Michael C Willis

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Activating group recycling in action: a rhodium-catalyzed carbothiolation route to substituted isoquinolines
    Milan Arambasic
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U K
    Org Lett 15:5162-5. 2013
  2. doi request reprint Tandem inverse-electron-demand hetero-/retro-Diels-Alder reactions for aromatic nitrogen heterocycle synthesis
    Radleigh A A Foster
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Chem Soc Rev 42:63-76. 2013
  3. doi request reprint Aryl methyl sulfides as substrates for rhodium-catalyzed alkyne carbothiolation: arene functionalization with activating group recycling
    Joel F Hooper
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    J Am Chem Soc 134:2906-9. 2012
  4. doi request reprint O-substituted alkyl aldehydes for rhodium-catalyzed intermolecular alkyne hydroacylation: the utility of methylthiomethyl ethers
    Scott R Parsons
    Department of Chemistry, University of Oxford, Oxford, UK
    Org Lett 13:998-1000. 2011
  5. doi request reprint Palladium-catalysed aminosulfonylation of aryl-, alkenyl- and heteroaryl halides: scope of the three-component synthesis of N-aminosulfonamides
    Edward J Emmett
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Org Biomol Chem 10:4007-14. 2012
  6. doi request reprint Palladium-catalyzed synthesis of benzimidazoles and quinazolinones from common precursors
    Jessie E R Sadig
    Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
    J Org Chem 77:9473-86. 2012
  7. doi request reprint Cascade palladium-catalyzed alkenyl aminocarbonylation/ intramolecular aryl amidation: an annulative synthesis of 2-quinolones
    Andrew C Tadd
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    Org Lett 11:583-6. 2009
  8. doi request reprint Catalytic enantioselective desymmetrisation as a tool for the synthesis of hodgkinsine and hodgkinsine B
    Robert H Snell
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, UK
    Chemistry 18:16754-64. 2012
  9. ncbi request reprint Intermolecular hydroacylation: high activity rhodium catalysts containing small-bite-angle diphosphine ligands
    Adrian B Chaplin
    Department of Chemistry, Inorganic Chemistry Laboratories, University of Oxford, South Parks Road, Oxford OX1 3QR, U K
    J Am Chem Soc 134:4885-97. 2012
  10. doi request reprint Palladium-Catalyzed Three-Component Diaryl Sulfone Synthesis Exploiting the Sulfur Dioxide Surrogate DABSO
    Edward J Emmett
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA UK http mcwillis chem ox ac uk MCW Home html
    Angew Chem Int Ed Engl 52:12679-83. 2013

Collaborators

  • Isabel Marco
  • Joel F Hooper
  • Edward J Emmett
  • Andrew S Weller
  • Adrian B Chaplin
  • Bao Nguyen
  • Alex S Deeming
  • Radleigh A A Foster
  • Matthias Castaing
  • Milan Arambasic
  • Barry R Hayter
  • Robert H Snell
  • Jessie E R Sadig
  • Carlos González-Rodríguez
  • Amber L Thompson
  • Holly Woolven
  • Scott R Parsons
  • Andrew C Tadd
  • James D Osborne
  • Claire J Russell
  • Alan J Hennessy
  • Sacha L Wason
  • Beatriz Estepa
  • Rowan D Young
  • Radleigh Foster
  • Robert L Woodward
  • Matthew J Durbin
  • Charlotte S Richards-Taylor
  • Alfonso García-Rubia
  • Florian Wakenhut
  • Ai Matsuno
  • Mark R Fielding
  • Andrew R Cowley
  • Helen E Randell-Sly
  • Gordon S Currie

