Adrian J Wolstenholme

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. ncbi Drug resistance in veterinary helminths
    Adrian J Wolstenholme
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Trends Parasitol 20:469-76. 2004
  2. pmc Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans
    Susan K Glendinning
    Departmenty of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 6:e22390. 2011
  3. ncbi The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: a comparison with Caenorhabditis elegans
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Invert Neurosci 7:219-26. 2007
  4. pmc Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes
    Hayley M Bennett
    Department of Infectious Diseases and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    J Neurochem 123:911-8. 2012
  5. ncbi The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, BA2 7AY, Bath, UK
    Int J Parasitol 33:1183-93. 2003
  6. doi FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways
    Ying Feng
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, U K
    Biochem J 456:219-29. 2013
  7. pmc An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus
    Samantha McCavera
    Dept of Biology and Biochemistry, University of Bath, UK
    Mol Pharmacol 75:1347-55. 2009
  8. ncbi An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Int J Parasitol 34:1075-81. 2004
  9. ncbi Distribution of glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus
    Virginia Portillo
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Comp Neurol 462:213-22. 2003
  10. pmc The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 5:e1000517. 2009

Collaborators

  • David B Sattelle
  • Georg von Samson-Himmelstjerna
  • Steven D Buckingham
  • Darran M Yates
  • Sally M Williamson
  • Ying Feng
  • Hayley M Bennett
  • Susan Wonnacott
  • Susan K Glendinning
  • Virginia Portillo
  • Debra J Woods
  • Samantha McCavera
  • Mladen Iovchev
  • Francoise Koumanov
  • Barnabas G Williams
  • Geoffrey D Holman
  • Kristin Lees
  • Andrew K Jones
  • Kate M Harper
  • Tracey Williams
  • Laurence Brown
  • Alan P Robertson
  • Richard J Martin
  • Adrian T Rogers
  • Thomas K Walsh
  • Suchitra Jagannathan
  • William L Pak
  • Plamen Kodrov
  • Eugene P Semenov

Detail Information

Publications12

  1. ncbi Drug resistance in veterinary helminths
    Adrian J Wolstenholme
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Trends Parasitol 20:469-76. 2004
    ..This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area...
  2. pmc Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans
    Susan K Glendinning
    Departmenty of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 6:e22390. 2011
    ..elegans, though some quantitative differences were observed between transgenic lines in some assays. C. elegans is a suitable system for studying parasitic nematode genes that may be involved in drug resistance...
  3. ncbi The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: a comparison with Caenorhabditis elegans
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Invert Neurosci 7:219-26. 2007
    ..malayi and T. spiralis, suggesting that care must be taken when using C. elegans as a model organism for distantly related nematodes...
  4. pmc Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes
    Hayley M Bennett
    Department of Infectious Diseases and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    J Neurochem 123:911-8. 2012
    ..This provides further evidence for a species-specific component of RIC-3 activity, and suggests that X. laevis RIC-3 is useful for enhancing the expression of invertebrate nAChRs in X. laevis oocytes...
  5. ncbi The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, BA2 7AY, Bath, UK
    Int J Parasitol 33:1183-93. 2003
    ....
  6. doi FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways
    Ying Feng
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, U K
    Biochem J 456:219-29. 2013
    ..We propose that fgt-1 constitutes a common axis for the lifespan extending effects of nutrient restriction and reduced insulin-like peptide signalling...
  7. pmc An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus
    Samantha McCavera
    Dept of Biology and Biochemistry, University of Bath, UK
    Mol Pharmacol 75:1347-55. 2009
    ....
  8. ncbi An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Int J Parasitol 34:1075-81. 2004
    ..Oocytes injected with DiGluClalpha3A cRNA failed to respond to L-glutamate. The qualitative responses obtained were consistent with the pharmacology observed for the GluClalpha3 subunits from C. elegans and H. contortus...
  9. ncbi Distribution of glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus
    Virginia Portillo
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Comp Neurol 462:213-22. 2003
    ..They also provide an explanation for the observed effects of the A/M anthelmintics...
  10. pmc The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 5:e1000517. 2009
    ..In vitro expression of these subunits may permit the development of parasite-specific screens for future anthelmintics...
  11. ncbi Frontiers in parasite neurobiology: parasite genomics, neural signalling and new targets for control
    Adrian J Wolstenholme
    Invert Neurosci 7:179-81. 2007
  12. ncbi Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel
    Mladen Iovchev
    Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    J Neurogenet 16:249-61. 2002
    ..They also provide new evidence for a function in the response to diethylether anaesthesia and, moreover, that HCLA function is not limited to the visual system...