Frederick C W Wu

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Commentary: Guideline for male testosterone therapy: a European perspective
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, University of Manchester, Manchester M13 9WL, United Kingdom
    J Clin Endocrinol Metab 92:418-9. 2007
  2. ncbi request reprint Assessment of sexual health in aging men in Europe: development and validation of the European Male Ageing Study sexual function questionnaire
    Daryl B O'Connor
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    J Sex Med 5:1374-85. 2008
  3. pmc The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility
    Kate L Holliday
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Mol Pain 8:72. 2012
  4. pmc Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, UK
    Calcif Tissue Int 89:446-55. 2011
  5. pmc A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Med Genet 12:19. 2011
  6. ncbi request reprint Identification of late-onset hypogonadism in middle-aged and elderly men
    Frederick C W Wu
    Andrology Research Unit, Developmental and Regenerative Biomedicine Research Group, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    N Engl J Med 363:123-35. 2010
  7. doi request reprint Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 93:2737-45. 2008
  8. doi request reprint Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study
    Abdelouahid Tajar
    The University of Manchester, Manchester Academic Health Science Centre, Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Clin Endocrinol Metab 95:1810-8. 2010
  9. pmc Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men
    Abdelouahid Tajar
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pain 152:1495-501. 2011
  10. doi request reprint Association of hypogonadism with vitamin D status: the European Male Ageing Study
    David M Lee
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK
    Eur J Endocrinol 166:77-85. 2012

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Commentary: Guideline for male testosterone therapy: a European perspective
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, University of Manchester, Manchester M13 9WL, United Kingdom
    J Clin Endocrinol Metab 92:418-9. 2007
  2. ncbi request reprint Assessment of sexual health in aging men in Europe: development and validation of the European Male Ageing Study sexual function questionnaire
    Daryl B O'Connor
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    J Sex Med 5:1374-85. 2008
    ..Assessment of male sexual dysfunction has been the focus of substantial scientific effort. Less research has focused on the development of instruments for the measurement of sexual functioning in aging men...
  3. pmc The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility
    Kate L Holliday
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Mol Pain 8:72. 2012
    ..The aim of this study was to validate the previously reported association between a common non-synonymous polymorphism (R1150W, rs6746030) in SCN9A and chronic widespread pain (CWP), in independent population-based cohorts...
  4. pmc Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, UK
    Calcif Tissue Int 89:446-55. 2011
    ..90 [0.92-16.88], P = 0.029). No significant association was observed between RANKL SNPs and pQCT parameters. Our findings suggest that genetic variation in OPG and RANK influences radius vBMD and geometry in men...
  5. pmc A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Med Genet 12:19. 2011
    ..The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested...
  6. ncbi request reprint Identification of late-onset hypogonadism in middle-aged and elderly men
    Frederick C W Wu
    Andrology Research Unit, Developmental and Regenerative Biomedicine Research Group, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    N Engl J Med 363:123-35. 2010
    ..We sought evidence-based criteria for identifying late-onset hypogonadism in the general population on the basis of an association between symptoms and a low testosterone level...
  7. doi request reprint Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 93:2737-45. 2008
    ..The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear...
  8. doi request reprint Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study
    Abdelouahid Tajar
    The University of Manchester, Manchester Academic Health Science Centre, Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Clin Endocrinol Metab 95:1810-8. 2010
    ..The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized...
  9. pmc Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men
    Abdelouahid Tajar
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pain 152:1495-501. 2011
    ..28; 95% CI 1.09 to 1.50) and also CWP (vs no pain, RRR=1.51; 95% CI 1.10 to 2.07). Similar results were found for FSH. Gonadotrophins, but not sex steroid hormone levels, are associated with musculoskeletal pain in men...
  10. doi request reprint Association of hypogonadism with vitamin D status: the European Male Ageing Study
    David M Lee
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK
    Eur J Endocrinol 166:77-85. 2012
    ..We investigated whether HPT axis hormones and hypogonadism are associated with serum levels of 25-hydroxyvitamin D (25(OH)D) in men...
  11. pmc The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men
    Kate L Holliday
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    PLoS ONE 6:e22037. 2011
    ....
  12. ncbi request reprint Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study
    John McBeth
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1448-52. 2010
    ..A study was undertaken to test the hypothesis that musculoskeletal pain is associated with low vitamin D levels but the relationship is explained by physical inactivity and/or other putative confounding factors...
  13. doi request reprint The ability of three different models of frailty to predict all-cause mortality: results from the European Male Aging Study (EMAS)
    Rathi Ravindrarajah
    Department of Medicine, Manchester Academic Health Science Centre, The University of Manchester, Manchester Royal Infirmary, Manchester, United Kingdom
    Arch Gerontol Geriatr 57:360-8. 2013
    ..Our data suggest that the choice of frailty model may not be of paramount importance when predicting future risk of death, enabling flexibility in the approach used. ..
