Allan H Young

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers
    A H Young
    Department of Neuroscience and Psychiatry, Royal Victoria Informary, University of Newcastle upon Tyne, UK
    Psychopharmacology (Berl) 145:260-6. 1999
  2. ncbi Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    Allan H Young
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 29:1538-45. 2004
  3. ncbi Cortisol in mood disorders
    Allan H Young
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, UK
    Stress 7:205-8. 2004
  4. ncbi Basal activity of the HPA axis and cognitive function in anorexia nervosa
    Julie A Seed
    Division of Psychology, University of Northumbria, New Castle upon Tyne, UK
    Int J Neuropsychopharmacol 5:17-25. 2002
  5. ncbi Tiagabine in the maintenance treatment of bipolar disorders
    A H Young
    Divison of Psychiatry, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK NW1 4LP
    Cochrane Database Syst Rev 3:CD005173. 2006
  6. ncbi Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability
    A H Young
    Royal Victoria Infirmary, Department of Psychiatry, Divison of Psychiatry, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK NW1 4LP
    Cochrane Database Syst Rev 3:CD004694. 2006
  7. ncbi Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients
    Allan H Young
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK
    Am J Psychiatry 159:1237-9. 2002
  8. ncbi Acute tryptophan depletion attenuates auditory event related potentials in bipolar disorder: a preliminary study
    Allan H Young
    Stanley Foundation Research Centre, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Affect Disord 69:83-92. 2002
  9. doi Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Psychiatr Res 42:1037-41. 2008
  10. ncbi Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 57:155-61. 2005

Detail Information

Publications77

  1. ncbi The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers
    A H Young
    Department of Neuroscience and Psychiatry, Royal Victoria Informary, University of Newcastle upon Tyne, UK
    Psychopharmacology (Berl) 145:260-6. 1999
    ..Corticosteroids are elevated in certain neuropsychiatric disorders and this may contribute to the neuropsychological impairments reported in these disorders...
  2. ncbi Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
    Allan H Young
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 29:1538-45. 2004
    ..These data require replication but provide preliminary evidence that glucocorticoid receptor antagonists may have useful cognitive-enhancing and possibly antidepressant properties in bipolar disorder...
  3. ncbi Cortisol in mood disorders
    Allan H Young
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, UK
    Stress 7:205-8. 2004
    ....
  4. ncbi Basal activity of the HPA axis and cognitive function in anorexia nervosa
    Julie A Seed
    Division of Psychology, University of Northumbria, New Castle upon Tyne, UK
    Int J Neuropsychopharmacol 5:17-25. 2002
    ..The limitations of cortisol as an indicator of HPA axis activity are discussed...
  5. ncbi Tiagabine in the maintenance treatment of bipolar disorders
    A H Young
    Divison of Psychiatry, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK NW1 4LP
    Cochrane Database Syst Rev 3:CD005173. 2006
    ..Tiagabine, an anticonvulsant, has been reported to have efficacy in prophylactic treatment of bipolar disorder in case reports and in case series...
  6. ncbi Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability
    A H Young
    Royal Victoria Infirmary, Department of Psychiatry, Divison of Psychiatry, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK NW1 4LP
    Cochrane Database Syst Rev 3:CD004694. 2006
    ..There is a need to clarify the evidence available, in the form of randomised controlled trials, for its use in the treatment of acute affective episodes in bipolar disorder..
  7. ncbi Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients
    Allan H Young
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK
    Am J Psychiatry 159:1237-9. 2002
    ..The authors examined the ratio of cortisol to DHEA in drug-free depressed patients and a matched comparison group...
  8. ncbi Acute tryptophan depletion attenuates auditory event related potentials in bipolar disorder: a preliminary study
    Allan H Young
    Stanley Foundation Research Centre, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Affect Disord 69:83-92. 2002
    ..The EEG may therefore be a sensitive marker of 5-HT function in bipolar disorder. We examined the effects of acute tryptophan depletion (ATD) on EEG activity in bipolar patients...
  9. doi Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Psychiatr Res 42:1037-41. 2008
    ..This may in part underlie the putative therapeutic effects of such drugs...
  10. ncbi Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophrenia
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 57:155-61. 2005
    ..We hypothesized that antiglucocorticoid treatments, particularly glucocorticoid receptor (GR) antagonists, would improve neurocognitive functioning and clinical symptoms in this disorder...
  11. doi Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder
    Gareth O Minton
    Institute of Neuroscience, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    Neuropsychopharmacology 34:2265-74. 2009
    ..This provides a mechanistic explanation for prefrontal dysfunction in bipolar and other affective disorders associated with glucocorticoid dysrhythmia...
