S W Wilson

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Morphogenesis underlying the development of the everted teleost telencephalon
    Mónica Folgueira
    Research Department of Cell and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Neural Dev 7:32. 2012
  2. pmc Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries
    Matthias Carl
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Neuron 55:393-405. 2007
  3. pmc Brain asymmetry is encoded at the level of axon terminal morphology
    Isaac H Bianco
    Department of Cell and Developmental Biology, UCL, Gower St, London WC1E 6BT, UK
    Neural Dev 3:9. 2008
  4. pmc MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system
    Marika Kapsimali
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Genome Biol 8:R173. 2007
  5. pmc Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish
    Yavor Hadzhiev
    Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany
    BMC Dev Biol 7:75. 2007
  6. pmc Early steps in the development of the forebrain
    Stephen W Wilson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 6:167-81. 2004
  7. pmc Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity
    Marika Kapsimali
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:5923-33. 2004
  8. pmc Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway
    Florencia Cavodeassi
    Department of Anatomy, University College London, Gower Street, London 6BT WC1, United Kingdom
    Neuron 47:43-56. 2005
  9. pmc Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos
    H Teraoka
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    J Neurobiol 60:275-88. 2004
  10. ncbi request reprint Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 126:2129-40. 1999

Detail Information

Publications45

  1. pmc Morphogenesis underlying the development of the everted teleost telencephalon
    Mónica Folgueira
    Research Department of Cell and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Neural Dev 7:32. 2012
    ..The mechanisms that generate these distinct morphologies are not well understood...
  2. pmc Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries
    Matthias Carl
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Neuron 55:393-405. 2007
    ..We identify a second role for the Wnt pathway in the left/right regulation of LPM Nodal pathway gene expression, and finally, we show that at later stages Axin1 is required for the elaboration of concordant neuroanatomical asymmetries...
  3. pmc Brain asymmetry is encoded at the level of axon terminal morphology
    Isaac H Bianco
    Department of Cell and Developmental Biology, UCL, Gower St, London WC1E 6BT, UK
    Neural Dev 3:9. 2008
    ..Functional lateralization is a conserved feature of the central nervous system (CNS). However, underlying left-right asymmetries within neural circuitry and the mechanisms by which they develop are poorly described...
  4. pmc MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system
    Marika Kapsimali
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Genome Biol 8:R173. 2007
    ..To provide an overview of the breadth of miRNA expression in the CNS, we performed a comprehensive analysis of the neuroanatomical expression profiles of 38 abundant conserved miRNAs in developing and adult zebrafish brain...
  5. pmc Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish
    Yavor Hadzhiev
    Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany
    BMC Dev Biol 7:75. 2007
    ..However, the extent to which the molecular mechanisms patterning paired and median fins are shared remains unknown...
  6. pmc Early steps in the development of the forebrain
    Stephen W Wilson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 6:167-81. 2004
    ..Here, we discuss early events in forebrain development--those that lead to the establishment of the anterior neural plate and the regional subdivision of this territory into the different domains of the prospective forebrain...
  7. pmc Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity
    Marika Kapsimali
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:5923-33. 2004
    ....
  8. pmc Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway
    Florencia Cavodeassi
    Department of Anatomy, University College London, Gower Street, London 6BT WC1, United Kingdom
    Neuron 47:43-56. 2005
    ....
  9. pmc Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos
    H Teraoka
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    J Neurobiol 60:275-88. 2004
    ..Our results show that the pathways involved in induction of hindbrain serotonergic neurons are likely to be conserved in all vertebrates and help establish the zebrafish as a model system to study this important neuronal class...
  10. ncbi request reprint Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 126:2129-40. 1999
    ..We conclude that aus represents a mutation involving a locus normally required for the regulation of ace expression during embryogenesis...
  11. pmc fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses
    K Anukampa Barth
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 15:844-50. 2005
    ..Revealing a link between visceral and brain asymmetry and lateralized behavior, our studies help to explain the complexity of the relationship between the lateralities of visceral and neural asymmetries...
