Jonathan D Wood

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. doi request reprint Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain
    Jonathan D Wood
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2RX, UK
    Hum Mol Genet 18:391-404. 2009
  2. pmc Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia
    Richard Butler
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Dis Model Mech 3:743-51. 2010
  3. ncbi request reprint Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients
    Paul R Kasher
    Academic Neurology Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Neurochem 110:34-44. 2009
  4. ncbi request reprint The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo
    Jonathan D Wood
    MRC Centre Development for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, UK
    Hum Mol Genet 15:2763-71. 2006

Collaborators

Detail Information

Publications4

  1. doi request reprint Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain
    Jonathan D Wood
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2RX, UK
    Hum Mol Genet 18:391-404. 2009
    ..GenBank accession number for Danio rerio disc1: EU273350...
  2. pmc Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia
    Richard Butler
    MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Dis Model Mech 3:743-51. 2010
    ..Thus, disruption of microtubule dynamics might underlie neuronal dysfunction in this model, and this system could be used to identify compounds that modulate microtubule dynamics, some of which might have therapeutic potential in HSP...
  3. ncbi request reprint Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients
    Paul R Kasher
    Academic Neurology Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Neurochem 110:34-44. 2009
    ..These results strongly support a direct role for defective axonal transport in the pathogenesis of HSP because of spastin mutation...
  4. ncbi request reprint The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo
    Jonathan D Wood
    MRC Centre Development for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, UK
    Hum Mol Genet 15:2763-71. 2006
    ..Taken together with other recent studies, our findings suggest that axon outgrowth defects may be a common feature of childhood SPG3A and SPG4 cases...