P Winn

Summary

Affiliation: University of St Andrews
Country: UK

Publications

  1. pmc A functional dissociation of the anterior and posterior pedunculopontine tegmental nucleus: excitotoxic lesions have differential effects on locomotion and the response to nicotine
    Helen L Alderson
    School of Psychology, St Andrews University, St Mary s Quad, South Street, St Andrews, Fife, KY16 9JP, UK
    Brain Struct Funct 213:247-53. 2008
  2. pmc The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis: do both have a role in sustained attention?
    Claire L Rostron
    Life Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    BMC Neurosci 9:16. 2008
  3. doi request reprint Experimental studies of pedunculopontine functions: are they motor, sensory or integrative?
    Philip Winn
    School of Psychology, University of St Andrews, St Mary s Quad, South Street, St Andrews, Fife, Scotland, UK
    Parkinsonism Relat Disord 14:S194-8. 2008
  4. ncbi request reprint Frontal syndrome as a consequence of lesions in the pedunculopontine tegmental nucleus: a short theoretical review
    P Winn
    School of Psychology, University of St Andrews, Fife, UK
    Brain Res Bull 47:551-63. 1998
  5. ncbi request reprint How best to consider the structure and function of the pedunculopontine tegmental nucleus: evidence from animal studies
    Philip Winn
    School of Psychology, University of St Andrews, St Mary s Quad, South Street, St Andrews, Fife KY16 9JP, United Kingdom
    J Neurol Sci 248:234-50. 2006
  6. ncbi request reprint The effects of excitotoxic lesions of the pedunculopontine tegmental nucleus on conditioned place preference to 4%, 12% and 20% sucrose solutions
    H L Alderson
    School of Psychology, University of St Andrews, Scotland, St Andrews, Fife, United Kingdom
    Brain Res Bull 56:599-605. 2001
  7. ncbi request reprint An examination of d-amphetamine self-administration in pedunculopontine tegmental nucleus-lesioned rats
    H L Alderson
    School of Psychology, University of St Andrews, St Mary s Quad, St Andrews, Fife, KY16 9JP, UK
    Neuroscience 125:349-58. 2004
  8. ncbi request reprint An assessment of the contributions of the pedunculopontine tegmental and cuneiform nuclei to anxiety and neophobia
    S C Walker
    School of Psychology, University of St Andrews, St Mary s Quad, South Street, St Andrews, Fife, KY16 9JP, UK
    Neuroscience 150:273-90. 2007
  9. ncbi request reprint Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat
    J M Phillips
    School of Psychology, University of St Andrews, Scotland, UK
    Behav Brain Res 90:73-7. 1998
  10. ncbi request reprint Behavioural sensitisation to repeated d-amphetamine: effects of excitotoxic lesions of the pedunculopontine tegmental nucleus
    H L Alderson
    School of Psychology, University of St Andrews, St Andrews, Fife, KY16 9JU, UK
    Neuroscience 118:311-5. 2003

