Ian C Zachary

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
    Caroline Pellet-Many
    Centre for Cardiovascular Science and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem J 435:609-18. 2011
  2. pmc Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Development 141:556-62. 2014
  3. doi request reprint How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns
    Ian C Zachary
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem Soc Trans 39:1583-91. 2011
  4. pmc The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease
    David I R Holmes
    BHF Laboratories and The Rayne Institute, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Genome Biol 6:209. 2005
  5. ncbi request reprint Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential
    Ian Zachary
    Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, The Rayne Institute, University College London, London, UK
    Neurosignals 14:207-21. 2005
  6. ncbi request reprint The role of neuropilins in cell signalling
    Ian C Zachary
    Centre for Cardiovascular Science and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem Soc Trans 37:1171-8. 2009
  7. ncbi request reprint VEGF signalling: integration and multi-tasking in endothelial cell biology
    I Zachary
    Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, U K
    Biochem Soc Trans 31:1171-7. 2003
  8. doi request reprint Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects
    Ian Zachary
    Centre for Cardiovascular Biology and Medicine, Department of Cardiovascular Science, Division of Medicine, University College London, London, UK
    Heart 97:181-9. 2011
  9. ncbi request reprint Vascular endothelial growth factor and anti-angiogenic peptides as therapeutic and investigational molecules
    Ian Zachary
    University College London, Department of Medicine, 5 University Street, London, WC1E 6JJ UK
    IDrugs 6:224-31. 2003
  10. ncbi request reprint Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
    I Zachary
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College London, 5 University Street, WC1E 6JJ, London, UK
    Cardiovasc Res 49:568-81. 2001

