Research Topics
Species | Shu Dong ZhangSummaryAffiliation: University of Leicester Country: UK Publications
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Detail Information
Publications
A statistical framework for the design of microarray experiments and effective detection of differential gene expressionShu Dong Zhang
MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
Bioinformatics 20:2821-8. 2004..Our motivation was to provide an easy to use measure of the success rate of DGE detection that could find routine use in the design of microarray experiments or in post-experiment assessment...- Effect of pooling samples on the efficiency of comparative studies using microarraysShu Dong Zhang
MRC Toxicology Unit Hodgkin Building, Lancaster Road University of Leicester, Leicester, UK
Bioinformatics 21:4378-83. 2005..It is also applicable to a wide range of biomedical comparative studies where sample pooling may be involved... 
A simple and robust method for connecting small-molecule drugs using gene-expression signaturesShu Dong Zhang
MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
BMC Bioinformatics 9:258. 2008..Lamb et al first proposed the Connectivity Map [Lamb et al (2006), Science 313, 1929-1935] to make successful connections among small molecules, genes, and diseases using genomic signatures...- sscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signaturesShu Dong Zhang
MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
BMC Bioinformatics 10:236. 2009..A simple and robust method for connectivity mapping with increased specificity and sensitivity was recently developed, and its utility demonstrated using experimentally derived gene signatures... 
Application of connectivity mapping in predictive toxicology based on gene-expression similarityJoshua L Smalley
Medical Research Council Toxicology Unit, University of Leicester, Systems Toxicology Group, Lancaster Road, Leicester, LE1 9HN, UK
Toxicology 268:143-6. 2010..Key criteria are therefore the means of choosing the signature to be matched and the means by which the match is made. In this article we explore these concepts with examples applicable to toxicology...- In pursuit of effective toxicogenomicsTimothy W Gant
MRC Toxicology Unit, University of Leicester, P O Box 138, Lancaster Road, Leicester LE1 9HN, UK
Mutat Res 575:4-16. 2005..Using both our data and data from public databases these issues are explored in this paper... - Novel genomic methods for drug discovery and mechanism-based toxicological assessmentTimothy W Gant
University of Leicester, Lancaster Road, UK
Curr Opin Drug Discov Devel 12:72-80. 2009..In this article we review the current and potential future status of established and novel genomic methods within drug discovery... - miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitroHailan Chen
Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, PO Box 138, Leicester LE1 9HN, UK
Biochem Biophys Res Commun 394:921-7. 2010..These findings provide an important step toward further elucidation of miR function and miR-related gene regulatory networks in the mammalian central nervous system...