Research Topics
Genomes and Genes
| Ian C ZacharySummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknownsIan C Zachary
Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
Biochem Soc Trans 39:1583-91. 2011..The present article focuses on some of the most important unresolved questions concerning the mechanism(s) through which NRP1 acts, and highlights recent findings which are beginning to generate insights into these questions...
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and diseaseDavid I R Holmes
BHF Laboratories and The Rayne Institute, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
Genome Biol 6:209. 2005....- Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospectsIan Zachary
Centre for Cardiovascular Biology and Medicine, Department of Cardiovascular Science, Division of Medicine, University College London, London, UK
Heart 97:181-9. 2011..This review discusses therapeutic angiogenesis in the light of recent scientific advances and clinical evidence, and considers the future challenges and prospects for therapeutic angiogenesis... - The role of neuropilins in cell signallingIan C Zachary
Centre for Cardiovascular Science and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
Biochem Soc Trans 37:1171-8. 2009..Growing evidence indicates, however, that NRP1 plays a selective role in signalling at least in part via its C-terminal domain and interaction with intracellular binding partners... 
Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potentialIan Zachary
Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, The Rayne Institute, University College London, London, UK
Neurosignals 14:207-21. 2005..However, more work is required to determine the specific functional role of direct neuronal effects of VEGF...- Vascular endothelial growth factor: how it transmits its signalI Zachary
Cruciform Project and Department of Medicine, University College, London, UK
Exp Nephrol 6:480-7. 1998..Recent findings have revealed novel signaling mechanisms which may mediate the biological actions of VEGF. In contrast, the signal transduction mechanisms triggered by Flt-1 remain largely unknown... - VEGF signalling: integration and multi-tasking in endothelial cell biologyI Zachary
Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, U K
Biochem Soc Trans 31:1171-7. 2003..Together, the multiplicity, functional versatility and integration of VEGF signalling provide a useful framework for understanding the mechanisms underlying the endothelial biological response to this key factor... - Vascular endothelial growth factor and anti-angiogenic peptides as therapeutic and investigational moleculesIan Zachary
University College London, Department of Medicine, 5 University Street, London, WC1E 6JJ UK
IDrugs 6:224-31. 2003..This article highlights recent progress toward the development of anti-angiogenic and vascular-specific peptides with a focus on peptidic VEGF receptor antagonists... - Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor familyI Zachary
Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College London, 5 University Street, WC1E 6JJ, London, UK
Cardiovasc Res 49:568-81. 2001..Recent findings suggest important roles for the vasodilators nitric oxide and prostacyclin, in linking post-receptor signaling networks to downstream biological effects and in mediating some in vivo endothelial functions of VEGF... - Vascular protection: A novel nonangiogenic cardiovascular role for vascular endothelial growth factorI Zachary
Department of Medicine, University College London, London, UK
Arterioscler Thromb Vasc Biol 20:1512-20. 2000.... - Vascular endothelial growth factorI Zachary
Wolfson Institute for Biomedical Research, University College London, UK
Int J Biochem Cell Biol 30:1169-74. 1998.... 
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylationBirger Herzog
BHF Laboratories, University College London, London WC1E 6JJ, UK
Mol Biol Cell 22:2766-76. 2011..Identification of key residues essential for VEGF binding and biological functions provides the basis for a rational design of antagonists of VEGF binding to NRP1...- Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2David I R Holmes
Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, United Kingdom
Cell Signal 20:569-79. 2008..These findings support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability... - Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cellsIan M Evans
UCL Division of Medicine, 5 University Street, London WC1E 6JJ, United Kingdom
Mol Cell Biol 31:1174-85. 2011.... - Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cellsIan M Evans
Department of Medicine, Centre for Cardiovascular Biology and Medicine, The Rayne Institute, University College London, UK
Biochem J 429:565-72. 2010..CRT5, a novel specific PKD inhibitor, will greatly facilitate the study of the role of PKD signalling mechanisms in angiogenesis... - Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130CasCaroline Pellet-Many
Centre for Cardiovascular Science and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
Biochem J 435:609-18. 2011..These results indicate a role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRα and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway... - Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinaseIan M Evans
Centre for Cardiovascular Biology and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
Cell Signal 20:1375-84. 2008.... - Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathwayPaul Frankel
Department of Medicine, Centre for Cardiovascular Biology and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
EMBO Rep 9:983-9. 2008..Our data establish distinct roles for NRP1 and NRP1-CS in modulating a new NRP1-p130Cas signalling pathway contributing to glioblastoma cell invasion in 3D... - Role of angiogenesis in cardiovascular disease: a critical appraisalRohit Khurana
Department of Medicine, University College London, London WC1E 6JJ, UK
