Xu sheng Zhang

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 161:419-33. 2002
  2. ncbi request reprint Modeling for neuromonitoring depth of anesthesia
    Xu sheng Zhang
    Siemens Medical Solutions USA, Inc, Danvers, Massachusetts, USA
    Crit Rev Biomed Eng 30:131-73. 2002
  3. pmc Increase in quantitative variation after exposure to environmental stresses and/or introduction of a major mutation: G x E interaction and epistasis or canalization?
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 180:687-95. 2008
  4. pmc The anomalous effects of biased mutation revisited: mean-optimum deviation and apparent directional selection under stabilizing selection
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 179:1135-41. 2008
  5. doi request reprint Mutation-selection balance for environmental variance
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Am Nat 171:394-9. 2008
  6. ncbi request reprint Competition can maintain genetic but not environmental variance in the presence of stabilizing selection
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 61:1532-45. 2007
  7. ncbi request reprint The phenotypic variance within plastic traits under migration-mutation-selection balance
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 60:1125-36. 2006
  8. ncbi request reprint Evolution and maintenance of the environmental component of the phenotypic variance: benefit of plastic traits under changing environments
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom
    Am Nat 166:569-80. 2005
  9. ncbi request reprint Evolution of the environmental component of the phenotypic variance: stabilizing selection in changing environments and the cost of homogeneity
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 59:1237-44. 2005
  10. pmc Predictions of patterns of response to artificial selection in lines derived from natural populations
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 169:411-25. 2005

Detail Information

Publications19

  1. pmc Pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 161:419-33. 2002
    ....
  2. ncbi request reprint Modeling for neuromonitoring depth of anesthesia
    Xu sheng Zhang
    Siemens Medical Solutions USA, Inc, Danvers, Massachusetts, USA
    Crit Rev Biomed Eng 30:131-73. 2002
    ....
  3. pmc Increase in quantitative variation after exposure to environmental stresses and/or introduction of a major mutation: G x E interaction and epistasis or canalization?
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 180:687-95. 2008
    ..On the basis of more realistic selection models, our analysis lends further support to the genetic theory of Hermisson and Wagner as an interpretation of hidden variance...
  4. pmc The anomalous effects of biased mutation revisited: mean-optimum deviation and apparent directional selection under stabilizing selection
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 179:1135-41. 2008
    ..We show by simulation that genetic drift, leptokurtosis of mutational effects, and pleiotropy can increase the mean-optimum deviation greatly, however, and that the apparent directional selection thereby caused can be substantial...
  5. doi request reprint Mutation-selection balance for environmental variance
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Am Nat 171:394-9. 2008
    ..This conclusion is not robust for small populations because some mutants may become fixed, which indicates that other selective forces must be involved, such as an intrinsic cost of homogeneity...
  6. ncbi request reprint Competition can maintain genetic but not environmental variance in the presence of stabilizing selection
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 61:1532-45. 2007
    ..If the magnitude of the environmental variance is not under genetic control, there is a complementary relationship between the levels of environmental and genetic variance such that the level of phenotypic variance is little affected...
  7. ncbi request reprint The phenotypic variance within plastic traits under migration-mutation-selection balance
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 60:1125-36. 2006
    ..Temporal variation in environmental quality increases V(G) while its spatial variance decreases V(G). Variation in environmental conditions may decrease the environmental variance in the plastic trait...
  8. ncbi request reprint Evolution and maintenance of the environmental component of the phenotypic variance: benefit of plastic traits under changing environments
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom
    Am Nat 166:569-80. 2005
    ..Under certain circumstances, however, the environmental variance may decrease with increase in variation in environmental quality...
  9. ncbi request reprint Evolution of the environmental component of the phenotypic variance: stabilizing selection in changing environments and the cost of homogeneity
    Xu sheng Zhang
    Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 59:1237-44. 2005
    ..It is shown that a small homogeneity cost is enough to maintain the observed levels of environmental variance, whereas a large amount of temporal variation in the optimal phenotype and the strength of selection would be necessary...
  10. pmc Predictions of patterns of response to artificial selection in lines derived from natural populations
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 169:411-25. 2005
    ..Comparison with data from laboratory selection experiments shows that, overall, the analysis did not provide clear support for the joint-effect model or a clear case for rejection...
  11. pmc Redistribution of gene frequency and changes of genetic variation following a bottleneck in population size
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 167:1475-92. 2004
    ....
  12. pmc Influence of dominance, leptokurtosis and pleiotropy of deleterious mutations on quantitative genetic variation at mutation-selection balance
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genetics 166:597-610. 2004
    ..Thus considerations of dominance coefficients of mutations lend further support to our previous conclusion that mutation-selection balance is a plausible mechanism of the maintenance of the genetic variance in natural populations...
  13. ncbi request reprint Multivariate stabilizing selection and pleiotropy in the maintenance of quantitative genetic variation
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 57:1761-75. 2003
    ....
  14. pmc Joint effects of pleiotropic selection and stabilizing selection on the maintenance of quantitative genetic variation at mutation-selection balance
    Xu sheng Zhang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 162:459-71. 2002
    ..This finding provides some promise that a high heritability can be explained under strong total stabilizing selection for what are regarded as typical values of mutation and selection parameters...
  15. doi request reprint Change and maintenance of variation in quantitative traits in the context of the Price equation
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Theor Popul Biol 77:14-22. 2010
    ..In this study, we use the Price equation to derive many such well-known results for the dynamics and equilibria of variances in a straightforward way and to develop them further...
  16. pmc On the pleiotropic structure of the genotype-phenotype map and the evolvability of complex organisms
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genetics 190:1131-7. 2012
    ..We demonstrate that these highly pleiotropic models can give results similar to those obtained in analyses of experimental data and that conclusions on limits to evolvability through pleiotropy are not robust...
  17. ncbi request reprint Effects on phenotypic variability of directional selection arising through genetic differences in residual variability
    William G Hill
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Genet Res 83:121-32. 2004
    ..The evidence for and implications of such variability in variance are discussed...
  18. doi request reprint Fisher's geometrical model of fitness landscape and variance in fitness within a changing environment
    Xu sheng Zhang
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 66:2350-68. 2012
    ..Therefore, mutation and changing environment together can maintain high genetic variance. These results therefore lend support to Fisher's geometric model of a fitness landscape...
  19. pmc Escherichia coli O157 infection on Scottish cattle farms: dynamics and control
    Xu sheng Zhang
    Centre for Infectious Diseases, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    J R Soc Interface 8:1051-8. 2011
    ..coli O157 infection from Scottish cattle farms, implying that eliminating the disease is impractical...