K J Wood

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Transplantation tolerance: lessons from experimental rodent models
    Cherry I Kingsley
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Transpl Int 20:828-41. 2007
  2. pmc B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naïve B cells
    S Heidt
    Transplant Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
    Am J Transplant 12:1784-92. 2012
  3. pmc Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
    J Hester
    Nuffield Department of Surgical Sciences, Transplantation Research Immunology Group, University of Oxford, UK
    Am J Transplant 12:2008-16. 2012
  4. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
  5. pmc Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model
    Fadi Issa
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford
    PLoS ONE 7:e53331. 2012
  6. pmc Ischemia-reperfusion injury accelerates human antibody-mediated transplant vasculopathy
    Ryoichi Goto
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Transplantation 96:139-45. 2013
  7. pmc Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model
    Douglas C Wu
    1 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK 2 Currently, Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland 3 Address correspondence to Professor Kathryn J Wood, D Phil, Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Transplantation 96:707-16. 2013
  8. doi request reprint Regulatory immune cells in transplantation
    Kathryn J Wood
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Immunol 12:417-30. 2012
  9. pmc T regulatory cells and the control of alloimmunity: from characterisation to clinical application
    Joanna Wieckiewicz
    Transplant Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
    Curr Opin Immunol 22:662-8. 2010
  10. pmc Regulatory T cells in transplantation
    K J Wood
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Transplant Proc 43:2135-6. 2011

Collaborators

Detail Information

Publications96

  1. pmc Transplantation tolerance: lessons from experimental rodent models
    Cherry I Kingsley
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Transpl Int 20:828-41. 2007
    ..This review highlights strategies designed to induce alloantigen specific immunological unresponsiveness leading to transplantation tolerance that have been developed through the use of experimental models...
  2. pmc B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naïve B cells
    S Heidt
    Transplant Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
    Am J Transplant 12:1784-92. 2012
    ..In conclusion, induction therapy with alemtuzumab results in a long-term shift toward naïve B cells with altered phenotypic and functional characteristics...
  3. pmc Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
    J Hester
    Nuffield Department of Surgical Sciences, Transplantation Research Immunology Group, University of Oxford, UK
    Am J Transplant 12:2008-16. 2012
    ..By inhibiting TA, T(reg) and rapamycin may prevent chronic transplant dysfunction and improve long-term allograft survival...
  4. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
    ..We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy...
  5. pmc Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model
    Fadi Issa
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford
    PLoS ONE 7:e53331. 2012
    ..Our findings highlight the importance of the careful selection of an effective subpopulation of Treg for clinical use according to the pathology of interest...
  6. pmc Ischemia-reperfusion injury accelerates human antibody-mediated transplant vasculopathy
    Ryoichi Goto
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Transplantation 96:139-45. 2013
    ..The pathogenesis of transplant vasculopathy (TV) is a multifactorial process. We hypothesized that ischemia-reperfusion injury and antibody-mediated damage contribute to the development of TV...
  7. pmc Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model
    Douglas C Wu
    1 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK 2 Currently, Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland 3 Address correspondence to Professor Kathryn J Wood, D Phil, Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Transplantation 96:707-16. 2013
    ..Here, we evaluated the ability of ex vivo expanded human Treg to prevent the rejection of islets of Langerhans in a humanized mouse model and examined the mechanisms involved...
  8. doi request reprint Regulatory immune cells in transplantation
    Kathryn J Wood
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Immunol 12:417-30. 2012
    ..We consider the potential of these regulatory immune cells to develop and function in transplant recipients and their potential use as cellular therapies to promote long-term graft function...
  9. pmc T regulatory cells and the control of alloimmunity: from characterisation to clinical application
    Joanna Wieckiewicz
    Transplant Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
    Curr Opin Immunol 22:662-8. 2010
    ..Nevertheless, pre-clinical and pilot clinical trials using Treg cells as cellular therapies have been initiated suggesting the safety and feasibility of such treatment...