Collaborators

Detail Information

Publications22

  1. pmc A functional dissociation of the anterior and posterior pedunculopontine tegmental nucleus: excitotoxic lesions have differential effects on locomotion and the response to nicotine
    Helen L Alderson
    School of Psychology, St Andrews University, St Mary s Quad, South Street, St Andrews, Fife, KY16 9JP, UK
    Brain Struct Funct 213:247-53. 2008
    ..The finding that anterior but not posterior PPTg affects motor activity has significance for developing therapeutic strategies for Parkinsonism using deep brain stimulation aimed here...
  2. pmc The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis: do both have a role in sustained attention?
    Claire L Rostron
    Life Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    BMC Neurosci 9:16. 2008
    ..Data for PPTg lesioned rats were compared to control rats, and rats with 192 IgG saporin infusions centred on the NbM. In addition to operant data, video data of rats' performance during the task were also analysed...
  3. doi request reprint Experimental studies of pedunculopontine functions: are they motor, sensory or integrative?
    Philip Winn
    School of Psychology, University of St Andrews, St Mary s Quad, South Street, St Andrews, Fife, Scotland, UK
    Parkinsonism Relat Disord 14:S194-8. 2008
    ..Understanding normal PPTg structure and function will provide insight into the role it has in Parkinson's disease and related disorders, and will benefit the development of surgical treatments aimed here...
  4. ncbi request reprint Frontal syndrome as a consequence of lesions in the pedunculopontine tegmental nucleus: a short theoretical review
    P Winn
    School of Psychology, University of St Andrews, Fife, UK
    Brain Res Bull 47:551-63. 1998
    ..Anatomical and behavioural data support the conclusion that there are functional connections between frontal systems and the PPTg. This review also discusses what psychological processes might be served by such connections...
  5. ncbi request reprint How best to consider the structure and function of the pedunculopontine tegmental nucleus: evidence from animal studies
    Philip Winn
    School of Psychology, University of St Andrews, St Mary s Quad, South Street, St Andrews, Fife KY16 9JP, United Kingdom
    J Neurol Sci 248:234-50. 2006
    ..If this is to be realized it will be best to have as clear an understanding as possible of pedunculopontine structure and function in order to maximize positive benefits...
  6. ncbi request reprint The effects of excitotoxic lesions of the pedunculopontine tegmental nucleus on conditioned place preference to 4%, 12% and 20% sucrose solutions
    H L Alderson
    School of Psychology, University of St Andrews, Scotland, St Andrews, Fife, United Kingdom
    Brain Res Bull 56:599-605. 2001
    ..The increased consumption of 12% and 20% sucrose shown by rats bearing such lesions is therefore not likely to be a product of altered reward perception...
  7. ncbi request reprint An examination of d-amphetamine self-administration in pedunculopontine tegmental nucleus-lesioned rats
    H L Alderson
    School of Psychology, University of St Andrews, St Mary s Quad, St Andrews, Fife, KY16 9JP, UK
    Neuroscience 125:349-58. 2004
    ..These deficits are overcome by priming with d-amphetamine. We suggest that alterations in striatal dopamine activity following PPTg lesions underlie these effects...
  8. ncbi request reprint An assessment of the contributions of the pedunculopontine tegmental and cuneiform nuclei to anxiety and neophobia
    S C Walker
    School of Psychology, University of St Andrews, St Mary s Quad, South Street, St Andrews, Fife, KY16 9JP, UK
    Neuroscience 150:273-90. 2007
    ....
  9. ncbi request reprint Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat
    J M Phillips
    School of Psychology, University of St Andrews, Scotland, UK
    Behav Brain Res 90:73-7. 1998
    ..This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion. indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion...
  10. ncbi request reprint Behavioural sensitisation to repeated d-amphetamine: effects of excitotoxic lesions of the pedunculopontine tegmental nucleus
    H L Alderson
    School of Psychology, University of St Andrews, St Andrews, Fife, KY16 9JU, UK
    Neuroscience 118:311-5. 2003
    ....
  11. ncbi request reprint Evidence for functional separation of alpha-1 and alpha-2 noradrenaline receptors by pre-synaptic terminal re-uptake mechanisms
    A J Clark
    Psychological Laboratory, University of St Andrews, Fife, UK
    Psychopharmacology (Berl) 103:366-74. 1991
    ..It is proposed that the alpha-2 subtype may be extrasynaptic, the alpha-1 subtype intrasynaptic...
