Adrian J Wolstenholme

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. ncbi Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics
    A J Wolstenholme
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Parasitology 131:S85-95. 2005
  2. ncbi The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: a comparison with Caenorhabditis elegans
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Invert Neurosci 7:219-26. 2007
  3. pmc An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus
    Samantha McCavera
    Dept of Biology and Biochemistry, University of Bath, UK
    Mol Pharmacol 75:1347-55. 2009
  4. pmc The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 5:e1000517. 2009
  5. pmc Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans
    Susan K Glendinning
    Departmenty of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 6:e22390. 2011
  6. ncbi The TRP channel superfamily: insights into how structure, protein-lipid interactions and localization influence function
    B J Reaves
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Biochem Soc Trans 35:77-80. 2007
  7. pmc FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways
    Ying Feng
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, U K
    Biochem J 456:219-29. 2013
  8. ncbi Dirofilaria immitis: identification of a novel ligand-gated ion channel-related polypeptide
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Exp Parasitol 108:182-5. 2004
  9. ncbi The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, BA2 7AY, Bath, UK
    Int J Parasitol 33:1183-93. 2003
  10. ncbi An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Int J Parasitol 34:1075-81. 2004

Collaborators

  • B J Reaves
  • David B Sattelle
  • Francoise Koumanov
  • Georg von Samson-Himmelstjerna
  • Steven D Buckingham
  • Frank Jackson
  • Andrew K Jones
  • Darran M Yates
  • Sally M Williamson
  • Thomas K Walsh
  • Ying Feng
  • Hayley M Bennett
  • Susan Wonnacott
  • Susan K Glendinning
  • Virginia Portillo
  • Debra J Woods
  • Samantha McCavera
  • S McCavera
  • Sabina Alam
  • Mladen Iovchev
  • Barnabas G Williams
  • Geoffrey D Holman
  • Kristin Lees
  • C L Cheeseman
  • L Horoszok
  • Kate M Harper
  • Tracey Williams
  • Laurence Brown
  • Alan P Robertson
  • Richard J Martin
  • Adrian T Rogers
  • Philip Skuce
  • T K Walsh
  • Alison A Donnan
  • David L Laughton
  • Andrew Walding
  • Suchitra Jagannathan
  • William L Pak
  • Plamen Kodrov
  • Eugene P Semenov
  • D J Woods
  • V Raymond
  • N S Delany

Detail Information

Publications20

  1. ncbi Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics
    A J Wolstenholme
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Parasitology 131:S85-95. 2005
    ....
  2. ncbi The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: a comparison with Caenorhabditis elegans
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Invert Neurosci 7:219-26. 2007
    ..malayi and T. spiralis, suggesting that care must be taken when using C. elegans as a model organism for distantly related nematodes...
  3. pmc An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus
    Samantha McCavera
    Dept of Biology and Biochemistry, University of Bath, UK
    Mol Pharmacol 75:1347-55. 2009
    ....
  4. pmc The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits
    Sally M Williamson
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 5:e1000517. 2009
    ..In vitro expression of these subunits may permit the development of parasite-specific screens for future anthelmintics...
  5. pmc Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans
    Susan K Glendinning
    Departmenty of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 6:e22390. 2011
    ..elegans, though some quantitative differences were observed between transgenic lines in some assays. C. elegans is a suitable system for studying parasitic nematode genes that may be involved in drug resistance...
  6. ncbi The TRP channel superfamily: insights into how structure, protein-lipid interactions and localization influence function
    B J Reaves
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Biochem Soc Trans 35:77-80. 2007
    ....
  7. pmc FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways
    Ying Feng
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, U K
    Biochem J 456:219-29. 2013
    ..We propose that fgt-1 constitutes a common axis for the lifespan extending effects of nutrient restriction and reduced insulin-like peptide signalling...
  8. ncbi Dirofilaria immitis: identification of a novel ligand-gated ion channel-related polypeptide
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Exp Parasitol 108:182-5. 2004
    ..RNAi experiments using a fragment of T27A1.4 with C. elegans failed to reveal any obvious phenotype, so the function of these channels remains unknown...
  9. ncbi The avermectin receptors of Haemonchus contortus and Caenorhabditis elegans
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, BA2 7AY, Bath, UK
    Int J Parasitol 33:1183-93. 2003
    ....
  10. ncbi An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis
    Darran M Yates
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Int J Parasitol 34:1075-81. 2004
    ..Oocytes injected with DiGluClalpha3A cRNA failed to respond to L-glutamate. The qualitative responses obtained were consistent with the pharmacology observed for the GluClalpha3 subunits from C. elegans and H. contortus...
  11. pmc Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes
    Hayley M Bennett
    Department of Infectious Diseases and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    J Neurochem 123:911-8. 2012
    ..This provides further evidence for a species-specific component of RIC-3 activity, and suggests that X. laevis RIC-3 is useful for enhancing the expression of invertebrate nAChRs in X. laevis oocytes...
  12. ncbi Detection and measurement of benzimidazole resistance alleles in Haemonchus contortus using real-time PCR with locked nucleic acid Taqman probes
    Thomas K Walsh
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Vet Parasitol 144:304-12. 2007
    ..Using the final fluorescence method, it was possible to differentiate populations with approximately 0, 5 and 10% resistance allele frequencies...
  13. ncbi Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers
    S McCavera
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Parasitology 134:1111-21. 2007
    ..This has led to suggestions that ML resistance may be polygenic. Possible reasons for this, and its consequences for the development of molecular tests for resistance, are explored...
  14. ncbi Human peripheral blood mononuclear cells express GABAA receptor subunits
    Sabina Alam
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Mol Immunol 43:1432-42. 2006
    ..The inhibitory effect of GABA was limited to a subset of PBMC. We conclude that cells within the human PBMC population, including lymphocytes, express functional GABAA receptors and these receptors may modulate immune responses...
  15. ncbi Drug resistance in veterinary helminths
    Adrian J Wolstenholme
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Trends Parasitol 20:469-76. 2004
    ..This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area...
  16. ncbi High-affinity ivermectin binding to recombinant subunits of the Haemonchus contortus glutamate-gated chloride channel
    C L Cheeseman
    Department of Biology and Biochemistry, University of Bath, BA2 7AY, Bath, UK
    Mol Biochem Parasitol 114:161-8. 2001
    ..The properties of orthologous GluCl subunits are likely to be conserved across species, but the repertoire and relative importance of those subunits may vary...
  17. pmc GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans
    L Horoszok
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY
    Br J Pharmacol 132:1247-54. 2001
    ..Further study of this receptor may provide insights into the molecular basis of non-competitive antagonism by these compounds...
  18. ncbi Distribution of glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus
    Virginia Portillo
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Comp Neurol 462:213-22. 2003
    ..They also provide an explanation for the observed effects of the A/M anthelmintics...
  19. ncbi Altered drug resistance and recovery from paralysis in Drosophila melanogaster with a deficient histamine-gated chloride channel
    Mladen Iovchev
    Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    J Neurogenet 16:249-61. 2002
    ..They also provide new evidence for a function in the response to diethylether anaesthesia and, moreover, that HCLA function is not limited to the visual system...
  20. ncbi Frontiers in parasite neurobiology: parasite genomics, neural signalling and new targets for control
    Adrian J Wolstenholme
    Invert Neurosci 7:179-81. 2007