C Geoffrey Woods

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings
    C Geoffrey Woods
    Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    Am J Hum Genet 76:717-28. 2005
  2. pmc Quantification of homozygosity in consanguineous individuals with autosomal recessive disease
    C Geoffrey Woods
    Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Am J Hum Genet 78:889-96. 2006
  3. pmc Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome
    C G Woods
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Am J Hum Genet 79:402-8. 2006
  4. pmc Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1
    Anne Gregor
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    BMC Med Genet 12:106. 2011
  5. pmc Human ASPM participates in spindle organisation, spindle orientation and cytokinesis
    Julie Higgins
    Section of Ophthalmology and Neuroscience, Wellcome Trust Brenner Building, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    BMC Cell Biol 11:85. 2010
  6. doi WDR62 is associated with the spindle pole and is mutated in human microcephaly
    Adeline K Nicholas
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Nat Genet 42:1010-4. 2010
  7. pmc A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy
    Ofélia P Carvalho
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    J Med Genet 48:131-5. 2011
  8. pmc A primary microcephaly protein complex forms a ring around parental centrioles
    Joo Hee Sir
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Nat Genet 43:1147-53. 2011
  9. pmc Pain perception is altered by a nucleotide polymorphism in SCN9A
    Frank Reimann
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 107:5148-53. 2010
  10. pmc Primary microcephaly: do all roads lead to Rome?
    Gemma K Thornton
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrookes Hospital, Cambridge, UK
    Trends Genet 25:501-10. 2009

Collaborators

Detail Information

Publications11

  1. pmc Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings
    C Geoffrey Woods
    Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    Am J Hum Genet 76:717-28. 2005
    ..So an understanding of this rare genetic disorder may offer us significant insights into neurogenic mitosis and the evolution of the most striking differences between us and our closest living relatives: brain size and cognitive ability...
  2. pmc Quantification of homozygosity in consanguineous individuals with autosomal recessive disease
    C Geoffrey Woods
    Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Am J Hum Genet 78:889-96. 2006
    ..This has important clinical and research implications...
  3. pmc Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome
    C G Woods
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Am J Hum Genet 79:402-8. 2006
    ..These findings illustrate the specific and conserved importance of WNT7A in multiple aspects of vertebrate limb development...
  4. pmc Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1
    Anne Gregor
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    BMC Med Genet 12:106. 2011
    ..Recently, homozygous or compound heterozygous defects in either gene were reported as causative for severe intellectual disability...
  5. pmc Human ASPM participates in spindle organisation, spindle orientation and cytokinesis
    Julie Higgins
    Section of Ophthalmology and Neuroscience, Wellcome Trust Brenner Building, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    BMC Cell Biol 11:85. 2010
    ..ASPM encodes a mitotic spindle pole associated protein. It is suggested that the MCPH phenotype arises from proliferation defects in neural progenitor cells (NPC)...
  6. doi WDR62 is associated with the spindle pole and is mutated in human microcephaly
    Adeline K Nicholas
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Nat Genet 42:1010-4. 2010
    ....
  7. pmc A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy
    Ofélia P Carvalho
    Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    J Med Genet 48:131-5. 2011
    ..The condition is linked to a new homozygous mutation in the NGF gene, c.[680C>A]+[681_682delGG]...
  8. pmc A primary microcephaly protein complex forms a ring around parental centrioles
    Joo Hee Sir
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Nat Genet 43:1147-53. 2011
    ..This work suggests that the CEP152-CEP63 ring-like structure ensures normal neurodevelopment and that its impairment particularly affects human cerebral cortex growth...
  9. pmc Pain perception is altered by a nucleotide polymorphism in SCN9A
    Frank Reimann
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 107:5148-53. 2010
    ..We conclude that individuals experience differing amounts of pain, per nociceptive stimulus, on the basis of their SCN9A rs6746030 genotype...
  10. pmc Primary microcephaly: do all roads lead to Rome?
    Gemma K Thornton
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrookes Hospital, Cambridge, UK
    Trends Genet 25:501-10. 2009
    ..Here, we focus on recent functional studies of MCPH proteins that reveal the centrosome as a final integration point for many regulatory pathways affecting prenatal neurogenesis in mammals...
  11. ncbi An SCN9A channelopathy causes congenital inability to experience pain
    James J Cox
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nature 444:894-8. 2006
    ..Our data suggest that SCN9A is an essential and non-redundant requirement for nociception in humans. These findings should stimulate the search for novel analgesics that selectively target this sodium channel subunit...