expression pattern and phenotype...
  11. ncbi request reprint Increased TNF expression in CD43++ murine blood monocytes
    Bernard Burke
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Immunol Lett 118:142-7. 2008
    ..These data indicate that the murine CD43++ monocyte subset exhibits features of pro-inflammatory monocytes and is functionally homologeous to the human CD14+CD16+ monocytes...
  12. ncbi request reprint Tolerance induced by the lipopeptide Pam3Cys is due to ablation of IL-1R-associated kinase-1
    Maciej Siedlar
    Institute for Immunology, University of Muenchen, Muenchen, Germany
    J Immunol 173:2736-45. 2004
    ....
  13. doi request reprint Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors
    Adam K A Wright
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Leukoc Biol 86:479-89. 2009
    ..The deficiency of MARCO expression in the predominant small sputum macrophages in CF may lead to impaired clearance of inhaled particles with increased inflammation and damage to the CF lung...
  14. ncbi request reprint IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3
    Karl J Staples
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    J Immunol 178:4779-85. 2007
    ..These data show that IL-10 induces IL-10 in monocyte-derived macrophages in an autocrine manner via activation of the transcription factor Stat3...
  15. doi request reprint Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression
    Annette Schaefer
    Department of Infection, Immunity and Inflammation, University of Leicester, UK
    Mol Immunol 46:1351-9. 2009
    ..These data demonstrate that IFNgamma down-regulates expression of the IL-10 gene by a novel mechanism that involves displacement of transactiving Stat3 by IFNgamma-induced Stat1...
  16. doi request reprint Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene
    Claudia Unterberger
    Clinical Cooperation Group, Inflammatory Lung Diseases, Helmholtz Zentrum Munchen, German Research Center for Environmental Health and Asklepios Fachklinik, Robert Koch Allee 29, 82131 Gauting, Germany
    Mol Immunol 45:3230-7. 2008
    ..These data show that glucocorticoid-induced expression of the IL-10 gene is mediated by the transcription factor STAT3...
  17. ncbi request reprint Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome
    Ian Todd
    Division of Immunology, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Arthritis Rheum 56:4182-8. 2007
    ..The aim of this study was to investigate whether the expression of circulating CD16+ monocytes is affected in patients with TRAPS...
  18. pmc A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion
    Sandra M Newton
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Center for Molecular Microbiology and Infection, and Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 103:15594-8. 2006
    ..The Rv1519 polymorphism in M. tuberculosis confers an immune subverting phenotype that contributes to the persistence and outbreak potential of this lineage...