Collaborators

Detail Information

Publications42

  1. pmc Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
    Caroline Pellet-Many
    Centre for Cardiovascular Science and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem J 435:609-18. 2011
    ..These results indicate a role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRα and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway...
  2. pmc Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Development 141:556-62. 2014
    ....
  3. doi request reprint How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns
    Ian C Zachary
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem Soc Trans 39:1583-91. 2011
    ..The present article focuses on some of the most important unresolved questions concerning the mechanism(s) through which NRP1 acts, and highlights recent findings which are beginning to generate insights into these questions...
  4. pmc The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease
    David I R Holmes
    BHF Laboratories and The Rayne Institute, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Genome Biol 6:209. 2005
    ....
  5. ncbi request reprint Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential
    Ian Zachary
    Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, The Rayne Institute, University College London, London, UK
    Neurosignals 14:207-21. 2005
    ..However, more work is required to determine the specific functional role of direct neuronal effects of VEGF...
  6. ncbi request reprint The role of neuropilins in cell signalling
    Ian C Zachary
    Centre for Cardiovascular Science and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem Soc Trans 37:1171-8. 2009
    ..Growing evidence indicates, however, that NRP1 plays a selective role in signalling at least in part via its C-terminal domain and interaction with intracellular binding partners...
  7. ncbi request reprint VEGF signalling: integration and multi-tasking in endothelial cell biology
    I Zachary
    Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, U K
    Biochem Soc Trans 31:1171-7. 2003
    ..Together, the multiplicity, functional versatility and integration of VEGF signalling provide a useful framework for understanding the mechanisms underlying the endothelial biological response to this key factor...
  8. doi request reprint Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects
    Ian Zachary
    Centre for Cardiovascular Biology and Medicine, Department of Cardiovascular Science, Division of Medicine, University College London, London, UK
    Heart 97:181-9. 2011
    ..This review discusses therapeutic angiogenesis in the light of recent scientific advances and clinical evidence, and considers the future challenges and prospects for therapeutic angiogenesis...
  9. ncbi request reprint Vascular endothelial growth factor and anti-angiogenic peptides as therapeutic and investigational molecules
    Ian Zachary
    University College London, Department of Medicine, 5 University Street, London, WC1E 6JJ UK
    IDrugs 6:224-31. 2003
    ..This article highlights recent progress toward the development of anti-angiogenic and vascular-specific peptides with a focus on peptidic VEGF receptor antagonists...
  10. ncbi request reprint Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
    I Zachary
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College London, 5 University Street, WC1E 6JJ, London, UK
    Cardiovasc Res 49:568-81. 2001
    ..Recent findings suggest important roles for the vasodilators nitric oxide and prostacyclin, in linking post-receptor signaling networks to downstream biological effects and in mediating some in vivo endothelial functions of VEGF...
  11. ncbi request reprint Vascular protection: A novel nonangiogenic cardiovascular role for vascular endothelial growth factor
    I Zachary
    Department of Medicine, University College London, London, UK
    Arterioscler Thromb Vasc Biol 20:1512-20. 2000
    ....
  12. ncbi request reprint Vascular endothelial growth factor
    I Zachary
    Wolfson Institute for Biomedical Research, University College London, UK
    Int J Biochem Cell Biol 30:1169-74. 1998
    ....
  13. ncbi request reprint Vascular endothelial growth factor: how it transmits its signal
    I Zachary
    Cruciform Project and Department of Medicine, University College, London, UK
    Exp Nephrol 6:480-7. 1998
    ..Recent findings have revealed novel signaling mechanisms which may mediate the biological actions of VEGF. In contrast, the signal transduction mechanisms triggered by Flt-1 remain largely unknown...
  14. pmc VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
    Birger Herzog
    BHF Laboratories, University College London, London WC1E 6JJ, UK
    Mol Biol Cell 22:2766-76. 2011
    ..Identification of key residues essential for VEGF binding and biological functions provides the basis for a rational design of antagonists of VEGF binding to NRP1...
  15. pmc Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    Ian M Evans
    UCL Division of Medicine, 5 University Street, London WC1E 6JJ, United Kingdom
    Mol Cell Biol 31:1174-85. 2011
    ....
  16. ncbi request reprint Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2
    David I R Holmes
    Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, United Kingdom
    Cell Signal 20:569-79. 2008
    ..These findings support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability...
  17. pmc Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
    Ian M Evans
    Department of Medicine, Centre for Cardiovascular Biology and Medicine, The Rayne Institute, University College London, UK
    Biochem J 429:565-72. 2010
    ..CRT5, a novel specific PKD inhibitor, will greatly facilitate the study of the role of PKD signalling mechanisms in angiogenesis...
  18. ncbi request reprint Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Cell Signal 20:1375-84. 2008
    ....
  19. pmc Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway
    Paul Frankel
    Department of Medicine, Centre for Cardiovascular Biology and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    EMBO Rep 9:983-9. 2008
    ..Our data establish distinct roles for NRP1 and NRP1-CS in modulating a new NRP1-p130Cas signalling pathway contributing to glioblastoma cell invasion in 3D...
  20. ncbi request reprint N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity
    Haiyan Jia
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street, London WC1E 6JJ UK
    Chembiochem 15:1161-70. 2014
    ..EG00086 is a potent blocker of VEGF-promoted cellular adhesion to extracellular matrices, and phosphorylation of p130Cas contributes to this effect. ..
  21. doi request reprint p130Cas: a key signalling node in health and disease
    Angela Barrett
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London WC1E 6JJ, United Kingdom
    Cell Signal 25:766-77. 2013
    ....
  22. ncbi request reprint Role of angiogenesis in cardiovascular disease: a critical appraisal
    Rohit Khurana
    Department of Medicine, University College London, London WC1E 6JJ, UK
    Circulation 112:1813-24. 2005
