I Stuart Wood

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, UK
    Br J Nutr 89:3-9. 2003
  2. ncbi request reprint Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 308:43-9. 2003
  3. doi request reprint Cellular hypoxia and adipose tissue dysfunction in obesity
    I Stuart Wood
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Proc Nutr Soc 68:370-7. 2009
  4. doi request reprint Modulation of adipokine production, glucose uptake and lactate release in human adipocytes by small changes in oxygen tension
    I Stuart Wood
    Obesity Biology Research Unit, Institute of Ageing and Chronic Diseases, University of Liverpool, Duncan Building, Liverpool, UK
    Pflugers Arch 462:469-77. 2011
  5. doi request reprint Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes
    Bohan Wang
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    J Endocrinol 198:127-34. 2008
  6. doi request reprint Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes
    Fátima Pérez de Heredia
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Pflugers Arch 459:509-18. 2010
  7. doi request reprint Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, University Clinical Department, Duncan Building, Liverpool L69 3GA, UK
    Br J Nutr 100:227-35. 2008
  8. doi request reprint Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFalpha
    Vivien H Ryan
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, L69 3GA, UK
    Pflugers Arch 460:603-16. 2010
  9. doi request reprint Obesity, its associated disorders and the role of inflammatory adipokines in companion animals
    Alexander J German
    School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK
    Vet J 185:4-9. 2010
  10. ncbi request reprint Hypoxia and the endocrine and signalling role of white adipose tissue
    Paul Trayhurn
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Liverpool, UK
    Arch Physiol Biochem 114:267-76. 2008

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, UK
    Br J Nutr 89:3-9. 2003
    ....
  2. ncbi request reprint Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 308:43-9. 2003
    ..Both GLUT-10 and GLUT-12 expression was also found in human adipose tissue (subcutaneous and omental) and SGBS adipocytes. It is concluded that white fat expresses a wide range of facilitative glucose transporters...
  3. doi request reprint Cellular hypoxia and adipose tissue dysfunction in obesity
    I Stuart Wood
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Proc Nutr Soc 68:370-7. 2009
    ....
  4. doi request reprint Modulation of adipokine production, glucose uptake and lactate release in human adipocytes by small changes in oxygen tension
    I Stuart Wood
    Obesity Biology Research Unit, Institute of Ageing and Chronic Diseases, University of Liverpool, Duncan Building, Liverpool, UK
    Pflugers Arch 462:469-77. 2011
    ..Adipocytes are sensitive to small changes in O₂ tension...
  5. doi request reprint Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes
    Bohan Wang
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    J Endocrinol 198:127-34. 2008
    ..Preadipocytes and adipocytes differ in their responsiveness to low O(2) tension, maturation of the response to hypoxia developing on differentiation...
  6. doi request reprint Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes
    Fátima Pérez de Heredia
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Pflugers Arch 459:509-18. 2010
    ..Increased lactate production and monocarboxylate transporter expression are likely to be key components of the adaptive response of adipocytes to low O(2) tension as adipose tissue mass expands in obesity...
  7. doi request reprint Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, University Clinical Department, Duncan Building, Liverpool L69 3GA, UK
    Br J Nutr 100:227-35. 2008
    ....
  8. doi request reprint Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFalpha
    Vivien H Ryan
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, L69 3GA, UK
    Pflugers Arch 460:603-16. 2010
    ....
  9. doi request reprint Obesity, its associated disorders and the role of inflammatory adipokines in companion animals
    Alexander J German
    School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK
    Vet J 185:4-9. 2010
    ....
  10. ncbi request reprint Hypoxia and the endocrine and signalling role of white adipose tissue
    Paul Trayhurn
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Liverpool, UK
    Arch Physiol Biochem 114:267-76. 2008
    ..Hypoxia also stimulates glucose transport by adipocytes and may have a pervasive effect on cell function within adipose tissue...
  11. ncbi request reprint The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFalpha in human adipocytes
    I Stuart Wood
    Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, University Clinical Departments, UK
    Biochem Biophys Res Commun 337:422-9. 2005
    ..IL-18 may be part of the inflammatory cascade within adipose tissue; however, human adipocytes do not appear to secrete significant amounts of IL-18...
  12. doi request reprint IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
    I Stuart Wood
    University Clinical Department, Obesity Biology Research Unit, School of Clinical Sciences, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK
    Biochem Biophys Res Commun 384:105-9. 2009
    ..Human adipocytes and preadipocytes express IL-33, but the various IL-1 family members exhibit major differences in responsiveness to TNFalpha...
  13. ncbi request reprint Adipose tissue and adipokines--energy regulation from the human perspective
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    J Nutr 136:1935S-1939S. 2006
    ..Although the focus remains very much on obesity in humans, the disorder and its sequelae are also a growing concern in companion animals...
  14. pmc PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes
    Bohan Wang
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 368:88-93. 2008
    ..MT-3 is a highly hypoxia-inducible gene in human adipocytes; the protein may protect adipocytes from hypoxic damage...
  15. pmc Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes
    I Stuart Wood
    Obesity Biology Unit, School of Clinical Sciences, University Clinical Departments, Royal Liverpool University Hospital, University of Liverpool, UK
    Biochem Biophys Res Commun 361:468-73. 2007
    ..4-fold) which was blocked by cytochalasin B. These results indicate that hypoxia increases monosaccharide uptake capacity in human adipocytes; this may contribute to adipose tissue dysregulation in obesity...
  16. pmc Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
    Bohan Wang
    Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University Clinical Departments, University of Liverpool, Liverpool, UK
    Pflugers Arch 455:479-92. 2007
    ..Hypoxia may underlie the development of the inflammatory response in adipocytes, leading to obesity-associated diseases...
  17. ncbi request reprint Adipokines: inflammation and the pleiotropic role of white adipose tissue
    Paul Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Br J Nutr 92:347-55. 2004
    ....
  18. ncbi request reprint Comment on: Hosagai et al. (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation: Diabetes 56:901-911
    Paul Trayhurn
    Diabetes 56:e14. 2007