  14. doi request reprint Cohort profile: the European Male Ageing Study
    David M Lee
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK
    Int J Epidemiol 42:391-401. 2013
    ..EMAS actively encourages new collaborations, data sharing for validation studies and participation in genetic study consortia. Potential collaborators should contact the principal investigator (F.C.W.W.) in the first instance...
  15. doi request reprint Frailty in relation to variations in hormone levels of the hypothalamic-pituitary-testicular axis in older men: results from the European male aging study
    Abdelouahid Tajar
    Arthritis Research United Kingdom Epidemiology Unit, University of Manchester, Manchester, UK
    J Am Geriatr Soc 59:814-21. 2011
    ..To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men...
  16. doi request reprint Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS)
    Abdelouahid Tajar
    Arthritis Research U K Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, United Kingdom
    J Clin Endocrinol Metab 97:1508-16. 2012
    ..Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T)...
  17. doi request reprint The effect of musculoskeletal pain on sexual function in middle-aged and elderly european men: results from the european male ageing study
    Abdelouahid Tajar
    Arthritis Research UK Epidemiology Unit, Oxford Road, The University of Manchester, Manchester M13 9PT, United Kingdom
    J Rheumatol 38:370-7. 2011
    ..To determine whether musculoskeletal pain was associated with impaired sexual function in a population sample of middle-aged and older men...
  18. doi request reprint Frailty and sexual health in older European men
    David M Lee
    Arthritis Research UK Epidemiology Unit, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Gerontol A Biol Sci Med Sci 68:837-44. 2013
    ..There has been little research on how late-life frailty interrelates with sexual health. Our objective was to examine the association of frailty with sexual functioning and satisfaction among older men...
  19. doi request reprint Association of HTR2A polymorphisms with chronic widespread pain and the extent of musculoskeletal pain: results from two population-based cohorts
    Barbara I Nicholl
    University of Manchester, Manchester, UK
    Arthritis Rheum 63:810-8. 2011
    ..The aim of the current study was to investigate whether genetic variation in genes across the serotoninergic system is associated with chronic widespread pain (CWP) and the number of pain sites reported...
  20. doi request reprint Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    Upendram Srinivas-Shankar
    Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
    J Clin Endocrinol Metab 95:639-50. 2010
    ..Further investigations are warranted to extend these results...
  21. doi request reprint The European Male Ageing Study (EMAS): design, methods and recruitment
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Int J Androl 32:11-24. 2009
    ..Such information is an important prerequisite to develop effective strategies to reduce age-related disabilities and optimise health and well-being into old-age...
  22. doi request reprint The association between different cognitive domains and age in a multi-centre study of middle-aged and older European men
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Int J Geriatr Psychiatry 24:1257-66. 2009
    ....
  23. pmc Influence of insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 on bone health: results from the European Male Ageing Study
    Stephen R Pye
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, UK
    Calcif Tissue Int 88:503-10. 2011
    ..IGFBP-1 was associated with bone health, though the effect could be explained by other factors. IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men...
  24. doi request reprint Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: results from the European Male Ageing Study
    John McBeth
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    J Rheumatol 36:2523-30. 2009
    ..To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men...
  25. doi request reprint Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study
    David M Lee
    ARC Epidemiology Unit, Department of Medicine, Manchester Academic and Health Sciences Centre, Manchester Royal Infirmary, The University of Manchester, Grafton Street, Manchester, UK
    Eur J Endocrinol 162:1155-64. 2010
    ..Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men...
  26. ncbi request reprint Association of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone with mortality among middle-aged and older European men
    David M Lee
    Cathie Marsh Centre for Census and Survey Research, School of Social Sciences, The University of Manchester, Manchester, UK
    Age Ageing 43:528-35. 2014
    ....
  27. doi request reprint Low testosterone in ageing men: a modifiable risk factor for frailty?
    Matthew D L O'Connell
    Andrology Research Unit, Developmental and Regenerative Biomedicine Research Group, Manchester Academic Health Science Centre MAHSC, The University of Manchester, Manchester Royal Infirmary, Manchester M13 9WL, UK
    Trends Endocrinol Metab 22:491-8. 2011
    ..Further research may usefully focus on novel pro-anabolic pharmaceutical agents, which together with other interventions will allow for optimal management of frailty...
  28. ncbi request reprint Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study
    Daryl B O'Connor
    Department of Endocrinology, Manchester Royal Infirmary, United Kingdom
    J Clin Endocrinol Metab 89:2837-45. 2004
    ..Future research should investigate the implications of these minor mood changes...
  29. doi request reprint Do the effects of testosterone on muscle strength, physical function, body composition, and quality of life persist six months after treatment in intermediate-frail and frail elderly men?
