J Axel Zeitler

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity
    Clare J Strachan
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 94:837-46. 2005
  2. doi request reprint Investigation of the terahertz vibrational modes of ZIF-8 and ZIF-90 with terahertz time-domain spectroscopy
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Chem Commun (Camb) 51:16037-40. 2015
  3. doi request reprint Probing hydrogen-bonding in binary liquid mixtures with terahertz time-domain spectroscopy: a comparison of Debye and absorption analysis
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Phys Chem Chem Phys 17:5999-6008. 2015
  4. ncbi request reprint Solid-state transition mechanism in carbamazepine polymorphs by time-resolved terahertz spectroscopy
    J Axel Zeitler
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Chemphyschem 8:1924-7. 2007
  5. doi request reprint In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms
    J Axel Zeitler
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    Eur J Pharm Biopharm 71:2-22. 2009
  6. doi request reprint Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating
    Louise Ho
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Eur J Pharm Biopharm 71:117-23. 2009
  7. doi request reprint Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 98:4866-76. 2009
  8. doi request reprint Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pharm Sci 99:392-402. 2010
  9. doi request reprint Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging
    Miriam Haaser
    School of Pharmacy, University of Otago, Dunedin, New Zealand TeraView Ltd, St John s Innovation Park, Cambridge, UK Cavendish Laboratory, University of Cambridge, Cambridge, UK
    Eur J Pharm Biopharm 85:1095-102. 2013
  10. doi request reprint Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, United Kingdom
    J Control Release 127:79-87. 2008

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity
    Clare J Strachan
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 94:837-46. 2005
    ..349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds...
  2. doi request reprint Investigation of the terahertz vibrational modes of ZIF-8 and ZIF-90 with terahertz time-domain spectroscopy
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Chem Commun (Camb) 51:16037-40. 2015
    ..The results support the hypothesis that the low energy vibrational modes do indeed play a significant role in host-guest interactions for ZIFs, such as gas loading. ..
  3. doi request reprint Probing hydrogen-bonding in binary liquid mixtures with terahertz time-domain spectroscopy: a comparison of Debye and absorption analysis
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Phys Chem Chem Phys 17:5999-6008. 2015
    ..When both components are aprotic, we show that the trend in absorption coefficients match well with the theoretical trend in strength of hydrogen bond interactions predicted based on steric and electronic properties of the components. ..
  4. ncbi request reprint Solid-state transition mechanism in carbamazepine polymorphs by time-resolved terahertz spectroscopy
    J Axel Zeitler
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Chemphyschem 8:1924-7. 2007
  5. doi request reprint In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms
    J Axel Zeitler
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    Eur J Pharm Biopharm 71:2-22. 2009
    ..Possible future developments in these fields are also discussed...
  6. doi request reprint Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating
    Louise Ho
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Eur J Pharm Biopharm 71:117-23. 2009
    ..Overall, TPI demonstrated potential to be employed as an analytical tool to help refine the coating unit operation and the scale-up procedure...
  7. doi request reprint Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 98:4866-76. 2009
    ..In this study, we demonstrated that TPI in conjunction with PLS analysis could be employed to assist with film coating process understanding and provide predictions on drug dissolution...
  8. doi request reprint Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pharm Sci 99:392-402. 2010
    ....
  9. doi request reprint Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging
    Miriam Haaser
    School of Pharmacy, University of Otago, Dunedin, New Zealand TeraView Ltd, St John s Innovation Park, Cambridge, UK Cavendish Laboratory, University of Cambridge, Cambridge, UK
    Eur J Pharm Biopharm 85:1095-102. 2013
    ..Overall, TPI investigation revealed substantial differences in the applied film coating quality between tablets coated in the two coaters, which in turn correlated with the subsequent dissolution performance...
  10. doi request reprint Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, United Kingdom
    J Control Release 127:79-87. 2008
    ..The contributing factors for these particular correlations are also discussed...
  11. ncbi request reprint Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy
    J Axel Zeitler
    School of Pharmacy, University of Otago, P O Box 913, Dunedin, New Zealand
    J Pharm Sci 96:2703-9. 2007
    ..It is possible to study both relaxation and crystallization processes by variable temperature TPS...
  12. ncbi request reprint Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting--a review
    J Axel Zeitler
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Pharmacol 59:209-23. 2007
    ..Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms...
  13. doi request reprint Correlating thermodynamic and kinetic parameters with amorphous stability
    Kirsten A Graeser
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    Eur J Pharm Sci 37:492-8. 2009
    ..However, it could also be shown that below T(g) no clear relationship between the various factors determined and physical stability exists, indicating that stability predictions on the basis of relaxation time alone may be inadequate...
  14. ncbi request reprint Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry
    J Axel Zeitler
    School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pharm Sci 95:2486-98. 2006
    ..The phase transitions can be monitored by terahertz pulsed spectroscopy. Polymorphic impurities of the samples can be detected in the room temperature spectra and their effect on the phase transition behavior can be studied...
  15. ncbi request reprint The influence of various excipients on the conversion kinetics of carbamazepine polymorphs in aqueous suspension
    Fang Tian
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    J Pharm Pharmacol 59:193-201. 2007
    ..0 MPa(1/2)). This study indicated the importance of both hydrogen bonding interaction and a suitable hydrophobicity (expressed by the solubility parameter) in the inhibition of the conversion of carbamazepine to the dihydrate...
  16. doi request reprint Impact of Processing Conditions on Inter-tablet Coating Thickness Variations Measured by Terahertz In-Line Sensing
    Hungyen Lin
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB2 3RA, UK
    J Pharm Sci 104:2513-22. 2015
    ..The terahertz sensor was able to pick up the resulting changes in average coating thickness in the coating drum and we report the impact of these process changes on the resulting coating quality...
