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Species | P YaqoobSummaryAffiliation: University of Reading Country: UK Publications
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Publications
The nutritional and clinical significance of lipid raftsParveen Yaqoob
Department of Food and Nutritional Sciences, University of Reading, Reading, UK
Curr Opin Clin Nutr Metab Care 13:156-66. 2010..This review examines the potential for dietary modification of raft structure and function in the immune system, brain and retinal tissue, the gut, and in cancer cells...
Fatty acids and the immune system: from basic science to clinical applicationsParveen Yaqoob
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, PO Box 226, Reading RG6 6AP, UK
Proc Nutr Soc 63:89-104. 2004..Studies are just beginning to show that dietary n-3 PUFA can be incorporated into plaque lipid in human subjects, where they may influence the morphology and stability of the atherosclerotic lesion...- Monounsaturated fatty acids in parenteral nutrition; evaluation of risks and benefitsParveen Yaqoob
The Hugh Sinclair Unit of Human Nutrition School of Food Biosciences University of Reading Whiteknights PO Box 226 Reading RG6 6AP United Kingdom
Br J Nutr 94:867-8. 2005 - Fatty acids as gatekeepers of immune cell regulationParveen Yaqoob
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights PO Box 226, RG6 6AP, Reading, UK
Trends Immunol 24:639-45. 2003..This Review examines the nature and regulation of cellular lipid pools in the immune system, their delivery of fatty acids or fatty acid derivatives to specific locations and their potential role in health and disease... - N-3 polyunsaturated fatty acids and inflammation in the arterial wallP Yaqoob
School of Food Biosciences, The University of Reading, Reading, UK
Eur J Med Res 8:337-54. 2003..This review critically evaluates the evidence for the anti-inflammatory effects of the n-3 PUFA in cells and on pathways which have a direct influence on atherogenesis in the arterial wall... - The nutritional significance of lipid raftsParveen Yaqoob
School of Chemistry, Food Biosciences and Pharmacy, The University of Reading, Reading, United Kingdom
Annu Rev Nutr 29:257-82. 2009..The roles of lipid rafts in cancer, in microbial pathogenesis, and in insulin resistance are only just emerging, but compelling evidence indicates the growing importance of membrane microdomains in health and disease... - Lipids and the immune response: from molecular mechanisms to clinical applicationsParveen Yaqoob
Hung Sinclair Unit of Human Nutrition, School of Fodd Biosciences, The University of Reading, Reading, UK
Curr Opin Clin Nutr Metab Care 6:133-50. 2003..The newly emerging area of diet-genotype interactions will also be discussed, with specific reference to the anti-inflammatory effects of fish oil... - Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged menSabine Tricon
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences and the School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
Am J Clin Nutr 83:744-53. 2006..However, feeding regimens that enhance the CLA content of milk also increase concentrations of trans-18:1 fatty acids. The implications for human health are not yet known... - Mechanisms underlying the immunomodulatory effects of n-3 PUFAParveen Yaqoob
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, and Institute of Cardiovascular and Metabolic Research, The University of Reading, Reading RG6 6AP, UK
Proc Nutr Soc 69:311-5. 2010..The enrichment of cell membranes with n-3 PUFA also modulates the production of eicosanoids, the full extent of which has not yet been realized; this represents a key area for future research... - Fatty acids and immune function: new insights into mechanismsParveen Yaqoob
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading RG6 6AP, United Kingdom
Br J Nutr 98:S41-5. 2007..These studies indicate the existence of several novel mechanisms by which altered fatty acid availability can modulate immune responses and impact upon clinical outcomes... - Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humansSabine Tricon
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
Am J Clin Nutr 80:614-20. 2004.... - Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjectsRichard Buckley
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, UK
Br J Nutr 92:477-83. 2004..000 and docosapentaenoic acid P=0.002, but not DHA P=0.193, were evident following EPA supplementation (P<0.05). Our present results indicate that DHA may be more efficacious than EPA in improving the plasma lipid profile... - Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humansSabine Tricon
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, United Kingdom
Am J Clin Nutr 80:1626-33. 2004.... - Chemical, physical, and sensory properties of dairy products enriched with conjugated linoleic acidE L Jones
School of Food Biosciences, The University of Reading, Reading RG6 6AP, UK
J Dairy Sci 88:2923-37. 2005..In conclusion, it is feasible to produce CLA-enriched dairy products with acceptable storage and sensory characteristics... - Conjugated linoleic acid and human health: a critical evaluation of the evidenceSabine Tricon
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, UK
Curr Opin Clin Nutr Metab Care 9:105-10. 2006..There appears to be little effect of conjugated linoleic acid on immune function and the effects on insulin sensitivity remain unclear... 