    ..Furthermore, current evidence from clinical trials of both proangiogenic and antiangiogenic therapies does not suggest that inhibition of angiogenesis is likely to be a viable therapeutic strategy for cardiovascular disease...
  23. ncbi request reprint A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling
    Angela Barrett
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, Rayne Building, University College London, London WC1E 6JJ, UK
    J Cell Sci 127:2647-58. 2014
    ..These data show a crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway. ..
  24. ncbi request reprint A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo
    James W B Bainbridge
    Institute of Ophthalmology, Bath Street, London, UK
    Biochem Biophys Res Commun 302:793-9. 2003
    ....
  25. ncbi request reprint Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3'-kinase-mediates PKC delta phosphorylation: role of PKC in angiogenesis
    Georgia Gliki
    Centre for Cardiovascular Biology, Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK
    Cell Biol Int 26:751-9. 2002
    ....
  26. ncbi request reprint Psychological stress activates interleukin-1beta gene expression in human mononuclear cells
    Lena Brydon
    The Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, UK
    Brain Behav Immun 19:540-6. 2005
    ..Stress-induced activation of mononuclear IL-1beta is a novel mechanism potentially linking stress and heart disease. This mechanism could also play a role in other inflammatory diseases exacerbated by stress...
  27. pmc Hostility and physiological responses to laboratory stress in acute coronary syndrome patients
    Lena Brydon
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, London, United Kingdom
    J Psychosom Res 68:109-16. 2010
    ..This study set out to test whether hostile individuals with advanced CAD were also more stress responsive...
  28. doi request reprint Protein kinase D in vascular biology and angiogenesis
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
    IUBMB Life 63:258-63. 2011
    ..PKD is also emerging as a potentially important mediator of tumor growth and tumor angiogenesis and there is growing interest in PKD as a novel therapeutic target in cancer...
  29. ncbi request reprint Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling
    Haiyan Jia
    Centre for Cardiovascular Biology and Medicine, Department of Medicine and Ark Therapeutics Limited, The Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
    J Biol Chem 281:13493-502. 2006
    ..The results also identify a key role for the C-terminal exon 8 domain in VEGF-A165 binding to NP-1...
  30. ncbi request reprint Protein kinase D in vascular biology and angiogenesis
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
    IUBMB Life 63:spcone. 2011
    ..Protein kinase D1/2 signaling in endothelial cells by Ian M. Evans and Ian C. Zachary, pp. 258-263...
  31. ncbi request reprint Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation
    Rohit Khurana
    BHF Laboratories, Department of Medicine, University College London, 5 University St, London WC1E 6JJ, United Kingdom
    Circulation 111:2828-36. 2005
    ....
  32. ncbi request reprint Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors
    David I R Holmes
    Department of Medicine, The Rayne Building, University College London, 5 University Street, London WC1E 6JJ, UK
    FEBS Lett 557:93-8. 2004
    ..These findings show for the first time that VEGF and PlGF induce mRNA expression of the transcription factors FosB and c-Fos, and suggest that these factors may play a role in the biological responses mediated by PlGF and Flt-1...
  33. ncbi request reprint Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production
    Lili Cheng
    Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    J Biol Chem 279:30654-61. 2004
    ..These findings support a specific role for NP-1 in mediating neurotrophic actions of VEGF family members and also identify a novel role for prostanoids in the inhibition of neuronal chemorepulsion...
  34. ncbi request reprint Vascular endothelial growth factor gene transfer inhibits neointimal macrophage accumulation in hypercholesterolemic rabbits
    Rohit Khurana
    BHF Laboratories, Department of Medicine, The Rayne Building, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Arterioscler Thromb Vasc Biol 24:1074-80. 2004
    ....
  35. ncbi request reprint Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells
    Marianne Löhr
    The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK
    Biochem Biophys Res Commun 300:609-13. 2003
    ..Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity...
  36. ncbi request reprint Angiogenesis-dependent and independent phases of intimal hyperplasia
    Rohit Khurana
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College, London, UK
    Circulation 110:2436-43. 2004
    ..Because percutaneous coronary interventions result in induction of periadventitial angiogenesis, we analyzed the role of this process in neointima formation...
  37. ncbi request reprint Neuropilins: structure, function and role in disease
    Caroline Pellet-Many
    Centre for Cardiovascular Science and Medicine, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem J 411:211-26. 2008
    ....
  38. ncbi request reprint Vascular endothelial growth factor synergistically enhances induction of E-selectin by tumor necrosis factor-alpha
    Anita K Stannard
    BHF Laboratories, Department of Medicine, The Rayne Building, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Arterioscler Thromb Vasc Biol 27:494-502. 2007
    ..The regulation of endothelial cell adhesion molecules (CAMs) by vascular endothelial growth factor (VEGF) was investigated in cell cultures and in a rabbit model of atherogenic neointima formation...
  39. ncbi request reprint Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells
    Haiyan Jia
    Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    J Biol Chem 279:36148-57. 2004
    ....
  40. ncbi request reprint Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1
    Dan Liu
    BHF Laboratories, Department of Medicine, University College London, London, UK
    Arterioscler Thromb Vasc Biol 23:2002-7. 2003
    ..The program of gene expression regulated by vascular endothelial growth factor (VEGF) remains poorly understood. The aim of this study was to identify VEGF-regulated genes in human umbilical vein endothelial cells...
  41. ncbi request reprint Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion
    Shelley R Boyd
    Moorfields Eye Hospital, City Road, London EC1V 2PD, England
    Arch Ophthalmol 120:1644-50. 2002
    ..To establish a role for vascular endothelial growth factor (VEGF) during the onset and clinical course of neovascularization of the iris (NVI) in ischemic central retinal vein occlusion...
  42. pmc Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis
    Jahangir Kabir
    Department of Medicine, BHF Laboratories, University College London, 5 University Street, London WC1E 6JJ, U K
    Biochem J 367:145-55. 2002
    ..Cycloheximide induces apoptosis through a pathway involving FAK proteolysis without dephosphorylation...