C Wiuf

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Recombination in human mitochondrial DNA?
    C Wiuf
    Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
    Genetics 159:749-56. 2001
  2. ncbi request reprint Inferring population history from genealogical trees
    Carsten Wiuf
    Department of Statistics, University of Oxford, Oxford, OX1 3TG, UK
    J Math Biol 46:241-64. 2003
  3. pmc The ancestry of a sample of sequences subject to recombination
    C Wiuf
    Institute of Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
    Genetics 151:1217-28. 1999
  4. pmc The coalescent with gene conversion
    C Wiuf
    Department of Statistics, University of Oxford, Oxford OX1 3TG, England
    Genetics 155:451-62. 2000
  5. ncbi request reprint Do delta F508 heterozygotes have a selective advantage?
    C Wiuf
    Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK
    Genet Res 78:41-7. 2001
  6. ncbi request reprint A simulation study of the reliability of recombination detection methods
    C Wiuf
    Department of Statistics, University of Oxford, United Kingdom
    Mol Biol Evol 18:1929-39. 2001
  7. pmc On the number of ancestors to a DNA sequence
    C Wiuf
    Institute of Biological Sciences, University of Aarhus, Denmark
    Genetics 147:1459-68. 1997
  8. ncbi request reprint Statistical alignment: computational properties, homology testing and goodness-of-fit
    J Hein
    Department of Genetics and Ecology The Institute of Biological Science, University of Aarhus, Building 540, Ny Munkegade, Arhus C, 8000, Denmark
    J Mol Biol 302:265-79. 2000
  9. ncbi request reprint A codon-based model designed to describe lentiviral evolution
    A K Pedersen
    Institute of Biological Sciences, University of Aarhus, Denmark
    Mol Biol Evol 15:1069-81. 1998
  10. ncbi request reprint Consistency of estimators of population scaled parameters using composite likelihood
    Carsten Wiuf
    Bioinformatics Research Center, University of Aarhus, Høegh Guldbergsgade 10, Building 1090, 8000 Aarhus C, Denmark
    J Math Biol 53:821-41. 2006

Collaborators

  • J Hein
  • B Knudsen
  • Hideki Innan
  • Tomasz K Wojdacz
  • M P H Stumpf
  • Magnus Nordborg
  • K Wang
  • Palle Villesen
  • David Posada
  • Andrei Sher
  • Ole F Christensen
  • Oliver Ratmann
  • Anders J Hansen
  • Eske Willerslev
  • Jian Li
  • Lasse S Kristensen
  • Malene Herbsleb
  • Bo Eskerod Madsen
  • Lars Dyrskjøt
  • P Lamy
  • Karsten Zieger
  • Tina B Brand
  • David A Gilichinsky
  • Jonas Binladen
  • Henrik Hager
  • Xiuqing Zhang
  • Shengting Li
  • Lise Lotte Hansen
  • Huanming Yang
  • Vera Timmermans-Wielenga
  • Britta B Thestrup
  • Lars Bolund
  • Fritz Rank
  • Michael Borre
  • Thomas Thykjaer
  • Torben F Orntoft
  • Regin Rønn
  • David L Mitchell
  • Lakshmi Paniker
  • N Tørring
  • L Dyrskjøt
  • C L Andersen
  • A K Pedersen
  • T Ørntoft
  • Claus L Andersen
  • Klaus Møller Ernst Jensen
  • Jens L Jensen
  • Torben Falck Ørntoft
  • Alan Cooper
  • M Thomas P Gilbert
  • Beth Shapiro
  • Michael Bunce
  • F B Christiansen