  10. pmc Regulatory T cells in transplantation
    K J Wood
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Transplant Proc 43:2135-6. 2011
    ..Preclinical attempts to use Treg as a cellular therapy have been successfully undertaken demonstrating the safety and feasibility of such treatment, suggesting that they have therapeutic potential...
  11. ncbi request reprint Embryonic stem cells and their differentiated derivatives have a fragile immune privilege but still represent novel targets of immune attack
    Douglas C Wu
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Stem Cells 26:1939-50. 2008
    ..These findings provide insight into the mechanisms of adaptive immunity toward ESCs and their derivatives. Disclosure of potential conflicts of interest is found at the end of this article...
  12. ncbi request reprint Regulatory T cells in transplantation tolerance
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Nat Rev Immunol 3:199-210. 2003
    ....
  13. ncbi request reprint Interferon gamma: friend or foe?
    Kathryn J Wood
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Transplantation 84:S4-5. 2007
    ..Moreover, addition of IFN-gamma to cocultures of T cells and APCs can drive the generation of T cells with regulatory activity. Thus, the influence of IFN-gamma on the immune response to a transplant is likely to be context dependent...
  14. ncbi request reprint Passenger leukocytes and microchimerism: what role in tolerance induction?
    Kathryn J Wood
    Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, United Kingdom
    Transplantation 75:17S-20S. 2003
    ....
  15. ncbi request reprint The transplantation society: Building on success
    Kathryn J Wood
    Transplantation 82:1566-70. 2006
  16. ncbi request reprint Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo
    Kathryn J Wood
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK OX3 9DU
    Trends Immunol 27:183-7. 2006
    ....
  17. ncbi request reprint Is B cell tolerance essential for transplantation tolerance?
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, UK
    Transplantation 79:S40-2. 2005
    ..This overview forms part of a debate discussing the potential role of B cell tolerance in transplantation and uses selected examples in the literature to address the question: is B cell tolerance essential for transplantation tolerance?..
  18. pmc Alloantigen-induced specific immunological unresponsiveness
    K J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Philos Trans R Soc Lond B Biol Sci 356:665-80. 2001
    ....
  19. ncbi request reprint Regulatory T cells: potential in organ transplantation
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom
    Transplantation 77:S6-8. 2004
    ....
  20. ncbi request reprint Gene therapy in transplantation
    K J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, UK
    Curr Opin Mol Ther 3:390-8. 2001
    ..Gene transfer to stem cells may eventually lead to accelerated tissue repair and regeneration. In addition, xenotransplantation and organ cloning techniques have the potential to resolve the current shortage of donor organs...
  21. ncbi request reprint Gene therapy and allotransplantation
    K J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, UK
    Curr Opin Immunol 9:662-8. 1997
    ..Any of these options offers many advantages over the systemic delivery of immunosuppressive agents currently employed in transplantation...
  22. doi request reprint Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells
    Kathryn J Wood
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Immunol Rev 241:119-32. 2011
    ..Findings from laboratory studies are informing the design of clinical protocols using regulatory T cells as a cellular therapy...
  23. ncbi request reprint CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection
    N D Jones
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 165:1111-8. 2000
    ..We conclude that CD40L is not an important costimulatory molecule for CD8+ T cell activation and that following transplantation donor APC can activate recipient CD8+ T cells directly without first being primed by CD4+ T cells...
  24. ncbi request reprint IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    M Hara
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:3789-96. 2001
    ....
  25. ncbi request reprint Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection
    N D Jones
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:2824-30. 2001
    ....
  26. ncbi request reprint Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulation
    S M Ensminger
    Nuffield Departments of Surgery and Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 167:532-41. 2001
    ..In conclusion, elevated intragraft IL-4 production results in an eosinophil infiltrate and is an important mechanism for CD8(+) T cell-independent transplant arteriosclerosis in the absence of CD40-CD154 costimulation...
