S Ye

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89
    S Ye
    Department of Cardiovascular Medicine, University of Oxford, UK
    FEBS Lett 450:268-72. 1999
  2. pmc Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis
    S Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Heart 89:1195-9. 2003
  3. ncbi request reprint Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study
    Shu Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton SO16 6YD, UK
    Eur J Hum Genet 11:437-43. 2003
  4. pmc An efficient procedure for genotyping single nucleotide polymorphisms
    S Ye
    Human Genetics Research Division, University of Southampton, Duthie Building Mp808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Nucleic Acids Res 29:E88-8. 2001
  5. ncbi request reprint Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome
    Shu Ye
    Human Genetics Division, School of Medicine, University of Southampton, UK
    Cardiovasc Res 69:636-45. 2006
  6. ncbi request reprint Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism
    S Ye
    Human Genetics Research Division, University of Southampton School of Medicine, United Kingdom
    Cancer Res 61:1296-8. 2001
  7. ncbi request reprint Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases
    S Ye
    Human Genetics Research Division, School of Medicine, University of Southampton, UK
    Matrix Biol 19:623-9. 2000
  8. ncbi request reprint Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis
    S Ye
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Immunogenet 34:81-5. 2007
  9. ncbi request reprint Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage
    B Zhang
    Human Genetics Research Division, Clinical Neurosciences Research Division, University of Southampton, School of Medicine, UK
    Stroke 32:2198-202. 2001
  10. ncbi request reprint Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population
    I Sayers
    Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, UK
    Clin Exp Allergy 33:1103-10. 2003

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89
    S Ye
    Department of Cardiovascular Medicine, University of Oxford, UK
    FEBS Lett 450:268-72. 1999
    ..As ZBP-89 expression is known to be increased in gastric carcinoma cells, induction of stromelysin expression may be a significant factor in tumour metastasis...
  2. pmc Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis
    S Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Heart 89:1195-9. 2003
    ..To test the hypothesis that gene-gene interaction of the renin-angiotensin system is associated with an effect on the extent of coronary atherosclerosis...
  3. ncbi request reprint Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study
    Shu Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton SO16 6YD, UK
    Eur J Hum Genet 11:437-43. 2003
    ....
  4. pmc An efficient procedure for genotyping single nucleotide polymorphisms
    S Ye
    Human Genetics Research Division, University of Southampton, Duthie Building Mp808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Nucleic Acids Res 29:E88-8. 2001
    ..The technique was applied to analyse a number of SNPs and the results were completely consistent with those from an independent method, restriction fragment length polymorphism analysis...
  5. ncbi request reprint Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome
    Shu Ye
    Human Genetics Division, School of Medicine, University of Southampton, UK
    Cardiovasc Res 69:636-45. 2006
    ..There is also some evidence suggesting that MMP genotyping could aid in identifying patients who are likely to have unfavourable prognosis and/or adverse response to treatment...
  6. ncbi request reprint Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism
    S Ye
    Human Genetics Research Division, University of Southampton School of Medicine, United Kingdom
    Cancer Res 61:1296-8. 2001
    ..0333; odds ratio = 2.51)]. These data suggest that the invasiveness of cutaneous malignant melanoma is influenced by variation in the MMP-1 gene promoter that affects MMP-1 expression...
  7. ncbi request reprint Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases
    S Ye
    Human Genetics Research Division, School of Medicine, University of Southampton, UK
    Matrix Biol 19:623-9. 2000
    ....
  8. ncbi request reprint Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis
    S Ye
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Immunogenet 34:81-5. 2007
    ..These results suggest that MMP3, MMP7, MMP12 and MMP13 genotypes may play a role in determining functional status of rheumatoid arthritis...
  9. ncbi request reprint Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage
    B Zhang
    Human Genetics Research Division, Clinical Neurosciences Research Division, University of Southampton, School of Medicine, UK
    Stroke 32:2198-202. 2001
    ..The possible impact of MMP gene polymorphisms on susceptibility to intracranial aneurysms is still controversial, with conflicting data from different reported studies...
  10. ncbi request reprint Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population
    I Sayers
    Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, UK
    Clin Exp Allergy 33:1103-10. 2003
    ..5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma...
  11. pmc VEGF polymorphisms and severity of atherosclerosis
    W M Howell
    Division of Laboratory Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    J Med Genet 42:485-90. 2005
    ..In the present study we have sought to clarify this by determining genotypes and haplotypes for three reportedly functional VEGF SNPs in a large series of well documented coronary atherosclerosis patients...