  12. ncbi request reprint Examination of the role of the pedunculopontine tegmental nucleus in radial maze tasks with or without a delay
    G L Keating
    School of Psychology, University of St Andrews, St Andrews, Fife, UK
    Neuroscience 112:687-96. 2002
    ....
  13. ncbi request reprint The effect of excitotoxic lesions of the pedunculopontine tegmental nucleus on performance of a progressive ratio schedule of reinforcement
    H L Alderson
    School of Psychology, University of St Andrews, Fife, UK
    Neuroscience 112:417-25. 2002
    ..We consider these data to indicate that the behavioural deficits in pedunculopontine-lesioned rats arise not from a sensory or hedonic change, but from alteration in the control of motor output...
  14. pmc A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat
    P Winn
    Department of Psychology, University of St Andrews, Fife
    Br J Pharmacol 102:904-8. 1991
    ..6. The results are discussed in terms of the actions of the various toxins at different receptors, differentially sensitive to AP5 and kynurenate...
  15. ncbi request reprint Effects of changing reward on performance of the delayed spatial win-shift radial maze task in pedunculopontine tegmental nucleus lesioned rats
    Claire L Taylor
    School of Psychology, University of St Andrews, St Andrews, Fife KY16 9JU, Scotland, UK
    Behav Brain Res 153:431-8. 2004
    ..Results suggest that PPTg DSWS deficits are not the result of altered motivation or hedonic appreciation of reward value (or reward change) and therefore support the hypothesis of executive cognitive deficits in PPTg lesioned rats...
  16. ncbi request reprint An examination of the effects of bilateral excitotoxic lesions of the pedunculopontine tegmental nucleus on responding to sucrose reward
    Glenda L Keating
    School of Psychology, University of St Andrews, St Andrews, Fife KY16 9JU, Scotland, UK
    Behav Brain Res 134:217-28. 2002
    ....
  17. ncbi request reprint Impaired delayed spatial win-shift behaviour on the eight arm radial maze following excitotoxic lesions of the medial prefrontal cortex in the rat
    Claire L Taylor
    School of Psychology, University of St Andrews, Fife, Scotland KY16 9JU, UK
    Behav Brain Res 147:107-14. 2003
    ....
  18. ncbi request reprint Determination of acetylcholine and dopamine content in thalamus and striatum after excitotoxic lesions of the pedunculopontine tegmental nucleus in rats
    Trisha A Jenkins
    School of Psychology, University of St Andrews, Fife KY16 9JU, UK
    Neurosci Lett 322:45-8. 2002
    ..The effects of PPTg lesion on thalamic ACh content are consistent with the hypothesis that it has effects on motor nuclei, but also indicate that PPTg lesions have complex and dynamic effects on thalamic ACh content...
  19. ncbi request reprint Intravenous self-administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus
    Helen L Alderson
    School of Psychology, St Andrews University, St Mary s Quad, South Street, St Andrews, Fife, KY16 9JP, UK
    Eur J Neurosci 23:2169-75. 2006
    ..The resulting change in nicotine self-administration behaviour was hypothesized to reflect either a reduction in intrinsic nicotine reward value, or enhancement of associative incentive salience...
  20. ncbi request reprint Involvement of the laterodorsal tegmental nucleus in the locomotor response to repeated nicotine administration
    Helen L Alderson
    School of Psychology, University of St Andrews, St Mary s Quad, South Street, St Andrews, Fife KY169JP, UK
    Neurosci Lett 380:335-9. 2005
    ..These data show that the functional integrity of the LDTg is required in order to show normal locomotor response to nicotine. One explanation for this is that loss of the LDTg affects synaptic activity in the VTA...
  21. ncbi request reprint Induction of c-fos in specific thalamic nuclei following stimulation of the pedunculopontine tegmental nucleus
    James A Ainge
    School of Psychology, University of St Andrews, St Andrews, Fife, KY16 9JU, Scotland
    Eur J Neurosci 20:1827-37. 2004
    ..The present data extend previous work establishing pedunculopontine-thalamic connections by specifying which particular nuclei are most affected by PPTg activation...
  22. ncbi request reprint Excitotoxic lesions of the pedunculopontine tegmental nucleus in rats impair performance on a test of sustained attention
    Rouba Kozak
    Department of Psychology, Ohio State University, 27 Townshend Hall, 1885 Neil Avenue, Columbus, OH 43210 1222, USA
    Exp Brain Res 162:257-64. 2005
    ..These data are taken to be consistent with the hypothesis that the pedunculopontine tegmental nucleus is an important part of a network maintaining attention...