John S Yudkin
Affiliation: University College London
- Global health-worker crisis: the UK could learn from CubaJohn S Yudkin
University College London, London N7 0AG, UK
Lancet 371:1397-9. 2008
- C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?J S Yudkin
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London N19 3UA, UK
Arterioscler Thromb Vasc Biol 19:972-8. 1999..Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease...
- Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndromeBeverley Balkau
INSERM Unit 258, Villejuif Cedex, France
Diabetes Metab 28:364-76. 2002....
- Assessing health systems for type 1 diabetes in sub-Saharan Africa: developing a 'Rapid Assessment Protocol for Insulin Access'David Beran
International Insulin Foundation, International Health and Medical Education Centre, University College London, Highgate Hill, London N19 5LW, UK
BMC Health Serv Res 6:17. 2006..We developed a Rapid Assessment Protocol for Insulin Access, comprising a series of questionnaires as well as a protocol for the gathering of other data through site visits, discussions, and document reviews...
- Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivoJ S Yudkin
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, Whittington, Hospital, United Kingdom
Thromb Res 96:1-9. 1999..We conclude that, at least in healthy subjects, subcutaneous adipose tissue does not contribute significantly to circulating levels of PAI-1...
- Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH studyJ S Yudkin
Diabetes and Cardiovascular Disease Academic Unit, Department of Medicine, University College London, London, UK
Metabolism 53:852-7. 2004..This raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation...
- "Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular diseaseJohn S Yudkin
Diabetes and Cardiovascular Disease Academic Unit, Department of Medicine, Royal Free and University College Medical School, The Archway Campus, Holborn Union Building, 2 10 Highgate Hill, London N19 5LW, UK
Lancet 365:1817-20. 2005..We also suggest a homology between this vasoactive periarteriolar fat and both periarterial and visceral fat, which may explain relations between visceral fat, insulin resistance, and vascular disease...
- Adipose tissue, insulin action and vascular disease: inflammatory signalsJ S Yudkin
Diabetes and Cardiovascular Risk Academic Unit, University College London, London, UK
Int J Obes Relat Metab Disord 27:S25-8. 2003..A clearer understanding of adipose tissue signalling, and its contribution to the state of low-grade inflammation of obesity, will require physiological, as well as cellular and molecular, studies...
- Inflammation, obesity, and the metabolic syndromeJ S Yudkin
University College London, Gower Street, London WC1E 6BT, UK
Horm Metab Res 39:707-9. 2007....
- Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly StudyJ S Yudkin
Department of Medicine, University College London Medical School, Whittington Hospital, London, UK
Diabetologia 45:327-36. 2002..However, in cross-sectional studies, relationships of concentrations of the insulin precursor molecules, proinsulin and des 31, 32 proinsulin, relate as strongly, or more strongly, to levels of risk factors and to (prevalent) CHD...
- Insulin resistance and the metabolic syndrome--or the pitfalls of epidemiologyJ S Yudkin
Department of Medicine, University College London, Archway Campus, Highgate Hill, London, UK
Diabetologia 50:1576-86. 2007..Integrated systems biology needs more complex approaches to investigate disease mechanisms, involving cell, organ, whole organism and population studies...
- Insulin for the world's poorest countriesJ S Yudkin
Royal Free and University College London School of Medicine, Whittington Hospital, UK
Lancet 355:919-21. 2000..No type 1 diabetic patient in the world's poorest countries need then die because they, or their government, cannot afford insulin...
- Developing risk stratification charts for diabetic and nondiabetic subjectsJ S Yudkin
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, Whittington Hospital, UK
Diabet Med 16:219-27. 1999..To provide estimates of the 10-year risk of coronary heart disease events for diabetic and nondiabetic men and women with different levels of risk factors and, for diabetic subjects, with and without microalbuminuria...
- Conceptualising global health: theoretical issues and their relevance for teachingMike Rowson
UCL Institute for Global Health, London, UK
Global Health 8:36. 2012....
- Diabetes care in sub-Saharan AfricaDavid Beran
International Insulin Foundation, International Health and Medical Education Centre, University College London, London N19 5LW, UK
Lancet 368:1689-95. 2006..We review the current evidence on diabetes care in sub-Saharan Africa and propose an 11-point action plan to address this problem in the region...
- Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH StudyDaniel Kelberman
Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, UK
Thromb Haemost 92:1122-8. 2004..Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europe...