    Matthew D L O'Connell
    Andrology Research Unit, Manchester Academic Health Science Centre, Manchester Royal Infirmary, The University of Manchester, Manchester, United Kingdom
    J Clin Endocrinol Metab 96:454-8. 2011
    ..Short-term testosterone (T) treatment in frail elderly men improves muscle mass and strength. It is unclear whether these effects can be maintained post treatment...
  30. pmc Influence of lifestyle factors on quantitative heel ultrasound measurements in middle-aged and elderly men
    Stephen R Pye
    ARC Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Calcif Tissue Int 86:211-9. 2010
    ..Modification of lifestyle, including increasing physical activity and stopping smoking, may help optimize bone strength and reduce the risk of fracture in middle-aged and elderly European men...
  31. doi request reprint No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
    Barbara I Nicholl
    Manchester Academic Health Science Centre, University of Manchester, UK
    Ann Rheum Dis 69:2009-12. 2010
    ..The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts...
  32. ncbi request reprint A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal contraception
    Cathy J Hay
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Clin Endocrinol Metab 90:2042-9. 2005
    ..one). In conclusion, the combination of 300 microg ENG with 400 mg TD every 4 wk was superior in terms of efficacy, hormone profiles, and safety. This represents a promising approach to male hormonal contraception...
  33. doi request reprint Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester M13 9PT, UK
    Eur J Endocrinol 161:947-54. 2009
    ..The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men...
  34. doi request reprint Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester M13 9PT, UK
    J Neurol Neurosurg Psychiatry 80:722-9. 2009
    ..The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men...
  35. ncbi request reprint Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone
    Pierre Marc G Bouloux
    Department of Endocrinology, The Royal Free Hospital, London, United Kingdom
    J Androl 24:604-11. 2003
    ..In conclusion, a weekly dose of 450 IU (3 x 150 IU or 2 x 225 IU) recFSH, in addition to hCG, was able to induce spermatogenesis in many hypogonadotropic azoospermic men who failed to respond to treatment with hCG alone...
  36. doi request reprint A magnetic resonance perspective of the pulse wave transit time by the Arteriograph device and potential for improving aortic length estimation for central pulse wave velocity
    Mohammad Reza Rezai
    Cardiovascular Research Group, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Blood Press Monit 18:111-8. 2013
    ..Simple reproducible methods of measuring arterial stiffness, a powerful index of prognosis, are becoming available...
  37. ncbi request reprint Hormonal approaches to male contraception: approaching reality
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, University of Manchester, Oxford Rd, Manchester M13 9WL, United Kingdom
    Mol Cell Endocrinol 250:2-7. 2006
    ....
  38. doi request reprint Frailty and muscle function: role for testosterone?
    U Srinivas-Shankar
    Department of Endocrinology, University of Manchester, Manchester Royal Infirmary, Manchester, UK
    Front Horm Res 37:133-49. 2009
    ..In this review, we discuss the syndrome of frailty, its relationship with low testosterone and the effects of testosterone supplementation in healthy and unhealthy/frail older men on muscle mass, strength and physical performance...
  39. pmc Androgen effects on skeletal muscle: implications for the development and management of frailty
    Matthew D L O'Connell
    Andrology Research Unit, Institute of Human Development, Centre for Endocrinology and Diabetes, University of Manchester, Manchester, United Kingdom
    Asian J Androl 16:203-12. 2014
    ....
  40. ncbi request reprint Drug insight: testosterone preparations
    Upendram Srinivas-Shankar
    Andrology Research Unit, Department of Endocrinology, Central Manchester University and Manchester Children s Hospital, Manchester M13 OJH, UK
    Nat Clin Pract Urol 3:653-65. 2006
    ..We then discuss the pharmacokinetics, advantages, and disadvantages of various formulations and summarize the various preparations currently available...
  41. ncbi request reprint Exogenous testosterone, aggression, and mood in eugonadal and hypogonadal men
    Daryl B O'Connor
    Department of Endocrinology, Manchester Royal Infirmary, Manchester M13 9WL, UK
    Physiol Behav 75:557-66. 2002
    ..Instead, for the first time, this study has identified the high level of negative affect experienced by hypogonadal patients. These findings have implications for T replacement therapy and male contraception...
  42. ncbi request reprint An investigation of the effectiveness of testosterone implants in combination with the prolactin inhibitor quinagolide in the suppression of spermatogenesis in men
    W Morton Hair
    MRC Human Reproductive Sciences Unit, The University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Hum Reprod 18:749-55. 2003
    ....
  43. doi request reprint Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, University of Sydney and Concord Hospital, Concord, New South Wales 2139, Australia
    J Clin Endocrinol Metab 93:1774-83. 2008
    ..Male hormonal contraceptive methods require effective suppression of sperm output...