J S Yudkin

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Inflammation, obesity, and the metabolic syndrome
    J S Yudkin
    University College London, Gower Street, London WC1E 6BT, UK
    Horm Metab Res 39:707-9. 2007
  2. ncbi request reprint Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
    J S Yudkin
    Department of Medicine, Centre for Diabetes and Cardiovascular Risk, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London, UK
    Atherosclerosis 148:209-14. 2000
  3. ncbi request reprint Associations of micro-albuminuria with intra-uterine growth retardation
    J S Yudkin
    Department of Medicine, University College London, UK
    Nephron 89:309-14. 2001
  4. ncbi request reprint Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups
    D K Nagi
    Academic Unit of Diabetes and Endocrinology, Whittington Hospital, London, United Kingdom
    Diabetes Care 16:621-9. 1993
  5. ncbi request reprint Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo
    V Mohamed-Ali
    Centre for Diabetes and Cardiovascular Risk, University College London Medical School, London N19 3UA, United Kingdom
    Am J Physiol 277:E971-5. 1999
  6. ncbi request reprint Insulin-like growth factor binding protein-1 in NIDDM: relationship with the insulin resistance syndrome
    V Mohamed-Ali
    Centre for Diabetes and Cardiovascular Risk, University College London Medical School, UK
    Clin Endocrinol (Oxf) 50:221-8. 1999
  7. ncbi request reprint Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivo
    J S Yudkin
    Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, Whittington, Hospital, United Kingdom
    Thromb Res 96:1-9. 1999
  8. ncbi request reprint Implications of the United Kingdom prospective diabetes study
    S E Baldeweg
    Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, London, United Kingdom
    Prim Care 26:809-27. 1999
  9. ncbi request reprint C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?
    J S Yudkin
    Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London N19 3UA, UK
    Arterioscler Thromb Vasc Biol 19:972-8. 1999
  10. ncbi request reprint EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro
    H Ireland
    Cardiovascular Genetics, Department Medicine, University College London, 5 University St, London, WC1E 6JF, UK
    Atherosclerosis 183:283-92. 2005

Detail Information

Publications34

  1. ncbi request reprint Inflammation, obesity, and the metabolic syndrome
    J S Yudkin
    University College London, Gower Street, London WC1E 6BT, UK
    Horm Metab Res 39:707-9. 2007
    ....
  2. ncbi request reprint Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
    J S Yudkin
    Department of Medicine, Centre for Diabetes and Cardiovascular Risk, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London, UK
    Atherosclerosis 148:209-14. 2000
    ..Thus we propose a role for IL-6 in the pathogenesis of CHD through a combination of autocrine, paracrine and endocrine mechanisms. This hypothesis lends itself to testing using interventions to influence IL-6 secretion and actions...
  3. ncbi request reprint Associations of micro-albuminuria with intra-uterine growth retardation
    J S Yudkin
    Department of Medicine, University College London, UK
    Nephron 89:309-14. 2001
    ..We have tested the hypothesis that micro-albuminuria in non-diabetic adults may be associated with markers of intra-uterine growth retardation...
  4. ncbi request reprint Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups
    D K Nagi
    Academic Unit of Diabetes and Endocrinology, Whittington Hospital, London, United Kingdom
    Diabetes Care 16:621-9. 1993
    ..To investigate the effects of metformin on glycemic control, insulin resistance, and risk factors for cardiovascular disease in NIDDM subjects from two ethnic groups (Caucasian and Asian) with different risks of cardiovascular disease...
  5. ncbi request reprint Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo
    V Mohamed-Ali
    Centre for Diabetes and Cardiovascular Risk, University College London Medical School, London N19 3UA, United Kingdom
    Am J Physiol 277:E971-5. 1999
    ....
  6. ncbi request reprint Insulin-like growth factor binding protein-1 in NIDDM: relationship with the insulin resistance syndrome
    V Mohamed-Ali
    Centre for Diabetes and Cardiovascular Risk, University College London Medical School, UK
    Clin Endocrinol (Oxf) 50:221-8. 1999
    ....
  7. ncbi request reprint Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivo
    J S Yudkin
    Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, Whittington, Hospital, United Kingdom
    Thromb Res 96:1-9. 1999
    ..We conclude that, at least in healthy subjects, subcutaneous adipose tissue does not contribute significantly to circulating levels of PAI-1...
  8. ncbi request reprint Implications of the United Kingdom prospective diabetes study
    S E Baldeweg
    Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, London, United Kingdom
    Prim Care 26:809-27. 1999
    ..This articles discusses the background, methodology and results of the UKPDS and develops recommendations for treatment and management of patients with type 2 diabetes in the clinical setting...