  12. ncbi Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:321-6. 2007
    ..The aim of the present study was to investigate BDNF levels in patients with bipolar disorder and schizophrenia before and after treatment with the glucocorticoid receptor antagonist mifepristone...
  13. ncbi Neurocognitive impairment in euthymic patients with bipolar affective disorder
    Jill M Thompson
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 186:32-40. 2005
    ..However, methodological issues such as the effect of residual mood symptoms and hypercortisolaemia may confound such studies...
  14. ncbi Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, UK
    Schizophr Res 90:258-65. 2007
    ..These data suggest that afternoon hypercortisolaemia is evident in symptomatic bipolar and schizophrenic patients compared to controls. However, an elevation in DHEA levels may represent a specific endocrine marker in schizophrenia...
  15. ncbi Impaired working memory monitoring in euthymic bipolar patients
    Jill M Thompson
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Bipolar Disord 9:478-89. 2007
    ..However, the component operations that contribute to this deficit remain unclear. The aim of the present study was to further profile the nature and specificity of WM impairment in euthymic BD...
  16. ncbi The effects of acute tryptophan depletion on neuropsychological function
    John H Hughes
    University of Newcastle upon Tyne, Department of Psychiatry, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 17:300-9. 2003
    ....
  17. ncbi Neuropsychological impairment in bipolar disorder: the relationship with glucocorticoid receptor function
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology, and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Bipolar Disord 8:85-90. 2006
    ..This suggests a potential link between neuropsychological and hypothalamic-pituitary-adrenal axis function. We examined the hypothesis that neuropsychological impairment in bipolar disorder is associated with abnormal GR function...
  18. ncbi Lithium, arginine vasopressin and the dex/CRH test in mood disordered patients
    Stuart Watson
    The Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Psychoneuroendocrinology 32:464-9. 2007
    ..These data demonstrate that patients taking lithium have elevated post-dexamethasone AVP levels compared to both healthy controls and patients not on lithium...
  19. pmc Effects of acute tryptophan depletion on executive function in healthy male volunteers
    Peter Gallagher
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
    BMC Psychiatry 3:10. 2003
    ....
  20. ncbi The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006
    ..9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility...
  21. ncbi Soft neurological signs do not increase with age in euthymic bipolar subjects
    Utpal Goswami
    Department of Psychiatry, West Park Hospital, Darlington, Co Durham, DL2 2TS, UK
    J Affect Disord 103:99-103. 2007
    ..This paper explores changes in SNS with ageing to ascertain whether BD is associated with a progressive neurological decline or a relatively fixed, persistent deficit...
  22. ncbi Executive and visuospatial sketchpad resources in euthymic bipolar disorder: Implications for visuospatial working memory architecture
    Jill M Thompson
    University of Newcastle upon Tyne, UK
    Memory 14:437-51. 2006
    ..ANCOVA indicated that impaired executive function underpinned patients' CBT performance. Implications for the interface between executive and slave systems of working memory are discussed...
  23. ncbi Effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat
    Lindsey Ferrie
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 9:729-35. 2006
    ..These data suggest that decreased dopamine release may mediate the mood stabilizing action of lithium. However, in this paradigm a rebound increase in dopamine release was not found after withdrawal from lithium treatment...
  24. ncbi Neurocognitive function following remission in major depressive disorder: potential objective marker of response?
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Aust N Z J Psychiatry 41:54-61. 2007
    ..Neurocognitive deficits have been widely reported in patients with mood disorders. However, relatively little is known of the short-term trajectory of neurocognitive improvement once treatment has been initiated...
  25. ncbi Temporal stability of the dex/CRH test in patients with rapid-cycling bipolar I disorder: a pilot study
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, U K
    Aust N Z J Psychiatry 39:244-8. 2005
    ..To examine the hypothesis that hypothalamic-pituitary-adrenal (HPA) axis function is a trait abnormality in bipolar disorder...
  26. doi Differential deficit in executive control in euthymic bipolar disorder
    Jill Maria Thompson
    Department of Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Abnorm Psychol 118:146-60. 2009
    ..Persistent cognitive difficulties in euthymic bipolar disorder (EBD) are thus usefully characterized as a generic dysexecutive syndrome...
  27. ncbi Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteers
    Andrea J Hearn
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle, UK
    Psychopharmacology (Berl) 171:458-64. 2004
    ..Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse...
  28. ncbi Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder
    Stuart Watson
    The Stanley Research Centre, University of Newcastle upon Tyne, The Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Psychiatry 184:496-502. 2004
    ....