  27. ncbi request reprint Semi-allogeneic (F1) versus fully allogeneic blood transfusions: differences in their ability to induce specific immunological unresponsiveness
    D L Roelen
    University of Oxford, Nuffield Department of Surgery, John Radcliffe Hospital, Headington, GB
    Eur J Immunol 26:1468-74. 1996
    ..These findings may be explained by the sharing of MHC antigens between recipient and transfusion donor...
  28. ncbi request reprint Adenoviral transfer of a single donor-specific MHC class I gene to recipient bone marrow cells can induce specific immunological unresponsiveness in vivo
    J W Fry
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Gene Ther 9:220-6. 2002
    ..In addition, detectable microchimerism is not a prerequisite for graft survival...
  29. pmc Bystander activation of iNKT cells occurs during conventional T-cell alloresponses
    J P Jukes
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Am J Transplant 12:590-9. 2012
    ....
  30. pmc IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells
    B Wei
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Am J Transplant 10:69-80. 2010
    ..Overall, these findings suggest that the IFN-gamma-induced STAT1-PKB/AKT signaling pathway plays a key role in upregulating the ability of alloantigen reactive Tregs to control graft rejection in vivo...
  31. ncbi request reprint Homeostatic repopulation by CD28-CD8+ T cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression
    P Trzonkowski
    Transplantation Research Immunology Group and Oxford Transplant Centre, Nuffield Department of Surgery, University of Oxford, UK
    Am J Transplant 8:338-47. 2008
    ..This delay might be associated with the clinical outcome as CD4(+) T cells, notably CD4(+) T effector memory cells, were shown to be associated with rejection...
  32. ncbi request reprint Genetic aspects of the blood transfusion effect
    W N Peugh
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, England
    Transplantation 46:438-43. 1988
    ..This may be the means by which blood from randomly selected donors has a beneficial effect on graft survival in clinical transplantation...
  33. ncbi request reprint Suppression mediated by anergic CD4+ T cells requires stimulation by MHC-peptide complexes and can be induced in the presence of costimulation
    O Witzke
    Nuffield Department of Surgery, John Radcliffe Hospital, Headington, University of Oxford, Oxford OX3 9DU, United Kingdom
    Transplantation 72:369-76. 2001
    ....
  34. ncbi request reprint Enumeration of human alloreactive helper T lymphocyte precursor frequencies by limiting dilution analysis of interleukin-2 production
    N T Young
    Nuffield Department of Surgery, University of Oxford, UK
    J Immunol Methods 195:33-41. 1996
    ....
  35. ncbi request reprint Nondepleting anti-CD4 antibodies in transplantation. Evidence that modulation is far less effective than prolonged CD4 blockade
    C R Darby
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom
    Transplantation 57:1419-26. 1994
    ....
  36. ncbi request reprint Altered proximal T-cell receptor signalling events in mouse CD4+ T cells in the presence of anti-CD4 monoclonal antibodies: evidence for reduced phosphorylation of Zap-70 and LAT
    C E Pullar
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Scand J Immunol 57:333-41. 2003
    ....
  37. ncbi request reprint The relative roles of major and minor histocompatibility antigens in the induction of immunologic unresponsiveness by blood transfusion
    R L Quigley
    Nuffield Department of Surgery, Oxford University, John Radcliffe Hospital, Headington, England
    Transfusion 29:789-93. 1989
    ....
  38. ncbi request reprint Genomic analysis identifies class II mismatches in serologically DR-compatible human renal allografts
    A Bushell
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Hum Immunol 23:191-206. 1988
    ....
  39. ncbi request reprint The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo
    M Niimi
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, United Kingdom
    J Immunol 161:5331-7. 1998
    ....
  40. ncbi request reprint Primary alloreactive cytotoxic T-lymphocytes are not commonly restricted by self-HLA class I antigens
    N T Young
    Nuffield Department of Surgery, University of Oxford, United Kingdom
    Hum Immunol 50:38-46. 1996
    ..Our results confirm the role of Class II antigens in the indirect presentation of alloantigen in vitro but suggest that HLA Class I antigens play a limited role in this phenomenon...