  12. pmc Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits
    M R Abdollahi
    Human Genetics Division, Duthie Building, Southampton General Hospital, Tremona Rd, Southampton, SO16 6YD, UK
    J Med Genet 42:396-401. 2005
    ..Angiotensin II type I receptor (AGTR1) A1166C has previously been associated with the development of hypertension and coronary disease, but its metabolic effects have not been investigated...
  13. ncbi request reprint A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort
    B Zhang
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, U K
    Biochem Soc Trans 31:444-6. 2003
    ..Implications for tissue and population prevalence are discussed. The mitochondrial long-PCR DNA banks established will be useful for a wide range of studies of somatic mutation and of germline haplotypes in relation to aging...
  14. ncbi request reprint Genetic variation at the matrix metalloproteinase-9 locus on chromosome 20q12.2-13.1
    B Zhang
    Department of Cardiovascular Medicine, University of Oxford, UK
    Hum Genet 105:418-23. 1999
    ..The results also provide experimental data on the extent of linkage disequilibrium in the general population, which is yet to be resolved...
  15. ncbi request reprint PIRA PCR designer for restriction analysis of single nucleotide polymorphisms
    X Ke
    Division of Human Genetics, University of Southampton, Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK
    Bioinformatics 17:838-9. 2001
    ..We describe in this report a www-based computer program that screens for the suitable mismatches, designs the primers, lists the appropriate restriction enzymes and other related information...
  16. pmc Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma
    I Sayers
    Human Genetics Research Division, University of Southampton, Southampton SO16 6YD, UK
    Thorax 58:417-24. 2003
    ..We have identified a novel promoter polymorphism at position -1072 (G/A) and a -444 (A/C) polymorphism has previously been reported. The role of these polymorphisms in the genetic susceptibility to asthma was examined...
  17. ncbi request reprint Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene
    I Sayers
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Eur J Hum Genet 11:619-22. 2003
    ..These findings have potential implications in the evaluation of combined corticosteroid and antileukotriene therapy in asthma...
  18. ncbi request reprint Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis
    R Laxton
    Human Genetics Division, School of Medicine, University of Southampton, Southampton, UK
    Genes Immun 6:539-41. 2005
    ....
  19. ncbi request reprint Microarray analysis of nicotine-induced changes in gene expression in endothelial cells
    S Zhang
    Human Genetics Research Division, School of Medicine, University of Southampton, Southampton, SO16 6YD, United Kingdom
    Physiol Genomics 5:187-92. 2001
    ..The data from this study are relevant to understanding the mechanisms underlying the pathophysiological effect of nicotine and smoking, particularly on endothelial function and pathogenesis of atherosclerosis...
  20. ncbi request reprint Haplotypic analysis of the MMP-9 gene in relation to coronary artery disease
    Angharad R Morgan
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    J Mol Med (Berl) 81:321-6. 2003
    ....
  21. ncbi request reprint Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction
    John W Holloway
    Human Genetics Division, School of Medicine, University of Southampton, Southampton, UK
    Pharmacogenet Genomics 15:15-21. 2005
    ....
  22. ncbi request reprint Haplotype effect of the matrix metalloproteinase-1 gene on risk of myocardial infarction
    Eve Pearce
    Human Genetics Division, School of Medicine, University of Southampton, United Kingdom
    Circ Res 97:1070-6. 2005
    ..Haplotype-specific differences in MMP1 mRNA level in atherosclerotic tissues were also detected. The data indicate that MMP1 gene variation is a genetic factor contributing to interindividual differences in MI risk...
  23. ncbi request reprint CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents
    Shuwen Huang
    Human Genetics Division, Duthie Building, Southampton General Hospital, UK
    Pharmacogenet Genomics 15:839-50. 2005
    ..Other genes are also implicated in smoking behaviour. We explored smoking behaviour and cotinine levels in relation to genotypes in adolescents...
  24. ncbi request reprint Haplotype effects on matrix metalloproteinase-1 gene promoter activity in cancer cells
    Eve G Pearce
    William Harvey Research Institute, Barts and the London School of Medicine, London EC1M 6BQ, UK
    Mol Cancer Res 5:221-7. 2007
    ....
  25. doi request reprint Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study
    Shu Ye
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine, London, United Kingdom
    J Am Coll Cardiol 52:378-84. 2008
    ....
  26. ncbi request reprint Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease
    Per Eriksson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 24:551-7. 2004
    ....
  27. ncbi request reprint TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis
    Ian A Yang
    Human Genetics Division Mailpoint 808, University of Southampton School of Medicine, Tremona Road, Southampton SO16 6YD, UK
    Atherosclerosis 170:187-90. 2003
    ..We analyzed this polymorphism in relation to susceptibility to and severity of coronary artery disease...