- Insight into the nature of the CRP-coronary event association using Mendelian randomizationJuan P Casas
Centre for Clinical Pharmacology, Department of Medicine, BHF Laboratories at University College London, UCL, London, UK
Int J Epidemiol 35:922-31. 2006..Since the distribution of this polymorphism occurs at random during gamete formation, its association with coronary events should not be biased or confounded...
- Looking beyond the issue of access to insulin: what is needed for proper diabetes care in resource poor settingsDavid Beran
International Insulin Foundation, Centre for International Health and Development, Institute of Child Health, University College London, 30, Guildford Street, London WC1N 1EH, UK
Diabetes Res Clin Pract 88:217-21. 2010..Strengthening health systems and developing sustainable and locally owned solutions are vital to improve health and health care for people with diabetes and other chronic conditions in resource poor settings...
- Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 geneArshia Panahloo
Department of Medicine, Royal Free and University College Medical School, Holborn Union Building, Archway Campus, Archway Road, Highgate Hill, London N19 3UA, UK
Atherosclerosis 168:297-304. 2003..In these patients, levels of PAI-1 are related to concentrations of proinsulin-like molecules and of proinflammatory cytokines...
- EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitroH Ireland
Cardiovascular Genetics, Department Medicine, University College London, 5 University St, London, WC1E 6JF, UK
Atherosclerosis 183:283-92. 2005..The increased CHD-risk and thrombin generation appears to be acting through increased shedding of the Gly allele from the cell surface...
- Amino acid depletion modulates vascular endothelial growth factor production during the life span of human vascular smooth muscle cellsK A Earle
Department of Medicine, Centre for Diabetes and Cardiovascular Risk, University College London, Whittington Hospital, United Kingdom
J Cell Physiol 176:359-64. 1998..The replicative capacity and constitutive production of VEGF in VSMCs in culture may be programmed by transient privation of amino acids. These observations are relevant to new concepts concerning the pathogenesis of vascular disease...
- Proteinuria and progressive renal disease: birth weight and microalbuminuriaJ S Yudkin
Department of Medicine, University College London, Whittington Hospital, UK
Nephrol Dial Transplant 12:10-3. 1997..We have explored the relationship of foetal growth and intrauterine starvation with microalbuminuria in non-diabetic subjects...
- Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional studyS A Stanner
Department of Medicine, University College London Medical School, Whittington Hospital
BMJ 315:1342-8. 1997..To investigate the relation between decreased maternal food intake and risk factors for coronary heart disease in adult life...
- Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivoV Mohamed-Ali
Centre for Diabetes and Cardiovascular Risk, University College London Medical School, London N19 3UA, United Kingdom
Am J Physiol 277:E971-5. 1999....
- Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?J S Yudkin
Department of Medicine, Centre for Diabetes and Cardiovascular Risk, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London, UK
Atherosclerosis 148:209-14. 2000..Thus we propose a role for IL-6 in the pathogenesis of CHD through a combination of autocrine, paracrine and endocrine mechanisms. This hypothesis lends itself to testing using interventions to influence IL-6 secretion and actions...
- Associations of micro-albuminuria with intra-uterine growth retardationJ S Yudkin
Department of Medicine, University College London, UK
Nephron 89:309-14. 2001..We have tested the hypothesis that micro-albuminuria in non-diabetic adults may be associated with markers of intra-uterine growth retardation...
- Implications of the United Kingdom prospective diabetes studyS E Baldeweg
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, London, United Kingdom
Prim Care 26:809-27. 1999..This articles discusses the background, methodology and results of the UKPDS and develops recommendations for treatment and management of patients with type 2 diabetes in the clinical setting...
- Insulin-like growth factor binding protein-1 in NIDDM: relationship with the insulin resistance syndromeV Mohamed-Ali
Centre for Diabetes and Cardiovascular Risk, University College London Medical School, UK
Clin Endocrinol (Oxf) 50:221-8. 1999....
- Fetal programming and the Leningrad Siege studyS A Stanner
British Nutrition Foundation, London, United Kingdom
Twin Res 4:287-92. 2001....
- Access to care for patients with insulin-requiring diabetes in developing countries: case studies of Mozambique and ZambiaDavid Beran
International Insulin Foundation, International Health and Medical Education Centre, University College London, Holborn Union Building, Archway Campus, 2 10, Highgate Hill, London N19 5LW, UK
Diabetes Care 28:2136-40. 2005..The objective of this study was to assess the barriers to care for patients with insulin-requiring diabetes in Mozambique and Zambia...