  41. pmc Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells
    R Goto
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Transplant 13:1655-64. 2013
    ..Delaying administration effectively inhibits the alloreactivity and promotes the dominance of intragraft Foxp3(+) T cells allowing long-term graft acceptance...
  42. ncbi request reprint GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function
    A Bushell
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Am J Transplant 7:759-68. 2007
    ....
  43. ncbi request reprint Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning
    S C Juvet
    Nuffield Department of Surgical Sciences, Transplantation Research Immunology Group, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Transplant 14:750-63. 2014
    ..We conclude by discussing the critical unanswered questions that face this field in the coming years. ..
  44. doi request reprint Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection
    Ulrich Steger
    Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, England
    Transplantation 85:1339-47. 2008
    ..The precise role that CD8+ T cells play in the rejection and acceptance of different types of allograft is unclear and has been shown to vary between donor-recipient combinations...
  45. ncbi request reprint Platelet-endothelial cell adhesion molecule-1 (CD31) expression on donor endothelial cells attenuates the development of transplant arteriosclerosis
    Stephan M Ensminger
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Transplantation 74:1267-73. 2002
    ....
  46. doi request reprint Investigation into the onset and progression of transplant arteriosclerosis in a mice aortic retransplantation model
    Ulrich Steger
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Microsurgery 28:182-6. 2008
    ..However our data demonstrate that development of chronic rejection can be inhibited, in this case by retransplantation into a syngeneic host...
  47. ncbi request reprint Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells
    Manuela Carvalho-Gaspar
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Immunol 180:6640-8. 2008
    ....
  48. ncbi request reprint A comparison of protocols used to generate insulin-producing cell clusters from mouse embryonic stem cells
    Ashleigh S Boyd
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Stem Cells 26:1128-37. 2008
    ..Further modifications to differentiation protocols will be essential to improve the generation of functional IPCCs from mouse ESCs...
  49. ncbi request reprint Syngeneic bone marrow transduced with a recombinant retroviral vector to express endoplasmic reticulum signal-sequence-deleted major histocompatibility complex class-I alloantigen can induce specific immunologic unresponsiveness in vivo
    Bernd M Spriewald
    Medical Department III, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Transplantation 75:537-41. 2003
    ..CONCLUSION Cell surface expression, and therefore direct recognition, of an MHC class I alloantigen is not required to induce long-term survival of fully allogeneic cardiac grafts after retroviral transduction of recipient BMCs...
  50. ncbi request reprint Retroviral transfer of donor MHC class I or MHC class II genes into recipient bone marrow cells can induce operational tolerance to alloantigens in vivo
    Wilson Wong
    Department of Nephrology and Transplantation, Guy s Hospital, London SE1 9RT, United Kingdom
    Hum Gene Ther 14:577-90. 2003
    ..These results have important implications for future strategies to enhance clinical allograft survival by delivery of donor alloantigens...
  51. pmc Allograft rejection mediated by memory T cells is resistant to regulation
    Jaeseok Yang
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 104:19954-9. 2007
    ....
  52. ncbi request reprint Interleukin-23 and TH17 cells in transplantation immunity: does 23+17 equal rejection?
    Ye Chen
    Transplant Research Immunology Group, Nuffield Department of Surgery, University of Oxford, UK
    Transplantation 84:1071-4. 2007
    ..This review will discuss current understanding of T-cell subsets in transplantation immunity and will explore the role of IL-23 and Th17 cells in allograft rejection, tolerance, and ischemia reperfusion injury...
  53. ncbi request reprint Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy
    Gang Feng
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Transplantation 86:578-89. 2008
    ..We have used adoptive transfer skin and islet allograft models to identify, develop and evaluate ex vivo protocols that generate donor-reactive, adaptive Treg...
  54. ncbi request reprint Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy
    Andre van van Maurik
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Immunol 169:5401-4. 2002
    ....
  55. ncbi request reprint CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    Cherry I Kingsley
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Immunol 168:1080-6. 2002
    ..In clinical transplantation, the generation of regulatory T cells that could provide dynamic control of rejection responses is a possible route to permanent graft survival without the need for long-term immunosuppression...