  12. ncbi request reprint Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
    Filipa Carreira-Barbosa
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:4037-46. 2003
    ..In addition, Pk1 interacts with Tri to mediate posterior migration of branchiomotor neurons, probably independent of the noncanonical Wnt pathway...
  13. ncbi request reprint Bmp activity establishes a gradient of positional information throughout the entire neural plate
    K A Barth
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 126:4977-87. 1999
    ..These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm...
  14. pmc A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Genes Dev 15:1427-34. 2001
    ..Our data reveal a crucial role for Axin1-dependent inhibition of the Wnt pathway in the early regional subdivision of the anterior neural plate into telencephalic, diencephalic, and eye-forming territories...
  15. ncbi request reprint The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity
    K B Rohr
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 29:341-51. 2001
    ..Thus, the Nodal pathway regulates ventral forebrain patterning through both Hedgehog signaling-dependent and -independent mechanisms...
  16. ncbi request reprint Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis
    Elise Cau
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:2455-66. 2003
    ..These populations do not simply correspond to the two described epiphysial cell types: photoreceptors and projection neurones. These results suggest that the genetic pathways that involve ash1a and ngn1 are common to both neuronal types...
  17. pmc Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones
    Will H Norton
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Development 132:645-58. 2005
    ....
  18. pmc Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation
    Filipa Carreira-Barbosa
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 136:383-92. 2009
    ..Fmi/Celsr therefore has a dual role in mediating two separate morphogenetic movements through its roles in mediating cell cohesion and Wnt/PCP signalling during zebrafish gastrulation...
  19. pmc Identification of alternatively spliced dab1 isoforms in zebrafish
    Arianna Costagli
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Dev Genes Evol 216:291-9. 2006
    ....
  20. ncbi request reprint Conserved and divergent patterns of Reelin expression in the zebrafish central nervous system
    Arianna Costagli
    Department of Anatomy and Developmental Biology, University College London, WC1E 6BT London, United Kingdom
    J Comp Neurol 450:73-93. 2002
    ..Thus, the differences in the telencephalic expression of reelin between teleosts and tetrapods are likely to be due to different roles for Reelin during eversion, a process that is specific for the teleost telencephalon...
  21. ncbi request reprint A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain
    M L Concha
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Neuron 28:399-409. 2000
    ..This indicates that Nodal signaling is not required for asymmetric development per se but is essential to determine the laterality of the asymmetry...
  22. ncbi request reprint Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality
    Miguel L Concha
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Neuron 39:423-38. 2003
    ..From these data, we propose that laterality is determined by a competitive interaction between the left and right epithalamus and that Nodal signaling biases the outcome of this competition...
  23. pmc Asymmetry in the epithalamus of vertebrates
    M L Concha
    Department of Anatomy and Developmental Biology, University College London, UK
    J Anat 199:63-84. 2001
    ..A consistency of the laterality within a population may play a role in social behaviours between individuals of the species...
  24. ncbi request reprint Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College, London, UK
    Nature 405:76-81. 2000
    ..Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation...
  25. ncbi request reprint A small population of anterior cells patterns the forebrain during zebrafish gastrulation
    C Houart
    Developmental Biology Research Centre, The Randall Institute, Kings College London, UK
    Nature 391:788-92. 1998
    ..These cells are required for patterning and survival of the anterior brain...
  26. ncbi request reprint Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis
    Arantza Barrios
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    Curr Biol 13:1571-82. 2003
    ..These observations suggest a role for Eph/Ephrin signaling in the regulation of somite epithelialization...
  27. ncbi request reprint Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity
    Masaya Take-Uchi
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Development 130:955-68. 2003
    ..Taking all these results together, we present a model of the partitioning of the optic vesicle along its proximo-distal axis...
  28. ncbi request reprint Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
    Development 129:4335-46. 2002
    ..Thus, cyp26 has an important role in linking the Fgf, Wnt and RA signals to regulate AP patterning of the neural ectoderm in the late blastula to gastrula embryo in zebrafish...
  29. pmc Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:3581-92. 2004
    ..We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue...
  30. ncbi request reprint Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon
    S Shanmugalingam
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 127:2549-61. 2000
    ..However, as ace mutant neural plate cells still retain at least some inductive activity, then other signals must also be produced by the anterior margin of the neural plate...