  9. ncbi request reprint C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?
    J S Yudkin
    Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London N19 3UA, UK
    Arterioscler Thromb Vasc Biol 19:972-8. 1999
    ..Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease...
  10. ncbi request reprint EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro
    H Ireland
    Cardiovascular Genetics, Department Medicine, University College London, 5 University St, London, WC1E 6JF, UK
    Atherosclerosis 183:283-92. 2005
    ..The increased CHD-risk and thrombin generation appears to be acting through increased shedding of the Gly allele from the cell surface...
  11. pmc Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study
    S A Stanner
    Department of Medicine, University College London Medical School, Whittington Hospital
    BMJ 315:1342-8. 1997
    ..To investigate the relation between decreased maternal food intake and risk factors for coronary heart disease in adult life...
  12. ncbi request reprint Proteinuria and progressive renal disease: birth weight and microalbuminuria
    J S Yudkin
    Department of Medicine, University College London, Whittington Hospital, UK
    Nephrol Dial Transplant 12:10-3. 1997
    ..We have explored the relationship of foetal growth and intrauterine starvation with microalbuminuria in non-diabetic subjects...
  13. ncbi request reprint Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study
    J S Yudkin
    Diabetes and Cardiovascular Disease Academic Unit, Department of Medicine, University College London, London, UK
    Metabolism 53:852-7. 2004
    ..This raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation...
  14. ncbi request reprint Insulin resistance and the metabolic syndrome--or the pitfalls of epidemiology
    J S Yudkin
    Department of Medicine, University College London, Archway Campus, Highgate Hill, London, UK
    Diabetologia 50:1576-86. 2007
    ..Integrated systems biology needs more complex approaches to investigate disease mechanisms, involving cell, organ, whole organism and population studies...
  15. ncbi request reprint Factors influencing threshold and choice of treatment for hypertension in NIDDM. Cardiovascular factors
    J S Yudkin
    Academic Unit of Diabetes and Endocrinology, Whittington Hospital, London, United Kingdom
    Diabetes Care 14:27-32. 1991
    ..abstract truncated at 250 words)..
  16. ncbi request reprint Developing risk stratification charts for diabetic and nondiabetic subjects
    J S Yudkin
    Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, Whittington Hospital, UK
    Diabet Med 16:219-27. 1999
    ..To provide estimates of the 10-year risk of coronary heart disease events for diabetic and nondiabetic men and women with different levels of risk factors and, for diabetic subjects, with and without microalbuminuria...
  17. ncbi request reprint Intracellular pH, intrauterine growth and the insulin resistance syndrome
    J H Pinkney
    Department of Medicine, Clinical Sciences Centre, University Hospital, Aintree, Liverpool, UK
    Clin Physiol 21:640-7. 2001
    ..In contrast, low intracellular pH(i) is related to both low birth weight and adult insulin resistance, suggesting it might be a 'programmed' cell phenotype, although this is not apparently explained by altered NHE kinetics...
  18. doi request reprint The insulin dilemma in resource-limited countries. A way forward?
    G V Gill
    Centre for International Health and Development, Institute for Child Health, London, UK
    Diabetologia 54:19-24. 2011
    ..The IIF has developed a position statement on the provision and choice of diabetes treatments in resource-limited settings which should be applicable wherever consideration of resources is a component of therapeutic decision making...
  19. ncbi request reprint Central obesity, depression and the hypothalamo-pituitary-adrenal axis in men and postmenopausal women
    J R Katz
    Department of Medicine, UCLMS, London N19 3UA, UK
    Int J Obes Relat Metab Disord 24:246-51. 2000
    ..We examined the relationship of adiposity to pituitary-adrenal responses to corticotrophin-releasing hormone (CRH) in men and postmenopausal women, controlling for the influence of depression...
  20. ncbi request reprint Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly Study
    J S Yudkin
    Department of Medicine, University College London Medical School, Whittington Hospital, London, UK
    Diabetologia 45:327-36. 2002
    ..However, in cross-sectional studies, relationships of concentrations of the insulin precursor molecules, proinsulin and des 31, 32 proinsulin, relate as strongly, or more strongly, to levels of risk factors and to (prevalent) CHD...
  21. ncbi request reprint Insulin for the world's poorest countries
    J S Yudkin
    Royal Free and University College London School of Medicine, Whittington Hospital, UK
    Lancet 355:919-21. 2000
    ..No type 1 diabetic patient in the world's poorest countries need then die because they, or their government, cannot afford insulin...