  56. ncbi request reprint Which donor cells facilitate the induction of specific immunological unresponsiveness to alloantigens in vivo?
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Transplantation 73:S16-8. 2002
    ....
  57. ncbi request reprint Indirect allorecognition can play an important role in the development of transplant arteriosclerosis
    Stephan M Ensminger
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Transplantation 73:279-86. 2002
    ..Our aim was to develop an animal model that allowed the contribution of the direct and indirect pathway of allorecognition in the evolution of transplant arteriosclerosis, the main feature of chronic allograft rejection, to be evaluated...
  58. ncbi request reprint Kinetics of transplant arteriosclerosis in MHC-Class I mismatched and fully allogeneic mouse aortic allografts
    Stephan M Ensminger
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Transplantation 73:1068-74. 2002
    ..The aim of our study was to investigate the impact of MHC disparity on the kinetics of the development of transplant arteriosclerosis...
  59. ncbi request reprint The role of the graft in establishing tolerance
    Mahzuz Karim
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Front Biosci 7:e129-54. 2002
    ..There is evidence that the graft itself may play an active part in establishing and maintaining donor-specific hyporesponsiveness and ultimately tolerance; the aim of this review is to analyze this role in more detail...
  60. ncbi request reprint Regulatory T cells in transplantation
    Mahzuz Karim
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DU, UK
    Curr Opin Immunol 14:584-91. 2002
    ..Such cells have now been identified in humans as well as in rodents...
  61. ncbi request reprint Spleen plays an important role in maintaining tolerance after removal of the vascularized heart graft
    Eiichi Chosa
    Department of Surgery II, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Transplantation 83:1226-33. 2007
    ..This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues...
  62. ncbi request reprint Linked unresponsiveness: early cytokine gene expression profiles in cardiac allografts following pretreatment of recipients with bone marrow cells expressing donor MHC alloantigen
    Bernd M Spriewald
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Cytokine 19:6-13. 2002
    ..In summary, the early cytokine expression pattern in allografts after bone marrow induced operational tolerance is influenced by the quantity of donor alloantigens expressed on the graft as well as on the bone marrow inoculum...
  63. ncbi request reprint Impact of both donor and recipient strains on cardiac allograft survival after blockade of the CD40-CD154 costimulatory pathway
    Andre van Maurik
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, UK
    Transplantation 74:740-3. 2002
    ..In this report, we examined the impact of the donor and the recipient strains on the success of CD40-CD154 blockade...
  64. ncbi request reprint Natural killer T cells: a bridge to tolerance or a pathway to rejection?
    John Paul Jukes
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Transplantation 84:679-81. 2007
    ..In this review, the potential role of NKT cells in transplantation will be discussed, particularly their role in rejection and the induction of a state of tolerance...
  65. ncbi request reprint An investigation to assess the potential of CD25highCD4+ T cells to regulate responses to donor alloantigens in clinically stable renal transplant recipients
    Ahmed Akl
    Urology and Nephrology Center, Mansoura University, Mansoura, Egypt
    Transpl Int 21:65-73. 2008
    ....
  66. ncbi request reprint Understanding FOXP3: progress towards achieving transplantation tolerance
    Elaine Long
    Transplant Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Transplantation 84:459-61. 2007
    ..Recent observations have identified forkhead box P3 (FOXP3) as a master gene required for the development and function of Treg. Improving our understanding of FOXP3 may facilitate methods for identifying and generating Treg...
  67. ncbi request reprint Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help
    Nick D Jones
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, UK
    J Immunol 176:2316-23. 2006
    ....
  68. ncbi request reprint Transplanting stem cells: potential targets for immune attack. Modulating the immune response against embryonic stem cell transplantation
    Ashleigh S Boyd
    Transplantation Research Immunology Group, Nuffield Department of Surgery, Level 6 John Radcliffe Hospital, Room 6810, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Adv Drug Deliv Rev 57:1944-69. 2005
    ..This review will focus on the potential mechanisms that the immune system could use to target ES cell-derived transplants and how unwanted responses might be prevented...