Selective effects of Lactobacillus casei Shirota on T cell activation, natural killer cell activity and cytokine productionH Dong
Department of Food and Nutritional Sciences, University of Reading, Reading, UK
Clin Exp Immunol 161:378-88. 2010..LcS also induced both proinflammatory and anti-inflammatory cytokine production in the absence of LPS, but in some cases inhibited LPS-induced cytokine production. Monocytes play an important role in LcS-induced immunological responses...- Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoproteinMaria Dolores Mesa
The Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Whiteknights, P.O. Box 226, Reading RG6 6AP, UK
Atherosclerosis 175:333-43. 2004..DHA does not appear to increase the susceptibility of LDL to oxidation to the same degree as EPA and has a tendency to decrease LDL-supported thrombin generation... - Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humansSamantha Kew
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, United Kingdom
Am J Clin Nutr 79:674-81. 2004..EPA alone does not, therefore, influence CD69 expression. No other marker of immune function assessed in this study was significantly affected by either EPA or DHA... - Cholesterol reduction using manufactured foods high in monounsaturated fatty acids: a randomized crossover studyC M Williams
Hugh Sinclair Unit of Human Nutrition, Department of Food Science and Technology, University of Reading, UK
Br J Nutr 81:439-46. 1999..The dietary approach used to alter fatty acid intakes would be appropriate for achieving reductions in saturated fat intakes in whole populations... - Impact of saturated, polyunsaturated and monounsaturated fatty acid-rich micelles on lipoprotein synthesis and secretion in Caco-2 cellsKim G Jackson
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG6 6AP, UK
Lipids 44:1081-9. 2009..Our electron micrographs are suggestive that some endocytotic uptake of MUFA-rich taurocholate micelles may promote greater lipoprotein synthesis and secretion in Caco-2 cells... - Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteersJelena Vulevic
Department of Food Biosciences, The University of Reading, Reading, United Kingdom
Am J Clin Nutr 88:1438-46. 2008..Galactooligosaccharides (GOSs) stimulate the growth of bifidobacteria in younger adults, but little is known about their effects in the elderly and their immunomodulatory capacity... - Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acidsKim G Jackson
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, Berkshire RG6 6AP, UK
Nutr Metab Cardiovasc Dis 16:405-17. 2006..We examined the effect of meal fatty acids on lipid and apolipoprotein concentrations of very low density lipoprotein (VLDL) and chylomicron/chylomicron remnants in lipid fractions with a Svedberg flotation rate (Sf) 60-400 and Sf 20-60... - Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cellsKim G Jackson
School of Food Biosciences, University of Reading, Reading, Berkshire, United Kingdom
J Lipid Res 47:393-403. 2006..008). In conclusion, these findings suggest an alternative or additional mechanism whereby acute fat ingestion can influence LDL clearance via competitive apoE-dependent effects of TRL on the LDL receptor... - Acute effects of meal fatty acids on postprandial NEFA, glucose and apo E response: implications for insulin sensitivity and lipoprotein regulation?Kim G Jackson
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
Br J Nutr 93:693-700. 2005..PUFA- and MUFA-rich lipoproteins. Elevated Apo E responses to high-SFA meals may have important implications for the hepatic metabolism of triacylglycerol-rich lipoproteins... - Degree of oxidation of low density lipoprotein affects expression of CD36 and PPARgamma, but not cytokine production, by human monocyte-macrophagesIan C Kavanagh
School of Food Biosciences, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, UK
Atherosclerosis 168:271-82. 2003..None of the oxLDL species appeared to be pro-inflammatory towards monocytes, either directly or indirectly through mediators derived from lymphocytes, regardless of the degree of oxidation... - Greater enrichment of triacylglycerol-rich lipoproteins with apolipoproteins E and C-III after meals rich in saturated fatty acids than after meals rich in unsaturated fatty acidsKim G Jackson
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, UK
Am J Clin Nutr 81:25-34. 2005.... - The effects of conjugated linoleic acid on human health-related outcomesSabine Tricon