  22. ncbi request reprint Amino acid depletion modulates vascular endothelial growth factor production during the life span of human vascular smooth muscle cells
    K A Earle
    Department of Medicine, Centre for Diabetes and Cardiovascular Risk, University College London, Whittington Hospital, United Kingdom
    J Cell Physiol 176:359-64. 1998
    ..The replicative capacity and constitutive production of VEGF in VSMCs in culture may be programmed by transient privation of amino acids. These observations are relevant to new concepts concerning the pathogenesis of vascular disease...
  23. ncbi request reprint The Diabetes UK Mozambique Twinning Programme. Results of improvements in diabetes care in Mozambique: a reassessment 6 years later using the Rapid Assessment Protocol for Insulin Access
    D Beran
    International Insulin Foundation, Centre for International Health and Development, Institute of Child Health, University College London, London, UK
    Diabet Med 27:855-61. 2010
    ..To assess improvements in diabetes care in Mozambique between 2003 and 2009 following the implementation of the Diabetes UK Twinning Programme...
  24. ncbi request reprint Variation in the progression of diabetic nephropathy according to racial origin
    K K Earle
    Royal Free and University College Medical School, Department of Medicine, Whittington Hospital, London, UK
    Nephrol Dial Transplant 16:286-90. 2001
    ..This observation could be related to differences in renoprotection from antihypertensive therapy...
  25. ncbi request reprint Effects of tumour necrosis factor-alpha in the human forearm: blood flow and endothelin-1 release
    J N Patel
    Department of Medicine, Royal Free and University College London School of Medicine, Whittington Campus, London N19 3UA, UK
    Clin Sci (Lond) 103:409-15. 2002
    ..In spite of this action, TNF-alpha has a vasodilatory effect, resulting in an increase in forearm blood flow...
  26. ncbi request reprint Adipose tissue, insulin action and vascular disease: inflammatory signals
    J S Yudkin
    Diabetes and Cardiovascular Risk Academic Unit, University College London, London, UK
    Int J Obes Relat Metab Disord 27:S25-8. 2003
    ..A clearer understanding of adipose tissue signalling, and its contribution to the state of low-grade inflammation of obesity, will require physiological, as well as cellular and molecular, studies...
  27. ncbi request reprint Adiposity, inflammation and hyperglycaemia in rural and urban Indian men: Coronary Risk of Insulin Sensitivity in Indian Subjects (CRISIS) Study
    C S Yajnik
    Diabetes Unit, King Edward Memorial Hospital and Research Centre, Sardar Moodliar Road, Pune, 411 011, India
    Diabetologia 51:39-46. 2008
    ....
  28. ncbi request reprint Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study
    P E Morange
    INSERM, U626, Universite de la Mediterranee, Marseille, France
    Arterioscler Thromb Vasc Biol 27:2250-7. 2007
    ....
  29. ncbi request reprint The central roles of obesity-associated dyslipidaemia, endothelial activation and cytokines in the Metabolic Syndrome--an analysis by structural equation modelling
    J C N Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Int J Obes Relat Metab Disord 26:994-1008. 2002
    ..To test this hypothesis, we used confirmatory factor analysis and structural equation modelling to fit these data to a model designed on theoretical grounds...
  30. ncbi request reprint Interaction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH study
    P E Morange
    Laboratoire d Hématologie CHU Timone, INSERM U626, 13385 Marseille Cedex 5, France
    Atherosclerosis 179:317-23. 2005
    ..02; CI 95 2.24-7.21), but not in C/C (OR: 0.75; CI 95 0.32-1.74, p=0.004 for interaction). The data indicate a role for CD14/C-260T in MI. The risk mediated by the polymorphism is highly dependent on IL-6 plasma levels...
  31. ncbi request reprint The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH study
    I Juhan-Vague
    Laboratoire d Hematologie, CHU Timone, Inserm EPI 99 36, Marseilles, France
    J Thromb Haemost 1:2322-9. 2003
    ..Although the potential role of plasminogen activator inhibitor-1 (PAI-1) in the development of coronary artery disease is strongly supported by its biological characteristics, results of clinical studies remain controversial...
  32. ncbi request reprint Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion
    M Wauters
    Department of Diabetology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Belgium
    Horm Metab Res 35:92-6. 2003
    ....
  33. ncbi request reprint Adiposity and hyperinsulinemia in Indians are present at birth
    C S Yajnik
    Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune 411011, India
    J Clin Endocrinol Metab 87:5575-80. 2002
    ..Prevention of insulin resistance syndrome in Indians will need to address regulation of fetal growth in addition to prevention of obesity in later life...
  34. ncbi request reprint Prognostic value of admission plasma glucose and HbA in acute myocardial infarction
    G Oswald
    Diabet Med 22:509-10; author reply 510. 2005