Victor A Zammit

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. doi request reprint Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia
    Victor A Zammit
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry KA4 7AL, UK
    Biochem J 451:1-12. 2013
  2. doi request reprint Carnitine, mitochondrial function and therapy
    Victor A Zammit
    University of Warwick, Clinical Sciences Research Institute, Coventry, England, UK
    Adv Drug Deliv Rev 61:1353-62. 2009
  3. doi request reprint Carnitine palmitoyltransferase 1: central to cell function
    Victor A Zammit
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, UK, CV4 7AL
    IUBMB Life 60:347-54. 2008
  4. doi request reprint Packing of transmembrane domain 2 of carnitine palmitoyltransferase-1A affects oligomerization and malonyl-CoA sensitivity of the mitochondrial outer membrane protein
    Zsuzsanna A Jenei
    Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
    FASEB J 25:4522-30. 2011
  5. doi request reprint Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells
    Haja R Wurie
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK
    FEBS J 279:3033-47. 2012
  6. pmc Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues
    Nigel T Price
    Warwick Medical School, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, United Kingdom
    J Biol Chem 285:7857-65. 2010
  7. pmc Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs
    Zsuzsanna A Jenei
    Department of Chemistry and Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Biol Chem 284:6988-97. 2009
  8. doi request reprint Diacylglycerol acyltransferases: Potential roles as pharmacological targets
    Victor A Zammit
    Clinical Sciences Research Institute, Warwick Medical School, Coventry CV4 7AL, UK
    Pharmacol Ther 118:295-302. 2008
  9. ncbi request reprint The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity
    Karen Borthwick
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital Coventry and Warwick Campus, Coventry CV2 2DX, UK
    J Biol Chem 281:32946-52. 2006
  10. pmc Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity
    Audrey Faye
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS Unité Mixte de Recherche 8104, Universite Rene Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Biochem J 387:67-76. 2005

Collaborators

  • Nigel Price
  • Rona R Ramsay
  • Andrew V Turnbull
  • Mario Bonomini
  • Arduino Arduini
  • Baukje M Elzinga
  • S Eaton
  • J Girard
  • C C Shoulders
  • Zsuzsanna A Jenei
  • Karen Borthwick
  • Ian J Waterman
  • Haja R Wurie
  • Vicky N Jackson
  • Beatrijs Bartelds
  • Ann M Dixon
  • Feike R van der Leij
  • Audrey Faye
  • Carina Prip-Buus
  • Koji Fukumoto
  • Arjen R Mensenkamp
  • Jaap R G Kuipers
  • Linda Buckett
  • Gemma Z L Warren
  • Muhammad Hasan
  • Stephanie Gobin
  • Catherine Esnous
  • Marja J A van Luyn
  • Louis M Havekes
  • Folkert Kuipers
  • Lewis Spitz
  • Henkjan J Verkade
  • Janny Takens
  • Agostino Pierro
  • Bas Teusink
  • Christopher J Mann
  • Rick Havinga
  • Gioia B Smid
  • Trijnie Dijkhuizen
  • Philip A Wood
  • Keith B Cox
  • Peter Terpstra
  • Nicolette C A Huijkman

