Research Topics
Genomes and Genes | Shi Yu YangSummaryAffiliation: University College London Country: UK Publications
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Publications
IGF-I activates caspases 3/7, 8 and 9 but does not induce cell death in colorectal cancer cellsShi Yu Yang
University College London, Division of Surgery and Interventional Science, Royal Free and University College Medical School, Rowland Hill Street, London, UK
BMC Cancer 9:158. 2009..Insulin-like growth factor I (IGF-I) has been known to play a prominent role in colorectal cancer development and progression. The role of IGF-I in cancer cell apoptosis is not completely understood...- Inducing apoptosis of human colon cancer cells by an IGF-I D domain analogue peptideShi Yu Yang
University Department of Surgery, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
Mol Cancer 7:17. 2008..This study was carried out to investigate the effect of a novel IGF-I receptor antagonist on apoptosis in colon cancer cells... 
Apoptosis and colorectal cancer: implications for therapyShi Yu Yang
University College London, Division of Surgery and Interventional Science, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Trends Mol Med 15:225-33. 2009..Recent progress in targeting apoptotic pathways and their regulators provide strategies for the exploration of novel therapies for CRC...- Pretreatment with insulin-like growth factor I protects skeletal muscle cells against oxidative damage via PI3K/Akt and ERK1/2 MAPK pathwaysShi Yu Yang
Division of Surgery and Interventional Science, UCL Medical School, University College London, London, UK
Lab Invest 90:391-401. 2010..Protecting muscle cells from oxidative damage presents a potential application in the treatment of the muscle wasting, which appears in many muscle pathologies including Duchenne muscle dystrophy and sarcopenia... 
Growth Factors and their receptors in cancer metastasesShi Yu Yang
Division of Surgery and Interventional Science, UCL Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
Front Biosci 16:531-8. 2011..The functions of growth factors and their receptors are also discussed. This review presents the efforts made in understanding this challenge to aid in the development of new treatment strategies for cancer metastases...- Inhibition of the p38 MAPK pathway sensitises human colon cancer cells to 5-fluorouracil treatmentShi Yu Yang
Division of Surgery and Interventional Science, UCL Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
Int J Oncol 38:1695-702. 2011..These findings suggest that p38 MAPK is involved in cancer cell survival, and that the inhibition of p38 MAPK can enhance 5-FU to kill colorectal cancer cells... - Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injuryMahmoud Abu-Amara
Liver Transplantation and Hepatobiliary Unit, Department of Electron Microscopy, Royal Free Hospital, and Academic Department of Surgery, University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
Clin Sci (Lond) 121:257-66. 2011..The mechanisms underlying this protection involve preservation of the sinusoidal structure and maintenance of blood flow through the hepatic microcirculation... - Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liverMahmoud Abu-Amara
Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
Liver Transpl 17:610-9. 2011..eNOS exerts its protective effects through the preservation of hepatic MBF. At 2 hours of reperfusion, eNOS protection is likely due to the increased activation of eNOS rather than increased expression... - An in vivo rat model for early development of colorectal cancer metastasis to liverJohn H P Robertson
GI and Hepatobiliary Research Group, Academic Division of Surgery and Interventional Sciences, University College London, London, UK
Int J Exp Pathol 89:447-57. 2008..In conclusion, cancer cell line-host selection has a significant effect on early colonic cancer liver metastasis development... - The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscleKenan Ates
Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, University College London, UK
FEBS Lett 581:2727-32. 2007..IGF-I significantly enhances myogenic differentiation whereas MGF E peptide blocks this pathway, resulting in an increased progenitor (stem) cell pool and thus potentially facilitating repair and maintenance of this postmitotic tissue... - Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approachesRichard M Evans
Department of Clinical Neurosciences, UCL Institute of Neurology, London, UK
Amyotroph Lateral Scler 11:172-7. 2010..We conclude that the pathology of ALS does not include a deficit in baseline levels of MGF and IGF-IEa mRNA splice variants in muscle... - Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancerRajaraman Durai
Academic Division of Surgical and Interventional Sciences, University College London, Hampstead Campus, and Royal Free Hampstead NHS Trust Hospital, London NW3 2FP, UK
Int J Oncol 30:883-8. 2007..This experiment shows that IGFBP-4 gene therapy increases tumour apoptosis via altering the expressions of Bcl-2 and Bax and decreasing the angiogenesis in colorectal cancer... - The nitric oxide pathway--evidence and mechanisms for protection against liver ischaemia reperfusion injuryMahmoud Abu-Amara
Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
Liver Int 32:531-43. 2012..In this review, the evidence for, and mechanisms of these protective actions of NO are discussed, and areas in need of further research are highlighted... - Recent advances in artificial nerve conduit design: strategies for the delivery of luminal fillersAmit Pabari
Centre for Nanotechnology and Regenerative Medicine, Division of Surgical and Interventional Sciences, University College London, UK
J Control Release 156:2-10. 2011.... - Biology of insulin-like growth factor binding protein-4 and its role in cancer (review)Rajaraman Durai
University Department of Surgery, Royal Free and University College Medical School, University College London, London, UK
Int J Oncol 28:1317-25. 2006..The effect of altered expression of IGFBP-4 in vivo in colon and other cancers needs to be explored as locally available IGFs appear to stimulate mitogenesis... - Functional blocking of specific integrins inhibit colonic cancer migrationJohn H Robertson
GI and Hepatobiliary Research Group, UCL Division of Surgery and Interventional Science, University College London, Rowland Hill Street, London, NW3 2PF, UK
Clin Exp Metastasis 26:769-80. 2009..In conclusion, integrin subunits alpha2, alpha6 and beta4 are expressed in unrelated colorectal cancer cell strains and appear to play a key role in cancer cell migration... - Principles and applications of gene therapy in colon cancerRajaraman Durai
Academic Division of Surgical and Interventional Sciences, University College London, Rowland Hill Street, London NW3 2PF, UK
J Gastrointestin Liver Dis 17:59-67. 2008..Further experiments and trials are underway to modify the vectors and genes to make sure gene therapy is safe, effective and long-lasting before it can be used in day-to-day practice... - The splicing of the IGF-I gene to yield different muscle growth factorsGeoffrey Goldspink
Department of Surgery, Royal Free and University College Medical School, University of London, London NW3 2PF, England, UK
Adv Genet 52:23-49. 2004 - Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse modelMahmoud Abu-Amara
Division of Surgery and Interventional Science, University College London, United Kingdom
Liver Transpl 17:70-82. 2011..With the availability of transgenic mice strains, this model should prove useful in unraveling the mechanisms of protection of hindlimb RIPC... - In vivo models for early development of colorectal liver metastasisJohn H P Robertson
GI and Hepatobiliary Research Group, Academic Division of Surgery and Interventional Sciences, University College London, London, UK
Int J Exp Pathol 89:1-12. 2008..The implications of these different techniques on the resulting metastasis picture will be analysed. Existing in vivo models are assessed regarding the accuracy of the metastatic picture they portray... - Insulin-like growth factor-1 gene splice variants as markers of muscle damage in levator ani muscle after the first vaginal deliveryEduardo Cortes
Pelvic Floor Unit, Royal Free Hospital and Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, London, UK
Am J Obstet Gynecol 193:64-70. 2005..We conducted a study on the expression of insulin-like growth factor-1 splice variants in the levator ani muscle after the first vaginal delivery... - Modern surgical management of peripheral nerve gapAmit Pabari
Department of Plastic Surgery, Royal Free Hampstead NHS Trust Hospital, and Centre for Nanotechnology, Biomaterials and Tissue Engineering, Division of Surgical and Interventional Sciences, University College London, London, UK
J Plast Reconstr Aesthet Surg 63:1941-8. 2010.... - Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell culturesMina Ryten
Autonomic Neuroscience Institute, Royal Free and University College Medical School, Royal Free Campus, London, UK
FASEB J 18:1404-6. 2004..Thus, this study provides the first evidence for a role for purinergic signaling in muscle regeneration and raises the possibility of new therapeutic strategies in the treatment of muscle disease... - Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiationShi Yu Yang
Molecular Tissue Repair Unit, Department of Surgery, Royal Free and University College Medical School, University College London, Rowland Hill Street, UK
FEBS Lett 522:156-60. 2002..The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected... - Nerve regeneration with aid of nanotechnology and cellular engineeringTina Sedaghati
UCL Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, UK
Biotechnol Appl Biochem 58:288-300. 2011..The goal is to determine potential alternatives for nerve regeneration and repair that are simply and directly applicable in clinical conditions... - Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscleUmber Cheema
Institute of Orthopaedics and Musculo Skeletal Science, University College London, Middlesex, United Kingdom
J Cell Physiol 202:67-75. 2005..These data indicate the importance of seeking to understand the physiological signals that determine the ratios of splice variants of some growth factor/tissue factor genes in the early stages of development of skeletal muscle...