Genomes and Genes
Affiliation: University of Cambridge
- Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studiesZheng Ye
Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Cambridge, United Kingdom
PLoS Med 3:e91. 2006..It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but a large number of studies have reported apparently conflicting results...
- Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studiesZheng Ye
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Eur J Cardiovasc Prev Rehabil 15:26-34. 2008..We undertook a meta-analysis of cohort studies to examine the relations between antioxidant vitamins (vitamins C, E, and beta-carotene) and CHD risk...
- Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary riskAlexander Thompson
Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, England CB1 8RN
JAMA 299:2777-88. 2008..The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary disease is uncertain. Study of CETP genotypes can help better understand the relevance of this pathway to lipid metabolism and disease risk...
- Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysisZheng Ye
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
Eur J Cancer 41:980-9. 2005..It is conceivable that GSTM1 and GSTT1 null genotypes may thus play a role in leukemogenesis. A review of the 30 case-control studies indicates that greater attention should be paid to the design of future studies...
- Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controlsZheng Ye
Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
Lancet 367:651-8. 2006..We did meta-analyses on seven such haemostatic genetic variants for which the available evidence on each comprises at least 5000 coronary disease cases and at least 5000 controls...
- Association of apolipoprotein E genotypes with lipid levels and coronary riskAnna M Bennet
Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
JAMA 298:1300-11. 2007..Previous reviews of associations of apolipoprotein E (apoE) genotype and coronary disease have been dominated by smaller studies that are liable to biases...
- Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation studyZheng Ye
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
Lancet Diabetes Endocrinol 3:35-42. 2015..We aimed to estimate the unconfounded, causal association between 25(OH)D concentration and risk of type 2 diabetes using a mendelian randomisation approach...
- Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fractionFumiaki Imamura
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
BMJ 351:h3576. 2015....
- The association between circulating lipoprotein(a) and type 2 diabetes: is it causal?Zheng Ye
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U K
Diabetes 63:332-42. 2014..However, a genetic variant that elevated Lp(a) levels was not associated with risk of T2D, suggesting that elevated Lp(a) levels are not causally associated with a lower risk of T2D. ..
- Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart diseaseMing Qing Xu
Bio X Life Science Research Centre, Shanghai Jiao Tong University, Shanghai, China
Circulation 116:1356-66. 2007..Many studies have examined the association between polymorphisms in the angiotensinogen gene and risk of coronary heart disease (CHD), but the results have been inconsistent...
- A meta-analysis of 20 case-control studies of the glutathione S-transferase M1 (GSTM1) status and colorectal cancer riskZheng Ye
Data Mining Group, Department of Computing, Imperial College London, UK
Med Sci Monit 9:SR83-91. 2003..To re-examine this controversy, we have undertaken a meta-analysis investigating the relationship of GSTM1 status and colon cancer risk...
- Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancerZheng Ye
Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, United Kingdom
Teratog Carcinog Mutagen 22:385-92. 2002..distal). This study suggests that the polymorphisms of CYP1A1 MspI, GSTM1, and GSTT1 are not associated with a significant risk of developing colon cancer in a United Kingdom population...
- The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysisZheng Ye
Bioinformatics Group, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
Mutagenesis 17:119-26. 2002..The OR for age at menarche (> or = 13) was 0.87 (95% CI 0.62-1.17). Our results suggest that CYP17 MspA1 polymorphism may be at best a weak modifier of breast cancer risk but is not a significant independent risk factor...
- Identification of polymorphisms in the human Reprimo gene using public EST dataZheng Ye
Center for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, United Kingdom
Teratog Carcinog Mutagen 22:485-93. 2002..4%) is much higher than rare allele frequency at position 839 (3.7%). Our results suggest that the human EST data may serve as a valuable source for the rapid identification of genetic variation...
- Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer riskZheng Ye
Bioinformatics Group, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, UK
Med Sci Monit 8:CR558-65. 2002..To clarify the influence of NAT2 rapid acetylation status on colon cancer risk, we have performed a meta-analysis of 20 published case-control studies (4431 cases, 4547 controls)...