Detail Information

Publications27

  1. pmc Recombination in human mitochondrial DNA?
    C Wiuf
    Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom
    Genetics 159:749-56. 2001
    ..09...
  2. ncbi request reprint Inferring population history from genealogical trees
    Carsten Wiuf
    Department of Statistics, University of Oxford, Oxford, OX1 3TG, UK
    J Math Biol 46:241-64. 2003
    ..g., the mutation rate typically converges at rate under the assumption that all historical mutations can be observed in the sample. In addition, various results for the distribution of maximum likelihood estimators are presented...
  3. pmc The ancestry of a sample of sequences subject to recombination
    C Wiuf
    Institute of Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
    Genetics 151:1217-28. 1999
    ..On the basis of simulations, it turns out that important properties of the coalescent with recombinations of the whole population are reflected in the properties of a sample of low size...
  4. pmc The coalescent with gene conversion
    C Wiuf
    Department of Statistics, University of Oxford, Oxford OX1 3TG, England
    Genetics 155:451-62. 2000
    ..Further, an expression for the expected number of topology shifts in a sample of present-day sequences caused by gene conversion events is derived...
  5. ncbi request reprint Do delta F508 heterozygotes have a selective advantage?
    C Wiuf
    Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK
    Genet Res 78:41-7. 2001
    ....
  6. ncbi request reprint A simulation study of the reliability of recombination detection methods
    C Wiuf
    Department of Statistics, University of Oxford, United Kingdom
    Mol Biol Evol 18:1929-39. 2001
    ..In addition to the results obtained through simulations, a series of new theoretical results on recombination is presented...
  7. pmc On the number of ancestors to a DNA sequence
    C Wiuf
    Institute of Biological Sciences, University of Aarhus, Denmark
    Genetics 147:1459-68. 1997
    ..In an ancestral population of actual size 1.3 million a minority of <6.4% will carry material ancestral to any present human. The estimated actual population size can be even higher, 5 million, reducing the percentage to 1.7%...
  8. ncbi request reprint Statistical alignment: computational properties, homology testing and goodness-of-fit
    J Hein
    Department of Genetics and Ecology The Institute of Biological Science, University of Aarhus, Building 540, Ny Munkegade, Arhus C, 8000, Denmark
    J Mol Biol 302:265-79. 2000
    ....
  9. ncbi request reprint A codon-based model designed to describe lentiviral evolution
    A K Pedersen
    Institute of Biological Sciences, University of Aarhus, Denmark
    Mol Biol Evol 15:1069-81. 1998
    ....
  10. ncbi request reprint Consistency of estimators of population scaled parameters using composite likelihood
    Carsten Wiuf
    Bioinformatics Research Center, University of Aarhus, Høegh Guldbergsgade 10, Building 1090, 8000 Aarhus C, Denmark
    J Math Biol 53:821-41. 2006
    ..g. mutation rates, demographic parameters and the recombination rate) is a consistent estimator as the number of regions tends to infinity...
  11. ncbi request reprint Rare alleles and selection
    C Wiuf
    Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, England
    Theor Popul Biol 59:287-96. 2001
    ..Amongst more, it is shown that for constant population size (rho=0) the distribution of D depends on sigma only through the absolute value /sigma/, not the direction of selection...
  12. pmc Are microRNAs located in genomic regions associated with cancer?
    P Lamy
    Bioinformatics Research Center BiRC, University of Aarhus, Hoegh Guldbergs Gade 10, Bldg 1090, Aarhus C, Denmark
    Br J Cancer 95:1415-8. 2006
    ..This suggests that miRNA expression is regulated through different mechanisms than mRNA expression...
  13. doi request reprint DNA copy number aberrations in breast cancer by array comparative genomic hybridization
    Jian Li
    Institute of Human Genetics, University of Aarhus, Denmark
    Genomics Proteomics Bioinformatics 7:13-24. 2009
    ..Our study provides clues for further investigations of the underlying mechanisms of breast carcinogenesis...
  14. pmc A periodic pattern of SNPs in the human genome
    Bo Eskerod Madsen
    Bioinformatics Research Center, University of Aarhus, Hoegh Guldbergs Gade 10, DK 8000 Aarhus C, Denmark
    Genome Res 17:1414-9. 2007
    ..The latter may have important consequences for SNP and association studies...
  15. pmc A likelihood approach to analysis of network data
    Carsten Wiuf
    Bioinformatics Research Center, University of Aarhus, Høegh Guldbergsgade 10, Building 1090, 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 103:7566-70. 2006