  29. ncbi Effects of acute tryptophan depletion on cognitive function in euthymic bipolar patients
    John H Hughes
    Stanley Foundation Research Centre, Department of Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Eur Neuropsychopharmacol 12:123-8. 2002
    ..Effects on specific 'executive' functions are less clear, and should be the focus for future research...
  30. ncbi QTc interval measurement and metabolic parameters in psychiatric patients taking typical or atypical antipsychotic drugs: a preliminary study
    Paul Mackin
    School of Neurology, Neurobiology, and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom
    J Clin Psychiatry 66:1386-91. 2005
    ..Abnormalities of glucose homeostasis, which may be more common in individuals with major mood disorders and schizophrenia, also affect the QTc interval...
  31. ncbi Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method
    Peter Gallagher
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Psychopharmacol 20:643-9. 2006
    ..2;R(2) 0.04). It is crucial that future studies are aware of these issues and are cognizant of the effects of the method of collection when examining steroid levels in saliva...
  32. ncbi Hippocampal volume change in depression: late- and early-onset illness compared
    Adrian J Lloyd
    School of Neurology, Neurobiology and Psychiatry, University of Psychiatry, University Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Psychiatry 184:488-95. 2004
    ..Evidence for structural hippocampal change in depression is limited despite reports of neuronal damage due to hypercortisolaemia and vascular pathology...
  33. ncbi A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder
    Lucy J Robinson
    School of Neurology, Neurobiology and Psychiatry Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
    J Affect Disord 93:105-15. 2006
    ..This review aims to combine data from available studies to identify the profile of neuropsychological deficits in euthymic bipolar patients and quantify their magnitude...
  34. ncbi The armamentarium of treatments for bipolar disorder: a review of the literature
    David A Cousins
    Newcastle Magnetic Resonance Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:411-31. 2007
    ..Our results suggest a growing role for atypical antipsychotics in the treatment of bipolar disorder and further data are anticipated...
  35. ncbi Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders
    Stuart Watson
    Department of Psychiatry, Leazes Wing, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle NE1 4LP, UK
    J Psychiatr Res 40:353-9. 2006
    ....
  36. ncbi The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity
    Vikas Kaura
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Eur Neuropsychopharmacol 17:108-15. 2007
    ..This effect on 5-HT neurotransmission may have relevance for mood disorders commonly associated with reproductive hormone events, such as premenstrual dysphoric disorder and postpartum depression...
  37. ncbi Effect of chronic lithium and withdrawal from chronic lithium on presynaptic dopamine function in the rat
    Lindsey Ferrie
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    J Psychopharmacol 19:229-34. 2005
    ....
  38. ncbi Facial expression perception: an objective outcome measure for treatment studies in mood disorders?
    Helen R Venn
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE1 4LP, UK
    Int J Neuropsychopharmacol 9:229-45. 2006
    ..This review suggests that measurement of facial expression perception may prove to be a useful experimental tool for assessing efficacy of antidepressant treatments...
  39. ncbi Tolerability of high-dose venlafaxine in depressed patients
    C Louise Harrison
    School of Neurology, Neurobiology and Psychiatry, Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 18:200-4. 2004
    ..e. up to 600 mg daily). However, increased frequency and severity of reported side-effects in the high-dose group are not associated with increased rates of discontinuation...
  40. ncbi Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: a preliminary report
    I Nicol Ferrier
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Bipolar Disord 6:319-22. 2004
    ..This study, therefore, examined neuropsychological function in healthy first-degree relatives of patients with BD...
  41. pmc Family history, early adversity and the hypothalamic-pituitary-adrenal (HPA) axis: Mediation of the vulnerability to mood disorders
    Stuart Watson
    Stanley Research Centre School of Neurology, Neurobiology and Psychiatry University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropsychiatr Dis Treat 3:647-53. 2007
    ..These data suggest that early adverse life events and genetic susceptibility have dissociable effects on glucocorticoid receptor-mediated negative feedback of the HPA axis in adult patients with severe mood disorders...
  42. ncbi Effect of chronic lithium treatment on D2/3 autoreceptor regulation of dopaminergic function in the rat
    Lindsey J Ferrie
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Pharmacol Biochem Behav 90:218-25. 2008
    ....
  43. ncbi Managing the aftermath of mania - Newcastle, 2 September 2005: Consensus Meeting Statement
    Allan H Young
    University of Newcastle, Newcastle upon Tyne, UK
    J Psychopharmacol 20:51-4. 2006
  44. ncbi Effect of chronic lithium treatment on glucocorticoid and 5-HT1A receptor messenger RNA in hippocampal and dorsal raphe nucleus regions of the rat brain
    Richard McQuade
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle upon Tyne NE2 4HH, UK
    J Psychopharmacol 18:496-501. 2004
    ....