Circulation 112:1813-24. 2005..Furthermore, current evidence from clinical trials of both proangiogenic and antiangiogenic therapies does not suggest that inhibition of angiogenesis is likely to be a viable therapeutic strategy for cardiovascular disease... - A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivoJames W B Bainbridge
Institute of Ophthalmology, Bath Street, London, UK
Biochem Biophys Res Commun 302:793-9. 2003.... - Psychological stress activates interleukin-1beta gene expression in human mononuclear cellsLena Brydon
The Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
Brain Behav Immun 19:540-6. 2005..Stress-induced activation of mononuclear IL-1beta is a novel mechanism potentially linking stress and heart disease. This mechanism could also play a role in other inflammatory diseases exacerbated by stress... - Hostility and physiological responses to laboratory stress in acute coronary syndrome patientsLena Brydon
Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom
J Psychosom Res 68:109-16. 2010..This study set out to test whether hostile individuals with advanced CAD were also more stress responsive... - Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3'-kinase-mediates PKC delta phosphorylation: role of PKC in angiogenesisGeorgia Gliki
Centre for Cardiovascular Biology, Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK
Cell Biol Int 26:751-9. 2002.... - Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signalingHaiyan Jia
Centre for Cardiovascular Biology and Medicine, Department of Medicine and Ark Therapeutics Limited, The Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
J Biol Chem 281:13493-502. 2006..The results also identify a key role for the C-terminal exon 8 domain in VEGF-A165 binding to NP-1... - Protein kinase D in vascular biology and angiogenesisIan M Evans
Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
IUBMB Life 63:258-63. 2011..PKD is also emerging as a potentially important mediator of tumor growth and tumor angiogenesis and there is growing interest in PKD as a novel therapeutic target in cancer... - Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulationRohit Khurana
BHF Laboratories, Department of Medicine, University College London, 5 University St, London WC1E 6JJ, United Kingdom
Circulation 111:2828-36. 2005.... - Protein kinase D in vascular biology and angiogenesisIan M Evans
Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
IUBMB Life 63:spcone. 2011..Protein kinase D1/2 signaling in endothelial cells by Ian M. Evans and Ian C. Zachary, pp. 258-263... - Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptorsDavid I R Holmes
Department of Medicine, The Rayne Building, University College London, 5 University Street, London WC1E 6JJ, UK
FEBS Lett 557:93-8. 2004..These findings show for the first time that VEGF and PlGF induce mRNA expression of the transcription factors FosB and c-Fos, and suggest that these factors may play a role in the biological responses mediated by PlGF and Flt-1... - Vascular endothelial growth factor gene transfer inhibits neointimal macrophage accumulation in hypercholesterolemic rabbitsRohit Khurana
BHF Laboratories, Department of Medicine, The Rayne Building, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
Arterioscler Thromb Vasc Biol 24:1074-80. 2004.... - Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid productionLili Cheng
Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
J Biol Chem 279:30654-61. 2004..These findings support a specific role for NP-1 in mediating neurotrophic actions of VEGF family members and also identify a novel role for prostanoids in the inhibition of neuronal chemorepulsion... - Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cellsHaiyan Jia
Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
J Biol Chem 279:36148-57. 2004.... - Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1Dan Liu
BHF Laboratories, Department of Medicine, University College London, London, UK
Arterioscler Thromb Vasc Biol 23:2002-7. 2003..The program of gene expression regulated by vascular endothelial growth factor (VEGF) remains poorly understood. The aim of this study was to identify VEGF-regulated genes in human umbilical vein endothelial cells... - Angiogenesis-dependent and independent phases of intimal hyperplasiaRohit Khurana
Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College, London, UK
Circulation 110:2436-43. 2004..CONCLUSIONS: Our findings indicate that adventitial angiogenesis stimulates intimal thickening but does not initiate it... - Neuropilins: structure, function and role in diseaseCaroline Pellet-Many
Centre for Cardiovascular Science and Medicine, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
Biochem J 411:211-26. 2008.... - Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cellsMarianne Löhr
The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK
Biochem Biophys Res Commun 300:609-13. 2003..Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity... - Vascular endothelial growth factor synergistically enhances induction of E-selectin by tumor necrosis factor-alphaAnita K Stannard
BHF Laboratories, Department of Medicine, The Rayne Building, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
Arterioscler Thromb Vasc Biol 27:494-502. 2007..The regulation of endothelial cell adhesion molecules (CAMs) by vascular endothelial growth factor (VEGF) was investigated in cell cultures and in a rabbit model of atherogenic neointima formation... - Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusionShelley R Boyd
Moorfields Eye Hospital, City Road, London EC1V 2PD, England
Arch Ophthalmol 120:1644-50. 2002.... - Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysisJahangir Kabir
Department of Medicine, BHF Laboratories, University College London, 5 University Street, London WC1E 6JJ, U.K
Biochem J 367:145-55. 2002..Cycloheximide induces apoptosis through a pathway involving FAK proteolysis without dephosphorylation...