  17. doi request reprint Hardness and density distributions of pharmaceutical tablets measured by terahertz pulsed imaging
    Robert K May
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    J Pharm Sci 102:2179-86. 2013
    ..These results show that TPI has an advantage over traditional diametral compression and is more suitable for nondestructive hardness and density distribution monitoring and control of pharmaceutical manufacturing processes...
  18. doi request reprint Terahertz in-line sensor for direct coating thickness measurement of individual tablets during film coating in real-time
    Robert K May
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    J Pharm Sci 100:1535-44. 2011
    ..Terahertz in-line coating process measurements show considerable potential for applications in real-time release, process analytical technology and quality by design...
  19. doi request reprint Broad spectrum measurement of the birefringence of an isothiocyanate based liquid crystal
    Oksana Trushkevych
    Centre for Advanced Photonics and Electronics, Engineering Department, Cambridge, CB3 0FA, UK
    Appl Opt 49:5212-6. 2010
    ..5-1.8 THz, and in the visible and near-infrared region (400 nm-1600 nm). We report high birefringence (Δn = 0.19-0.395) and low loss in this material. This is attractive for tunable microwave and terahertz device applications...
  20. doi request reprint The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants
    Samy Yassin
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK
    J Pharm Sci 104:3440-50. 2015
    ..2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3440-3450, 2015. ..
  21. doi request reprint Structure and dynamics of aqueous 2-propanol: a THz-TDS, NMR and neutron diffraction study
    James McGregor
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    Phys Chem Chem Phys 17:30481-91. 2015
    ..Based on the acquired data, a description of the structure of 2-propanol/water across the composition range is presented. ..
  22. doi request reprint Mesoscopic structuring and dynamics of alcohol/water solutions probed by terahertz time-domain spectroscopy and pulsed field gradient nuclear magnetic resonance
    Ruoyu Li
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, United Kingdom
    J Phys Chem B 118:10156-66. 2014
    ..At x3 an equivalence of the alkyl and alcohol hydroxyl diffusion coefficients is determined by PFG-NMR, suggesting that the molecular mobility of the alcohol molecules becomes independent of that of the water molecules. ..
  23. doi request reprint Glassy dynamics of sorbitol solutions at terahertz frequencies
    Juraj Sibik
    Department of Chemical Engineering and Biotechnology, University of Cambridge, New Museums Site, Pembroke Street, Cambridge, CB2 3RA, UK
    Phys Chem Chem Phys 15:11931-42. 2013
    ....
  24. doi request reprint Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy
    Juraj Sibik
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, United Kingdom
    Mol Pharm 12:3062-8. 2015
    ..We believe that this technique has immediate applications to quantify the stability of amorphous drug materials. ..
  25. doi request reprint Quantifying Pharmaceutical Film Coating with Optical Coherence Tomography and Terahertz Pulsed Imaging: An Evaluation
    Hungyen Lin
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB2 3RA, UK
    J Pharm Sci 104:3377-85. 2015
    ..The finding further confirms that OCT is a suitable modality for characterising pharmaceutical dosage forms with thin film coatings, whereas TPI is well suited for thick coatings...
  26. pmc Diffusion and swelling measurements in pharmaceutical powder compacts using terahertz pulsed imaging
    Samy Yassin
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK
    J Pharm Sci 104:1658-67. 2015
    ..Our results highlight a new application area of TPI in the pharmaceutical sciences that could be of interest in the development and quality testing of advanced drug delivery systems as well as immediate release formulations...
  27. ncbi request reprint A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acid
    Ruoyu Li
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK
    Phys Chem Chem Phys 12:5329-40. 2010
    ....
  28. doi request reprint Accurate determination of optical coefficients from chemical samples using terahertz time-domain spectroscopy and effective medium theory
    Edward P Parrott
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Opt Lett 34:3722-4. 2009
    ..The technique can also be extended to estimate the porosity of the samples and provide a true, preparation-independent value for the optical properties of the sample material...
  29. doi request reprint Probing phase transitions in simvastatin with terahertz time-domain spectroscopy
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, United Kingdom
    Mol Pharm 12:810-5. 2015
    ..The results are in agreement with molecular dynamics simulations, which indicate that changes in the rotational freedom of the ester tail in the molecule govern the polymorphism in simvastatin. ..
  30. doi request reprint Validation of Terahertz coating thickness measurements using X-ray microtomography
    Isabelle Sophie Russe
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, U K
    Mol Pharm 9:3551-9. 2012
    ..01. We conclude that TPI is a robust technique and that, due to its very simple measurement principle, it is an ideal measurement technique to quantify the coating thickness in process control and quality monitoring applications. ..
  31. pmc Crystallization and phase changes in paracetamol from the amorphous solid to the liquid phase
    Juraj Sibik
    Department of Chemical Engineering and Biotechnology, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3RA, United Kingdom
    Mol Pharm 11:1326-34. 2014
    ..We determined an effective rate constant of k = 0.056 min(-1) with a corresponding onset of crystallization at T = 329.5 K for a heating rate of 0.4 K min(-1). ..
  32. ncbi request reprint Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopy
    J Axel Zeitler
    TeraView Ltd, St John s Innovation Park, Cambridge CB4 0WS, United Kingdom
    Int J Pharm 334:78-84. 2007
    ..The rotational spectrum of water vapour is very characteristic in the far infrared and can easily be discerned from the terahertz spectrum of the solid state form...