  31. pmc Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
    ..Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could equally well be exploited to stimulate tissue vascularization in ischemic disease...
  32. pmc The zebrafish flotte lotte mutant reveals that the local retinal environment promotes the differentiation of proliferating precursors emerging from their stem cell niche
    Kara L Cerveny
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E6BT, UK
    Development 137:2107-15. 2010
    ....
  33. ncbi request reprint Programmed cell death in zebrafish rohon beard neurons is influenced by TrkC1/NT-3 signaling
    J A Williams
    Department of Anatomy and Developmental Biology, University College of London, London, United Kingdom
    Dev Biol 226:220-30. 2000
    ....
  34. ncbi request reprint Heparan sulfate 6-o-sulfotransferase is essential for muscle development in zebrafish
    Robert J Bink
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    J Biol Chem 278:31118-27. 2003
    ..In conclusion, our results show that transfer of sulfate to specific positions on glycosaminoglycans is essential for muscle development...
  35. pmc Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl
    Jae Yeon Jeong
    Department of Biopharmaceutical Sciences, Program in Human Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:5143-8. 2006
    ..These findings identify Ngn1 as a determinant of brain DA neurons and provide insights into how Tof/Fezl regulates the development of these clinically important neuronal types...
  36. ncbi request reprint Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud
    Heiner Grandel
    Max Planck Institute for Molecular Cell Biology and Genetics Dresden, Pfotenhauer Strasse 108, 01307 Dresden, Germany
    Development 129:2851-65. 2002
    ....
  37. ncbi request reprint N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites
    Ichiro Masai
    Masai Initiative Research Unit, The Institute of Physical and Chemical Research RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Development 130:2479-94. 2003
    ..Although in vitro studies have implicated Fgf receptors in modulating the axon outgrowth promoting properties of Ncad, most aspects of the Ncad mutant phenotype are not phenocopied by treatments that block Fgf receptor function...
  38. ncbi request reprint Lefty antagonism of Squint is essential for normal gastrulation
    Benjamin Feldman
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Curr Biol 12:2129-35. 2002
    ..Furthermore, we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 transcription...
  39. ncbi request reprint A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication
    Martin Paukert
    Department of Physiology II and Max Planck Institute of Developmental Biology, 72076 Tubingen, Germany
    J Biol Chem 279:18783-91. 2004
    ..This pattern suggests a predominant role for zASICs in neuronal communication. Our results suggest a conserved function for receptors of extracellular H(+) in the central nervous system of vertebrates...
  40. pmc Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation
    Florian Ulrich
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 130:5375-84. 2003
    ....
  41. pmc Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus
    Hidenori Aizawa
    Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Curr Biol 15:238-43. 2005
    ....
  42. pmc Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression
    Gaia Gestri
    Sezione di Biologia Cellulare e dello Sviluppo, Dipartimento di Fisiologia, e Biochimica, Universita degli Studi di Pisa, Via Carducci 13, 56010 Ghezzano Pisa, Italy
    Development 132:2401-13. 2005
    ..These results suggest a very early role for Six3 in specification of the anterior neural plate, through the regulation of cell proliferation and the inhibition of BMP signalling...
  43. ncbi request reprint Pax2.1 is required for the development of thyroid follicles in zebrafish
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, D 50923 Köln, Germany
    Development 129:3751-60. 2002
    ..Thus, in zebrafish, some remaining thyroid hormone synthesis takes place independent of the pathway leading to thyroid follicle formation. We suggest that the noi(-/-) mutant serves as a new zebrafish model for hypothyroidism...
  44. ncbi request reprint Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development
    Juliette Mathieu
    U 368 INSERM, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Development 129:3055-65. 2002
    ..Finally we show that it is the prechordal plate and not the head endoderm that provides the early signals essential for establishment of the hypothalamus...
  45. pmc The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis
    Thomas A Hawkins
    Department of Anatomy and Developmental Biology, UCL, London, UK
    Development 135:1147-56. 2008
    ..Our studies reveal a surprisingly specific developmental role for a single Hsp90 gene in a regulatory pathway controlling late steps in sarcomere assembly...