J Duncan Young
Affiliation: University of Oxford
- Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trialDuncan Young
Adult Intensive Care Unit, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, England
JAMA 309:2121-9. 2013..Tracheostomy is a widely used intervention in adult critical care units. There is little evidence to guide clinicians regarding the optimal timing for this procedure...
- High-frequency oscillation for acute respiratory distress syndromeDuncan Young
John Radcliffe Hospital and the University of Oxford, Oxford, United Kingdom
N Engl J Med 368:806-13. 2013..High-frequency oscillatory ventilation (HFOV) may reduce this secondary damage...
- Beta Agonist Lung Injury TrIal-2 (BALTI-2) trial protocol: a randomised, double-blind, placebo-controlled of intravenous infusion of salbutamol in the acute respiratory distress syndromeGavin D Perkins
University of Warwick, Warwick Medical School Clinical Trials Unit, Warwick, CV4 7AL, UK
Trials 12:113. 2011....
- Bench to bedside: A role for erythropoietin in sepsisAndrew P Walden
Adult Intensive Care Unit, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
Crit Care 14:227. 2010..An observational cohort study examining the microvascular effects of erythropoietin is underway and the evidence would support further phase II and III clinical trials examining this molecule as an adjunctive treatment in sepsis...
- The heart and circulation in severe sepsisJ D Young
Adult Intensive Care Unit, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Br J Anaesth 93:114-20. 2004
- Clinical trials of monitoring in anaesthesia, critical care and acute ward care: a reviewD Young
Nuffield Department of Anaesthetics John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Br J Anaesth 97:39-45. 2006..This review highlights some of the studies that have assessed new monitors in anaesthesia, critical care, and other areas of acute care...
- The use of pre- pro- and synbiotics in adult intensive care unit patients: systematic reviewPeter J Watkinson
Intensive Care Society Trials Group, Kadoorie Centre, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Clin Nutr 26:182-92. 2007....
- Study protocol: the Intensive Care Outcome Network ('ICON') studyJohn A Griffiths
ICS Trials Group, Kadoorie Centre, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
BMC Health Serv Res 8:132. 2008..The current lack of rigorous longitudinal studies means that the true prevalence of these physical and psychological problems remains undetermined...
- Abnormal cerebral blood volume in regions of contused and normal appearing brain following traumatic brain injury using perfusion magnetic resonance imagingM R Garnett
Department of Biochemistry, University of Oxford, United Kingdom
J Neurotrauma 18:585-93. 2001..The current study has shown that regions of both normal appearing and contused brain may have an abnormal rCBV and that alterations in rCBV may play a role in determining the clinical outcome of patients...
- Altered cellular metabolism following traumatic brain injury: a magnetic resonance spectroscopy studyM R Garnett
Department of Biochemistry, University of Oxford, United Kingdom
J Neurotrauma 18:231-40. 2001....
- A national survey of intensive care follow-up clinicsJ A Griffiths
Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford, UK
Anaesthesia 61:950-5. 2006..Nearly half of the follow-up clinics (39 clinics, 49%) have pre-negotiated access to at least one other out-patient service...
- Integrated monitoring and analysis for early warning of patient deteriorationL Tarassenko
Department of Engineering Science, Parks Road, University of Oxford, Oxford OX1 3PJ, UK
Br J Anaesth 97:64-8. 2006..Retrospective analysis has also shown that the data fusion algorithm in BioSign is capable of detecting critical events in advance of single-channel alerts...
- The prevalence of post traumatic stress disorder in survivors of ICU treatment: a systematic reviewJohn Griffiths
The John Radcliffe Hospital, Intensive Care Society Trials Group, Kadoorie Centre, Headley Way, OX3 9DU, Headington, Oxford, UK
Intensive Care Med 33:1506-18. 2007..To determine the prevalence of post traumatic stress disorder in survivors of intensive care treatment...
- Systematic review and meta-analysis of studies of the timing of tracheostomy in adult patients undergoing artificial ventilationJohn Griffiths
Adult Intensive Care Unit, John Radcliffe Hospital, Oxford OX3 9DU
BMJ 330:1243. 2005..To compare outcomes in critically ill patients undergoing artificial ventilation who received a tracheostomy early or late in their treatment...
- Modifiable factors influencing relatives' decision to offer organ donation: systematic reviewArabella L Simpkin
Intensive Care Society Clinical Trials Group, Kadoorie Centre, John Radcliffe Hospital, Headington, Oxford OX3 9DU
BMJ 338:b991. 2009..To identify modifiable factors that influence relatives' decision to allow organ donation...
- A randomised controlled trial of the effect of continuous electronic physiological monitoring on the adverse event rate in high risk medical and surgical patientsP J Watkinson
Intensive Care Society Clinical Trials Group, John Radcliffe Hospital, Oxford, UK
Anaesthesia 61:1031-9. 2006..We conclude that mandated electronic vital signs monitoring in high risk medical and surgical patients has no effect on adverse events or mortality...
- Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shockM C Reade
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
Br J Anaesth 94:468-73. 2005..Haem oxygenase is upregulated by oxidative stress, but little is known about haem oxygenase expression in human sepsis. Haem oxygenase may modulate nitric oxide production, and may also have a direct effect on vascular tone...
- "On the subject of multilevel modelling in vascular surgery"V G Hadjianastassiou
Eur J Vasc Endovasc Surg 34:494. 2007
- New method to evaluate the practice of positive pressure ventilation in intensive care unitsR J Roche
Nuffield Department of Anaesthetics and Intensive Care Unit, Oxford, UK
Br J Anaesth 91:419-20. 2003..Many general intensive care units in the UK are being slow to adopt this approach and we therefore set out to devise a method to audit ventilation and possibly influence practice in these units...
- Of mice and men (and rats): implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsisM C Reade
Br J Anaesth 90:115-8. 2003
- Development and testing of a hierarchical method to code the reason for admission to intensive care units: the ICNARC Coding Method. Intensive Care National Audit & Research CentreJ D Young
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, UK
Br J Anaesth 87:543-8. 2001..1%) in the primary reason for admission. Five conditions account for 19.4% of all primary reasons for admission. This is the first method to be developed empirically for coding the reason for intensive care admission...