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Genomes and Genes | Susan WraySummaryAffiliation: University of Liverpool Country: UK Publications
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Publications
Insights into the uterusSusan Wray
Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
Exp Physiol 92:621-31. 2007..It is only by gaining a better understanding of uterine physiology and pathophysiology that progress will be made and research findings translated into clinical benefit for women and their families...- Role of the calcium store in uterine contractilitySusan Wray
University of Liverpool, Department of Physiology, Crown Street, Liverpool L69 3BX, United Kingdom
Semin Cell Dev Biol 18:315-20. 2007..Recent data on the role of local Ca signals from the SR in contributing to membrane excitability and contractility are discussed, along with interactions with ion channels in lipid microdomains... - Mechanisms of action of pH-induced effects on vascular smooth muscleSusan Wray
The Physiological Laboratory, The University of Liverpool, Liverpool, UK
Mol Cell Biochem 263:163-72. 2004..There are still numerous gaps in our understanding of the actions of pH and as more data become available, we will be able to better understand the major mechanisms involved... - Airway smooth muscle dysfunction precedes teratogenic congenital diaphragmatic hernia and may contribute to hypoplastic lung morphogenesisNeil C Featherstone
Medical Research Council Clinical Training Fellow, Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool L69 3BX, UK
Am J Respir Cell Mol Biol 35:571-8. 2006..Elucidation of such an ASM lesion may allow pharmacologic amelioration not only of ASM hyperreactivity and its sequelae, but also of hypoplastic lung growth itself... 
Cholesterol depletion alters coronary artery myocyte Ca(2+) signalling in a stimulus-specific mannerClodagh Prendergast
University of Liverpool, Merseyside, UK
Cell Calcium 47:84-91. 2010..These data are discussed in terms of the involvement of caveolae in receptor localisation, Ca(2+) entry pathways and SR Ca(2+) release, and the role of these in agonist signalling...- Evidence that a Ca2+ sparks/STOCs coupling mechanism is responsible for the inhibitory effect of caffeine on electro-mechanical coupling in guinea pig ureteric smooth muscleL Borisova
The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
Cell Calcium 42:303-11. 2007..These data suggest that the inhibitory effect of caffeine on the action potential, Ca2+ transients and force in ureteric smooth muscle is caused by activation of Ca2+ sparks/STOCs coupling mechanism... - Electrophysiological characterization and functional importance of calcium-activated chloride channel in rat uterine myocytesK Jones
Department of Physiology, The University of Liverpool, Liverpool, L69 3BX, UK
Pflugers Arch 448:36-43. 2004.... 
Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometriumKaren Noble
Department of Physiology, University of Liverpool, UK
Cell Calcium 47:47-54. 2010..They contribute more to quiescence that BK channels...- Rho-kinase inhibition and electromechanical coupling in rat and guinea-pig ureter smooth muscle: Ca2+-dependent and -independent mechanismsS Shabir
Department of Physiology, The University of Liverpool, Liverpool L69 3BX, UK
J Physiol 560:839-55. 2004..Thus Rho-kinase can modulate phasic smooth muscle in the absence of agonist, and the mechanisms are both Ca(2+)-dependent, involving ion channels, and Ca(2+)-independent, involving MLC phosphorylation activity... - Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometriumR D Smith
Dept of Physiology, The University of Liverpool, Crown St, Liverpool, L69 3BX, UK
Am J Physiol Cell Physiol 288:C982-8. 2005..It may be one of the mechanisms operating to maintain uterine quiescence throughout gestation and may also contribute to difficulties in labor suffered by obese women... - The effects of metabolic inhibition on intracellular calcium and contractility of human myometriumE Monir-Bishty
Department of Physiology, University of Liverpool, UK
BJOG 110:1050-6. 2003..Stimulation of the hypoxic uterus was not effective, which may explain the unpredictability of oxytocin application in some dysfunctional labours... - Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approachKaren Noble
Department of Physiology, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
J Physiol 570:29-35. 2006.... - Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnanciesSarah Arrowsmith
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
PLoS ONE 7:e36787. 2012..We show that postdates pregnancy is associated with poor myometrial activity and suggest that this may contribute to increased myometrial quiescence and hence, prolonged gestation... - Ca2+ entry, efflux and release in smooth muscleA Matthew
Department of Physiology, The University of Liverpool, Liverpool L69 3BX, UK
Biol Res 37:617-24. 2004..It is suggested that SR Ca2+ targets K+ channels on the surface membrane and thereby feedback to inhibit excitability and contraction... - A review of recent insights into the role of the sarcoplasmic reticulum and Ca entry in uterine smooth muscleKaren Noble
Department of Physiology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L693BX, UK