Detail Information

Publications19

  1. doi request reprint Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia
    Victor A Zammit
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry KA4 7AL, UK
    Biochem J 451:1-12. 2013
    ....
  2. doi request reprint Carnitine, mitochondrial function and therapy
    Victor A Zammit
    University of Warwick, Clinical Sciences Research Institute, Coventry, England, UK
    Adv Drug Deliv Rev 61:1353-62. 2009
    ....
  3. doi request reprint Carnitine palmitoyltransferase 1: central to cell function
    Victor A Zammit
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, UK, CV4 7AL
    IUBMB Life 60:347-54. 2008
  4. doi request reprint Packing of transmembrane domain 2 of carnitine palmitoyltransferase-1A affects oligomerization and malonyl-CoA sensitivity of the mitochondrial outer membrane protein
    Zsuzsanna A Jenei
    Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
    FASEB J 25:4522-30. 2011
    ....
  5. doi request reprint Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells
    Haja R Wurie
    Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK
    FEBS J 279:3033-47. 2012
    ..Therefore, we describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1...
  6. pmc Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues
    Nigel T Price
    Warwick Medical School, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, United Kingdom
    J Biol Chem 285:7857-65. 2010
    ....
  7. pmc Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs
    Zsuzsanna A Jenei
    Department of Chemistry and Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Biol Chem 284:6988-97. 2009
    ..In silico molecular modeling of rCPT1A TM2 highlighted the favorable orientation of GXXXG and GXXXA motifs in the formation of the TM2 hexamer...
  8. doi request reprint Diacylglycerol acyltransferases: Potential roles as pharmacological targets
    Victor A Zammit
    Clinical Sciences Research Institute, Warwick Medical School, Coventry CV4 7AL, UK
    Pharmacol Ther 118:295-302. 2008
    ..The metabolic complexities of triglyceride synthesis, with particular reference to the diacylglycerol acyltransferases (DGATs) are considered in this short review...
  9. ncbi request reprint The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity
    Karen Borthwick
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital Coventry and Warwick Campus, Coventry CV2 2DX, UK
    J Biol Chem 281:32946-52. 2006
    ..The data suggest that the sequence spanning the loop-TM2 boundary determines the disposition of this TM in the membrane so as to alter the conformation of the C-terminal segment and thus affect its interaction with malonyl-CoA...
  10. pmc Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity
    Audrey Faye
    Departement d Endocrinologie, Institut Cochin, INSERM U567, CNRS Unité Mixte de Recherche 8104, Universite Rene Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Biochem J 387:67-76. 2005
    ....
  11. ncbi request reprint Differential effects of fenofibrate or simvastatin treatment of rats on hepatic microsomal overt and latent diacylglycerol acyltransferase activities
    Ian J Waterman
    Cell Biochemistry, Hannah Research Institute, Ayr, Scotland
    Diabetes 51:1708-13. 2002
    ....
  12. ncbi request reprint Insulin stimulation of hepatic triacylglycerol secretion in the insulin-replete state: implications for the etiology of peripheral insulin resistance
    Victor A Zammit
    Cell Biochemistry, Hannah Research Institute, Ayr KA6 5HL, Scotland, United Kingdom
    Ann N Y Acad Sci 967:52-65. 2002
    ....
  13. ncbi request reprint Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes
    Ian J Waterman
    Hannah Research Institute, Ayr, Scotland, United Kingdom
    J Lipid Res 43:1555-62. 2002
    ..We conclude that post-translational modification may play an important role in the overt and latent distribution of DGAT activity in the liver microsomal membrane...
  14. pmc Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme
    Nigel T Price
    Hannah Research Institute, Ayr KA6 5HL, UK
    Biochem J 372:871-9. 2003
    ..The ovine N-terminal segment influences the kinetics of the enzyme for both its substrates, such that the K (m) for palmitoyl-CoA is decreased and that for carnitine is increased for the chimaera, relative to the parental ovine M-CPT 1...
  15. ncbi request reprint Myocardial carnitine palmitoyltransferase I expression and long-chain fatty acid oxidation in fetal and newborn lambs
    Beatrijs Bartelds
    Dept of Pediatrics, University of Groningen, Research Lab CMCV 2, Hanzeplein 1, NL 9713 GZ Groningen, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H2243-8. 2004
    ..M-CPT I is expressed throughout perinatal development, making it a primary target for metabolic modulation of myocardial FA oxidation...
  16. doi request reprint The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function
    Victor A Zammit
    Cell Metab 8:175; author reply 176. 2008
  17. ncbi request reprint The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice
    Arjen R Mensenkamp
    Department of Cell Biology, Faculty of Medical Sciences, University Hospital Groningen, 9713 GZ Groningen, The Netherlands
    J Hepatol 40:599-606. 2004
    ..Apolipoprotein E (apoE)-deficient mice develop hepatic steatosis and secrete reduced levels of VLDL-TG...
  18. ncbi request reprint Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats
    Koji Fukumoto
    Department of Paediatric Surgery, Institute of Child Health, 30, Guilford Street, London WC1N 1EH, UK
    Biochim Biophys Acta 1683:1-6. 2004
    ..5 M dithionite, during immunoprecipitation, greatly decreased immunopositivity for M- and L-CPTI on WB. M-CPTI appears to be a novel target for peroxynitrite during endotoxaemia, which would alter myocardial substrate selection...
  19. ncbi request reprint Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals
    Feike R van der Leij
    Department of Pediatrics, Groningen University Institute for Drug Exploration, University of Groningen and Beatrix Children s Hospital, Groningen 9700RB, The Netherlands
    J Biol Chem 277:26994-7005. 2002
    ..Therefore, the involvement of splice variation of M-CPT I in the modulation of malonyl-CoA inhibition of fatty acid oxidation may be less relevant than hitherto assumed...