J S Yudkin
Affiliation: University College London
- Inflammation, obesity, and the metabolic syndromeJ S Yudkin
University College London, Gower Street, London WC1E 6BT, UK
Horm Metab Res 39:707-9. 2007....
- Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?J S Yudkin
Department of Medicine, Centre for Diabetes and Cardiovascular Risk, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London, UK
Atherosclerosis 148:209-14. 2000..Thus we propose a role for IL-6 in the pathogenesis of CHD through a combination of autocrine, paracrine and endocrine mechanisms. This hypothesis lends itself to testing using interventions to influence IL-6 secretion and actions...
- Associations of micro-albuminuria with intra-uterine growth retardationJ S Yudkin
Department of Medicine, University College London, UK
Nephron 89:309-14. 2001..We have tested the hypothesis that micro-albuminuria in non-diabetic adults may be associated with markers of intra-uterine growth retardation...
- Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groupsD K Nagi
Academic Unit of Diabetes and Endocrinology, Whittington Hospital, London, United Kingdom
Diabetes Care 16:621-9. 1993..To investigate the effects of metformin on glycemic control, insulin resistance, and risk factors for cardiovascular disease in NIDDM subjects from two ethnic groups (Caucasian and Asian) with different risks of cardiovascular disease...
- Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivoV Mohamed-Ali
Centre for Diabetes and Cardiovascular Risk, University College London Medical School, London N19 3UA, United Kingdom
Am J Physiol 277:E971-5. 1999....
- Insulin-like growth factor binding protein-1 in NIDDM: relationship with the insulin resistance syndromeV Mohamed-Ali
Centre for Diabetes and Cardiovascular Risk, University College London Medical School, UK
Clin Endocrinol (Oxf) 50:221-8. 1999....
- Lack of evidence for secretion of plasminogen activator inhibitor-1 by human subcutaneous adipose tissue in vivoJ S Yudkin
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, Whittington, Hospital, United Kingdom
Thromb Res 96:1-9. 1999..We conclude that, at least in healthy subjects, subcutaneous adipose tissue does not contribute significantly to circulating levels of PAI-1...
- Implications of the United Kingdom prospective diabetes studyS E Baldeweg
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, London, United Kingdom
Prim Care 26:809-27. 1999..This articles discusses the background, methodology and results of the UKPDS and develops recommendations for treatment and management of patients with type 2 diabetes in the clinical setting...
- C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?J S Yudkin
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, London N19 3UA, UK
Arterioscler Thromb Vasc Biol 19:972-8. 1999..Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease...
- EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitroH Ireland
Cardiovascular Genetics, Department Medicine, University College London, 5 University St, London, WC1E 6JF, UK
Atherosclerosis 183:283-92. 2005..The increased CHD-risk and thrombin generation appears to be acting through increased shedding of the Gly allele from the cell surface...
- Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional studyS A Stanner
Department of Medicine, University College London Medical School, Whittington Hospital
BMJ 315:1342-8. 1997..To investigate the relation between decreased maternal food intake and risk factors for coronary heart disease in adult life...
- Proteinuria and progressive renal disease: birth weight and microalbuminuriaJ S Yudkin
Department of Medicine, University College London, Whittington Hospital, UK
Nephrol Dial Transplant 12:10-3. 1997..We have explored the relationship of foetal growth and intrauterine starvation with microalbuminuria in non-diabetic subjects...
- Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH studyJ S Yudkin
Diabetes and Cardiovascular Disease Academic Unit, Department of Medicine, University College London, London, UK
Metabolism 53:852-7. 2004..This raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation...
- Insulin resistance and the metabolic syndrome--or the pitfalls of epidemiologyJ S Yudkin
Department of Medicine, University College London, Archway Campus, Highgate Hill, London, UK
Diabetologia 50:1576-86. 2007..Integrated systems biology needs more complex approaches to investigate disease mechanisms, involving cell, organ, whole organism and population studies...
- Factors influencing threshold and choice of treatment for hypertension in NIDDM. Cardiovascular factorsJ S Yudkin
Academic Unit of Diabetes and Endocrinology, Whittington Hospital, London, United Kingdom
Diabetes Care 14:27-32. 1991..abstract truncated at 250 words)..
- Developing risk stratification charts for diabetic and nondiabetic subjectsJ S Yudkin
Centre for Diabetes and Cardiovascular Risk, Department of Medicine, University College London Medical School, Whittington Hospital, UK
Diabet Med 16:219-27. 1999..To provide estimates of the 10-year risk of coronary heart disease events for diabetic and nondiabetic men and women with different levels of risk factors and, for diabetic subjects, with and without microalbuminuria...
- Intracellular pH, intrauterine growth and the insulin resistance syndromeJ H Pinkney
Department of Medicine, Clinical Sciences Centre, University Hospital, Aintree, Liverpool, UK
Clin Physiol 21:640-7. 2001..In contrast, low intracellular pH(i) is related to both low birth weight and adult insulin resistance, suggesting it might be a 'programmed' cell phenotype, although this is not apparently explained by altered NHE kinetics...
- The insulin dilemma in resource-limited countries. A way forward?G V Gill
Centre for International Health and Development, Institute for Child Health, London, UK
Diabetologia 54:19-24. 2011..The IIF has developed a position statement on the provision and choice of diabetes treatments in resource-limited settings which should be applicable wherever consideration of resources is a component of therapeutic decision making...
