Affiliation: University of Oxford
- Evaluating the results of genomewide linkage scans of complex traits by locus countingSteven Wiltshire
Imperial College Genetics and Genomics Research Institute, Imperial College, London, United Kingdom
Am J Hum Genet 71:1175-82. 2002..By taking account of the effects of reduced data informativeness on the expected number of regions showing evidence for linkage, a more meaningful, and less conservative, evaluation of the results from such linkage studies is possible...
- How useful is the fine-scale mapping of complex trait linkage peaks? Evaluating the impact of additional microsatellite genotyping on the posterior probability of linkageSteven Wiltshire
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Genet Epidemiol 28:1-10. 2005....
- Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24Steven Wiltshire
Wellcome Trust Centre for Human Genetics, Oxford, U K
Diabetes 53:855-60. 2004..These data provide additional evidence that genes mapping to these chromosomal regions are involved in the susceptibility to, and/or development of, type 2 diabetes...
- Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidateChristopher J Groves
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Diabetes 55:1884-9. 2006....
- Examining the statistical properties of fine-scale mapping in large-scale association studiesSteven Wiltshire
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Genet Epidemiol 32:204-14. 2008..Our findings help inform the interpretation and design of dense SNP-mapping follow-up studies, thus facilitating discrimination between a genuine genetic effect and chance fluctuation (false positive)...
- Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetesSteven Wiltshire
Imperial College Genetics and Genomics Research Institute and Division of Medicine, Imperial College, London, United Kingdom
Am J Hum Genet 70:543-6. 2002..Our findings extend similar recent studies in Scandinavian and Quebecois populations, adding further evidence that height is indeed under the control of multiple genes...
- A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locusNicholas I Leaves
Asthma Genetics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK
Eur J Hum Genet 10:177-82. 2002..00001): maternally derived alleles did not exhibit significant linkage. The results indicate that two disparate loci may be influencing asthma from chromosome 7...
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesAndrew P Morris
Wellcome Trust Centre for Human Genetics, University of Oxford, UK
Nat Genet 44:981-90. 2012..Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis...
- The value of gene-based selection of tag SNPs in genome-wide association studiesSteven Wiltshire
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Eur J Hum Genet 14:1209-14. 2006..In HapMap CEU samples (with northern and western European ancestry), we observed roughly equivalent coverage for equal investment for both tagging strategies...
- Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndromeLema Haddad
Complex Traits Analysis Group, Department of Medicine, Imperial College Genetics and Genomics Research Institute, Imperial College School of Medicine, London W12 0NN, UK
J Clin Endocrinol Metab 87:2606-10. 2002..40-1.71). No associations were seen with intermediate traits of relevance to diabetes and PCOS pathogenesis. We have found no evidence from these analyses that CAPN10 gene variation influences susceptibility to PCOS...
- Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual riskChristopher J Groves
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
Diabetes 55:2640-4. 2006..4 x 10(-14) combining case-control and family-based analyses for rs4506565) exceeds genome-wide significance criteria and clearly establishes TCF7L2 as a type 2 diabetes susceptibility gene of substantial importance...
- Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetesMaria Gueorguiev
Reader in Endocrine Research, Department of Endocrinology, Room 114C, John Vane Science Centre, Barts and the London Medical School, Charterhouse Square, London, UK
J Clin Endocrinol Metab 92:2201-4. 2007..Recently, a quantitative trait locus for stature was reported on chromosome 3p26 in patients with type 2 diabetes...
- Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11Timothy M Frayling
Department of Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK
Diabetes 52:1857-63. 2003..Our data confirm our hypothesis that families segregating young-onset type 2 diabetes represent a more powerful resource for defining susceptibility genes by linkage...
- A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetesFlorence Demenais
EMI 0006, INSERM Universite d Evry, Evry, France
Hum Mol Genet 12:1865-73. 2003..This meta-analysis has led to identification of a novel region on chromosome 17 linked to type 2 diabetes; this region has not been highlighted in any published scan to date but on the basis of these data justifies further exploration...
- Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis ConsortiumWeihua Guan
Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
Hum Hered 66:35-49. 2008..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
- Celestial3D: a novel method for 3D visualization of familial dataAngeline M Loh
Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, The University of Western Australia, Perth, Australia
Bioinformatics 24:1210-1. 2008..Currently no other methods are available for displaying extended pedigrees in 3Ds. We have made freely available a software tool--'Celestial3D'--that implements these novel techniques...
- Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease populationKim W Carter
Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
Hum Genet 124:199-206. 2008....
- Comprehensive analysis of tagging sequence variants in DTNBP1 shows no association with schizophrenia or with its composite neurocognitive endophenotypesKirsten Peters
Laboratory for Molecular Genetics, Western Australian Institute for Medical Research, University of Western Australia, Nedlands, Western Australia, Australia
Am J Med Genet B Neuropsychiatr Genet 147:1159-66. 2008..The framework and results of this study should facilitate further attempts at re-analysis of DTNBP1, in terms of standardized approaches to both phenotype definition and analysis of genetic variation...
- The apolipoprotein AII rs5082 variant is associated with reduced risk of coronary artery disease in an Australian male populationJing Xiao
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Australia
Atherosclerosis 199:333-9. 2008..We conclude that the APOAII rs5082 polymorphism appears to be cardioprotective in this representative Caucasian Australian population...
- An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study GroupDavid A Dyment
The Wellcome Trust Center for Human Genetics, Oxford, UK
Hum Mol Genet 13:1005-15. 2004..This observation is most consistent with a model of genetic heterogeneity between HLA and other genetic loci. These findings offer guidance for future genetic studies including dense SNP linkage disequilibrium analysis...
- Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibilityChristopher J Groves
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Site, Old Road, Headington, Oxford OX3 7LJ, U K
Diabetes 52:1300-5. 2003....
- High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 peopleJose C Florez
Diabetes Unit, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Diabetes 55:128-35. 2006..Nominally significant differences in quantitative traits are consistent with statistical noise. We conclude that common genetic variation at IDE is unlikely to confer clinically significant risk of type 2 diabetes in Caucasians...
- Two-dimensional genome-scan identifies novel epistatic loci for essential hypertensionJordana Tzenova Bell
Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 15:1365-74. 2006..This approach has discovered novel loci for hypertension and offers a unique potential to use existing data to uncover novel regions involved in complex human diseases...