J Axel Zeitler

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity
    Clare J Strachan
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 94:837-46. 2005
  2. doi request reprint Probing hydrogen-bonding in binary liquid mixtures with terahertz time-domain spectroscopy: a comparison of Debye and absorption analysis
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Phys Chem Chem Phys 17:5999-6008. 2015
  3. doi request reprint In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms
    J Axel Zeitler
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    Eur J Pharm Biopharm 71:2-22. 2009
  4. ncbi request reprint Solid-state transition mechanism in carbamazepine polymorphs by time-resolved terahertz spectroscopy
    J Axel Zeitler
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Chemphyschem 8:1924-7. 2007
  5. doi request reprint Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating
    Louise Ho
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Eur J Pharm Biopharm 71:117-23. 2009
  6. doi request reprint Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 98:4866-76. 2009
  7. doi request reprint Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pharm Sci 99:392-402. 2010
  8. doi request reprint Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging
    Miriam Haaser
    School of Pharmacy, University of Otago, Dunedin, New Zealand TeraView Ltd, St John s Innovation Park, Cambridge, UK Cavendish Laboratory, University of Cambridge, Cambridge, UK
    Eur J Pharm Biopharm 85:1095-102. 2013
  9. ncbi request reprint Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy
    J Axel Zeitler
    School of Pharmacy, University of Otago, P O Box 913, Dunedin, New Zealand
    J Pharm Sci 96:2703-9. 2007
  10. doi request reprint Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, United Kingdom
    J Control Release 127:79-87. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity
    Clare J Strachan
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 94:837-46. 2005
    ..349% and limits of detection as low as approximately 1% were obtained, demonstrating that TPS is an analytical technique of potential in quantifying solid-state properties of pharmaceutical compounds...
  2. doi request reprint Probing hydrogen-bonding in binary liquid mixtures with terahertz time-domain spectroscopy: a comparison of Debye and absorption analysis
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Phys Chem Chem Phys 17:5999-6008. 2015
    ..When both components are aprotic, we show that the trend in absorption coefficients match well with the theoretical trend in strength of hydrogen bond interactions predicted based on steric and electronic properties of the components. ..
  3. doi request reprint In-vitro tomography and non-destructive imaging at depth of pharmaceutical solid dosage forms
    J Axel Zeitler
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    Eur J Pharm Biopharm 71:2-22. 2009
    ..Possible future developments in these fields are also discussed...
  4. ncbi request reprint Solid-state transition mechanism in carbamazepine polymorphs by time-resolved terahertz spectroscopy
    J Axel Zeitler
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Chemphyschem 8:1924-7. 2007
  5. doi request reprint Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating
    Louise Ho
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Eur J Pharm Biopharm 71:117-23. 2009
    ..Overall, TPI demonstrated potential to be employed as an analytical tool to help refine the coating unit operation and the scale-up procedure...
  6. doi request reprint Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Sci 98:4866-76. 2009
    ..In this study, we demonstrated that TPI in conjunction with PLS analysis could be employed to assist with film coating process understanding and provide predictions on drug dissolution...
  7. doi request reprint Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imaging
    Louise Ho
    School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pharm Sci 99:392-402. 2010
    ....
  8. doi request reprint Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging
    Miriam Haaser
    School of Pharmacy, University of Otago, Dunedin, New Zealand TeraView Ltd, St John s Innovation Park, Cambridge, UK Cavendish Laboratory, University of Cambridge, Cambridge, UK
    Eur J Pharm Biopharm 85:1095-102. 2013
    ..Overall, TPI investigation revealed substantial differences in the applied film coating quality between tablets coated in the two coaters, which in turn correlated with the subsequent dissolution performance...
  9. ncbi request reprint Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy
    J Axel Zeitler
    School of Pharmacy, University of Otago, P O Box 913, Dunedin, New Zealand
    J Pharm Sci 96:2703-9. 2007
    ..It is possible to study both relaxation and crystallization processes by variable temperature TPS...
  10. doi request reprint Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance
    Louise Ho
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, United Kingdom
    J Control Release 127:79-87. 2008
    ..The contributing factors for these particular correlations are also discussed...
  11. ncbi request reprint Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting--a review
    J Axel Zeitler
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    J Pharm Pharmacol 59:209-23. 2007
    ..Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms...
  12. ncbi request reprint The influence of various excipients on the conversion kinetics of carbamazepine polymorphs in aqueous suspension
    Fang Tian
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    J Pharm Pharmacol 59:193-201. 2007
    ..0 MPa(1/2)). This study indicated the importance of both hydrogen bonding interaction and a suitable hydrophobicity (expressed by the solubility parameter) in the inhibition of the conversion of carbamazepine to the dihydrate...
