Research Topics
| J Axel ZeitlerSummaryAffiliation: University of Cambridge Country: UK Publications
| Collaborators
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Detail Information
Publications
Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinityClare J Strachan
School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
J Pharm Sci 94:837-46. 2005..349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds...
In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage formsJ Axel Zeitler
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
Eur J Pharm Biopharm 71:2-22. 2009..Possible future developments in these fields are also discussed...- Solid-state transition mechanism in carbamazepine polymorphs by time-resolved terahertz spectroscopyJ Axel Zeitler
School of Pharmacy, University of Otago, Dunedin, New Zealand
Chemphyschem 8:1924-7. 2007 - Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coatingLouise Ho
School of Pharmacy, University of Otago, Dunedin, New Zealand
Eur J Pharm Biopharm 71:117-23. 2009..Overall, TPI demonstrated potential to be employed as an analytical tool to help refine the coating unit operation and the scale-up procedure... - Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imagingLouise Ho
School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
J Pharm Sci 98:4866-76. 2009..In this study, we demonstrated that TPI in conjunction with PLS analysis could be employed to assist with film coating process understanding and provide predictions on drug dissolution... - Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imagingLouise Ho
School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
J Pharm Sci 99:392-402. 2010.... - Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performanceLouise Ho
School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, United Kingdom
J Control Release 127:79-87. 2008..The contributing factors for these particular correlations are also discussed... - Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopyJ Axel Zeitler
School of Pharmacy, University of Otago, P O Box 913, Dunedin, New Zealand
J Pharm Sci 96:2703-9. 2007..It is possible to study both relaxation and crystallization processes by variable temperature TPS... - Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting--a reviewJ Axel Zeitler
School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
J Pharm Pharmacol 59:209-23. 2007..Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms... - The influence of various excipients on the conversion kinetics of carbamazepine polymorphs in aqueous suspensionFang Tian
School of Pharmacy, University of Otago, Dunedin, New Zealand
J Pharm Pharmacol 59:193-201. 2007..0 MPa(1/2)). This study indicated the importance of both hydrogen bonding interaction and a suitable hydrophobicity (expressed by the solubility parameter) in the inhibition of the conversion of carbamazepine to the dihydrate... - Correlating thermodynamic and kinetic parameters with amorphous stabilityKirsten A Graeser
School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
Eur J Pharm Sci 37:492-8. 2009..However, it could also be shown that below T(g) no clear relationship between the various factors determined and physical stability exists, indicating that stability predictions on the basis of relaxation time alone may be inadequate... - Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetryJ Axel Zeitler
School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
J Pharm Sci 95:2486-98. 2006..The phase transitions can be monitored by terahertz pulsed spectroscopy. Polymorphic impurities of the samples can be detected in the room temperature spectra and their effect on the phase transition behavior can be studied... - Broad spectrum measurement of the birefringence of an isothiocyanate based liquid crystalOksana Trushkevych
Centre for Advanced Photonics and Electronics, Engineering Department, Cambridge, CB3 0FA, UK
Appl Opt 49:5212-6. 2010..5-1.8 THz, and in the visible and near-infrared region (400 nm-1600 nm). We report high birefringence (Δn = 0.19-0.395) and low loss in this material. This is attractive for tunable microwave and terahertz device applications... - Accurate determination of optical coefficients from chemical samples using terahertz time-domain spectroscopy and effective medium theoryEdward P Parrott
Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
Opt Lett 34:3722-4. 2009..The technique can also be extended to estimate the porosity of the samples and provide a true, preparation-independent value for the optical properties of the sample material... - A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acidRuoyu Li
Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK
Phys Chem Chem Phys 12:5329-40. 2010.... - Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopyJ Axel Zeitler
TeraView Ltd, St John s Innovation Park, Cambridge CB4 0WS, United Kingdom
Int J Pharm 334:78-84. 2007..The rotational spectrum of water vapour is very characteristic in the far infrared and can easily be discerned from the terahertz spectrum of the solid state form...