- Getting the message across: mechanisms of physiological cross talk by adipose tissueDo Eun Lee
Department of Internal Medicine, Division of Endocrinology, Winthrop University Hospital, London, United Kingdom
Am J Physiol Endocrinol Metab 296:E1210-29. 2009....
- Mechanisms of vascular disease in hypertension with special reference to diabetesJohn S Yudkin
Diabetes and Cardiovascular Disease Academic Unit, Royal Free and University College Medical School, London, England
Semin Vasc Med 2:139-48. 2002..The article also explores the relationship between blood pressure lowering and outcome, concluding that it is not yet fully understood how elevation of blood pressure increases risk or how reducing it produces benefit...
- Factors influencing threshold and choice of treatment for hypertension in NIDDM. Cardiovascular factorsJ S Yudkin
Academic Unit of Diabetes and Endocrinology, Whittington Hospital, London, United Kingdom
Diabetes Care 14:27-32. 1991..abstract truncated at 250 words)..
- Variation in the progression of diabetic nephropathy according to racial originK K Earle
Royal Free and University College Medical School, Department of Medicine, Whittington Hospital, London, UK
Nephrol Dial Transplant 16:286-90. 2001..This observation could be related to differences in renoprotection from antihypertensive therapy...
- Effects of tumour necrosis factor-alpha in the human forearm: blood flow and endothelin-1 releaseJ N Patel
Department of Medicine, Royal Free and University College London School of Medicine, Whittington Campus, London N19 3UA, UK
Clin Sci (Lond) 103:409-15. 2002..In spite of this action, TNF-alpha has a vasodilatory effect, resulting in an increase in forearm blood flow...
- Intracellular pH, intrauterine growth and the insulin resistance syndromeJ H Pinkney
Department of Medicine, Clinical Sciences Centre, University Hospital, Aintree, Liverpool, UK
Clin Physiol 21:640-7. 2001..In contrast, low intracellular pH(i) is related to both low birth weight and adult insulin resistance, suggesting it might be a 'programmed' cell phenotype, although this is not apparently explained by altered NHE kinetics...
- The evolution of global health teaching in undergraduate medical curriculaMike Rowson
UCL Institute for Global Health, 30 Guilford Street, London, UK
Global Health 8:35. 2012..In this article we trace the evolution of this teaching and present recommendations for how the discipline might develop in future years...
- Introducing medical students to global health issues: a Bachelor of Science degree in international healthJohn S Yudkin
International Health and Medical Education Centre, University College London, Holborn Union Building, Archway Campus, 2-10 Highgate Hill, N19 5LW, London, UK
Lancet 362:822-4. 2003
- Central obesity, depression and the hypothalamo-pituitary-adrenal axis in men and postmenopausal womenJ R Katz
Department of Medicine, UCLMS, London N19 3UA, UK
Int J Obes Relat Metab Disord 24:246-51. 2000..We examined the relationship of adiposity to pituitary-adrenal responses to corticotrophin-releasing hormone (CRH) in men and postmenopausal women, controlling for the influence of depression...
- The association between birth weight and capillary recruitment is independent of blood pressure and insulin sensitivity: a study in prepubertal childrenRichard G Ijzerman
Department of Internal Medicine, Institute for Cardiovascular Research-Vrije Universiteit VU University Medical Center Amsterdam, The Netherlands
J Hypertens 20:1957-63. 2002..These findings are consistent with the hypothesis that an impaired capillary recruitment plays a mechanistic role in the association of birth weight with blood pressure and insulin resistance in adult life...
- TNF-alpha levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-alpha and insulin resistanceRichard G Ijzerman
Department of Internal Medicine, Institute for Cardiovascular Research-Vrije Universiteit, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
Clin Sci (Lond) 110:361-8. 2006..Our data suggest that these relationships are initiated during growth from childhood to adulthood...
- Regulation of vascular function and insulin sensitivity by adipose tissue: focus on perivascular adipose tissueEtto C Eringa
Laboratory for Physiology, UV University Medical Center, Amsterdam, The Netherlands
Microcirculation 14:389-402. 2007....