Hugh Sinclair Unit of Human Nutrition, School of Food Bioscienes, University of Reading, Whiteknights, UK
Proc Nutr Soc 64:171-82. 2005..These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution... - Monounsaturated fatty acids and immune functionP Yaqoob
The Hugh Sinclair Unit of Human Nutrition, University of Reading, Reading, UK
Eur J Clin Nutr 56:S9-S13. 2002..It remains to be seen whether MUFA will be clinically useful in immunonutrition... - The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitroS Crouvezier
Hugh Sinclaire Unit of Human Nutrition, Department of Food Science and Technology, University of Reading, Berkshire, UK
Cytokine 13:280-6. 2001.... - Dietary fatty acids and chylomicron synthesis and secretionC M Williams
Hugh Sinclair Unit Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
Biochem Soc Trans 32:55-8. 2004.... - Differences in cell morphology, lipid and apo B secretory capacity in caco-2 cells following long term treatment with saturated and monounsaturated fatty acidsPaul A Bateman
Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, School of Chemistry, Food Biosciences and Pharmacy, The University of Reading, Reading Berkshire, UK
Biochim Biophys Acta 1771:475-85. 2007..In conclusion, previously reported differences in lipoprotein secretion by caco-2 cells supplemented with saturated fatty acids (SFA) and OA may partly reflect early cytotoxic effects of SFA on cellular integrity and function... - Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophagesAnna M Palmer
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Whiteknights, P.O. Box 226, Reading RG6 6AP, United Kingdom
Atherosclerosis 180:233-44. 2005..In conclusion, THP monocyte-derived macrophages demonstrate a preference for VLDL-1, both through the LPL pathway and by direct uptake of whole particles... - Effects of lipid emulsions on lipid body formation and eicosanoid production by human peripheral blood mononuclear and polymorphonuclear cellsRenata M Nanhuck
Department of Food Biosciences, School of Chemistry, Food Biosciences and Pharmacy, The University of Reading, Whiteknights PO Box 226, Reading RG6 6AP, United Kingdom
Clin Nutr 28:556-64. 2009.... - New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT)Sarah Knaggs
School of Chemistry, University of Reading, Whiteknights, Reading, UK
Org Biomol Chem 3:4002-10. 2005..Finally, HPLC studies and preliminary cytotoxicity studies in a melanotic and an amelanotic cell line, that illustrate the feasibility of the approach, are presented... - Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy menGraham C Burdge
Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX UK
J Lipid Res 45:736-41. 2004..These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily... - Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trialFrank Thies
Institute of Human Nutrition, University of Southampton, Basset Crescent East, Southampton, UK
Lancet 361:477-85. 2003..Stability of plaques could explain reductions in non-fatal and fatal cardiovascular events associated with increased n-3 PUFA intake... - Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acidsGraham C Burdge
Institute of Human Nutrition, Biomedical Sciences Building, University of Southhampton, Bassett Crescent East, Southhampton, S016 7PX, UK
Br J Nutr 94:237-43. 2005..001) and PBMC (84 %; P = 0.004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids... - Lipid rafts--composition, characterization, and controversiesPhilip C Calder
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton S016 7PX, UK
J Nutr 137:545-7. 2007 - Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanomaJosep Bonjoch
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain
J Med Chem 51:6604-8. 2008..Increased uptake of the lead candidate in a tyrosinase-rich cell line, compared with a tyrosinase-absent cell line, is reported, with results correlating well with that for a drug currently approved for BNCT... - Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cellsAna Marquez-Martin
Instituto de la Grasa (C.S.I.C.) Avda, , 41012 Seville, Spain
Cytokine 36:211-7. 2006..In conclusion, this study demonstrates that pentacyclic triterpenes in orujo oil exhibit pro- and anti-inflammatory properties depending on chemical structure and dose, and may be useful in modulating the immune response... - Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrationsElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
Atherosclerosis 196:298-305. 2008..To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these...