  28. ncbi request reprint Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease
    Shu Ye
    Human Genetics Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Eur Heart J 24:1668-71. 2003
    ..In addition, we examined a polymorphism in the human MMP-3 gene that was previously reported to be associated with progression of coronary atherosclerosis...
  29. ncbi request reprint Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction
    Seyyare Beyzade
    Human Genetics Division, Southampton University Medical School, Southampton, United Kingdom
    J Am Coll Cardiol 41:2130-7. 2003
    ..The aim of this study was to assess matrix metalloproteinase-3 (MMP3) gene variation in relation to the degree of coronary atherosclerosis and risk of myocardial infarction (MI) in patients with coronary artery disease...
  30. pmc Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease
    S L F Pender
    J Med Genet 41:e112. 2004
  31. ncbi request reprint Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis
    Theodosios Kyriakou
    Human Genetics Division, School of Medicine, University of Southampton, Southampton, UK
    Arterioscler Thromb Vasc Biol 25:418-23. 2005
    ..This study was performed to test the reported association between the -565C>T polymorphism and atherosclerosis severity and to investigate whether this variant per se had an effect on promoter activity of the ABCA1 gene...
  32. ncbi request reprint Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster
    Ian N M Day
    Human Genetics Division, Duthie Building Mp808, Tremona Road, School of Medicine, Southampton University Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 89:5569-76. 2004
    ..GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome...
  33. ncbi request reprint Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages
    Conrad P Hodgkinson
    Human Genetics Division, University of Southampton School of Medicine, Southampton, United Kingdom
    Biochem Biophys Res Commun 308:505-10. 2003
    ..These findings are relevant to understanding the effect of PPARgamma activation on gene expression and cognate pathways in macrophages...
  34. ncbi request reprint Functional Toll-like receptor 4 mutations modulate the response to fibrinogen
    Conrad P Hodgkinson
    Clinical Pharmacology, William Harvey Research Institute, John Vane Science Centre, Charterhouse Square, London, UK
    Thromb Haemost 100:301-7. 2008
    ..This study indicates that fibrinogen activates TLR4, explaining how fibrinogen promotes inflammatory protein expression...
  35. pmc Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis
    Julie Decock
    Laboratory for Experimental Oncology LEO, K, U, Leuven, Campus University Hospital Gasthuisberg, O and N1 bus 815, Herestraat 49, 3000 Leuven, Belgium
    BMC Cancer 8:77. 2008
    ..Elevated levels of matrix metalloproteinases have been found to associate with poor prognosis in various carcinomas. This study aimed at evaluating plasma levels of MMP1, MMP8 and MMP13 as diagnostic and prognostic markers of breast cancer...
  36. ncbi request reprint Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis
    Julie Decock
    Laboratory for Experimental Oncology, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Cancer Res 67:10214-21. 2007
    ..The data suggest that MMP8 gene variation may influence breast cancer prognosis and support the notion that MMP8 has an inhibitory effect on cancer metastasis...
  37. ncbi request reprint Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients
    Theodosios Kyriakou
    Human Genetics Division, School of Medicine, University of Southampton, UK
    Hum Mol Genet 16:1412-22. 2007
    ..A trend towards higher symptom onset age in 825I allele carriers was observed. The data indicate an influence of common ABCA1 functional polymorphisms on age of symptom onset in CAD patients...
  38. ncbi request reprint Evolutionary path to the heart
    Shu Ye
    Eur J Hum Genet 13:132-3. 2005
  39. ncbi request reprint PCR designer for restriction analysis of various types of sequence mutation
    Xiayi Ke
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Bioinformatics 18:1688-9. 2002
    ..The program, supported by a WWW web interface, is intended to be used online...
  40. ncbi request reprint Insulin-like growth factor-I genotype and birthweight
    Ian N M Day
    Lancet 360:945; author reply 945-6. 2002
  41. pmc Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population
    Khalid K Alharbi
    Human Genetics Division, School of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, United Kingdom
    Genome Res 15:967-77. 2005
    ..In contrast with case collections, CpG mutations predominated. MeltMADGE will enable definition of the full population spectrum of rare, paucimorphic, severe, moderate (forme fruste), and silent mutations and effects...
  42. doi request reprint Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression
    Conrad P Hodgkinson
    Centre of Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
    Pharmacogenet Genomics 18:803-13. 2008
    ..We investigated possible mechanisms underlying this synergy of statin treatment and TLR4 genotype...