Frances K Wiseman
Affiliation: University College London
- Down syndrome--recent progress and future prospectsFrances K Wiseman
Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, UK
Hum Mol Genet 18:R75-83. 2009..In particular, the use of chromosome engineering to generate new trisomic mouse models and large-scale studies of genotype-phenotype relationships in patients are likely to significantly contribute to the future understanding of DS...
- Generation of a panel of antibodies against proteins encoded on human chromosome 21Frances K Wiseman
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
J Negat Results Biomed 9:7. 2010..To this end, we have generated a panel of antibodies raised against proteins encoded by genes on human chromosome 21 that are known to be expressed in the adult brain of Tc1 mice..
- Cognitive enhancement therapy for a model of Down syndromeFrances K Wiseman
Department of Neurodegenerative Disease, University College London, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Sci Transl Med 1:7ps9. 2009..This study highlights the function of the norepinephrine-ergic system in Down syndrome and suggests possible treatment options for people with Down syndrome...
- Altered regulation of tau phosphorylation in a mouse model of down syndrome agingOlivia Sheppard
University College London Institute of Neurology, London, UK
Neurobiol Aging 33:828.e31-44. 2012..It is possible that a similar mechanism may also occur in people with DS...
- Structural correlates of active-staining following magnetic resonance microscopy in the mouse brainJon O Cleary
Centre for Advanced Biomedical Imaging, Department of Medicine and Institute of Child Health, University College London, London, UK
Neuroimage 56:974-83. 2011....
- Mouse models of aneuploidyOlivia Sheppard
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
ScientificWorldJournal 2012:214078. 2012..Thus, creating and studying mouse models of aneuploidy and copy number variation is important for understanding what it is to be human, in both the normal and genomically altered states...
- A genetic cause of Alzheimer disease: mechanistic insights from Down syndromeFrances K Wiseman
Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Nat Rev Neurosci 16:564-74. 2015..Further study of the mechanisms underlying the development of Alzheimer disease in people with Down syndrome could provide insights into the mechanisms that cause dementia in the general population...