Stephen J Yeaman

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis
    S J Yeaman
    Centre for Liver Research, School of Biochemistry and Genetics, University of Newcastle, Newcastle upon Tyne, UK
    Immunol Rev 174:238-49. 2000
  2. pmc Hormone-sensitive lipase--new roles for an old enzyme
    Stephen J Yeaman
    School of Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Biochem J 379:11-22. 2004
  3. ncbi request reprint Regulation of glycogen synthesis in human muscle cells
    S J Yeaman
    School of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Biochem Soc Trans 29:537-41. 2001
  4. ncbi request reprint Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?
    Audrey E Brown
    School of Clinical Medical Sciences, Univ of Newcastle Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Am J Physiol Endocrinol Metab 294:E97-102. 2008
  5. ncbi request reprint Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis
    M F Bassendine
    Department of Medicine, Medical School, University of Newcastle, Newcastle upon Tyne, U K
    Semin Liver Dis 17:49-60. 1997
  6. doi request reprint Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008
  7. ncbi request reprint Role of glycogen content in insulin resistance in human muscle cells
    Gary J Litherland
    Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 211:344-52. 2007
  8. ncbi request reprint Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 30:65-70. 1999
  9. ncbi request reprint Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy
    D E Jones
    Centre for Liver Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Liver 20:351-6. 2000
  10. ncbi request reprint Regulation of glycogen synthesis by amino acids in cultured human muscle cells
    J L Armstrong
    School of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 276:952-6. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis
    S J Yeaman
    Centre for Liver Research, School of Biochemistry and Genetics, University of Newcastle, Newcastle upon Tyne, UK
    Immunol Rev 174:238-49. 2000
    ....
  2. pmc Hormone-sensitive lipase--new roles for an old enzyme
    Stephen J Yeaman
    School of Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Biochem J 379:11-22. 2004
    ..Altered expression of HSL in different cell types may be associated with a number of pathological states, including obesity, atherosclerosis and Type II diabetes...
  3. ncbi request reprint Regulation of glycogen synthesis in human muscle cells
    S J Yeaman
    School of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Biochem Soc Trans 29:537-41. 2001
    ..Evidence suggests that glucose and the glycogen content of the muscle have a key role in this stimulation but the molecular mechanism has yet to be fully explained...
  4. ncbi request reprint Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?
    Audrey E Brown
    School of Clinical Medical Sciences, Univ of Newcastle Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Am J Physiol Endocrinol Metab 294:E97-102. 2008
    ..In conclusion, under conditions of impaired mitochondrial respiration there was no evidence of impaired insulin signaling or glucose uptake following insulin exposure in this model system...
  5. ncbi request reprint Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis
    M F Bassendine
    Department of Medicine, Medical School, University of Newcastle, Newcastle upon Tyne, U K
    Semin Liver Dis 17:49-60. 1997
    ..The apparent importance of autoreactive responses to these self-antigens does, however, raise the possibility that antigen-specific immunotherapy may offer a novel route to therapy in PBC...
  6. doi request reprint Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008
    ..These observations suggest a clear mechanism for the generation of an auto-immunogenic neo-antigen of relevance for the pathogenesis of primary biliary cirrhosis...
  7. ncbi request reprint Role of glycogen content in insulin resistance in human muscle cells
    Gary J Litherland
    Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 211:344-52. 2007
    ..Our data suggest that diminished insulin signaling alone is insufficient to impair glucose disposal, and indicate a role for glycogen accumulation in inducing insulin resistance in human muscle cells...
  8. ncbi request reprint Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 30:65-70. 1999
    ..Conclusions drawn from these data may have important implications for our understanding, and therapeutic manipulation, of PBC in humans...
  9. ncbi request reprint Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy
    D E Jones
    Centre for Liver Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Liver 20:351-6. 2000
    ....
  10. ncbi request reprint Regulation of glycogen synthesis by amino acids in cultured human muscle cells
    J L Armstrong
    School of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 276:952-6. 2001
    ..Furthermore, it demonstrates that glycogen synthase kinase 3 can be inactivated within cells independent of activation of protein kinase B and p90(rsk)...
  11. ncbi request reprint Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells
    Audrey E Brown
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Mol Genet Metab 91:318-24. 2007
    ..Suppression of calpain-10 expression did not affect insulin-stimulated glycogen synthesis nor insulin-signalling via PKB, suggesting that calpain-10 may exert a direct regulatory effect upon the glucose uptake mechanism...
  12. ncbi request reprint Control of glycogen synthesis by glucose, glycogen, and insulin in cultured human muscle cells
    R Halse
    School of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Diabetes 50:720-6. 2001
    ....
  13. ncbi request reprint Calpain inhibition and insulin action in cultured human muscle cells
    L J Logie
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Mol Genet Metab 85:54-60. 2005
    ....
  14. ncbi request reprint Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex
    David E J Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, United Kingdom
    Lab Invest 82:211-9. 2002
    ..This model may provide a useful system for investigating the etiology and treatment of PBC...
  15. ncbi request reprint Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase
    Reza Halse
    School of Biochemistry and Genetics, Medical School, University of Newcastle, Newcastle upon Tyne, U K
    Diabetes 52:9-15. 2003
    ..These data support a role for AMPK in both stimulating glucose uptake and inhibiting GS in intact cells, thus promoting glucose flux through glycolysis...
  16. ncbi request reprint Cultured muscle cells from insulin-resistant type 2 diabetes patients have impaired insulin, but normal 5-amino-4-imidazolecarboxamide riboside-stimulated, glucose uptake
    E A McIntyre
    School of Clinical Medical Sciences, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Clin Endocrinol Metab 89:3440-8. 2004
    ..This supports an intrinsic abnormality of the diabetic muscle cells that is most likely to have a genetic basis...
  17. ncbi request reprint Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells
    Emily L Abbot
    Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, UK
    FEBS J 272:3004-14. 2005
    ..In addition, PPARs appear to independently regulate specific PDK isoform transcipt levels, which are likely to impart important metabolic mediation of fuel utilization by the muscle...
  18. ncbi request reprint Key role for ceramides in mediating insulin resistance in human muscle cells
    Laura Pickersgill
    Institute of Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 282:12583-9. 2007
    ..Furthermore, the triacylglycerol derived from oleate was able to exert a protective role in sequestering palmitate, thus preventing its conversion to ceramide...
  19. ncbi request reprint Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin
    Lisa O'Rourke
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 277:42557-62. 2002
    ....