Shen Hsi Yang

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif
    Shen Hsi Yang
    Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 30:2193-205. 2010
  2. pmc The ETS domain transcription factor Elk-1 contains a novel class of repression domain
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, 2205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Cell Biol 22:5036-46. 2002
  3. ncbi request reprint Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell 12:63-74. 2003
  4. ncbi request reprint Transcriptional regulation by the MAP kinase signaling cascades
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Gene 320:3-21. 2003
  5. ncbi request reprint SUMO promotes HDAC-mediated transcriptional repression
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell 13:611-7. 2004
  6. pmc Otx2 and Oct4 Drive Early Enhancer Activation during Embryonic Stem Cell Transition from Naive Pluripotency
    Shen Hsi Yang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Cell Rep 7:1968-81. 2014
  7. pmc Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1
    Lin Zhang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 27:2861-9. 2007
  8. pmc PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation
    Amanda O'Donnell
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK
    EMBO Rep 14:1084-91. 2013
  9. pmc A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation
    Shen Hsi Yang
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS Genet 8:e1003112. 2012
  10. doi request reprint MAP kinase signalling cascades and transcriptional regulation
    Shen Hsi Yang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Gene 513:1-13. 2013

Detail Information

Publications11

  1. pmc The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif
    Shen Hsi Yang
    Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 30:2193-205. 2010
    ..The significance of the SIM2-dependent functions of Pc2 is demonstrated in the control of the precise expression of lineage-specific genes during embryonic stem cell differentiation...
  2. pmc The ETS domain transcription factor Elk-1 contains a novel class of repression domain
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, 2205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Cell Biol 22:5036-46. 2002
    ..Thus, the Elk-1 R motif and the p300 CRD1 motif represent a new class of repression domains that are regulated in a context-dependent manner...
  3. ncbi request reprint Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell 12:63-74. 2003
    ..Thus, the reciprocal regulation of the activation and repressive activities are coupled by MAP kinase modification of Elk-1...
  4. ncbi request reprint Transcriptional regulation by the MAP kinase signaling cascades
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Gene 320:3-21. 2003
    ..In this review, we summarise the current knowledge of MAPK-mediated gene regulation, and focus on how complexities in signaling outcomes are achieved and how this relates to physiological processes...
  5. ncbi request reprint SUMO promotes HDAC-mediated transcriptional repression
    Shen Hsi Yang
    School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell 13:611-7. 2004
    ..Thus, our data demonstrate an important integration point for two protein-modifying pathways in the cell, the SUMO and deacetylation pathways, that combine to promote transcriptional repression...
  6. pmc Otx2 and Oct4 Drive Early Enhancer Activation during Embryonic Stem Cell Transition from Naive Pluripotency
    Shen Hsi Yang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Cell Rep 7:1968-81. 2014
    ..Therefore, the Oct4-Otx2 regulatory axis actively establishes a new regulatory chromatin landscape during the early events that accompany exit from ground state pluripotency. ..
  7. pmc Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1
    Lin Zhang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 27:2861-9. 2007
    ....
  8. pmc PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation
    Amanda O'Donnell
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK
    EMBO Rep 14:1084-91. 2013
    ..Thus, our work has revealed an additional facet of PARP1 function in promoting dynamic remodelling of promoter-associated nucleosomes to allow transcriptional activation in response to cellular signalling. ..
  9. pmc A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation
    Shen Hsi Yang
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS Genet 8:e1003112. 2012
    ....
  10. doi request reprint MAP kinase signalling cascades and transcriptional regulation
    Shen Hsi Yang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Gene 513:1-13. 2013
    ..Finally, we summarise progress in studying the physiological functions of key MAPK transcriptional targets...
  11. pmc MAP kinase-mediated c-fos regulation relies on a histone acetylation relay switch
    Amanda O'Donnell
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Mol Cell 29:780-5. 2008
    ....