  69. ncbi request reprint Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade
    Matthew O Brook
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom
    Transplantation 80:253-4. 2005
  70. ncbi request reprint Increased expression of transforming growth factor-beta and eosinophil infiltration is associated with the development of transplant arteriosclerosis in long-term surviving cardiac allografts
    Bernd M Spriewald
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom
    Transplantation 76:1105-11. 2003
    ..This study investigated the impact of three different protocols capable of inducing long-term allograft survival on the development of transplant arteriosclerosis and immune response in cardiac allografts...
  71. ncbi request reprint Induction of transplantation tolerance-the potential of regulatory T cells
    Ahmed Akl
    Nuffield Department of Surgery, The John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
    Transpl Immunol 14:225-30. 2005
    ..Intensive investigation of these cells in recent years has started to uncover the mechanisms of active suppression by regulatory T cells in this setting...
  72. pmc IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
    Birgit Sawitzki
    Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, England, UK
    J Exp Med 201:1925-35. 2005
    ..These data support a unique role for IFN-gamma in the functional activity of alloantigen-reactive T reg cells during the development of operational tolerance to donor alloantigens in vivo...
  73. ncbi request reprint CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation
    Mahzuz Karim
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    Blood 105:4871-7. 2005
    ....
  74. ncbi request reprint Regulatory cells in transplantation
    Kathryn J Wood
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Novartis Found Symp 252:177-88; discussion 188-93, 203-10. 2003
    ....
  75. ncbi request reprint Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation
    Ying Li
    Department of Transplantation and Immunology, Horizontal Medical Research Organization, Transplant Tolerance Unit, Kyoto University, Faculty of Medicine, Kyoto, Japan
    Am J Transplant 4:2118-25. 2004
    ..Although the contribution of those subsets to the tolerant state remains elusive, the results may provide important clues for reliable indicators of tolerance after LDLT...
  76. ncbi request reprint Transplantation tolerance by donor MHC gene transfer
    Wilson Wong
    Department of Nephrology and Transplantation, Guy s Hospital, London SE1 9RT, UK
    Curr Gene Ther 4:329-36. 2004
    ....
  77. ncbi request reprint Intrathymic delivery of plasmid-encoding endoplasmic reticulum signal-sequence-deleted MHC class I alloantigen can induce long-term allograft survival
    Bernd M Spriewald
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Transpl Int 17:458-62. 2004
    ..These data show that direct allorecognition of the tolerogen was not required for the induction of long-term allograft survival following the introduction of plasmid-encoded MHC alloantigen into the thymus...
  78. ncbi request reprint Dependency of direct pathway CD4+ T cells on CD40-CD154 costimulation is determined by nature and microenvironment of primary contact with alloantigen
    Andre van Maurik
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 172:2163-70. 2004
    ..Taken together, these results clearly demonstrate that naive alloreactive CD4(+) T cells have distinct requirements for CD40-CD154 costimulation depending on the form and microenvironment of primary alloantigen contact...
  79. ncbi request reprint Pretransplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: a potential explanation for the blood-transfusion effect
    Andrew Bushell
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Transplantation 76:449-55. 2003
    ....
  80. ncbi request reprint The impact of memory T cells on rejection and the induction of tolerance
    Matthew O Brook
    Transplantation 82:1-9. 2006
    ..A clearer understanding of how Tm function and their requirements to mount an effective response to alloantigen will be key to further attempts to translate tolerance induction protocols from the experimental setting to the clinic...
  81. ncbi request reprint CD25+CD4+ regulatory T cells develop in mice not only during spontaneous acceptance of liver allografts but also after acute allograft rejection
    Ulrich Steger
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Transplantation 82:1202-9. 2006
    ..Here, we investigated whether liver allograft acceptance is characterized by, and depends upon, the presence of donor reactive CD25CD4 regulatory T cells...
