J L W Yau

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Continuous blockade of brain mineralocorticoid receptors impairs spatial learning in rats
    J L Yau
    Molecular Endocrinology Laboratory, Molecular Medicine Centre, Western General Hospital, Edinburgh, Scotland, UK
    Neurosci Lett 277:45-8. 1999
  2. pmc 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments
    Megan C Holmes
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 30:6916-20. 2010
  3. pmc Local amplification of glucocorticoids in the aging brain and impaired spatial memory
    Joyce L W Yau
    Centre for Cognitive Ageing and Cognitive Epidemiology and Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh Edinburgh, UK
    Front Aging Neurosci 4:24. 2012
  4. pmc 11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control
    Joyce L W Yau
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 31:4188-93. 2011
  5. ncbi request reprint Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice
    Joyce L W Yau
    Endocrinology Unit, Molecular University of Edinburgh, Queen s Medical Research Institute, EH16 4TJ Edinburgh, United Kingdom
    J Neurosci 27:10487-96. 2007
  6. ncbi request reprint Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats
    Joyce L W Yau
    Endocrinology Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 26:11034-40. 2006
  7. ncbi request reprint Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine
    Joyce L W Yau
    Endocrinology Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Brain Res Mol Brain Res 129:189-92. 2004
  8. ncbi request reprint Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
    J L W Yau
    Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neuroscience 121:307-14. 2003
  9. ncbi request reprint Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus
    J L Yau
    Molecular Endocrinology Laboratory, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neurosci Lett 309:141-4. 2001
  10. ncbi request reprint The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats
    Joyce L W Yau
    Centre for the Study of the Ageing Brain, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Brain Res Mol Brain Res 106:117-23. 2002

Detail Information

Publications17

  1. ncbi request reprint Continuous blockade of brain mineralocorticoid receptors impairs spatial learning in rats
    J L Yau
    Molecular Endocrinology Laboratory, Molecular Medicine Centre, Western General Hospital, Edinburgh, Scotland, UK
    Neurosci Lett 277:45-8. 1999
    ..Morning plasma corticosterone levels and adrenal and thymic weights were unchanged. Chronic central MR antagonism impairs spatial memory in the watermaze independent of changes in receptors or circulating glucocorticoid levels...
  2. pmc 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments
    Megan C Holmes
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 30:6916-20. 2010
    ..Thus, excess 11beta-HSD1 in forebrain is a cause of as well as a therapeutic target in memory impairments with aging...
  3. pmc Local amplification of glucocorticoids in the aging brain and impaired spatial memory
    Joyce L W Yau
    Centre for Cognitive Ageing and Cognitive Epidemiology and Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh Edinburgh, UK
    Front Aging Neurosci 4:24. 2012
    ....
  4. pmc 11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control
    Joyce L W Yau
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 31:4188-93. 2011
    ....
  5. ncbi request reprint Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice
    Joyce L W Yau
    Endocrinology Unit, Molecular University of Edinburgh, Queen s Medical Research Institute, EH16 4TJ Edinburgh, United Kingdom
    J Neurosci 27:10487-96. 2007
    ..These data suggest that 11beta-HSD1 deficiency enhances synaptic potentiation in the aged hippocampus and this may underlie the better maintenance of learning and memory with aging, which occurs in the absence of increased neurogenesis...
  6. ncbi request reprint Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats
    Joyce L W Yau
    Endocrinology Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Neurosci 26:11034-40. 2006
    ....
  7. ncbi request reprint Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine
    Joyce L W Yau
    Endocrinology Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Brain Res Mol Brain Res 129:189-92. 2004
    ..Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions...
  8. ncbi request reprint Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
    J L W Yau
    Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neuroscience 121:307-14. 2003
    ..05) in dentate neurons from AD subjects compared with controls. A decline in CYP7B activity may contribute the loss of effects of DHEA with ageing and perhaps to the pathophysiology of AD...
  9. ncbi request reprint Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus
    J L Yau
    Molecular Endocrinology Laboratory, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neurosci Lett 309:141-4. 2001
    ..These data suggest that acute but not chronic stress regulates 5-HT7 receptor mRNA expression in a manner that is likely to be independent of its glucocorticoid actions...
  10. ncbi request reprint The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats
    Joyce L W Yau
    Centre for the Study of the Ageing Brain, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Brain Res Mol Brain Res 106:117-23. 2002
    ..It appears that increased hippocampal MR (at least in the CA2 region) which may underlie the enhancement in memory processing in young rats, is insufficient to improve memory in already cognitively impaired aged rats...
  11. ncbi request reprint Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats
    Joyce L W Yau
    Centre for the Study of the Ageing Brain, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Neurosci 22:1436-42. 2002
    ..These data suggest that long-term treatment with amitriptyline decreases the prevalence of cognitive impairment in aged rats and that this may, in part, be a consequence of reduced plasma corticosterone levels and reduced anxiety...
  12. pmc Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments
    J L Yau
    Center for the Study of the Aging Brain, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 98:4716-21. 2001
    ..The data emphasize the crucial importance of local enzymes in determining intracellular glucocorticoid activity. Selective 11beta-HSD-1 inhibitors may protect against hippocampal function decline with age...
  13. ncbi request reprint Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture
    M Lai
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Neuroscience 118:975-84. 2003
    ..Thusly, manipulation of neurotransmitter or antidepressant levels in the brain may aid in reversing hypothalamic-pituitary-adrenal axis hyperactivity by restoring hippocampal corticosteroid receptor balance...
  14. pmc Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice
    Karen Sooy
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Neurosci 30:13867-72. 2010
    ..These data support the use of selective 11β-HSD1 inhibitors in the treatment of age-related cognitive impairments...
  15. ncbi request reprint The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice
    Joyce L W Yau
    Endocrinology Unit, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Neuropsychopharmacology 32:2520-9. 2007
    ..These data support the notion that the MDR PGP is one of the molecular targets through which antidepressants regulate the HPA axis...
  16. ncbi request reprint 11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles
    Megan C Holmes
    Molecular Endocrinology, Molecular Medicine Centre, College of Medicine and Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Ann N Y Acad Sci 1007:357-66. 2003
    ..This review highlights the important and very different roles the two enzymes play in the brain, outlining recent results obtained from studying mice with a targeted gene deletion in the 11beta-HSD1 or 11beta-HSD2 genes...
  17. pmc 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics
    Thekkepat C Sandeep
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 101:6734-9. 2004
    ..11beta-HSD1 inhibition may be a new approach to prevent/ameliorate cognitive decline...