  45. ncbi Culture and assessment of manic symptoms
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 189:379-80. 2006
    ..001) and between India and UK (P<0.001) rater groups. Overall, differences between India and US rater groups were less marked (P=0.28). These differences suggest that cultural biases influence the interpretation of manic symptoms...
  46. ncbi Perception of facial expressions of emotion in bipolar disorder
    Helen R Venn
    Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Bipolar Disord 6:286-93. 2004
    ..We examined whether altered perception of emotion reflects an underlying trait-like effect in affective disorder by examining facial expression perception in euthymic bipolar patients...
  47. doi The role of dopamine in bipolar disorder
    David A Cousins
    Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Bipolar Disord 11:787-806. 2009
    ..This article examines the role of dopamine in bipolar disorder, incorporating recent advances into established models where possible...
  48. ncbi Lithium in maintenance therapy for bipolar disorder
    Allan H Young
    University of Newcastle, Newcastle upon Tyne, UK
    J Psychopharmacol 20:17-22. 2006
    ..It is also associated with an increased liability for new episodes, both manic and depressive, consequent upon stoppage of treatment. These factors limit the clinical effectiveness of lithium...
  49. ncbi Growth in early life and childhood IQ at age 11 years: the Newcastle Thousand Families Study
    Mark S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Int J Epidemiol 34:673-7. 2005
    ..This study aimed at investigating the potential relationships between childhood IQ at age 11 years and birth weight and height at the ages of 9 and 13 years, after adjusting for the confounding factors available to this investigation...
  50. ncbi Developing the BALANCE trail--the role of the pilot study and start-up phase
    Jennifer M Rendell
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Bipolar Disord 6:26-31. 2004
    ..This report describes the adaptations to the initial design and trial procedures following the initial phases of the study. The rationale for the trial and full protocol have been published elsewhere...
  51. doi Sex dependence of brain size and shape in bipolar disorder: an exploratory study
    Clare E Mackay
    Department of Psychiatry, Prince of Wales International Centre for SANE Research POWIC, University of Oxford, Warneford Hospital, Oxford, UK
    Bipolar Disord 12:306-11. 2010
    ..Anomalies of asymmetry and sex differences in brain structure have frequently been described in schizophrenic illnesses but have seldom been explored in bipolar disorder...
  52. ncbi Corticosterone modulation of somatodendritic 5-HT1A receptor function in mice
    Mei See Man
    Psychobiology Research Group, School of Neuroscience and Psychiatry, University of Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 16:245-52. 2002
    ..In addition, the degree of attenuation depends on CORT concentrations at the time of testing. These findings may have implications regarding mechanisms of adaptation to stress...
  53. ncbi A randomized controlled trial of fluvoxamine in prostatodynia, a male somatoform pain disorder
    Douglas Turkington
    Department of Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 63:778-81. 2002
    ..It presents with urogenital pain and urinary symptoms. Failure of conventional treatment and a successful uncontrolled pilot study with fluvoxamine in this condition prompted this study...
  54. ncbi Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression
    Melville M Leitch
    Psychobiology Research Group, Stanley Research Centre, The Medical School, University of Newcastle upon Tyne, UK
    Neuropsychopharmacology 28:119-25. 2003
    ..These findings suggest that resolution of cortisol abnormalities may be a valuable target for pharmacotherapy in the treatment of depression...
  55. ncbi Rapid cycling bipolar disorder: historical overview and focus on emerging treatments
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Bipolar Disord 6:523-9. 2004
    ....
  56. ncbi The pharmacological treatment of bipolar affective disorder: practice is improving but could still be better
    Adrian J Lloyd
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Newcastle upon Tyne, UK
    J Psychopharmacol 17:230-3. 2003
    ..However, it still falls short in a number of respects of such recommendations as exist and this requires further examination and monitoring...
  57. ncbi Evidence for a late onset bipolar-I disorder sub-group from 50 years
    Stephen R J Moorhead
    Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Affect Disord 73:271-7. 2003
    ..We examined the relationship between age of onset and family history in bipolar-I disorder in an attempt to identify subgroups...
  58. ncbi Absence of auditory 'global interference' in autism
    Jessica M Foxton
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Brain 126:2703-9. 2003
    ..This was attributed to the absence of interference from an auditory coherent whole. The results are consistent with the presence of abnormal interactions between local and global auditory perception in ASD...