    ..We illustrate the power of this approach by estimating growth parameters for the Caenorhabditis elegans protein interaction network...
  16. pmc The probability and chromosomal extent of trans-specific polymorphism
    Carsten Wiuf
    Department of Statistics, University of Oxford, Oxford, OX1 3TG, United Kingdom
    Genetics 168:2363-72. 2004
    ..When trans-specific polymorphism is obvious, on the other hand, it may be reasonable to argue that selection must be acting on multiple sites or that recombination is suppressed in the surrounding region...
  17. pmc Inference on recombination and block structure using unphased data
    Carsten Wiuf
    Bioinformatics Research Center, University of Aarhus, 8000 Aarhus C, Denmark
    Genetics 166:537-45. 2004
    ..The new statistics are applied to real data from human genes. The results from this application are discussed with reference to recent suggestions that recombination in the human genome is highly heterogeneous...
  18. pmc Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM
    Lasse S Kristensen
    Institute of Human Genetics, University of Aarhus, The Bartholin Building, Aarhus C, Denmark
    BMC Cancer 9:453. 2009
    ..Sensitive Melting Analysis after Real Time - Methylation Specific PCR (SMART-MSP) and Methylation Sensitive - High Resolution Melting (MS-HRM) are two methods for single locus DNA methylation detection based on HRM...
  19. ncbi request reprint On the minimum number of topologies explaining a sample of DNA sequences
    Carsten Wiuf
    Variagenics, 60 Hampshire Street, Cambridge, Massachusetts 02139 1548, USA
    Theor Popul Biol 62:357-63. 2002
    ..Further, a number of theorems relating general lists of topologies to the number T(M) is presented. The results are discussed in relation to the true minimum number of recombination events required to explain an alignment...
  20. pmc Bioinformatic identification of FGF, p38-MAPK, and calcium signalling pathways associated with carcinoma in situ in the urinary bladder
    Malene Herbsleb
    Molecular Diagnostic Laboratory, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    BMC Cancer 8:37. 2008
    ..Carcinoma in situ (CIS) is believed to be a precursor of invasive bladder cancer. Identification of CIS is a valuable prognostic factor since radical treatment strategies can be offered these patients before the disease becomes invasive...
  21. pmc Using likelihood-free inference to compare evolutionary dynamics of the protein networks of H. pylori and P. falciparum
    Oliver Ratmann
    Department of Public Health and Epidemiology, Imperial College London, London, United Kingdom
    PLoS Comput Biol 3:e230. 2007
    ....
  22. ncbi request reprint Simulating haplotype blocks in the human genome
    David Posada
    Variagenics Inc, 60 Hampshire St, Cambridge, MA 02139 1548, USA
    Bioinformatics 19:289-90. 2003
    ..The samples generated can be very useful to better understand the architecture of the human genome and to investigate its impact in association studies searching for disease genes...
  23. ncbi request reprint Diverse plant and animal genetic records from Holocene and Pleistocene sediments
    Eske Willerslev
    Department of Evolutionary Biology, Zoological Institute, University of Copenhagen, Universitetsparken 15, Denmark DK 2100 Ø
    Science 300:791-5. 2003
    ..Therefore, many sedimentary deposits may contain unique, and widespread, genetic records of paleoenvironments...
  24. ncbi request reprint Some notes on the combinatorial properties of haplotype tagging
    Carsten Wiuf
    Variagenics, 60 Hampshire Street, Cambridge, MA 02139, USA
    Math Biosci 185:205-16. 2003
    ..We derive a number of results that relate the number of markers required to tag a set of haplotypes to the set of markers themselves...
  25. pmc Crosslinks rather than strand breaks determine access to ancient DNA sequences from frozen sediments
    Anders J Hansen
    Genetics 173:1175-9. 2006
    ..Additionally, a clear relationship was found between DNA damage and sample age, contradicting previously raised concerns about the possible leaching of free DNA molecules between permafrost layers...
  26. ncbi request reprint Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors
    Karsten Zieger
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University, Denmark
    Clin Cancer Res 11:7709-19. 2005
    ..The aim of this clinical follow-up study was to investigate the role of FGFR3 mutations in bladder cancer development in a longitudinal study...
  27. pmc A coalescent model of recombination hotspots
    Carsten Wiuf
    Variagenics, Cambridge, Massachusetts 02139, USA
    Genetics 164:407-17. 2003
    ..A number of new analytical results about the model are derived...