Shu Dong Zhang

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Effect of pooling samples on the efficiency of comparative studies using microarrays
    Shu Dong Zhang
    MRC Toxicology Unit Hodgkin Building, Lancaster Road University of Leicester, Leicester, UK
    Bioinformatics 21:4378-83. 2005
  2. ncbi request reprint A statistical framework for the design of microarray experiments and effective detection of differential gene expression
    Shu Dong Zhang
    MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
    Bioinformatics 20:2821-8. 2004
  3. pmc A simple and robust method for connecting small-molecule drugs using gene-expression signatures
    Shu Dong Zhang
    MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
    BMC Bioinformatics 9:258. 2008
  4. pmc sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures
    Shu Dong Zhang
    MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
    BMC Bioinformatics 10:236. 2009
  5. doi request reprint Application of connectivity mapping in predictive toxicology based on gene-expression similarity
    Joshua L Smalley
    Medical Research Council Toxicology Unit, University of Leicester, Systems Toxicology Group, Lancaster Road, Leicester, LE1 9HN, UK
    Toxicology 268:143-6. 2010
  6. ncbi request reprint Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin
    Katie Ridd
    MRC Toxicology Unit, University of Leicester, Leicester, LE1 9HN, UK
    Carcinogenesis 27:1556-66. 2006
  7. ncbi request reprint In pursuit of effective toxicogenomics
    Timothy W Gant
    MRC Toxicology Unit, University of Leicester, P O Box 138, Lancaster Road, Leicester LE1 9HN, UK
    Mutat Res 575:4-16. 2005
  8. ncbi request reprint Novel genomic methods for drug discovery and mechanism-based toxicological assessment
    Timothy W Gant
    University of Leicester, Lancaster Road, UK
    Curr Opin Drug Discov Devel 12:72-80. 2009
  9. doi request reprint miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro
    Hailan Chen
    Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, PO Box 138, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 394:921-7. 2010

Collaborators

  • Timothy W Gant
  • Pierluigi Nicotera
  • Emma L Taylor
  • Peter Greaves
  • Hailan Chen
  • Joshua L Smalley
  • Katie Ridd
  • Paola Tucci
  • Giuseppe Genchi
  • Gerry Melino
  • Ruby Shalom-Feuerstein
  • Joan Riley
  • Daniel Aberdam
  • Massimiliano Agostini
  • Mariuca Vasa-Nicotera
  • Richard A Knight
  • Reginald Davies
  • Alison Wolfreys
  • Richard E Edwards
  • Andrew G Smith

Detail Information

Publications9

  1. ncbi request reprint Effect of pooling samples on the efficiency of comparative studies using microarrays
    Shu Dong Zhang
    MRC Toxicology Unit Hodgkin Building, Lancaster Road University of Leicester, Leicester, UK
    Bioinformatics 21:4378-83. 2005
    ..It is desirable to have exact formulas for these calculations and have the approximate results checked against the exact ones. We show that the difference between the approximate and the exact results can be large...
  2. ncbi request reprint A statistical framework for the design of microarray experiments and effective detection of differential gene expression
    Shu Dong Zhang
    MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
    Bioinformatics 20:2821-8. 2004
    ..Our motivation was to provide an easy to use measure of the success rate of DGE detection that could find routine use in the design of microarray experiments or in post-experiment assessment...
  3. pmc A simple and robust method for connecting small-molecule drugs using gene-expression signatures
    Shu Dong Zhang
    MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
    BMC Bioinformatics 9:258. 2008
    ..Lamb et al first proposed the Connectivity Map [Lamb et al (2006), Science 313, 1929-1935] to make successful connections among small molecules, genes, and diseases using genomic signatures...
  4. pmc sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures
    Shu Dong Zhang
    MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
    BMC Bioinformatics 10:236. 2009
    ..A simple and robust method for connectivity mapping with increased specificity and sensitivity was recently developed, and its utility demonstrated using experimentally derived gene signatures...
  5. doi request reprint Application of connectivity mapping in predictive toxicology based on gene-expression similarity
    Joshua L Smalley
    Medical Research Council Toxicology Unit, University of Leicester, Systems Toxicology Group, Lancaster Road, Leicester, LE1 9HN, UK
    Toxicology 268:143-6. 2010
    ..Key criteria are therefore the means of choosing the signature to be matched and the means by which the match is made. In this article we explore these concepts with examples applicable to toxicology...
  6. ncbi request reprint Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin
    Katie Ridd
    MRC Toxicology Unit, University of Leicester, Leicester, LE1 9HN, UK
    Carcinogenesis 27:1556-66. 2006
    ..Thus we have identified profiles of differential gene expression associated with the tumorigenesis and promotion stages for skin carcinogenesis in the mouse...
  7. ncbi request reprint In pursuit of effective toxicogenomics
    Timothy W Gant
    MRC Toxicology Unit, University of Leicester, P O Box 138, Lancaster Road, Leicester LE1 9HN, UK
    Mutat Res 575:4-16. 2005
    ..Using both our data and data from public databases these issues are explored in this paper...
  8. ncbi request reprint Novel genomic methods for drug discovery and mechanism-based toxicological assessment
    Timothy W Gant
    University of Leicester, Lancaster Road, UK
    Curr Opin Drug Discov Devel 12:72-80. 2009
    ..In this article we review the current and potential future status of established and novel genomic methods within drug discovery...
  9. doi request reprint miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro
    Hailan Chen
    Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, PO Box 138, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 394:921-7. 2010
    ..These findings provide an important step toward further elucidation of miR function and miR-related gene regulatory networks in the mammalian central nervous system...