Eur J Obstet Gynecol Reprod Biol 144:S11-9. 2009.... - Action potential refractory period in ureter smooth muscle is set by Ca sparks and BK channelsT Burdyga
Department of Physiology, The University of Liverpool, Liverpool L69 3BX, UK
Nature 436:559-62. 2005..This insight into the control of excitability and hence function provides a focus for therapies directed at pathologies of smooth muscle... - Temporal and spatial variations in spontaneous Ca events and mechanical activity in pregnant rat myometriumTheodor Burdyga
Department of Physiology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L693BX, UK
Eur J Obstet Gynecol Reprod Biol 144:S25-32. 2009..The aim of this study was to investigate the temporal and spatial characteristics of spontaneous Ca signals in pregnant rat myometrium... - A new technique for simultaneous and in situ measurements of Ca2+ signals in arteriolar smooth muscle and endothelial cellsT Burdyga
The Physiological Laboratory, Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
Cell Calcium 34:27-33. 2003..We conclude that this approach is a convenient and useful method for studying inter- and intracellular Ca(2+) signalling events and communication between cell types, particularly in very small vessels... - Expression and distribution of Na, K-ATPase isoforms in the human uterusRachel V Floyd
Department of Physiology, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
Reprod Sci 17:366-76. 2010..In pregnancy, there was a switch in isoform expression, resulting in increased beta3 and decreased FXYD2 at the protein and messenger RNA (mRNA) levels. Na, K-ATPase isoform alterations may modulate uterine contractility during labor... - Contractility and calcium signaling of human myometrium are profoundly affected by cholesterol manipulation: implications for labor?- Jie Zhang
University of Liverpool, Liverpool, UK
Reprod Sci 14:456-66. 2007..Cholesterol may contribute to uterine quiescence but could cause difficulties in labor in obese/dyslipidemic women, consistent with their increased cesarean delivery rates... - The effects of pH change on Ca(++) signaling and force in pregnant human myometriumS Joanne Pierce
Department of Physiology, University of Liverpool, United Kingdom
Am J Obstet Gynecol 188:1031-8. 2003.... - Modulation of agonist-induced Ca2+ release by SR Ca2+ load: direct SR and cytosolic Ca2+ measurements in rat uterine myocytesAnatoly Shmygol
Department of Physiology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
Cell Calcium 37:215-23. 2005..Our results suggest that in uterine smooth muscle cells decrease in the SR Ca2+ load below its normal resting level substantially reduces the IP3-mediated Ca2+ release, while Ca2+ overload of the SR has no impact on such release... - Calcium signalling in smooth muscleSusan Wray
Department of Physiology, The University of Liverpool, Liverpool L69 3BX, UK
Cell Calcium 38:397-407. 2005..e. the refractory period. Finally, the relation between different Ca2+ signals, e.g. sparks, waves and transients, to smooth muscle activity in health and disease is becoming clearer and will be discussed... - Sarcoplasmic reticulum function and contractile consequences in ureteric smooth musclesTheodor Burdyga
Department of Physiology, The University of Liverpool, UK
Novartis Found Symp 246:208-17; discussion 217-20, 221-7. 2002..Eventually, we will be able to apply this knowledge to the human ureter, to increase our understanding of its functioning in health and disease... - The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteriesS Mumtaz
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, UK
Cell Calcium 49:66-77. 2011..In conclusion our data show how SERCA function is crucial to shaping endothelial cell Ca signals and its dynamic interplay with both CCE and ER Ca releases... - Modulation of ureteric Ca signaling and contractility in humans and rats by uropathogenic E. coliRachel V Floyd
Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
Am J Physiol Renal Physiol 298:F900-8. 2010..Thus, UPEC impairs ureteric contractility in a Ca-dependent manner, largely caused by stimulation of potassium channels and this mechanism is dependent on host-urothelium interaction... - Calcium signaling and uterine contractilitySusan Wray
Department of Physiology, The University of Liverpool, Liverpool, United Kingdom
J Soc Gynecol Investig 10:252-64. 2003.... - The role of the sarcoplasmic reticulum in neonatal uterine smooth muscle: enhanced role compared to adult ratKaren Noble
Department of Physiology, The University of Liverpool, Liverpool L69 3BX, UK
J Physiol 545:557-66. 2002.... - Calcium transporters and signalling in smooth musclesRachel Floyd
The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
Cell Calcium 42:467-76. 2007.... - Spontaneous propagating calcium waves underpin airway peristalsis in embryonic rat lungNeil C Featherstone
Division of Child Health, Royal Liverpool Children s Hospital Alder Hey, School of Biological Sciences, University of Liverpool, Liverpool L69 3BX, UK
Am J Respir Cell Mol Biol 33:153-60. 2005..Thus, if airway peristalsis regulates lung growth, these findings mean that airway smooth muscle Ca2+ waves in turn regulate prenatal lung morphogenesis... - Differential cellular expression of FXYD1 (phospholemman) and FXYD2 (gamma subunit of Na, K-ATPase) in normal human tissues: a study using high density human tissue microarraysRachel V Floyd