Detail Information

Publications16

  1. pmc Activating group recycling in action: a rhodium-catalyzed carbothiolation route to substituted isoquinolines
    Milan Arambasic
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U K
    Org Lett 15:5162-5. 2013
    ..The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines. ..
  2. doi request reprint Tandem inverse-electron-demand hetero-/retro-Diels-Alder reactions for aromatic nitrogen heterocycle synthesis
    Radleigh A A Foster
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Chem Soc Rev 42:63-76. 2013
    ..In this tutorial review we discuss the range of commonly used dienophiles and aza-dienes for this process whilst highlighting the reactivity trends, and illustrating their applications...
  3. doi request reprint Aryl methyl sulfides as substrates for rhodium-catalyzed alkyne carbothiolation: arene functionalization with activating group recycling
    Joel F Hooper
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    J Am Chem Soc 134:2906-9. 2012
    ..The utility of the alkenyl sulfide products is also demonstrated in simple carbo- and heterocycle-forming processes. We also provide mechanistic evidence for the course of this new process...
  4. doi request reprint O-substituted alkyl aldehydes for rhodium-catalyzed intermolecular alkyne hydroacylation: the utility of methylthiomethyl ethers
    Scott R Parsons
    Department of Chemistry, University of Oxford, Oxford, UK
    Org Lett 13:998-1000. 2011
    ..The product MTM ethers can be converted to the free hydroxyl group either in situ, by the addition of water to the completed reaction, or in a separate operation, by the action of silver nitrate...
  5. doi request reprint Palladium-catalysed aminosulfonylation of aryl-, alkenyl- and heteroaryl halides: scope of the three-component synthesis of N-aminosulfonamides
    Edward J Emmett
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Org Biomol Chem 10:4007-14. 2012
    ..The ability to employ hydrazine·SO(2) complexes as both the N-nucleophile and SO(2) source is also illustrated...
  6. doi request reprint Palladium-catalyzed synthesis of benzimidazoles and quinazolinones from common precursors
    Jessie E R Sadig
    Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
    J Org Chem 77:9473-86. 2012
    ..Both processes tolerate a wide range of functional groups...
  7. doi request reprint Cascade palladium-catalyzed alkenyl aminocarbonylation/ intramolecular aryl amidation: an annulative synthesis of 2-quinolones
    Andrew C Tadd
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    Org Lett 11:583-6. 2009
    ..Delaying the introduction of the CO atmosphere allows an amination/carbonylation sequence and the preparation of an isoquinolone...
  8. doi request reprint Catalytic enantioselective desymmetrisation as a tool for the synthesis of hodgkinsine and hodgkinsine B
    Robert H Snell
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, UK
    Chemistry 18:16754-64. 2012
    ..The power of these transformations is showcased in an efficient formal and total synthesis of the natural products hodgkinsine and hodgkinsine B, respectively...
  9. ncbi request reprint Intermolecular hydroacylation: high activity rhodium catalysts containing small-bite-angle diphosphine ligands
    Adrian B Chaplin
    Department of Chemistry, Inorganic Chemistry Laboratories, University of Oxford, South Parks Road, Oxford OX1 3QR, U K
    J Am Chem Soc 134:4885-97. 2012
    ....
  10. doi request reprint Palladium-Catalyzed Three-Component Diaryl Sulfone Synthesis Exploiting the Sulfur Dioxide Surrogate DABSO
    Edward J Emmett
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA UK http mcwillis chem ox ac uk MCW Home html
    Angew Chem Int Ed Engl 52:12679-83. 2013
    ..An electron-poor XantPhos-type ligand suppresses aryl-aryl exchange and is key to obtaining high yields. ..
  11. doi request reprint Traceless chelation-controlled rhodium-catalyzed intermolecular alkene and alkyne hydroacylation
    Joel F Hooper
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Chemistry 19:3125-30. 2013
    ..Aryl- and alkenyl aldehydes can be combined with both alkenes, alkynes and allenes to give traceless products in high yields. A preliminary mechanistic proposal is also presented...
  12. ncbi request reprint Catalytic enantioselective intermolecular hydroacylation: rhodium-catalyzed combination of beta-S-aldehydes and 1,3-disubstituted allenes
    James D Osborne
    Department of Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford, UK
    J Am Chem Soc 130:17232-3. 2008
    ..The nonconjugated enone products are obtained in good yields and with high enantioselectivities...
  13. doi request reprint DABCO-bis(sulfur dioxide), DABSO, as a convenient source of sulfur dioxide for organic synthesis: utility in sulfonamide and sulfamide preparation
    Holly Woolven
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Org Lett 13:4876-8. 2011
    ..Alternatively, reaction with anilines and iodine leads to the formation of a series of sulfamides. Cheletropic addition between DABSO and 2,3-dimethylbutadiene provides the corresponding sulfolene...
  14. doi request reprint 2-aminobenzaldehydes as versatile substrates for rhodium-catalyzed alkyne hydroacylation: application to dihydroquinolone synthesis
    Matthias Castaing
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA UK http mcwillis chem ox ac uk MCW Home html
    Angew Chem Int Ed Engl 52:13280-3. 2013
    ..The products of this reaction, amino-substituted enones, were efficiently converted into the corresponding dihydro-4-quinolones. ..
  15. pmc DABSO-based, three-component, one-pot sulfone synthesis
    Alex S Deeming
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom
    Org Lett 16:150-3. 2014
    ..The metal sulfinates can be trapped in situ with a wide range of C-electrophiles, including alkyl, allyl, and benzyl halides, epoxides, and (hetero)aryliodoniums. ..
  16. ncbi request reprint Palladium-catalyzed aminosulfonylation of aryl halides
    Bao Nguyen
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    J Am Chem Soc 132:16372-3. 2010
    ..The colorless crystalline solid DABCO·(SO(2))(2) was used as a convenient source of sulfur dioxide. The reaction tolerates significant variation of both the aryl iodide and hydrazine coupling partners...