- Central obesity, depression and the hypothalamo-pituitary-adrenal axis in men and postmenopausal womenJ R Katz
Department of Medicine, UCLMS, London N19 3UA, UK
Int J Obes Relat Metab Disord 24:246-51. 2000..We examined the relationship of adiposity to pituitary-adrenal responses to corticotrophin-releasing hormone (CRH) in men and postmenopausal women, controlling for the influence of depression...
- Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly StudyJ S Yudkin
Department of Medicine, University College London Medical School, Whittington Hospital, London, UK
Diabetologia 45:327-36. 2002..However, in cross-sectional studies, relationships of concentrations of the insulin precursor molecules, proinsulin and des 31, 32 proinsulin, relate as strongly, or more strongly, to levels of risk factors and to (prevalent) CHD...
- Insulin for the world's poorest countriesJ S Yudkin
Royal Free and University College London School of Medicine, Whittington Hospital, UK
Lancet 355:919-21. 2000..No type 1 diabetic patient in the world's poorest countries need then die because they, or their government, cannot afford insulin...
- Amino acid depletion modulates vascular endothelial growth factor production during the life span of human vascular smooth muscle cellsK A Earle
Department of Medicine, Centre for Diabetes and Cardiovascular Risk, University College London, Whittington Hospital, United Kingdom
J Cell Physiol 176:359-64. 1998..The replicative capacity and constitutive production of VEGF in VSMCs in culture may be programmed by transient privation of amino acids. These observations are relevant to new concepts concerning the pathogenesis of vascular disease...
- The Diabetes UK Mozambique Twinning Programme. Results of improvements in diabetes care in Mozambique: a reassessment 6 years later using the Rapid Assessment Protocol for Insulin AccessD Beran
International Insulin Foundation, Centre for International Health and Development, Institute of Child Health, University College London, London, UK
Diabet Med 27:855-61. 2010..To assess improvements in diabetes care in Mozambique between 2003 and 2009 following the implementation of the Diabetes UK Twinning Programme...
- Variation in the progression of diabetic nephropathy according to racial originK K Earle
Royal Free and University College Medical School, Department of Medicine, Whittington Hospital, London, UK
Nephrol Dial Transplant 16:286-90. 2001..This observation could be related to differences in renoprotection from antihypertensive therapy...
- Effects of tumour necrosis factor-alpha in the human forearm: blood flow and endothelin-1 releaseJ N Patel
Department of Medicine, Royal Free and University College London School of Medicine, Whittington Campus, London N19 3UA, UK
Clin Sci (Lond) 103:409-15. 2002..In spite of this action, TNF-alpha has a vasodilatory effect, resulting in an increase in forearm blood flow...
- Adipose tissue, insulin action and vascular disease: inflammatory signalsJ S Yudkin
Diabetes and Cardiovascular Risk Academic Unit, University College London, London, UK
Int J Obes Relat Metab Disord 27:S25-8. 2003..A clearer understanding of adipose tissue signalling, and its contribution to the state of low-grade inflammation of obesity, will require physiological, as well as cellular and molecular, studies...
- Adiposity, inflammation and hyperglycaemia in rural and urban Indian men: Coronary Risk of Insulin Sensitivity in Indian Subjects (CRISIS) StudyC S Yajnik
Diabetes Unit, King Edward Memorial Hospital and Research Centre, Sardar Moodliar Road, Pune, 411 011, India
Diabetologia 51:39-46. 2008....
- Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH studyP E Morange
INSERM, U626, Universite de la Mediterranee, Marseille, France
Arterioscler Thromb Vasc Biol 27:2250-7. 2007....
- The central roles of obesity-associated dyslipidaemia, endothelial activation and cytokines in the Metabolic Syndrome--an analysis by structural equation modellingJ C N Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, NT, Hong Kong, China
Int J Obes Relat Metab Disord 26:994-1008. 2002..To test this hypothesis, we used confirmatory factor analysis and structural equation modelling to fit these data to a model designed on theoretical grounds...
- Interaction between the C-260T polymorphism of the CD14 gene and the plasma IL-6 concentration on the risk of myocardial infarction: the HIFMECH studyP E Morange
Laboratoire d Hématologie CHU Timone, INSERM U626, 13385 Marseille Cedex 5, France
Atherosclerosis 179:317-23. 2005..02; CI 95 2.24-7.21), but not in C/C (OR: 0.75; CI 95 0.32-1.74, p=0.004 for interaction). The data indicate a role for CD14/C-260T in MI. The risk mediated by the polymorphism is highly dependent on IL-6 plasma levels...
- The plasminogen activator inhibitor-1 -675 4G/5G genotype influences the risk of myocardial infarction associated with elevated plasma proinsulin and insulin concentrations in men from Europe: the HIFMECH studyI Juhan-Vague
Laboratoire d Hematologie, CHU Timone, Inserm EPI 99 36, Marseilles, France
J Thromb Haemost 1:2322-9. 2003..Although the potential role of plasminogen activator inhibitor-1 (PAI-1) in the development of coronary artery disease is strongly supported by its biological characteristics, results of clinical studies remain controversial...
- Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretionM Wauters
Department of Diabetology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Belgium
Horm Metab Res 35:92-6. 2003....
- Adiposity and hyperinsulinemia in Indians are present at birthC S Yajnik
Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune 411011, India
J Clin Endocrinol Metab 87:5575-80. 2002..Prevention of insulin resistance syndrome in Indians will need to address regulation of fetal growth in addition to prevention of obesity in later life...
- Prognostic value of admission plasma glucose and HbA in acute myocardial infarctionG Oswald
Diabet Med 22:509-10; author reply 510. 2005