  82. ncbi request reprint In vivo models of inflammation: immune rejection and skin transplantation in vivo
    Isabelle Binet
    University Hospital of Geneva, Switzerland
    Methods Mol Biol 225:239-48. 2003
  83. ncbi request reprint Dependency of the trans vivo delayed type hypersensitivity response on the action of regulatory T cells: implications for monitoring transplant tolerance
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Transplantation 84:392-9. 2007
    ..Here we tested the hypothesis that the assay can reveal control of allograft rejection by CD25CD4 regulatory T cells (Treg)...
  84. ncbi request reprint Mouse endothelial CD40 expression does not play a role during the development of transplant arteriosclerosis
    Stephan M Ensminger
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Endothelium 10:111-7. 2003
    ..Therefore, in contrast to rat or human ECs, CD40 expression by mouse ECs does not seem to play a major role in this form of allograft rejection...
  85. ncbi request reprint Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivo
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Transplantation 83:1459-65. 2007
    ..CD25+CD4+ regulatory T cells have been shown to suppress alloimmunity in various experimental settings. Here, we hypothesized that alloantigen-reactive regulatory T cells would reduce the severity of transplant arteriosclerosis...
  86. pmc Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection
    Vanessa Oliveira
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 38:1677-88. 2008
    ..This study shows that alloantigen stimulation in the presence of anti-CD4 in vitro provides a simple and effective strategy to generate alloreactive Treg...
  87. ncbi request reprint Regulatory T cells--a journey from rodents to the clinic
    Elaine T Long
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Front Biosci 12:4042-9. 2007
    ..This review will focus on how rodent experimental models have helped us to figure out how Tregs could be induced in humans and harnessed to enable long-term transplant acceptance...
  88. ncbi request reprint Impact of hepatic rearterialization on reperfusion injury and outcome after mouse liver transplantation
    Ulrich Steger
    Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, England
    Transplantation 76:327-32. 2003
    ..The aim of the current study was to investigate the impact of arterial reconstruction on long-term graft survival, histologic alterations, ischemic liver damage, and early immunologic activation pathways...
  89. ncbi request reprint Recipient memory-like lymphocytes remain unresponsive to graft antigens after CAMPATH-1H induction with reduced maintenance immunosuppression
    Piotr Trzonkowski
    Transplantation Research Immunology Group and Oxford Transplant Centre, Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom
    Transplantation 82:1342-51. 2006
    ..Treatment with CAMPATH-1H at the time of transplantation allows reduced maintenance immunosuppression. We hypothesized that CAMPATH-1H induction would modulate the response of repopulating leukocytes to donor alloantigens...
  90. ncbi request reprint Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process
    Mahzuz Karim
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Immunol 172:923-8. 2004
    ..These observations may have important implications for the design of protocols, both experimental and clinical, for the induction of tolerance to autoantigens or alloantigens in adults with limited thymic function...
  91. ncbi request reprint Chemokine gene expression during allograft rejection: comparison of two quantitative PCR techniques
    Manuela Carvalho-Gaspar
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, OX3 9 DU United Kingdom
    J Immunol Methods 301:41-52. 2005
    ....
  92. ncbi request reprint Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
    Takaaki Koshiba
    Department of Transplantation and Immunology, Horizontal Medical Research Organization, Faculty of Medicine, Kyoto University, 54 Kawaramachi Shogoin, Sakyo ku, Kyoto City 606 8507, Japan
    Transpl Immunol 17:94-7. 2007
    ..This warrants serial protocol biopsy before and after complete cessation of immunosuppression even in the presence of normal liver function...
  93. ncbi request reprint Increased transplant arteriosclerosis in the absence of CCR7 is associated with reduced expression of Foxp3
    Stephan M Ensminger
    Department of Cardiac Surgery, Friedrich Alexander University Erlangen Nuernberg, Germany
    Transplantation 86:590-600. 2008
    ..In this study, we report an important role for chemokine receptor CCR7 in the development of transplant arteriosclerosis...
  94. pmc Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells
    Gang Feng
    Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 38:2512-27. 2008
    ....