Physiological Laboratory, Department of Physiology, School of Biomedical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
Ann Anat 192:7-16. 2010..This study reveals, in human tissues, the specific expression of FXYD proteins, which may associate with Na, K-ATPase in selected cell types and modulate its catalytic properties... - Sarcoplasmic reticulum function in smooth muscleSusan Wray
Department of Physiology, School of Biomedical Sciences, University of Liverpool, Liverpool, Merseyside L69 3BX, United Kingdom
Physiol Rev 90:113-78. 2010..While the sheer versatility of smooth muscle makes it foolish to have a "one model fits all" approach to this subject, we have tried to synthesize conclusions wherever possible... - Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specificRachel V Floyd
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, United Kingdom
J Infect Dis 206:1589-96. 2012..coli... - What do we know about what happens to myometrial function as women age?Sarah Arrowsmith
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
J Muscle Res Cell Motil 33:209-17. 2012..It is tempting therefore to speculate that unlike other well documented declines in female reproductive functions with age, the myometrium remains able to function into a woman's 7th decade... - A new slow releasing, H₂S generating compound, GYY4137 relaxes spontaneous and oxytocin-stimulated contractions of human and rat pregnant myometriumHayley Robinson
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
PLoS ONE 7:e46278. 2012.... - Functional architecture of the SR calcium store in uterine smooth muscleAnatoly Shmygol
Physiological Laboratory, University of Liverpool Crown Street, Liverpool L69 3BX, UK
Cell Calcium 35:501-8. 2004..In this paper we review the literature and our own work on the SR calcium store in uterine smooth muscle cells... - In situ calcium signaling: no calcium sparks detected in rat myometriumTheodor Burdyga
Department of Physiology, The University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
Ann N Y Acad Sci 1101:85-96. 2007..This may be important for producing the powerful long-lasting contractions of the uterus required during labor... - Vimentin-positive, c-kit-negative interstitial cells in human and rat uterus: a role in pacemaking?R A Duquette
Department of Physiology, The University of Liverpool, Liverpool, United Kingdom
Biol Reprod 72:276-83. 2005..This is the first description of ICC-like cells in myometrium and their role in the uterus is discussed, as possible inhibitors of intrinsic smooth-muscle activity... - A short review of twin pregnancy and how oxytocin receptor expression may differ in multiple pregnancyPeter Turton
Department of Physiology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L693BX, UK
Eur J Obstet Gynecol Reprod Biol 144:S40-4. 2009..New hypotheses based on increased experimental work are called for. Such information may throw light on specific mechanisms leading to the increased incidence of pre-term delivery in twins... - How structure, Ca signals, and cellular communications underlie function in precapillary arteriolesLyudmyla Borisova
Physiology Department, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool, UK
Circ Res 105:803-10. 2009..However, their small size has limited study and little is known concerning the calcium signals in their endothelial and muscle cells and how these relate to function... - PH-induced changes in calcium: functional consequences and mechanisms of action in guinea pig portal veinR D Smith
Department of Physiology, The University of Liverpool, United Kingdom
Am J Physiol Heart Circ Physiol 283:H2518-26. 2002.... - Morphology, calcium signaling and mechanical activity in human ureterRachel V Floyd
Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
J Urol 180:398-405. 2008.... - Role of the sarcoplasmic reticulum in uterine smooth muscleSusan Wray
Department of Physiology, The University of Liverpool, UK
Novartis Found Symp 246:6-18; discussion 18-25, 48-51. 2002..This technique will be used to better characterize the uterine SR, its control and relevance to normal and abnormal labours... - Characterisation of the ionic currents in freshly isolated rat ureter smooth muscle cells: evidence for species-dependent currentsR D Smith
The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
Pflugers Arch 445:444-53. 2002..We relate these currents to their possible contribution to the characteristically extremely long lasting action potential in the rat ureter... - A comparison of the contractile properties of myometrium from singleton and twin pregnanciesPeter Turton
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
PLoS ONE 8:e63800. 2013..Furthermore, we wished to determine if contractile activity correlates with increasing level of stretch, using neonatal birth weights as a marker of uterine stretch... - Dysfunctional labor and myometrial lactic acidosisSiobhan Quenby
Department of Obstetrics and Gynaecology, University of Liverpool, Liverpool, United Kingdom
Obstet Gynecol 103:718-23. 2004..Following in vitro studies that showed acidification could depress uterine contraction, we hypothesized that it could contribute to dysfunctional labors... - On the mechanisms whereby temperature affects excitation-contraction coupling in smooth muscleTheodor V Burdyga