  13. doi request reprint Correlating thermodynamic and kinetic parameters with amorphous stability
    Kirsten A Graeser
    School of Pharmacy, University of Otago, P O Box 56, Dunedin, New Zealand
    Eur J Pharm Sci 37:492-8. 2009
    ..However, it could also be shown that below T(g) no clear relationship between the various factors determined and physical stability exists, indicating that stability predictions on the basis of relaxation time alone may be inadequate...
  14. ncbi request reprint Characterization of temperature-induced phase transitions in five polymorphic forms of sulfathiazole by terahertz pulsed spectroscopy and differential scanning calorimetry
    J Axel Zeitler
    School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand
    J Pharm Sci 95:2486-98. 2006
    ..The phase transitions can be monitored by terahertz pulsed spectroscopy. Polymorphic impurities of the samples can be detected in the room temperature spectra and their effect on the phase transition behavior can be studied...
  15. doi request reprint Hardness and density distributions of pharmaceutical tablets measured by terahertz pulsed imaging
    Robert K May
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    J Pharm Sci 102:2179-86. 2013
    ..These results show that TPI has an advantage over traditional diametral compression and is more suitable for nondestructive hardness and density distribution monitoring and control of pharmaceutical manufacturing processes...
  16. doi request reprint Terahertz in-line sensor for direct coating thickness measurement of individual tablets during film coating in real-time
    Robert K May
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, UK
    J Pharm Sci 100:1535-44. 2011
    ..Terahertz in-line coating process measurements show considerable potential for applications in real-time release, process analytical technology and quality by design...
  17. doi request reprint Broad spectrum measurement of the birefringence of an isothiocyanate based liquid crystal
    Oksana Trushkevych
    Centre for Advanced Photonics and Electronics, Engineering Department, Cambridge, CB3 0FA, UK
    Appl Opt 49:5212-6. 2010
    ..5-1.8 THz, and in the visible and near-infrared region (400 nm-1600 nm). We report high birefringence (Δn = 0.19-0.395) and low loss in this material. This is attractive for tunable microwave and terahertz device applications...
  18. doi request reprint Mesoscopic structuring and dynamics of alcohol/water solutions probed by terahertz time-domain spectroscopy and pulsed field gradient nuclear magnetic resonance
    Ruoyu Li
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, United Kingdom
    J Phys Chem B 118:10156-66. 2014
    ..At x3 an equivalence of the alkyl and alcohol hydroxyl diffusion coefficients is determined by PFG-NMR, suggesting that the molecular mobility of the alcohol molecules becomes independent of that of the water molecules. ..
  19. doi request reprint Glassy dynamics of sorbitol solutions at terahertz frequencies
    Juraj Sibik
    Department of Chemical Engineering and Biotechnology, University of Cambridge, New Museums Site, Pembroke Street, Cambridge, CB2 3RA, UK
    Phys Chem Chem Phys 15:11931-42. 2013
    ....
  20. ncbi request reprint A study into the effect of subtle structural details and disorder on the terahertz spectrum of crystalline benzoic acid
    Ruoyu Li
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK
    Phys Chem Chem Phys 12:5329-40. 2010
    ....
  21. doi request reprint Accurate determination of optical coefficients from chemical samples using terahertz time-domain spectroscopy and effective medium theory
    Edward P Parrott
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, UK
    Opt Lett 34:3722-4. 2009
    ..The technique can also be extended to estimate the porosity of the samples and provide a true, preparation-independent value for the optical properties of the sample material...
  22. doi request reprint Probing phase transitions in simvastatin with terahertz time-domain spectroscopy
    Nicholas Y Tan
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, United Kingdom
    Mol Pharm 12:810-5. 2015
    ..The results are in agreement with molecular dynamics simulations, which indicate that changes in the rotational freedom of the ester tail in the molecule govern the polymorphism in simvastatin. ..
  23. pmc Crystallization and phase changes in paracetamol from the amorphous solid to the liquid phase
    Juraj Sibik
    Department of Chemical Engineering and Biotechnology, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3RA, United Kingdom
    Mol Pharm 11:1326-34. 2014
    ..We determined an effective rate constant of k = 0.056 min(-1) with a corresponding onset of crystallization at T = 329.5 K for a heating rate of 0.4 K min(-1). ..
  24. doi request reprint Validation of Terahertz coating thickness measurements using X-ray microtomography
    Isabelle Sophie Russe
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, U K
    Mol Pharm 9:3551-9. 2012
    ..01. We conclude that TPI is a robust technique and that, due to its very simple measurement principle, it is an ideal measurement technique to quantify the coating thickness in process control and quality monitoring applications. ..
  25. ncbi request reprint Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopy
    J Axel Zeitler
    TeraView Ltd, St John s Innovation Park, Cambridge CB4 0WS, United Kingdom
    Int J Pharm 334:78-84. 2007
    ..The rotational spectrum of water vapour is very characteristic in the far infrared and can easily be discerned from the terahertz spectrum of the solid state form...