- Post-load hyperglycaemia-an inappropriate therapeutic targetJohn S Yudkin
Lancet 359:166-7. 2002
- The DREAM trialJohn S Yudkin
Lancet 368:2049-50; author reply 2050-1. 2006
- Larger thigh and hip circumferences are associated with better glucose tolerance: the Hoorn studyMarieke B Snijder
Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
Obes Res 11:104-11. 2003..Muscle mass might be better reflected by thigh circumference. The aim of this study was to investigate the contributions of thigh and hip circumferences, independent of waist circumference, to measures of glucose metabolism...
- Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn StudyMarieke B Snijder
Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Netherlands
Am J Clin Nutr 77:1192-7. 2003..However, smaller hip or thigh circumference may also explain the predictive value of the WHR or WTR for type 2 diabetes...
- Prospective relation of C-reactive protein with type 2 diabetes: response to Han et alMarieke B Snijder
Diabetes Care 26:1656-7; author reply 1657-8. 2003
- Hyperglycaemia as a cardiovascular risk factor in diabetesJohn S Yudkin
Lancet 372:1036-7. 2008
- Common variants in the thrombomodulin gene as a risk for myocardial infarction in the north of Europe (HIFMECH Study)Constantine Konstantoulas
Thromb Haemost 91:628-30. 2004
- Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima IndiansChristian Weyer
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street Rm 5 41, Phoenix, AZ 85016, USA
Atherosclerosis 161:233-42. 2002..Thus, obesity and insulin resistance appear to be associated with low-grade inflammation and endothelial dysfunction, respectively, even in an obesity- and diabetes-prone population with relatively low propensity for atherosclerosis...
- Very tight glucose control: May be high risk, low benefitJohn S Yudkin
BMJ 336:683. 2008
- Increased proinsulin concentrations and excess risk of coronary heart disease in patients with diabetes and prediabetesJohn S Yudkin
Circulation 106:e202. 2002
- Access to medicines versus access to treatment: the case of type 1 diabetesDavid Beran
International Insulin Foundation, London, England
Bull World Health Organ 86:648-9. 2008
- Confounders in chronic stress at work and metabolic syndromeJohn S Yudkin
BMJ 332:1153-4. 2006
- The Y-Y paradoxChittaranjan S Yajnik
Diabetes Unit, KEM Hospital Research Centre, Rasta Peth, Pune 411011, India
Lancet 363:163. 2004
- Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn studyMarieke B Snijder
Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
Diabetes Care 27:372-7. 2004..The main goal was to determine which tissue in the trunk and legs, fat or lean tissue, is associated with measures of glucose metabolism...
- Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetesAndrea Natali
Department of Internal Medicine, CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Diabetes Care 27:1349-57. 2004..The aim of this study was to test whether vascular reactivity is modified by improving metabolic control and peripheral insulin resistance in type 2 diabetes...
- Metformin and its liver targets in the treatment of type 2 diabetesJerry Radziuk
Department of Medicine, Ottawa Hospital and University of Ottawa, ON, Canada
Curr Drug Targets Immune Endocr Metabol Disord 3:151-69. 2003....
- Regional body composition as a determinant of arterial stiffness in the elderly: The Hoorn StudyMarieke B Snijder
Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
J Hypertens 22:2339-47. 2004..To estimate the relation of precisely measured regional body composition with peripheral and central arterial stiffness in the elderly...
- Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vesselsAndrea Natali
Department of Internal Medicine, Via Roma 67, 56100 Pisa, Italy
Eur Heart J 26:464-71. 2005..In vitro, haemoglobin neutralizes nitric oxide very effectively. Whether red blood cells participate in the regulation of endothelial function in vivo has not been established...
- A theme issue by, for, and about Africa: tackling the challenge of diabetesDavid Beran
BMJ 331:779-80. 2005
- PROactive studyJohn S Yudkin
Lancet 367:24-5; author reply 26-7. 2006
- Prognosis of diabetes in the developing worldJohn S Yudkin
Lancet 362:1420-1. 2003
- Preventing stroke with ramipril. Superiority of particular class of antihypertensive agent remains to be shownJohn S Yudkin
BMJ 325:439. 2002
- To: Gerstein HC, Pogue J, Mann JFE, Lonn E, Dagenais GR, McQueen M, Yusuf S, for the HOPE investigators (2005) The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospectiJohn S Yudkin
Diabetologia 49:611-2; author reply 613-4. 2006