The Physiological Laboratory, University of Liverpool, Liverpool, L69 3BX, United Kingdom
J Gen Physiol 119:93-104. 2002..Although the biochemical and mechanical events accompanying contraction are likely to be affected in similar ways by temperature, differences in electrical events lead to subsequent differences in these processes between smooth muscles... - Na,K-ATPase isoforms in pregnant and nonpregnant rat uterusRachel Floyd
Physiological Laboratory, University of Liverpool, United Kingdom
Ann N Y Acad Sci 986:614-6. 2003 - Two centuries of excitation-contraction couplingSusan Wray
Physiological Laboratory, Liverpool University, Crown Street, P.O. Box 147, Liverpool L69 3BX, UK
Cell Calcium 35:485-9. 2004 - Modulating signaling events in smooth muscle: cleavage of annexin 2 abolishes its binding to lipid raftsEduard B Babiychuk
Department of Cell Biology, Institute of Anatomy, University of Bern, Switzerland
FASEB J 16:1177-84. 2002..Proteolysis abolishes annexin binding to the plasma membrane and might result in rearrangement of membrane constituents followed by the interruption of segregation-dependent signaling events... - In situ GABAergic modulation of synchronous gonadotropin releasing hormone-1 neuronal activityJoseph Patrick Moore
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 22:8932-41. 2002.... - Direct action of estradiol on gonadotropin-releasing hormone-1 neuronal activity via a transcription-dependent mechanismJennifer L Temple
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 24:6326-33. 2004..These data suggest that, via ERbeta, E2 can rapidly act as a hormone-activated transcription complex and are the first to show that E2 directly increases GnRH-1 neuronal activity and synchronization... - Domain architecture of the smooth-muscle plasma membrane: regulation by annexinsAnnette Draeger
Department of Cell Biology, Institute of Anatomy, University of Bern, Bern 9, CH 3000, Switzerland
Biochem J 387:309-14. 2005.... - Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytesA Shmygol
Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK
J Physiol 581:445-56. 2007.... - Functional and molecular characterization of voltage-gated sodium channels in uteri from nonpregnant ratsMarian Seda
Instituto de Investigaciones Quimicas, 41092 Sevilla, Spain
Biol Reprod 77:855-63. 2007..In addition, our data show that TTX-sensitive VGSC are able to mediate phasic contractions maintained over long periods of time in the uteri of nonpregnant rats... - Inhibitory effects of ginger oil on spontaneous and PGF2alpha-induced contraction of rat myometriumNopparat Buddhakala
Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand
Planta Med 74:385-91. 2008..In conclusion, ginger oil is a potent inhibitor of phasic activity in rat uterus, irrespective of how it was produced. Our data suggest that the effects are largely due to citral, and could be via inhibition of L-type Ca channels... - Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouseYoko Toba
Cellular and Developmental Neurobiology Section, NINDS, NIH, Bethesda, MD 20892, USA
Eur J Neurosci 22:79-92. 2005..These results indicate that extracellular calcium is required for initiating GnRH-1 neuronal migration and that these events are partially dependent on N-type VGCC signals... - Prenatal LHRH neurons in nasal explant cultures express estrogen receptor beta transcriptNeda Sharifi
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 143:2503-7. 2002.... - Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neuronsPaolo Giacobini
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
J Neurosci 24:4737-48. 2004.... - Cholecystokinin directly inhibits neuronal activity of primary gonadotropin-releasing hormone cells through cholecystokinin-1 receptorPaolo Giacobini
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3714, USA
Endocrinology 148:63-71. 2007..This study provides evidence that CCK acts directly on GnRH-1 neurons to attenuate GnRH-1 neuronal activity via CCK-1R activation... - Gonadotropin-releasing hormone-1 neuronal activity is independent of hyperpolarization-activated cyclic nucleotide-modulated channels but is sensitive to protein kinase a-dependent phosphorylationStephanie Constantin
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Endocrinology 149:3500-11. 2008..In addition, blockade of HCN channels did not modify basal GnRH-1 neuronal activity when GABAergic input was intact or removed, negating a role for these channels in basal GABAergic or GnRH-1 neuronal activity... - Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migrationPaolo Giacobini
Department of Human and Animal Biology, University of Torino, 10123 Torino, Italy
J Neurosci 27:431-45. 2007..Together, these data indicate that HGF signaling via Met receptor influences the development of GnRH-1... - Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficienciesTiziana Cogliati
Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889, USA
Mol Endocrinol 21:3013-27. 2007.... - Bovine serum albumin-estrogen compounds differentially alter gonadotropin-releasing hormone-1 neuronal activityJennifer L Temple
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 146:558-63. 2005..These data indicate that these compounds cannot be used interchangeably and clearly have different binding properties and/or different effects on target tissues...