  59. ncbi Recovery from chronic fatigue syndrome with modafinil
    Douglas Turkington
    Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Hum Psychopharmacol 19:63-4. 2004
  60. ncbi GABA-ergic drugs: exit stage left, enter stage right
    Heather Ashton
    Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Psychopharmacol 17:174-8. 2003
    ..It remains to be seen whether long-term use leads to tolerance, dependence and withdrawal or discontinuation reactions...
  61. ncbi Antiglucocoticoid treatments for depression
    Allan H Young
    Department of Psychiatry, University of British Columbia, Vancoover, BC Canada
    Aust N Z J Psychiatry 40:402-5. 2006
    ..To selectively review the literature germane to antiglucocoticoid treatments for depression...
  62. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  63. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  64. ncbi Neurocognitive impairment in drug-free patients with major depressive disorder
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Br J Psychiatry 182:214-20. 2003
    ..Although neurocognitive impairment has been widely reported in major depressive disorder (MDD), confounding factors, such as the effects of psychotropic medication, have rarely been controlled for...
  65. ncbi Effectiveness of mood stabilizers and antipsychotics in the maintenance phase of bipolar disorder: a systematic review of randomized controlled trials
    Lesley A Smith
    Medical Research Matters, Eynsham, UK
    Bipolar Disord 9:394-412. 2007
    ..Bipolar disorder (BD) is a leading cause of disability. Systematic reviews of randomized trials for the treatment of the maintenance phase of BD are lacking...
  66. ncbi The nature of abnormal language processing in euthymic bipolar I disorder: evidence for a relationship between task demand and prefrontal function
    Vivienne A Curtis
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Bipolar Disord 9:358-69. 2007
    ..We used functional magnetic resonance imaging (fMRI) to investigate the core components of language processing as well as the impact of task demand in a group of bipolar subjects...
  67. ncbi A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada
    Int Clin Psychopharmacol 22:212-20. 2007
    ..Overall, the combination of quetiapine with lithium or divalproex was well tolerated...
  68. ncbi Neuropsychological dysfunction, soft neurological signs and social disability in euthymic patients with bipolar disorder
    Utpal Goswami
    Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
    Br J Psychiatry 188:366-73. 2006
    ..Neurocognitive deficits exist in euthymic patients with bipolar disorder, but relationships between symptoms, psychosocial and neurological factors remain uncertain...
  69. ncbi Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK
    Elaine K Green
    Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK
    Br J Psychiatry 188:21-5. 2006
    ..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...
  70. ncbi The art and science of switching of antipsychotic medications, part 1
    Peter J Weiden
    Department of Psychiatry, Schizophrenia Research Program, State University of New York Downstate Medical Center, Brooklyn, USA
    J Clin Psychiatry 67:e15. 2006
    ....
  71. ncbi International Consensus Group on Bipolar I Depression Treatment Guidelines
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    J Clin Psychiatry 65:571-9. 2004
  72. ncbi Corticosteroid-serotonin interactions in depression: a review of the human evidence
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, Christchurch, New Zealand
    Psychopharmacology (Berl) 173:1-17. 2004
    ..It has been suggested that corticosteroid-serotonin interactions are central to the pathophysiology of depression. These interactions have been investigated in healthy and depressed humans, primarily using neuroendocrine techniques...
  73. ncbi Bipolar patients show mood-congruent biases in sensitivity to facial expressions of emotion when exhibiting depressed symptoms, but not when exhibiting manic symptoms
    John Gray
    St Nicholas Hospital and University of Newcastle upon Tyne, UK
    Cogn Neuropsychiatry 11:505-20. 2006
    ....
  74. ncbi The British Association for Psychopharmacology guidelines for treatment of bipolar disorder: a summary
    Guy M Goodwin
    J Psychopharmacol 17:3-6. 2003
    ..It is timely since awareness of the specific needs of bipolar patients is growing and there is an increased choice of effective treatments for all phases of the illness...
  75. ncbi Elevated prolactin responses to L-tryptophan infusion in medication-free depressed patients
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine, New Zealand
    Psychopharmacology (Berl) 169:77-83. 2003
    ..Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds...
  76. ncbi Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia
    Carmen M Martin-Ruiz
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 54:1222-33. 2003
    ..The etiology of dementia that occurs in patients with schizophrenia is not well understood. Nicotinic acetylcholine receptors have been implicated in cognitive function, and deficits in these receptors have been reported in schizophrenia...
  77. ncbi Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies
    Anke Sambeth
    Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Neurosci Biobehav Rev 31:516-29. 2007
    ..The findings provide further support for a critical role of serotonin in declarative episodic memory...